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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BRD9-TPPP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BRD9-TPPP
	FusionPDB ID: 10230
	FusionGDB2.0 ID: 10230
		Hgene	Tgene
	Gene symbol	BRD9	TPPP
	Gene ID	65980	11076
	Gene name	bromodomain containing 9	tubulin polymerization promoting protein
	Synonyms	LAVS3040\|PRO9856	TPPP/p25\|TPPP1\|p24\|p25\|p25alpha
	Cytomap	5p15.33	5p15.33
	Type of gene	protein-coding	protein-coding
	Description	bromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29	tubulin polymerization-promoting protein25 kDa brain-specific proteinbrain specific protein p25 alphaglycogen synthase kinase 3 (GSK3) inhibitor p24p25-alpha
	Modification date	20200315	20200322
	UniProtAcc	Q9H8M2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000494422, ENST00000435709, ENST00000323510, ENST00000388890, ENST00000467963, ENST00000483173,	ENST00000360578,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 15 X 7=1050	4 X 2 X 3=24
	# samples	12	5
	** MAII score	log2(12/1050*10)=-3.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BRD9 [Title/Abstract] AND TPPP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TPPP(693393)-BRD9(880004), # samples:5 BRD9(886707)-TPPP(666238), # samples:2
Anticipated loss of major functional domain due to fusion event.	BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. BRD9-TPPP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TPPP	GO:0001578	microtubule bundle formation	17105200\|26289831
Tgene	TPPP	GO:0030953	astral microtubule organization	22328514
Tgene	TPPP	GO:0032273	positive regulation of protein polymerization	15590652
Tgene	TPPP	GO:0046785	microtubule polymerization	18028908
Tgene	TPPP	GO:0051418	microtubule nucleation by microtubule organizing center	31522887
Tgene	TPPP	GO:0070507	regulation of microtubule cytoskeleton organization	23093407
Tgene	TPPP	GO:1904428	negative regulation of tubulin deacetylation	20308065\|23093407

Fusion gene breakpoints across BRD9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TPPP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-83-5908-01A	BRD9	chr5	886707	-	TPPP	chr5	666238	-
ChimerDB4	LUAD	TCGA-83-5908	BRD9	chr5	886706	-	TPPP	chr5	666238	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000388890	BRD9	chr5	886707	-	ENST00000360578	TPPP	chr5	666238	-	5168	485	0	833	277
ENST00000323510	BRD9	chr5	886707	-	ENST00000360578	TPPP	chr5	666238	-	5228	545	0	893	297
ENST00000483173	BRD9	chr5	886707	-	ENST00000360578	TPPP	chr5	666238	-	5497	814	104	1162	352
ENST00000467963	BRD9	chr5	886707	-	ENST00000360578	TPPP	chr5	666238	-	5683	1000	167	1348	393
ENST00000388890	BRD9	chr5	886706	-	ENST00000360578	TPPP	chr5	666238	-	5168	485	0	833	277
ENST00000323510	BRD9	chr5	886706	-	ENST00000360578	TPPP	chr5	666238	-	5228	545	0	893	297
ENST00000483173	BRD9	chr5	886706	-	ENST00000360578	TPPP	chr5	666238	-	5497	814	104	1162	352
ENST00000467963	BRD9	chr5	886706	-	ENST00000360578	TPPP	chr5	666238	-	5683	1000	167	1348	393

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000388890	ENST00000360578	BRD9	chr5	886707	-	TPPP	chr5	666238	-	0.00370277	0.9962972
ENST00000323510	ENST00000360578	BRD9	chr5	886707	-	TPPP	chr5	666238	-	0.00278283	0.9972172
ENST00000483173	ENST00000360578	BRD9	chr5	886707	-	TPPP	chr5	666238	-	0.024895385	0.9751047
ENST00000467963	ENST00000360578	BRD9	chr5	886707	-	TPPP	chr5	666238	-	0.002833531	0.99716645
ENST00000388890	ENST00000360578	BRD9	chr5	886706	-	TPPP	chr5	666238	-	0.00370277	0.9962972
ENST00000323510	ENST00000360578	BRD9	chr5	886706	-	TPPP	chr5	666238	-	0.00278283	0.9972172
ENST00000483173	ENST00000360578	BRD9	chr5	886706	-	TPPP	chr5	666238	-	0.024895385	0.9751047
ENST00000467963	ENST00000360578	BRD9	chr5	886706	-	TPPP	chr5	666238	-	0.002833531	0.99716645

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10230_10230_1_BRD9-TPPP_BRD9_chr5_886706_ENST00000323510_TPPP_chr5_666238_ENST00000360578_length(amino acids)=297AA_BP=0
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
IRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGR

--------------------------------------------------------------

>10230_10230_2_BRD9-TPPP_BRD9_chr5_886706_ENST00000388890_TPPP_chr5_666238_ENST00000360578_length(amino acids)=277AA_BP=0
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVIRGKSCRTITFEQFQEALEE
LAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYD

--------------------------------------------------------------

>10230_10230_3_BRD9-TPPP_BRD9_chr5_886706_ENST00000467963_TPPP_chr5_666238_ENST00000360578_length(amino acids)=393AA_BP=0
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVIRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKG

--------------------------------------------------------------

>10230_10230_4_BRD9-TPPP_BRD9_chr5_886706_ENST00000483173_TPPP_chr5_666238_ENST00000360578_length(amino acids)=352AA_BP=1
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVIRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAV

--------------------------------------------------------------

>10230_10230_5_BRD9-TPPP_BRD9_chr5_886707_ENST00000323510_TPPP_chr5_666238_ENST00000360578_length(amino acids)=297AA_BP=0
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
IRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGR

--------------------------------------------------------------

>10230_10230_6_BRD9-TPPP_BRD9_chr5_886707_ENST00000388890_TPPP_chr5_666238_ENST00000360578_length(amino acids)=277AA_BP=0
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVIRGKSCRTITFEQFQEALEE
LAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYD

--------------------------------------------------------------

>10230_10230_7_BRD9-TPPP_BRD9_chr5_886707_ENST00000467963_TPPP_chr5_666238_ENST00000360578_length(amino acids)=393AA_BP=0
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVIRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKG

--------------------------------------------------------------

>10230_10230_8_BRD9-TPPP_BRD9_chr5_886707_ENST00000483173_TPPP_chr5_666238_ENST00000360578_length(amino acids)=352AA_BP=1
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVIRGKSCRTITFEQFQEALEELAKKRFKDKSSEEAV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:693393/chr5:880004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRD9 Q9H8M2	.
FUNCTION: Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269\|PubMed:22464331, ECO:0000269\|PubMed:26365797, ECO:0000269\|PubMed:29374058, ECO:0000269\|PubMed:32457312}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000323510

64_95

181.66666666666666

502.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000388890

64_95

161.66666666666666

482.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000467963

64_95

277.6666666666667

598.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000483173

64_95

224.66666666666666

545.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000323510

64_95

181.66666666666666

502.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000388890

64_95

161.66666666666666

482.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000467963

64_95

277.6666666666667

598.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000483173

64_95

224.66666666666666

545.0

Compositional bias

Note=Lys-rich

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000467963

153_223

277.6666666666667

598.0

Domain

Bromo

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000483173

153_223

224.66666666666666

545.0

Domain

Bromo

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000467963

153_223

277.6666666666667

598.0

Domain

Bromo

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000483173

153_223

224.66666666666666

545.0

Domain

Bromo

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000467963

214_216

277.6666666666667

598.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000483173

214_216

224.66666666666666

545.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000467963

214_216

277.6666666666667

598.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000483173

214_216

224.66666666666666

545.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Tgene

TPPP

chr5:886706

chr5:666238

ENST00000360578

171_192

103.66666666666667

220.0

Region

Disordered

Tgene

TPPP

chr5:886707

chr5:666238

ENST00000360578

171_192

103.66666666666667

220.0

Region

Disordered

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000323510

153_223

181.66666666666666

502.0

Domain

Bromo

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000388890

153_223

161.66666666666666

482.0

Domain

Bromo

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000323510

153_223

181.66666666666666

502.0

Domain

Bromo

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000388890

153_223

161.66666666666666

482.0

Domain

Bromo

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000323510

214_216

181.66666666666666

502.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886706

chr5:666238

ENST00000388890

214_216

161.66666666666666

482.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000323510

214_216

181.66666666666666

502.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Hgene

BRD9

chr5:886707

chr5:666238

ENST00000388890

214_216

161.66666666666666

482.0

Region

Histone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding

Tgene

TPPP

chr5:886706

chr5:666238

ENST00000360578

1_46

103.66666666666667

220.0

Region

Disordered

Tgene

TPPP

chr5:886707

chr5:666238

ENST00000360578

1_46

103.66666666666667

220.0

Region

Disordered

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

BRD9

BRD4, WHSC1L1, CATIP, SS18, SMARCD1, MUS81, NFE2L1, CXXC4, BCL7C, BCL7A, SMARCC2, TRIM25, UBE2A, RUNX1, DPF2, INO80, INO80E, THAP3, WDR5, MED8, TRRAP, GEMIN5, ACTL6A, MCM2, CNOT1, CENPA, MED14, PSME3, ATG16L1, NR2C2, GLTSCR1, SMARCA4, GLTSCR1L, ESR1, CHMP4B, ECT2, PRC1, BRD2, BRD3, SMARCC1, SMARCA2, NOLC1, CKAP4, RCN2, SLC25A13, PGAM5, SLC25A11, TCOF1, MSH6, SLC25A12, DNAJA2, SLC16A1, LBR, TUFM, CSNK2A1, RIN3, DPF1, SMARCD3, BRD7, ARID1A, ARID2, ARID1B, DPF3, STK11IP, SMARCD2, SMARCB1, SS18L1, PBRM1, PHF10, SMARCE1, ACTC1, RAD51, ATRX, ZCCHC10, SS18L2, RNPS1, MAPKAPK2, PPARG, HSPBP1, SRRM2, JMJD6, AP3B1, PNN, RDH13, EPB41L2, CWC22, NAF1, RANBP6, TUBA1B, JMY,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BRD9
TPPP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to BRD9-TPPP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to BRD9-TPPP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BRD9	C0036920	Sezary Syndrome	1	CTD_human