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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF564-CACNA1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF564-CACNA1A
FusionPDB ID: 102383
FusionGDB2.0 ID: 102383
HgeneTgene
Gene symbol

ZNF564

CACNA1A

Gene ID

163050

773

Gene namezinc finger protein 564calcium voltage-gated channel subunit alpha1 A
Synonyms-APCA|BI|CACNL1A4|CAV2.1|EA2|EIEE42|FHM|HPCA|MHP|MHP1|SCA6
Cytomap

19p13.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 564voltage-dependent P/Q-type calcium channel subunit alpha-1Abrain calcium channel 1brain calcium channel Icalcium channel, L type, alpha-1 polypeptidecalcium channel, voltage-dependent, P/Q type, alpha 1A subunitfetal brain Ca2+ voltage-gated channel
Modification date2020031320200329
UniProtAcc.

O00555

Ensembl transtripts involved in fusion geneENST idsENST00000339282, ENST00000416136, 
ENST00000360228, ENST00000573710, 
ENST00000574822, ENST00000592864, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 3 X 7=18932 X 28 X 10=8960
# samples 1434
** MAII scorelog2(14/189*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/8960*10)=-4.71989208080726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF564 [Title/Abstract] AND CACNA1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF564(12662144)-CACNA1A(13397780), # samples:2
ZNF564(12662144)-CACNA1A(13630317), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF564-CACNA1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF564-CACNA1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF564-CACNA1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF564-CACNA1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCACNA1A

GO:0007204

positive regulation of cytosolic calcium ion concentration

10753886

TgeneCACNA1A

GO:0008219

cell death

16595610

TgeneCACNA1A

GO:0050804

modulation of chemical synaptic transmission

23376566

TgeneCACNA1A

GO:0070588

calcium ion transmembrane transport

24836863|26716990

TgeneCACNA1A

GO:1904645

response to amyloid-beta

18216187|23376566

TgeneCACNA1A

GO:1904646

cellular response to amyloid-beta

21883149


check buttonFusion gene breakpoints across ZNF564 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CACNA1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-S9-A6WM-01AZNF564chr19

12662144

-CACNA1Achr19

13397780

-
ChimerDB4LGGTCGA-S9-A6WMZNF564chr19

12662143

-CACNA1Achr19

13397780

-
ChimerDB4LGGTCGA-S9-A6WMZNF564chr19

12662144

-CACNA1Achr19

13397780

-
ChimerDB4UCECTCGA-AP-A5FX-01AZNF564chr19

12662144

-CACNA1Achr19

13630317

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339282ZNF564chr1912662144-ENST00000592864CACNA1Achr1913630317-72920053409118
ENST00000416136ZNF564chr1912662144-ENST00000592864CACNA1Achr1913630317-6341053031494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339282ENST00000592864ZNF564chr1912662144-CACNA1Achr1913630317-0.76375260.23624739
ENST00000416136ENST00000592864ZNF564chr1912662144-CACNA1Achr1913630317-0.87192970.12807034

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102383_102383_1_ZNF564-CACNA1A_ZNF564_chr19_12662144_ENST00000339282_CACNA1A_chr19_13630317_ENST00000592864_length(amino acids)=118AA_BP=49
MFRVRCVWVPVSASPVAPVAPPQRLARWDLHRPERAVGRTPGHPGSQEMEATRGCASPKQGSKPRRGKQRTLDLRNPTMRSKGNLLDDDK

--------------------------------------------------------------

>102383_102383_2_ZNF564-CACNA1A_ZNF564_chr19_12662144_ENST00000416136_CACNA1A_chr19_13630317_ENST00000592864_length(amino acids)=94AA_BP=25
MARWDLHRPERAVGRTPGHPGSQEMEATRGCASPKQGSKPRRGKQRTLDLRNPTMRSKGNLLDDDKERAQDESCMPGKVLIRPCDKSSGK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:12662144/chr19:13397780)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CACNA1A

O00555

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). They are however insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:P54282, ECO:0000269|PubMed:10049321, ECO:0000269|PubMed:10753886, ECO:0000269|PubMed:11723274, ECO:0000269|PubMed:15293273, ECO:0000269|PubMed:19232643, ECO:0000269|PubMed:24836863, ECO:0000269|PubMed:26716990}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471839_18500.02507.0Calcium bindingOntology_term=ECO:0000250
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471839_185002262.0Calcium bindingOntology_term=ECO:0000250
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471001_10060.02507.0Compositional biasNote=Poly-Arg
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471203_12060.02507.0Compositional biasNote=Poly-Glu
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000036022804713_180.02507.0Compositional biasNote=Poly-Gly
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280472210_22190.02507.0Compositional biasNote=Poly-His
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280472220_22230.02507.0Compositional biasNote=Poly-Pro
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280472313_23230.02507.0Compositional biasNote=Poly-Gln
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047726_7310.02507.0Compositional biasNote=Poly-Glu
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471001_100602262.0Compositional biasNote=Poly-Arg
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471203_120602262.0Compositional biasNote=Poly-Glu
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000057371004713_1802262.0Compositional biasNote=Poly-Gly
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100472210_221902262.0Compositional biasNote=Poly-His
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100472220_222302262.0Compositional biasNote=Poly-Pro
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100472313_232302262.0Compositional biasNote=Poly-Gln
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047726_73102262.0Compositional biasNote=Poly-Glu
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047383_4000.02507.0RegionBinding to the beta subunit
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047383_40002262.0RegionBinding to the beta subunit
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471230_15130.02507.0RepeatNote=III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471550_18130.02507.0RepeatNote=IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047472_7160.02507.0RepeatNote=II
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000036022804785_3630.02507.0RepeatNote=I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471230_151302262.0RepeatNote=III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471550_181302262.0RepeatNote=IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047472_71602262.0RepeatNote=II
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000057371004785_36302262.0RepeatNote=I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047118_1350.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471261_12760.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471297_13080.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471328_13380.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471358_13760.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471397_14830.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471509_15630.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047156_1670.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471593_15970.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471618_16250.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471645_16510.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471671_16890.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471710_17810.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471807_25060.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047186_1900.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471_980.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047210_2280.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047249_3350.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047361_4860.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047506_5200.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047541_5480.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047568_5770.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047597_6150.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047636_6880.02507.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047714_12410.02507.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047118_13502262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471261_127602262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471297_130802262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471328_133802262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471358_137602262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471397_148302262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471509_156302262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047156_16702262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471593_159702262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471618_162502262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471645_165102262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471671_168902262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471710_178102262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471807_250602262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047186_19002262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471_9802262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047210_22802262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047249_33502262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047361_48602262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047506_52002262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047541_54802262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047568_57702262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047597_61502262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047636_68802262.0Topological domainExtracellular
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047714_124102262.0Topological domainCytoplasmic
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471242_12600.02507.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471277_12960.02507.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471309_13270.02507.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471339_13570.02507.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047136_1550.02507.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471377_13960.02507.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471484_15080.02507.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471564_15920.02507.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471598_16170.02507.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471626_16440.02507.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471652_16700.02507.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047168_1850.02507.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471690_17090.02507.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000003602280471782_18060.02507.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047191_2090.02507.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047229_2480.02507.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047336_3600.02507.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047487_5050.02507.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047521_5400.02507.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047549_5670.02507.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047578_5960.02507.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047616_6350.02507.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000360228047689_7130.02507.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000036022804799_1170.02507.0TransmembraneHelical%3B Name%3DS1 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471242_126002262.0TransmembraneHelical%3B Name%3DS1 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471277_129602262.0TransmembraneHelical%3B Name%3DS2 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471309_132702262.0TransmembraneHelical%3B Name%3DS3 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471339_135702262.0TransmembraneHelical%3B Name%3DS4 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047136_15502262.0TransmembraneHelical%3B Name%3DS2 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471377_139602262.0TransmembraneHelical%3B Name%3DS5 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471484_150802262.0TransmembraneHelical%3B Name%3DS6 of repeat III
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471564_159202262.0TransmembraneHelical%3B Name%3DS1 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471598_161702262.0TransmembraneHelical%3B Name%3DS2 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471626_164402262.0TransmembraneHelical%3B Name%3DS3 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471652_167002262.0TransmembraneHelical%3B Name%3DS4 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047168_18502262.0TransmembraneHelical%3B Name%3DS3 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471690_170902262.0TransmembraneHelical%3B Name%3DS5 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST000005737100471782_180602262.0TransmembraneHelical%3B Name%3DS6 of repeat IV
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047191_20902262.0TransmembraneHelical%3B Name%3DS4 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047229_24802262.0TransmembraneHelical%3B Name%3DS5 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047336_36002262.0TransmembraneHelical%3B Name%3DS6 of repeat I
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047487_50502262.0TransmembraneHelical%3B Name%3DS1 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047521_54002262.0TransmembraneHelical%3B Name%3DS2 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047549_56702262.0TransmembraneHelical%3B Name%3DS3 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047578_59602262.0TransmembraneHelical%3B Name%3DS4 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047616_63502262.0TransmembraneHelical%3B Name%3DS5 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST00000573710047689_71302262.0TransmembraneHelical%3B Name%3DS6 of repeat II
TgeneCACNA1Achr19:12662144chr19:13630317ENST0000057371004799_11702262.0TransmembraneHelical%3B Name%3DS1 of repeat I

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-144_831.0554.0DomainKRAB
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14103_1251.0554.0Zinc fingerC2H2-type 1
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14141_1631.0554.0Zinc fingerC2H2-type 2
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14169_1911.0554.0Zinc fingerC2H2-type 3
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14197_2191.0554.0Zinc fingerC2H2-type 4
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14225_2471.0554.0Zinc fingerC2H2-type 5
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14253_2751.0554.0Zinc fingerC2H2-type 6
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14281_3031.0554.0Zinc fingerC2H2-type 7
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14309_3311.0554.0Zinc fingerC2H2-type 8
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14337_3591.0554.0Zinc fingerC2H2-type 9
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14365_3871.0554.0Zinc fingerC2H2-type 10
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14393_4151.0554.0Zinc fingerC2H2-type 11
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14421_4431.0554.0Zinc fingerC2H2-type 12
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14449_4711.0554.0Zinc fingerC2H2-type 13
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14477_4991.0554.0Zinc fingerC2H2-type 14
HgeneZNF564chr19:12662144chr19:13630317ENST00000339282-14505_5271.0554.0Zinc fingerC2H2-type 15


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF564
CACNA1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF564-CACNA1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF564-CACNA1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource