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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF586-AURKC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF586-AURKC
FusionPDB ID: 102456
FusionGDB2.0 ID: 102456
HgeneTgene
Gene symbol

ZNF586

AURKC

Gene ID

54807

6795

Gene namezinc finger protein 586aurora kinase C
Synonyms-AIE2|AIK3|ARK3|AurC|HEL-S-90|SPGF5|STK13|aurora-C
Cytomap

19q13.43

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 586aurora kinase CARK-3aurora 3aurora-related kinase 3aurora/IPL1-related kinase 3aurora/IPL1/EG2 protein 2epididymis secretory protein Li 90serine/threonine kinase 13 (aurora/IPL1-like)serine/threonine-protein kinase 13serine/threonine-protein kina
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000598183, ENST00000598885, 
ENST00000391702, ENST00000396150, 
ENST00000396154, ENST00000599802, 
ENST00000302804, ENST00000448930, 
ENST00000598785, ENST00000599062, 
ENST00000415300, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 5=1505 X 4 X 3=60
# samples 75
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF586 [Title/Abstract] AND AURKC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF586(58301768)-AURKC(57743110), # samples:1
Anticipated loss of major functional domain due to fusion event.ZNF586-AURKC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF586-AURKC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF586-AURKC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF586-AURKC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAURKC

GO:0006468

protein phosphorylation

15670791


check buttonFusion gene breakpoints across ZNF586 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AURKC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914ZNF586chr19

58301768

+AURKCchr19

57743110

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000598885ZNF586chr1958301768+ENST00000415300AURKCchr1957743110+1217345171216400
ENST00000598183ZNF586chr1958301768+ENST00000415300AURKCchr1957743110+1211339111210400

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000598885ENST00000415300ZNF586chr1958301768+AURKCchr1957743110+0.0036994660.99630046
ENST00000598183ENST00000415300ZNF586chr1958301768+AURKCchr1957743110+0.0035289490.99647105

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102456_102456_1_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598183_AURKC_chr19_57743110_ENST00000415300_length(amino acids)=400AA_BP=66
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLVATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRR
EIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLI

--------------------------------------------------------------

>102456_102456_2_ZNF586-AURKC_ZNF586_chr19_58301768_ENST00000598885_AURKC_chr19_57743110_ENST00000415300_length(amino acids)=400AA_BP=66
MSGPSGDAGSGRAREEWLWPLHTGGSEVRRRRWSRPGTGQRQEHRRARVPPPPRVMAAAAALRAPAQSSVTFEDVAVNFSLEEWSLLNEA
QGCLYHDVMLETLTLISSLVATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRR
EIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58301768/chr19:57743110)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAURKCchr19:58301768chr19:57743110ENST000003028040743_29319.333333333333332310.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000004153000743_2930.3333333333333333291.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000004489300743_2930276.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000005987850643_2930276.0DomainProtein kinase
TgeneAURKCchr19:58301768chr19:57743110ENST000003028040749_5719.333333333333332310.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000004153000749_570.3333333333333333291.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000004489300749_570276.0Nucleotide bindingATP
TgeneAURKCchr19:58301768chr19:57743110ENST000005987850649_570276.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+1415_870360.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+1215_870211.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+1315_870403.0DomainKRAB
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14122_1440360.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14150_1720360.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14178_2000360.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14206_2280360.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14234_2560360.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14262_2840360.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14290_3120360.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14317_3390360.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14345_3670360.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+14373_3950360.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000391702+1488_1160360.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12122_1440211.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12150_1720211.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12178_2000211.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12206_2280211.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12234_2560211.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12262_2840211.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12290_3120211.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12317_3390211.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12345_3670211.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+12373_3950211.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000396150+1288_1160211.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13122_1440403.0Zinc fingerC2H2-type 2%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13150_1720403.0Zinc fingerC2H2-type 3%3B degenerate
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13178_2000403.0Zinc fingerC2H2-type 4
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13206_2280403.0Zinc fingerC2H2-type 5
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13234_2560403.0Zinc fingerC2H2-type 6
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13262_2840403.0Zinc fingerC2H2-type 7
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13290_3120403.0Zinc fingerC2H2-type 8
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13317_3390403.0Zinc fingerC2H2-type 9
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13345_3670403.0Zinc fingerC2H2-type 10
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+13373_3950403.0Zinc fingerC2H2-type 11
HgeneZNF586chr19:58301768chr19:57743110ENST00000396154+1388_1160403.0Zinc fingerC2H2-type 1%3B degenerate


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF586
AURKC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF586-AURKC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF586-AURKC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource