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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ZNF773-PPP2R1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ZNF773-PPP2R1A
FusionPDB ID: 102900
FusionGDB2.0 ID: 102900
HgeneTgene
Gene symbol

ZNF773

PPP2R1A

Gene ID

374928

5518

Gene namezinc finger protein 773protein phosphatase 2 scaffold subunit Aalpha
SynonymsZNF419BMRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65A
Cytomap

19q13.43

19q13.41

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 773zinc finger protein 419Bserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (P
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000282292, ENST00000593916, 
ENST00000598770, ENST00000599847, 
ENST00000473455, ENST00000462990, 
ENST00000477989, ENST00000444322, 
ENST00000322088, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 3 X 2=1210 X 12 X 4=480
# samples 212
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ZNF773 [Title/Abstract] AND PPP2R1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ZNF773(58011481)-PPP2R1A(52705197), # samples:2
Anticipated loss of major functional domain due to fusion event.ZNF773-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ZNF773-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP2R1A

GO:0007059

chromosome segregation

16580887


check buttonFusion gene breakpoints across ZNF773 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5RV-01AZNF773chr19

58011481

+PPP2R1Achr19

52705197

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000593916ZNF773chr1958011481+ENST00000322088PPP2R1Achr1952705197+33441991661890574
ENST00000598770ZNF773chr1958011481+ENST00000322088PPP2R1Achr1952705197+33241791461870574
ENST00000599847ZNF773chr1958011481+ENST00000322088PPP2R1Achr1952705197+33201751421866574
ENST00000282292ZNF773chr1958011481+ENST00000322088PPP2R1Achr1952705197+33181731401864574

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000593916ENST00000322088ZNF773chr1958011481+PPP2R1Achr1952705197+0.0014182990.99858177
ENST00000598770ENST00000322088ZNF773chr1958011481+PPP2R1Achr1952705197+0.0013516270.99864835
ENST00000599847ENST00000322088ZNF773chr1958011481+PPP2R1Achr1952705197+0.0013737290.99862623
ENST00000282292ENST00000322088ZNF773chr1958011481+PPP2R1Achr1952705197+0.0013701070.9986299

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>102900_102900_1_ZNF773-PPP2R1A_ZNF773_chr19_58011481_ENST00000282292_PPP2R1A_chr19_52705197_ENST00000322088_length(amino acids)=574AA_BP=11
MAAATLRDPAQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVR
DKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKV
LELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVP
AFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD
ECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSN
LKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNST

--------------------------------------------------------------

>102900_102900_2_ZNF773-PPP2R1A_ZNF773_chr19_58011481_ENST00000593916_PPP2R1A_chr19_52705197_ENST00000322088_length(amino acids)=574AA_BP=11
MAAATLRDPAQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVR
DKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKV
LELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVP
AFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD
ECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSN
LKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNST

--------------------------------------------------------------

>102900_102900_3_ZNF773-PPP2R1A_ZNF773_chr19_58011481_ENST00000598770_PPP2R1A_chr19_52705197_ENST00000322088_length(amino acids)=574AA_BP=11
MAAATLRDPAQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVR
DKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKV
LELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVP
AFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD
ECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSN
LKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNST

--------------------------------------------------------------

>102900_102900_4_ZNF773-PPP2R1A_ZNF773_chr19_58011481_ENST00000599847_PPP2R1A_chr19_52705197_ENST00000322088_length(amino acids)=574AA_BP=11
MAAATLRDPAQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVR
DKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKV
LELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVP
AFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKD
ECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSN
LKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNST

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:58011481/chr19:52705197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015400_58926.0590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr19:58011481chr19:52705197ENST0000032208801547_32126.0590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr19:58011481chr19:52705197ENST0000032208801585_23926.0590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015124_16126.0590.0RepeatNote=HEAT 4
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015162_20026.0590.0RepeatNote=HEAT 5
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015201_23926.0590.0RepeatNote=HEAT 6
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015240_27826.0590.0RepeatNote=HEAT 7
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015279_32126.0590.0RepeatNote=HEAT 8
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015322_36026.0590.0RepeatNote=HEAT 9
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015361_39926.0590.0RepeatNote=HEAT 10
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015400_43826.0590.0RepeatNote=HEAT 11
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015439_47726.0590.0RepeatNote=HEAT 12
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015478_51626.0590.0RepeatNote=HEAT 13
TgenePPP2R1Achr19:58011481chr19:52705197ENST0000032208801547_8426.0590.0RepeatNote=HEAT 2
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015517_55526.0590.0RepeatNote=HEAT 14
TgenePPP2R1Achr19:58011481chr19:52705197ENST00000322088015556_58926.0590.0RepeatNote=HEAT 15
TgenePPP2R1Achr19:58011481chr19:52705197ENST0000032208801585_12326.0590.0RepeatNote=HEAT 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+1415_8611.0443.0DomainKRAB
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+1415_8611.0442.0DomainKRAB
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14191_21311.0443.0Zinc fingerC2H2-type 1
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14219_24111.0443.0Zinc fingerC2H2-type 2
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14247_26911.0443.0Zinc fingerC2H2-type 3
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14275_29711.0443.0Zinc fingerC2H2-type 4
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14303_32511.0443.0Zinc fingerC2H2-type 5
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14331_35311.0443.0Zinc fingerC2H2-type 6
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14359_38111.0443.0Zinc fingerC2H2-type 7
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14387_40911.0443.0Zinc fingerC2H2-type 8
HgeneZNF773chr19:58011481chr19:52705197ENST00000282292+14415_43711.0443.0Zinc fingerC2H2-type 9
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14191_21311.0442.0Zinc fingerC2H2-type 1
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14219_24111.0442.0Zinc fingerC2H2-type 2
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14247_26911.0442.0Zinc fingerC2H2-type 3
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14275_29711.0442.0Zinc fingerC2H2-type 4
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14303_32511.0442.0Zinc fingerC2H2-type 5
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14331_35311.0442.0Zinc fingerC2H2-type 6
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14359_38111.0442.0Zinc fingerC2H2-type 7
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14387_40911.0442.0Zinc fingerC2H2-type 8
HgeneZNF773chr19:58011481chr19:52705197ENST00000598770+14415_43711.0442.0Zinc fingerC2H2-type 9
TgenePPP2R1Achr19:58011481chr19:52705197ENST000003220880158_39926.0590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr19:58011481chr19:52705197ENST000003220880158_4626.0590.0RepeatNote=HEAT 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ZNF773
PPP2R1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ZNF773-PPP2R1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ZNF773-PPP2R1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource