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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BRWD1-DSCAM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BRWD1-DSCAM
FusionPDB ID: 10342
FusionGDB2.0 ID: 10342
HgeneTgene
Gene symbol

BRWD1

DSCAM

Gene ID

54014

1826

Gene namebromodomain and WD repeat domain containing 1DS cell adhesion molecule
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CHD2|CHD2-42|CHD2-52
Cytomap

21q22.2

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143Down syndrome cell adhesion molecule
Modification date2020031320200313
UniProtAcc

Q9NSI6

Q8TD84

Ensembl transtripts involved in fusion geneENST idsENST00000333229, ENST00000342449, 
ENST00000380800, ENST00000341322, 
ENST00000470108, 		ENST00000400454, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 28 X 10=784013 X 11 X 6=858
# samples 3215
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BRWD1 [Title/Abstract] AND DSCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BRWD1(40641825)-DSCAM(41385313), # samples:2
Anticipated loss of major functional domain due to fusion event.BRWD1-DSCAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-DSCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDSCAM

GO:0042327

positive regulation of phosphorylation

19196994

TgeneDSCAM

GO:0048842

positive regulation of axon extension involved in axon guidance

18585357


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DSCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1LG-01ABRWD1chr21

40636385

-DSCAMchr21

41607576

+
ChimerDB4OVTCGA-24-2289-01ABRWD1chr21

40641825

-DSCAMchr21

41385313

-
ChimerDB4OVTCGA-24-2289BRWD1chr21

40641824

-DSCAMchr21

41385313

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-424618582351905556
ENST00000342449BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-39971609791656525
ENST00000380800BRWD1chr2140641825-ENST00000400454DSCAMchr2141385313-4017162961676556
ENST00000333229BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-424618582351905556
ENST00000342449BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-39971609791656525
ENST00000380800BRWD1chr2140641824-ENST00000400454DSCAMchr2141385313-4017162961676556

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0083493650.99165064
ENST00000342449ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0076808410.99231917
ENST00000380800ENST00000400454BRWD1chr2140641825-DSCAMchr2141385313-0.0076418450.99235815
ENST00000333229ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0083493650.99165064
ENST00000342449ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0076808410.99231917
ENST00000380800ENST00000400454BRWD1chr2140641824-DSCAMchr2141385313-0.0076418450.99235815

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10342_10342_1_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------

>10342_10342_2_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=525AA_BP=510
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL

--------------------------------------------------------------

>10342_10342_3_BRWD1-DSCAM_BRWD1_chr21_40641824_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------

>10342_10342_4_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000333229_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------

>10342_10342_5_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000342449_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=525AA_BP=510
MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLD
KEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHR
RILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHT
GSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEK
IAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL

--------------------------------------------------------------

>10342_10342_6_BRWD1-DSCAM_BRWD1_chr21_40641825_ENST00000380800_DSCAM_chr21_41385313_ENST00000400454_length(amino acids)=556AA_BP=541
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40641825/chr21:41385313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD1

Q9NSI6

DSCAM

Q8TD84

FUNCTION: May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.FUNCTION: Cell adhesion molecule that plays a role in neuronal self-avoidance (PubMed:11453658). Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity). {ECO:0000250|UniProtKB:E1C8P7, ECO:0000250|UniProtKB:Q4VA61, ECO:0000269|PubMed:11453658}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542184_223510.02321.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542226_265510.02321.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542268_311510.02321.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542322_365510.02321.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542366_405510.02321.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542424_463510.02321.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542466_506510.02321.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541184_223510.02270.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541226_265510.02270.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541268_311510.02270.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541322_365510.02270.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541366_405510.02270.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541424_463510.02270.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541466_506510.02270.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542184_223510.02200.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542226_265510.02200.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542268_311510.02200.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542322_365510.02200.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542366_405510.02200.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542424_463510.02200.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542466_506510.02200.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542184_223510.02321.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542226_265510.02321.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542268_311510.02321.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542322_365510.02321.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542366_405510.02321.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542424_463510.02321.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542466_506510.02321.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541184_223510.02270.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541226_265510.02270.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541268_311510.02270.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541322_365510.02270.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541366_405510.02270.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541424_463510.02270.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541466_506510.02270.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542184_223510.02200.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542226_265510.02200.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542268_311510.02200.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542322_365510.02200.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542366_405510.02200.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542424_463510.02200.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542466_506510.02200.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421539_1548510.02321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421687_1692510.02321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542661_668510.02321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542821_824510.02321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411539_1548510.02270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411687_1692510.02270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541661_668510.02270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541821_824510.02270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421539_1548510.02200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421687_1692510.02200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542661_668510.02200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542821_824510.02200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421539_1548510.02321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421687_1692510.02321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542661_668510.02321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542821_824510.02321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411539_1548510.02270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411687_1692510.02270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541661_668510.02270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541821_824510.02270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421539_1548510.02200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421687_1692510.02200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542661_668510.02200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542821_824510.02200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421177_1247510.02321.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-15421330_1400510.02321.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411177_1247510.02270.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-15411330_1400510.02270.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421177_1247510.02200.0DomainBromo 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-15421330_1400510.02200.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421177_1247510.02321.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-15421330_1400510.02321.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411177_1247510.02270.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-15411330_1400510.02270.0DomainBromo 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421177_1247510.02200.0DomainBromo 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-15421330_1400510.02200.0DomainBromo 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000333229-1542514_553510.02321.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40641824chr21:41385313ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000342449-1541514_553510.02270.0RepeatNote=WD 8
HgeneBRWD1chr21:40641824chr21:41385313ENST00000380800-1542514_553510.02200.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000333229-1542514_553510.02321.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40641825chr21:41385313ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000342449-1541514_553510.02270.0RepeatNote=WD 8
HgeneBRWD1chr21:40641825chr21:41385313ENST00000380800-1542514_553510.02200.0RepeatNote=WD 8
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331091_11871895.33333333333332013.0DomainFibronectin type-III 3
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331191_12851895.33333333333332013.0DomainFibronectin type-III 4
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133125_2161895.33333333333332013.0DomainNote=Ig-like C2-type 2
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331285_13771895.33333333333332013.0DomainNote=Ig-like C2-type 10
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331379_14731895.33333333333332013.0DomainFibronectin type-III 5
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331474_15751895.33333333333332013.0DomainFibronectin type-III 6
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133225_3051895.33333333333332013.0DomainNote=Ig-like C2-type 3
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133313_4011895.33333333333332013.0DomainNote=Ig-like C2-type 4
TgeneDSCAMchr21:40641824chr21:41385313ENST00000400454313339_1291895.33333333333332013.0DomainNote=Ig-like C2-type 1
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133407_5001895.33333333333332013.0DomainNote=Ig-like C2-type 5
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133504_5921895.33333333333332013.0DomainNote=Ig-like C2-type 6
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133596_6851895.33333333333332013.0DomainNote=Ig-like C2-type 7
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133690_7831895.33333333333332013.0DomainNote=Ig-like C2-type 8
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133787_8831895.33333333333332013.0DomainNote=Ig-like C2-type 9
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133885_9821895.33333333333332013.0DomainFibronectin type-III 1
TgeneDSCAMchr21:40641824chr21:41385313ENST000004004543133987_10861895.33333333333332013.0DomainFibronectin type-III 2
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331091_11871895.33333333333332013.0DomainFibronectin type-III 3
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331191_12851895.33333333333332013.0DomainFibronectin type-III 4
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133125_2161895.33333333333332013.0DomainNote=Ig-like C2-type 2
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331285_13771895.33333333333332013.0DomainNote=Ig-like C2-type 10
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331379_14731895.33333333333332013.0DomainFibronectin type-III 5
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331474_15751895.33333333333332013.0DomainFibronectin type-III 6
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133225_3051895.33333333333332013.0DomainNote=Ig-like C2-type 3
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133313_4011895.33333333333332013.0DomainNote=Ig-like C2-type 4
TgeneDSCAMchr21:40641825chr21:41385313ENST00000400454313339_1291895.33333333333332013.0DomainNote=Ig-like C2-type 1
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133407_5001895.33333333333332013.0DomainNote=Ig-like C2-type 5
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133504_5921895.33333333333332013.0DomainNote=Ig-like C2-type 6
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133596_6851895.33333333333332013.0DomainNote=Ig-like C2-type 7
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133690_7831895.33333333333332013.0DomainNote=Ig-like C2-type 8
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133787_8831895.33333333333332013.0DomainNote=Ig-like C2-type 9
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133885_9821895.33333333333332013.0DomainFibronectin type-III 1
TgeneDSCAMchr21:40641825chr21:41385313ENST000004004543133987_10861895.33333333333332013.0DomainFibronectin type-III 2
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331617_20121895.33333333333332013.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331617_20121895.33333333333332013.0RegionRequired for netrin-mediated axon repulsion of neuronal growth cones
TgeneDSCAMchr21:40641824chr21:41385313ENST00000400454313318_15951895.33333333333332013.0Topological domainExtracellular
TgeneDSCAMchr21:40641825chr21:41385313ENST00000400454313318_15951895.33333333333332013.0Topological domainExtracellular
TgeneDSCAMchr21:40641824chr21:41385313ENST0000040045431331596_16161895.33333333333332013.0TransmembraneHelical
TgeneDSCAMchr21:40641825chr21:41385313ENST0000040045431331596_16161895.33333333333332013.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BRWD1
DSCAM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BRWD1-DSCAM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BRWD1-DSCAM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource