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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BRWD1-SMC1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BRWD1-SMC1A
FusionPDB ID: 10359
FusionGDB2.0 ID: 10359
HgeneTgene
Gene symbol

BRWD1

SMC1A

Gene ID

54014

8243

Gene namebromodomain and WD repeat domain containing 1structural maintenance of chromosomes 1A
SynonymsC21orf107|DCAF19|N143|WDR9|WRD9CDLS2|DXS423E|SB1.8|SMC1|SMC1L1|SMC1alpha|SMCB
Cytomap

21q22.2

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143structural maintenance of chromosomes protein 1ASMC protein 1ASMC-1-alphaSMC1 (structural maintenance of chromosomes 1, yeast)-like 1epididymis secretory sperm binding proteinsegregation of mitotic chromosomes 1
Modification date2020031320200329
UniProtAcc

Q9NSI6

.
Ensembl transtripts involved in fusion geneENST idsENST00000333229, ENST00000380800, 
ENST00000341322, ENST00000342449, 
ENST00000470108, 		ENST00000375340, 
ENST00000469129, ENST00000322213, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 28 X 10=78407 X 6 X 4=168
# samples 327
** MAII scorelog2(32/7840*10)=-4.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BRWD1 [Title/Abstract] AND SMC1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BRWD1(40568424)-SMC1A(53442118), # samples:3
Anticipated loss of major functional domain due to fusion event.BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD1-SMC1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMC1A

GO:0072423

response to DNA damage checkpoint signaling

11877377


check buttonFusion gene breakpoints across BRWD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMC1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6987-01ABRWD1chr21

40568424

-SMC1AchrX

53442118

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333229BRWD1chr2140568424-ENST00000322213SMC1AchrX53442118-164466899235104913418
ENST00000380800BRWD1chr2140568424-ENST00000322213SMC1AchrX53442118-1621766706102623418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333229ENST00000322213BRWD1chr2140568424-SMC1AchrX53442118-0.0007016180.99929833
ENST00000380800ENST00000322213BRWD1chr2140568424-SMC1AchrX53442118-0.0005430620.99945694

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10359_10359_1_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000333229_SMC1A_chrX_53442118_ENST00000322213_length(amino acids)=3418AA_BP=2221
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWT
ADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVP
QMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDV
IDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASIS
VTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEV
RYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWK
KQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSA
LFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSG
VTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSL
ANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSE
DEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC
NRTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQC
SSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVS
LENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKID
APSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRK
RSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKSNLMDAISFVLGEKTSNLRVKTLRDLI
HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALF
EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK
NKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE
LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL
REIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSV
YGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI
KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKE
AELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG
VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKN
QHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG
SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKA
KQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIH

--------------------------------------------------------------

>10359_10359_2_BRWD1-SMC1A_BRWD1_chr21_40568424_ENST00000380800_SMC1A_chrX_53442118_ENST00000322213_length(amino acids)=3418AA_BP=2221
MRRGDASPVRPRRGLHAPLARSLPPPAPRPAMAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEH
NRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNL
VEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYE
NTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLC
SSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSS
EEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFN
MIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNP
HPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPR
RGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQ
LSHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWT
ADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVP
QMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDV
IDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASIS
VTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEV
RYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWK
KQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSA
LFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSG
VTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSL
ANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSE
DEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC
NRTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQC
SSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVS
LENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKID
APSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRK
RSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKGKSNLMDAISFVLGEKTSNLRVKTLRDLI
HGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALF
EEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASK
NKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE
LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKL
REIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSV
YGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHI
KKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKE
AELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIG
VRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKN
QHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSG
SQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKA
KQAFEQIKKERFDRFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:40568424/chrX:53442118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD1

Q9NSI6

.
FUNCTION: May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421539_15482190.33333333333352321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421687_16922190.33333333333352321.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142661_6682190.33333333333352321.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142821_8242190.33333333333352321.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421539_15482190.33333333333352200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421687_16922190.33333333333352200.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142661_6682190.33333333333352200.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142821_8242190.33333333333352200.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421177_12472190.33333333333352321.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-41421330_14002190.33333333333352321.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421177_12472190.33333333333352200.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-41421330_14002190.33333333333352200.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142184_2232190.33333333333352321.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142226_2652190.33333333333352321.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142268_3112190.33333333333352321.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142322_3652190.33333333333352321.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142366_4052190.33333333333352321.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142424_4632190.33333333333352321.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142466_5062190.33333333333352321.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000333229-4142514_5532190.33333333333352321.0RepeatNote=WD 8
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142184_2232190.33333333333352200.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142226_2652190.33333333333352200.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142268_3112190.33333333333352200.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142322_3652190.33333333333352200.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142366_4052190.33333333333352200.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142424_4632190.33333333333352200.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142466_5062190.33333333333352200.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000380800-4142514_5532190.33333333333352200.0RepeatNote=WD 8
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025104_12436.3333333333333361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025163_50336.3333333333333361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025660_93536.3333333333333361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025991_106836.3333333333333361234.0Coiled coilOntology_term=ECO:0000255
TgeneSMC1Achr21:40568424chrX:53442118ENST000003222130251128_116336.3333333333333361234.0Compositional biasNote=Ala/Asp-rich (DA-box)
TgeneSMC1Achr21:40568424chrX:53442118ENST00000322213025515_62936.3333333333333361234.0DomainNote=SMC hinge

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151539_15480121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151687_16920121.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15661_6680121.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15821_8240121.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411539_154802270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411687_169202270.0Compositional biasNote=Poly-Glu
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141661_66802270.0Compositional biasNote=Poly-Gln
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141821_82402270.0Compositional biasNote=Poly-Ser
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151177_12470121.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-151330_14000121.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411177_124702270.0DomainBromo 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-1411330_140002270.0DomainBromo 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15184_2230121.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15226_2650121.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15268_3110121.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15322_3650121.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15366_4050121.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15424_4630121.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15466_5060121.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000341322-15514_5530121.0RepeatNote=WD 8
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141184_22302270.0RepeatNote=WD 1
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141226_26502270.0RepeatNote=WD 2
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141268_31102270.0RepeatNote=WD 3
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141322_36502270.0RepeatNote=WD 4
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141366_40502270.0RepeatNote=WD 5
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141424_46302270.0RepeatNote=WD 6
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141466_50602270.0RepeatNote=WD 7
HgeneBRWD1chr21:40568424chrX:53442118ENST00000342449-141514_55302270.0RepeatNote=WD 8
TgeneSMC1Achr21:40568424chrX:53442118ENST0000032221302532_3936.3333333333333361234.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BRWD1
SMC1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BRWD1-SMC1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BRWD1-SMC1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource