| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:BSPRY-NPM1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: BSPRY-NPM1 | FusionPDB ID: 10412 | FusionGDB2.0 ID: 10412 | Hgene | Tgene | Gene symbol | BSPRY | NPM1 | Gene ID | 54836 | 4869 |
| Gene name | B-box and SPRY domain containing | nucleophosmin 1 | |
| Synonyms | - | B23|NPM | |
| Cytomap | 9q32 | 5q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | B box and SPRY domain-containing proteinB-box and SPRY-domain containing proteinzetin 1 | nucleophosminnucleolar protein NO38nucleophosmin (nucleolar phosphoprotein B23, numatrin)nucleophosmin/nucleoplasmin family, member 1testicular tissue protein Li 128 | |
| Modification date | 20200320 | 20200329 | |
| UniProtAcc | Q5W0U4 | P06748 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000462085, ENST00000374183, | ENST00000296930, ENST00000351986, ENST00000517671, ENST00000393820, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 1 X 1 X 1=1 | 10 X 9 X 3=270 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/270*10)=-1.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: BSPRY [Title/Abstract] AND NPM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | BSPRY(116123017)-NPM1(170837531), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | BSPRY-NPM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BSPRY-NPM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BSPRY-NPM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BSPRY-NPM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BSPRY-NPM1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BSPRY-NPM1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. BSPRY-NPM1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NPM1 | GO:0006281 | DNA repair | 19188445 |
| Tgene | NPM1 | GO:0006334 | nucleosome assembly | 11602260 |
| Tgene | NPM1 | GO:0006913 | nucleocytoplasmic transport | 16041368 |
| Tgene | NPM1 | GO:0008104 | protein localization | 18420587 |
| Tgene | NPM1 | GO:0008284 | positive regulation of cell proliferation | 22528486 |
| Tgene | NPM1 | GO:0032071 | regulation of endodeoxyribonuclease activity | 19188445 |
| Tgene | NPM1 | GO:0034644 | cellular response to UV | 19160485 |
| Tgene | NPM1 | GO:0043066 | negative regulation of apoptotic process | 12882984 |
| Tgene | NPM1 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 12882984 |
| Tgene | NPM1 | GO:0045727 | positive regulation of translation | 12882984 |
| Tgene | NPM1 | GO:0045893 | positive regulation of transcription, DNA-templated | 22528486 |
| Tgene | NPM1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 19160485 |
| Tgene | NPM1 | GO:0060699 | regulation of endoribonuclease activity | 19188445 |
| Tgene | NPM1 | GO:0060735 | regulation of eIF2 alpha phosphorylation by dsRNA | 12882984 |
| Tgene | NPM1 | GO:1902751 | positive regulation of cell cycle G2/M phase transition | 22528486 |
| Fusion gene breakpoints across BSPRY (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across NPM1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-LL-A5YO-01A | BSPRY | chr9 | 116123017 | - | NPM1 | chr5 | 170837531 | + |
| ChimerDB4 | BRCA | TCGA-LL-A5YO-01A | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000374183 | BSPRY | chr9 | 116123017 | + | ENST00000517671 | NPM1 | chr5 | 170837531 | + | 927 | 570 | 39 | 608 | 189 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000374183 | ENST00000517671 | BSPRY | chr9 | 116123017 | + | NPM1 | chr5 | 170837531 | + | 0.10972364 | 0.8902764 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >10412_10412_1_BSPRY-NPM1_BSPRY_chr9_116123017_ENST00000374183_NPM1_chr5_170837531_ENST00000517671_length(amino acids)=189AA_BP= MSAEGAEPGPGSGSGPGPGPLCPEHGQALSWFCGSERRPVCAACAGLGGRCRGHRIRRAEERAEELRNKIVDQCERLQLQSAAITKYVAD VLPGKNQRAVSMASAARELVIQRLSLVRSLCESEEQRLLEQVHGEEERAHQSILTQRVHWAEALQKLDTIRTGLVGMLTHLDDLQLIAIQ -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:116123017/chr5:170837531) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BSPRY | NPM1 |
| FUNCTION: May regulate epithelial calcium transport by inhibiting TRPV5 activity. {ECO:0000250}. | FUNCTION: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). {ECO:0000269|PubMed:12882984, ECO:0000269|PubMed:16107701, ECO:0000269|PubMed:17015463, ECO:0000269|PubMed:18809582, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20352051, ECO:0000269|PubMed:21084279, ECO:0000269|PubMed:22002061, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25956029}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BSPRY | chr9:116123017 | chr5:170837531 | ENST00000374183 | + | 3 | 6 | 17_65 | 177.0 | 403.0 | Zinc finger | Note=B box-type |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 120_132 | 0 | 260.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 161_188 | 0 | 260.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 1_9 | 0 | 260.0 | Compositional bias | Note=Met-rich | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 152_157 | 0 | 260.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 191_197 | 0 | 260.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000393820 | 0 | 10 | 243_294 | 0 | 260.0 | Region | Note=Required for nucleolar localization |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | BSPRY | chr9:116123017 | chr5:170837531 | ENST00000374183 | + | 3 | 6 | 212_402 | 177.0 | 403.0 | Domain | B30.2/SPRY |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 120_132 | 282.0 | 295.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 161_188 | 282.0 | 295.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 1_9 | 282.0 | 295.0 | Compositional bias | Note=Met-rich | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 120_132 | 253.0 | 266.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 161_188 | 253.0 | 266.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 1_9 | 253.0 | 266.0 | Compositional bias | Note=Met-rich | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 120_132 | 282.0 | 295.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 161_188 | 282.0 | 295.0 | Compositional bias | Note=Asp/Glu-rich (highly acidic) | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 1_9 | 282.0 | 295.0 | Compositional bias | Note=Met-rich | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 152_157 | 282.0 | 295.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 191_197 | 282.0 | 295.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 152_157 | 253.0 | 266.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 191_197 | 253.0 | 266.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 152_157 | 282.0 | 295.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 191_197 | 282.0 | 295.0 | Motif | Nuclear localization signal | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000296930 | 9 | 11 | 243_294 | 282.0 | 295.0 | Region | Note=Required for nucleolar localization | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000351986 | 8 | 10 | 243_294 | 253.0 | 266.0 | Region | Note=Required for nucleolar localization | |
| Tgene | NPM1 | chr9:116123017 | chr5:170837531 | ENST00000517671 | 10 | 12 | 243_294 | 282.0 | 295.0 | Region | Note=Required for nucleolar localization |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| NPM1 | TCERG1, LYAR, USF2, HIST3H3, SWAP70, HAND2, NCL, OTUB1, AKT1, CDT1, RRP1B, Rrp1b, GRB2, CENPF, CASKIN1, CDC14A, PIK3R1, NUP98, PPID, GRB7, NCAPG, NUMA1, NSUN2, PADI4, TP53, BARD1, BRCA1, H2AFX, CDKN2A, HMGA2, HMGA1, HCVgp1, YY1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, EP300, tat, PML, RARA, CTNNBL1, FANCA, FANCC, TFAP2A, HDAC1, HDAC2, SMARCA4, DOT1L, ACACA, HNRNPM, HNRNPU, DDX21, HIST1H1C, SIRT1, YBX1, PC, YBX3, H1FX, HIST1H1A, ESR1, Trp53, Cdkn2a, CDK5RAP3, ZNF668, UBC, RYK, SMN1, CD4, YWHAQ, USP36, CTCF, HDAC5, CDKN1A, NOP56, CENPA, AFF1, DYRK2, TOP1, CDK2, SREK1, SENP3, RB1, PARP1, HJURP, ARRB1, ARRB2, SIRT7, NPM3, NPM1, FBXO25, IRF1, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, MDM2, PA2G4, PPP2R1A, MID1, GZF1, APEX1, COPS2, PLCG1, FBXO6, GAPDH, SIAH1, PTBP1, SRSF1, APP, RPL14, RPS6, RPL24, RPL6, NAP1L1, HNRNPR, RPS4X, PRPF6, LAMP2, SURF4, RPL10L, NAP1L4, ZYX, NUP62, NUP50, RPL5, YWHAE, FMNL1, CPSF6, HNRNPH1, PAPOLG, JUNB, MC4R, HIVEP2, CPSF1, CPSF2, CPSF4, CPSF3, FN1, VCAM1, CSNK2A1, NOS2, UBL4A, ITGA4, CBX2, CBX4, CBX8, PHB, EIF2AK2, XPO1, GZMM, PAN2, CD81, IGSF8, ICAM1, PRKCZ, KIF11, SQSTM1, FLNA, LLGL1, HSP90AA1, TRIM21, TUBA1C, HSP90AB1, PARD6B, CDC37, TUBB3, MRPL46, KCTD2, CLTC, MRPL50, VCP, KCTD5, MRPL12, HSPA5, PTRF, MRPL52, EEF1A1, KCTD17, TAB1, BAG2, ANXA2, EIF5A, PPIL4, MRPL38, STK38, FLNB, LGALS1, C1QBP, COPB1, MRPL37, MRPL49, KEAP1, PRDX4, WDR26, PSMC4, SDPR, SLC25A3, RPS12, EEF1B2, NIPSNAP1, EEF1G, MRPL39, DDX3X, RNH1, OSBPL1A, EIF3H, MRPL54, ENO1, MYCBP, MRPL18, MAP1B, PSMD1, EEF1D, DNAJC13, HSPB1, CFL1, FLNC, PPP1CC, RPLP1, CEP152, SNRPD1, ATP5A1, ARHGAP5, PRKAR1A, MRPL53, GID8, YWHAZ, CCT2, EIF3E, LAMB2, DICER1, CHCHD4, MRPL19, SNRPD2, GRWD1, TPR, PSMD4, PSMC5, PPP2CA, UNC5C, SLC25A5, PTPN14, RPS5, TTC27, BOLA2, EIF4A1, TUFM, S100A10, IMPG1, NUDT21, UTRN, MRPL44, EIF3M, MRPL43, PKM, IMPDH2, TRRAP, CHCHD6, RANBP6, EIF3I, TAB2, MRPL24, DZIP1, IPO5, AGR2, MRPS30, ICT1, PRDX6, TCP1, RCOR1, GRN, TXN, RPLP0, PCBP1, MRPL28, MRPL10, TAF3, EPAS1, CHCHD3, TXNDC12, ELMO2, SRRT, MRPL11, EIF2S1, SNRPF, KTN1, FGD6, UQCRH, RBBP4, DNAJA1, CTTN, USP15, NUDCD1, RPS28, JAK1, PROS1, PYGB, KDR, EEF2, FASN, AKAP11, CSNK2B, DNAJA2, EIF3G, DHX15, MRPS26, HNRNPA0, DOCK4, PRKCI, VASP, COPE, SAMM50, TEX15, PSME3, PPM1G, COPG1, CALU, S100A11, HSPA4, PSMD12, POLR2E, TRIM28, SLAIN2, RPL10, GOLGA2, GOLGA3, PRKCA, IPO9, PARK7, SPIN1, PPA1, BANP, DSTN, GNAI2, HOXA7, ABCC1, RELA, ACY1, TARDBP, PARK2, KPNA1, ARMCX3, LIMCH1, OSBP, TRMT61A, rev, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, ELF4, AURKA, HUWE1, FUS, COX8A, NPM2, MOV10, NXF1, PHF6, CUL7, OBSL1, CCDC8, SIRT6, EBNA1BP2, NOL12, RPL10A, POP4, ZNF22, NSA2, TAF1D, NIFK, RPL26L1, NIP7, RPL4, RPF1, CCDC137, KNOP1, RBM28, RPL7A, POP1, DDX24, FTSJ3, RRS1, RPL3, ZFP62, ZNF512, DDX56, DDX27, GLYR1, MAK16, CEBPZ, RSL1D1, HP1BP3, REXO4, DDX31, MYBBP1A, NOP16, C3orf17, RRP8, GNL2, PAPD5, RSL24D1, SURF6, GTPBP4, KIAA0020, NOP2, NVL, GLTSCR2, URB1, RPL23A, GPATCH4, TEX10, RPS8, NOC3L, BRIX1, DDX54, PWP1, RBM34, NMNAT1, CENPC, SENP5, RPL36AL, PAK1IP1, ZNF800, RPL7L1, RPL37A, RPF2, PELP1, NOC2L, RPP40, RBMX2, CENPV, PPAN-P2RY11, SDAD1, RPP38, RPP25, SPTY2D1, RPP25L, POP7, RPS6KB2, UTP15, NTRK1, EWSR1, CLK1, HIST1H3E, BYSL, CHD1, DDX1, DECR1, EIF1AX, EIF4G2, FBL, FAU, HIST1H1D, HIST1H1B, RPSA, MKI67, MPG, EXOSC10, RPL7, RPL8, RPL9, RPL11, RPL13, RPL15, RPL17, RPL18, RPL18A, RPL19, RPL21, RPL22, RPL27, RPL27A, RPL29, RPL32, RPL37, RPL38, RPS2, RPS3, RPS3A, RPS9, RPS10, RPS11, RPS13, RPS14, RPS15, RPS16, RPS17, RPS18, RPS19, RPS20, RPS21, RPS23, RPS24, RPS25, RPS27, RPS29, SKIV2L, SRP72, XPC, IFRD2, HIST1H2BC, SMARCA5, CGGBP1, EIF3A, EIF3C, PABPC4, USP10, TTC37, JADE3, ABCF2, G3BP1, GNB2L1, EMG1, IGF2BP3, PSIP1, SUPT16H, RPL35, PDCD11, LARP4B, RRP12, LARP1, RPL13A, RPL36, MTHFD1L, AHCTF1, FAM98A, SERBP1, GNL3, SND1, NOB1, RPS27L, DDX47, EIF3L, RTCB, TRMT112, DHX29, MTPAP, NAT10, TSR1, NKRF, MEPCE, BCCIP, PNO1, MRPS22, WDR18, SCAF1, NOL6, DDX50, CCDC86, MUS81, ZNF622, DHX57, H2AFV, LARP4, WBSCR22, Eif3a, Eif3e, Ktn1, Rpl35, Srp72, Rrbp1, GAN, HEMGN, TMUB1, CRY1, DNAJB4, MCM2, GLI1, Mdm2, SP1, U2AF2, RC3H1, EIF2S2, EGFR, WWP2, CD24, ZNF746, DDX51, MAGED2, HNRNPA2B1, HNRNPD, HNRNPA1, RPL23, RPS7, HIST1H2BB, HIST1H2AA, CBX3, CYLD, INO80B, LMNA, YAP1, MTF1, BRD1, HDAC6, FBXW7, CENPW, API5, CTNNB1, MAP2K3, BMP4, CCNT1, DIMT1, MATN2, TRIP4, CUL4B, UBE2M, PRPF8, EFTUD2, AAR2, PIH1D1, CHD3, RNF4, CHD4, LARP7, RNF31, TNF, FAM188B, SPDL1, HEXIM1, SNAI1, RECQL4, GPC1, REST, ZFP36L2, MYC, CDK9, Prkab1, NEK2, METTL3, METTL14, KIAA1429, RC3H2, PSMA3, ACTC1, ESR2, FAF1, RBX1, BRCA2, DISC1, NR2C2, UBQLN2, MTDH, GADD45A, AGRN, ATXN3, VRK1, VRK3, DYRK1A, SNRNP70, ITFG1, GHET1, ARAF, HMGB1, BIRC3, NFX1, BRD7, N, SOX2, PPIA, CACYBP, RNR1, CMTR1, ARIH2, PLEKHA4, RAD18, PINK1, WHSC1, FANCD2, SAMD12, LINC01554, ZC3H18, CAMK2A, FYN, PTPN12, RPS6KA3, STX7, IL7R, GPC3, RP1, KMT2A, SUZ12, BSX, LEMD1, ZCCHC7, SYNE2, ZBTB9, R3HDM4, ZNF496, PIKFYVE, COL8A1, PMS2, TRDN, PLCZ1, ASPM, TTN, SETD2, BDP1, C4orf47, CFAP54, HIST2H2BC, AIM2, SYT7, LTN1, EPRS, FST, LMOD1, MCAM, RPL34, MYT1, DYNC1I2, KIF22, ZNF181, ATAT1, TRMT10B, RBM44, ANKS3, FILIP1, FAM9A, SUPT20H, THOC2, CENPI, BICD1, CCL13, JPH2, NDST4, SARDH, SLC27A6, LECT2, HMGN4, OPA1, ITGB1, HIVEP1, PNRC1, PDE4DIP, CAPRIN2, C1orf110, MICAL1, STAB2, CEP63, NGRN, CAMSAP3, ARHGEF9, SNIP1, ORF14, ILF3, LRRC31, DUX4, CIT, ANLN, AURKB, CHMP4B, CHMP4C, ECT2, KIF14, KIF20A, KIF23, PRC1, BRD3, SP110, TRIM24, ZMYND8, LRRC59, NMRAL1, SUMO2, Rnf183, BRD4, NUPR1, RBM45, CIC, Apc2, RBM39, FBP1, ASXL1, vpr, RIN3, DNAJC19, DNAJC25, DNAJC2, OGT, DDRGK1, UFL1, CD3EAP, DDX23, HIST1H2BG, ACTG1, ALKBH4, DNAJC10, GLUD2, HIST1H2AE, HIST1H3F, HIST1H4J, HLCS, HSPA1B, MALT1, PEG10, PLD3, UBB, AIP, BCORL1, BID, CSK, LCK, PSMG1, RAB21, RBM11, VDAC1, RPL31, ZNF330, TRIM37, FZR1, WDR5, PAGE4, NUDCD2, NAA40, BGLT3, CCDC140, RPL23AP32, MTG2, NGDN, UTP18, PRPF4B, WDR74, WDR36, DKC1, DDX52, EPB41L5, ZBTB11, H2AFY, CIRH1A, SRSF5, DUSP11, DDX10, TSPYL1, IMP3, RBM19, NOM1, ZC3HAV1, RPP14, UTP14A, WDR12, DNTTIP2, MPHOSPH10, RRP1, WDR3, BUD13, RPLP2, C14orf169, ZNF771, AATF, C1orf35, OASL, NLE1, BMS1, BOP1, STAU2, TAF1C, WDR55, ZNF638, RFC1, FYTTD1, WDR43, C7orf50, SRPK2, LUC7L, FAM111A, PBRM1, NOL10, TAF1A, TBL3, ZNF770, BAZ1B, ESF1, TTF1, LAS1L, RPP30, ZNF16, RRP15, ABT1, SPRTN, ULK1, TRAF6, BTF3, SLFN11, NLRP7, RCHY1, DIDO1, CCNF, FAM129A, ATR, ATM, PSMD9, ZEB1, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| BSPRY | |
| NPM1 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to BSPRY-NPM1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to BSPRY-NPM1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NPM1 | C0026998 | Acute Myeloid Leukemia, M1 | 6 | CTD_human;ORPHANET |
| Tgene | NPM1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 6 | CTD_human;ORPHANET |
| Tgene | NPM1 | C0023467 | Leukemia, Myelocytic, Acute | 5 | CGI;CTD_human |
| Tgene | NPM1 | C0023487 | Acute Promyelocytic Leukemia | 2 | CGI;CTD_human;ORPHANET |
| Tgene | NPM1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Tgene | NPM1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | NPM1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | NPM1 | C0206182 | Lymphomatoid Papulosis | 1 | ORPHANET |
| Tgene | NPM1 | C0265965 | Dyskeratosis Congenita | 1 | CTD_human;GENOMICS_ENGLAND |
| Tgene | NPM1 | C1148551 | X-Linked Dyskeratosis Congenita | 1 | CTD_human |
| Tgene | NPM1 | C1301362 | Primary Cutaneous Anaplastic Large Cell Lymphoma | 1 | ORPHANET |
| Tgene | NPM1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Tgene | NPM1 | C2930974 | Acute erythroleukemia | 1 | CTD_human |
| Tgene | NPM1 | C2930975 | Acute erythroleukemia - M6a subtype | 1 | CTD_human |
| Tgene | NPM1 | C2930976 | Acute myeloid leukemia FAB-M6 | 1 | CTD_human |
| Tgene | NPM1 | C2930977 | Acute erythroleukemia - M6b subtype | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies