UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:BTN2A1-SPINT2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: BTN2A1-SPINT2
	FusionPDB ID: 10546
	FusionGDB2.0 ID: 10546
		Hgene	Tgene
	Gene symbol	BTN2A1	SPINT2
	Gene ID	11120	10653
	Gene name	butyrophilin subfamily 2 member A1	serine peptidase inhibitor, Kunitz type 2
	Synonyms	BK14H9.1\|BT2.1\|BTF1\|BTN2.1\|DJ3E1.1	DIAR3\|HAI-2\|HAI2\|Kop\|PB
	Cytomap	6p22.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	butyrophilin subfamily 2 member A1	kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183
	Modification date	20200313	20200315
	UniProtAcc	Q7KYR7	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000312541, ENST00000429381, ENST00000469185, ENST00000541522,	ENST00000301244, ENST00000454580, ENST00000587090,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 4=64	11 X 6 X 8=528
	# samples	4	13
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/528*10)=-2.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: BTN2A1 [Title/Abstract] AND SPINT2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BTN2A1(26460056)-SPINT2(38778515), # samples:1
Anticipated loss of major functional domain due to fusion event.	BTN2A1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BTN2A1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BTN2A1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BTN2A1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPINT2	GO:0022408	negative regulation of cell-cell adhesion	19592578
Tgene	SPINT2	GO:2000146	negative regulation of cell motility	19592578

Fusion gene breakpoints across BTN2A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPINT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-30-1857	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1725	635	190	1116	308
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1562	635	190	1116	308
ENST00000469185	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1579	635	190	1116	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1768	678	233	1159	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1605	678	233	1159	308
ENST00000312541	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1622	678	233	1159	308
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1631	541	84	1022	312
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1468	541	84	1022	312
ENST00000541522	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1485	541	84	1022	312
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000301244	SPINT2	chr19	38778515	+	1732	642	197	1123	308
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000587090	SPINT2	chr19	38778515	+	1569	642	197	1123	308
ENST00000429381	BTN2A1	chr6	26460056	+	ENST00000454580	SPINT2	chr19	38778515	+	1586	642	197	1123	308

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000469185	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000540556	0.99945945
ENST00000469185	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000585601	0.99941444
ENST00000469185	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000589951	0.99941003
ENST00000312541	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000501685	0.99949825
ENST00000312541	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000554883	0.99944514
ENST00000312541	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000555186	0.9994448
ENST00000541522	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001414619	0.99858546
ENST00000541522	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001513991	0.998486
ENST00000541522	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.001564492	0.99843556
ENST00000429381	ENST00000301244	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000553491	0.99944645
ENST00000429381	ENST00000587090	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000604645	0.9993954
ENST00000429381	ENST00000454580	BTN2A1	chr6	26460056	+	SPINT2	chr19	38778515	+	0.000611339	0.9993887

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10546_10546_1_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_2_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_3_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000312541_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_4_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_5_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_6_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000429381_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_7_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_8_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_9_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000469185_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=308AA_BP=147
MLWVLMESAAALHFSRPASLLLLLLSLCALVSAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERT
EEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSEDHSS
DMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLG

--------------------------------------------------------------

>10546_10546_10_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000301244_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------

>10546_10546_11_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000454580_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------

>10546_10546_12_BTN2A1-SPINT2_BTN2A1_chr6_26460056_ENST00000541522_SPINT2_chr19_38778515_ENST00000587090_length(amino acids)=312AA_BP=151
MCLVVPVPLGRLERRGTTGESSRTSGEKKKQRLILEAQFIVVGPTDPILATVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGG
RERTEEQMEEYRGRTTFVSKDISRGSVALVIHNITAQENGTYRCYFQEGRSYDEAILHLVVAENATGDLATSRNAADSSVPSAPRRQDSE
DHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:26460056/chr19:38778515)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTN2A1 Q7KYR7	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

29_141

143.33333333333334

528.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

29_141

143.33333333333334

335.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

29_141

143.33333333333334

331.0

Domain

Note=Ig-like V-type

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

219_252

92.33333333333333

253.0

Topological domain

Cytoplasmic

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

219_252

35.333333333333336

196.0

Topological domain

Cytoplasmic

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

198_218

92.33333333333333

253.0

Transmembrane

Helical

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

198_218

35.333333333333336

196.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

310_506

143.33333333333334

528.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

310_506

143.33333333333334

335.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

310_506

143.33333333333334

331.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

29_141

82.33333333333333

467.0

Domain

Note=Ig-like V-type

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

310_506

82.33333333333333

467.0

Domain

B30.2/SPRY

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

270_527

143.33333333333334

528.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

29_248

143.33333333333334

528.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

270_527

143.33333333333334

335.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

29_248

143.33333333333334

335.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

270_527

143.33333333333334

331.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

29_248

143.33333333333334

331.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

270_527

82.33333333333333

467.0

Topological domain

Cytoplasmic

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

29_248

82.33333333333333

467.0

Topological domain

Extracellular

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000312541

249_269

143.33333333333334

528.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000429381

249_269

143.33333333333334

335.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000469185

249_269

143.33333333333334

331.0

Transmembrane

Helical

Hgene

BTN2A1

chr6:26460056

chr19:38778515

ENST00000541522

249_269

82.33333333333333

467.0

Transmembrane

Helical

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000301244

28_197

92.33333333333333

253.0

Topological domain

Extracellular

Tgene

SPINT2

chr6:26460056

chr19:38778515

ENST00000454580

28_197

35.333333333333336

196.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
BTN2A1
SPINT2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to BTN2A1-SPINT2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to BTN2A1-SPINT2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source