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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:C12orf49-MDM2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: C12orf49-MDM2
FusionPDB ID: 10837
FusionGDB2.0 ID: 10837
HgeneTgene
Gene symbol

C12orf49

MDM2

Gene ID

79794

4193

Gene namechromosome 12 open reading frame 49MDM2 proto-oncogene
Synonyms-ACTFS|HDMX|LSKB|hdm2
Cytomap

12q24.22

12q15

Type of geneprotein-codingprotein-coding
DescriptionUPF0454 protein C12orf49E3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, hum
Modification date2020031320200329
UniProtAcc.

Q00987

Ensembl transtripts involved in fusion geneENST idsENST00000261318, ENST00000536380, 
ENST00000548356, 		ENST00000258148, 
ENST00000299252, ENST00000348801, 
ENST00000350057, ENST00000360430, 
ENST00000393410, ENST00000393412, 
ENST00000393413, ENST00000478070, 
ENST00000517852, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000258149, ENST00000356290, 
ENST00000428863, ENST00000462284, 
ENST00000540827, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 4 X 2=6412 X 10 X 6=720
# samples 612
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: C12orf49 [Title/Abstract] AND MDM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)C12orf49(117175595)-MDM2(69229609), # samples:2
Anticipated loss of major functional domain due to fusion event.C12orf49-MDM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf49-MDM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf49-MDM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf49-MDM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C12orf49-MDM2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
C12orf49-MDM2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

TgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

TgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

TgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

TgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

TgeneMDM2

GO:0034504

protein localization to nucleus

10360174

TgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

TgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

TgeneMDM2

GO:0045184

establishment of protein localization

10360174

TgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

TgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

TgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

TgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

TgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

TgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across C12orf49 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MDM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5856-01AC12orf49chr12

117175595

-MDM2chr12

69229609

+
ChimerDB4GBMTCGA-06-5856-01AC12orf49chr12

117175595

-MDM2chr12

69233054

+
ChimerDB4GBMTCGA-06-5856C12orf49chr12

117175594

-MDM2chr12

69229608

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261318C12orf49chr12117175594-ENST00000462284MDM2chr1269229608+66672721611081306
ENST00000261318C12orf49chr12117175594-ENST00000356290MDM2chr1269229608+66642721611081306
ENST00000261318C12orf49chr12117175594-ENST00000540827MDM2chr1269229608+66642721611081306
ENST00000261318C12orf49chr12117175594-ENST00000258149MDM2chr1269229608+66642721611081306
ENST00000261318C12orf49chr12117175594-ENST00000428863MDM2chr1269229608+65862721611003280
ENST00000536380C12orf49chr12117175594-ENST00000462284MDM2chr1269229608+66752801691089306
ENST00000536380C12orf49chr12117175594-ENST00000356290MDM2chr1269229608+66722801691089306
ENST00000536380C12orf49chr12117175594-ENST00000540827MDM2chr1269229608+66722801691089306
ENST00000536380C12orf49chr12117175594-ENST00000258149MDM2chr1269229608+66722801691089306
ENST00000536380C12orf49chr12117175594-ENST00000428863MDM2chr1269229608+65942801691011280
ENST00000261318C12orf49chr12117175595-ENST00000462284MDM2chr1269229609+66672721611081306
ENST00000261318C12orf49chr12117175595-ENST00000356290MDM2chr1269229609+66642721611081306
ENST00000261318C12orf49chr12117175595-ENST00000540827MDM2chr1269229609+66642721611081306
ENST00000261318C12orf49chr12117175595-ENST00000258149MDM2chr1269229609+66642721611081306
ENST00000261318C12orf49chr12117175595-ENST00000428863MDM2chr1269229609+65862721611003280
ENST00000536380C12orf49chr12117175595-ENST00000462284MDM2chr1269229609+66752801691089306
ENST00000536380C12orf49chr12117175595-ENST00000356290MDM2chr1269229609+66722801691089306
ENST00000536380C12orf49chr12117175595-ENST00000540827MDM2chr1269229609+66722801691089306
ENST00000536380C12orf49chr12117175595-ENST00000258149MDM2chr1269229609+66722801691089306
ENST00000536380C12orf49chr12117175595-ENST00000428863MDM2chr1269229609+65942801691011280
ENST00000261318C12orf49chr12117175595-ENST00000393412MDM2chr1269233054+1088272161847228
ENST00000261318C12orf49chr12117175595-ENST00000258148MDM2chr1269233054+866272161847228
ENST00000536380C12orf49chr12117175595-ENST00000393412MDM2chr1269233054+1096280169855228
ENST00000536380C12orf49chr12117175595-ENST00000258148MDM2chr1269233054+874280169855228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261318ENST00000462284C12orf49chr12117175594-MDM2chr1269229608+8.46E-050.9999155
ENST00000261318ENST00000356290C12orf49chr12117175594-MDM2chr1269229608+8.38E-050.9999162
ENST00000261318ENST00000540827C12orf49chr12117175594-MDM2chr1269229608+8.38E-050.9999162
ENST00000261318ENST00000258149C12orf49chr12117175594-MDM2chr1269229608+8.38E-050.9999162
ENST00000261318ENST00000428863C12orf49chr12117175594-MDM2chr1269229608+0.0001818720.99981815
ENST00000536380ENST00000462284C12orf49chr12117175594-MDM2chr1269229608+8.39E-050.9999161
ENST00000536380ENST00000356290C12orf49chr12117175594-MDM2chr1269229608+8.32E-050.9999168
ENST00000536380ENST00000540827C12orf49chr12117175594-MDM2chr1269229608+8.32E-050.9999168
ENST00000536380ENST00000258149C12orf49chr12117175594-MDM2chr1269229608+8.32E-050.9999168
ENST00000536380ENST00000428863C12orf49chr12117175594-MDM2chr1269229608+0.0001808250.9998192
ENST00000261318ENST00000462284C12orf49chr12117175595-MDM2chr1269229609+8.46E-050.9999155
ENST00000261318ENST00000356290C12orf49chr12117175595-MDM2chr1269229609+8.38E-050.9999162
ENST00000261318ENST00000540827C12orf49chr12117175595-MDM2chr1269229609+8.38E-050.9999162
ENST00000261318ENST00000258149C12orf49chr12117175595-MDM2chr1269229609+8.38E-050.9999162
ENST00000261318ENST00000428863C12orf49chr12117175595-MDM2chr1269229609+0.0001818720.99981815
ENST00000536380ENST00000462284C12orf49chr12117175595-MDM2chr1269229609+8.39E-050.9999161
ENST00000536380ENST00000356290C12orf49chr12117175595-MDM2chr1269229609+8.32E-050.9999168
ENST00000536380ENST00000540827C12orf49chr12117175595-MDM2chr1269229609+8.32E-050.9999168
ENST00000536380ENST00000258149C12orf49chr12117175595-MDM2chr1269229609+8.32E-050.9999168
ENST00000536380ENST00000428863C12orf49chr12117175595-MDM2chr1269229609+0.0001808250.9998192
ENST00000261318ENST00000393412C12orf49chr12117175595-MDM2chr1269233054+0.0013268380.9986732
ENST00000261318ENST00000258148C12orf49chr12117175595-MDM2chr1269233054+0.0019663370.9980337
ENST00000536380ENST00000393412C12orf49chr12117175595-MDM2chr1269233054+0.0013713460.99862874
ENST00000536380ENST00000258148C12orf49chr12117175595-MDM2chr1269233054+0.0018843550.99811566

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10837_10837_1_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000261318_MDM2_chr12_69229608_ENST00000258149_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_2_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000261318_MDM2_chr12_69229608_ENST00000356290_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_3_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000261318_MDM2_chr12_69229608_ENST00000428863_length(amino acids)=280AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDED
YWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQP

--------------------------------------------------------------

>10837_10837_4_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000261318_MDM2_chr12_69229608_ENST00000462284_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_5_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000261318_MDM2_chr12_69229608_ENST00000540827_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_6_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000536380_MDM2_chr12_69229608_ENST00000258149_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_7_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000536380_MDM2_chr12_69229608_ENST00000356290_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_8_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000536380_MDM2_chr12_69229608_ENST00000428863_length(amino acids)=280AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDED
YWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQP

--------------------------------------------------------------

>10837_10837_9_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000536380_MDM2_chr12_69229608_ENST00000462284_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_10_C12orf49-MDM2_C12orf49_chr12_117175594_ENST00000536380_MDM2_chr12_69229608_ENST00000540827_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_11_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69229609_ENST00000258149_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_12_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69229609_ENST00000356290_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_13_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69229609_ENST00000428863_length(amino acids)=280AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDED
YWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQP

--------------------------------------------------------------

>10837_10837_14_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69229609_ENST00000462284_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_15_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69229609_ENST00000540827_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

--------------------------------------------------------------

>10837_10837_16_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69233054_ENST00000258148_length(amino acids)=228AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQA
EEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQG

--------------------------------------------------------------

>10837_10837_17_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000261318_MDM2_chr12_69233054_ENST00000393412_length(amino acids)=228AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQA
EEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQG

--------------------------------------------------------------

>10837_10837_18_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69229609_ENST00000258149_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

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>10837_10837_19_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69229609_ENST00000356290_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

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>10837_10837_20_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69229609_ENST00000428863_length(amino acids)=280AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDED
YWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQES
EDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQP

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>10837_10837_21_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69229609_ENST00000462284_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

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>10837_10837_22_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69229609_ENST00000540827_length(amino acids)=306AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEV
YQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKT
IVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKT

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>10837_10837_23_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69233054_ENST00000258148_length(amino acids)=228AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQA
EEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQG

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>10837_10837_24_C12orf49-MDM2_C12orf49_chr12_117175595_ENST00000536380_MDM2_chr12_69233054_ENST00000393412_length(amino acids)=228AA_BP=37
MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQDYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQA
EEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:117175595/chr12:69229609)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MDM2

Q00987

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC12orf49chr12:117175594chr12:69229608ENST00000261318-151_1637.0206.0Topological domainCytoplasmic
HgeneC12orf49chr12:117175595chr12:69229609ENST00000261318-151_1637.0206.0Topological domainCytoplasmic
HgeneC12orf49chr12:117175595chr12:69233054ENST00000261318-151_1637.0206.0Topological domainCytoplasmic
HgeneC12orf49chr12:117175594chr12:69229608ENST00000261318-1517_3537.0206.0TransmembraneHelical
HgeneC12orf49chr12:117175595chr12:69229609ENST00000261318-1517_3537.0206.0TransmembraneHelical
HgeneC12orf49chr12:117175595chr12:69233054ENST00000261318-1517_3537.0206.0TransmembraneHelical
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959210_215167.0437.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959243_301167.0437.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103210_21522.0266.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103243_30122.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203210_2150219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302210_2150.0219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302243_3010.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314210_21527.0271.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314243_30127.0271.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711243_301228.0498.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959210_215167.0437.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959243_301167.0437.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103210_21522.0266.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103243_30122.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026210_21552.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026243_30152.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203210_2150219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302210_2150.0219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302243_3010.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314210_21527.0271.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314243_30127.0271.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711243_301228.0498.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715210_21527.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715243_30127.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979243_301245.0437.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235210_215130.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235243_301130.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113210_21574.0266.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113243_30174.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046210_215130.0322.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046243_301130.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024210_215105.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024243_301105.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213210_21527.0219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213243_30127.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302210_21527.0219.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302243_30127.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324210_21579.0271.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324243_30179.0271.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735210_215105.0297.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735243_301105.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST000003488010326_10922.0266.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000003604300426_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000003934120326_1090219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000003934130226_1090.0219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000004288631426_10927.0271.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000005408271526_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000003488010326_10922.0266.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000003604300426_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000003934120326_1090219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000003934130226_1090.0219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000004288631426_10927.0271.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000005408271526_10927.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000003934121326_10927.0219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000003934130226_10927.0219.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959179_185167.0437.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959190_202167.0437.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959466_473167.0437.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103179_18522.0266.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103190_20222.0266.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103466_47322.0266.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203179_1850219.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203190_2020219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203466_4730219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302179_1850.0219.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302190_2020.0219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302466_4730.0219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314179_18527.0271.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314190_20227.0271.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314466_47327.0271.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711466_473228.0498.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959179_185167.0437.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959190_202167.0437.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959466_473167.0437.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103179_18522.0266.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103190_20222.0266.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103466_47322.0266.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026179_18552.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026190_20252.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026466_47352.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203179_1850219.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203190_2020219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203466_4730219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302179_1850.0219.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302190_2020.0219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302466_4730.0219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314179_18527.0271.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314190_20227.0271.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314466_47327.0271.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711466_473228.0498.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715179_18527.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715190_20227.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715466_47327.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979466_473245.0437.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235179_185130.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235190_202130.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235466_473130.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113179_18574.0266.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113190_20274.0266.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113466_47374.0266.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046179_185130.0322.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046190_202130.0322.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046466_473130.0322.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024179_185105.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024190_202105.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024466_473105.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213179_18527.0219.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213190_20227.0219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213466_47327.0219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302179_18527.0219.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302190_20227.0219.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302466_47327.0219.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324179_18579.0271.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324190_20279.0271.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324466_47379.0271.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911466_473306.0498.0MotifNucleolar localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735179_185105.0297.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735190_202105.0297.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735466_473105.0297.0MotifNucleolar localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959210_304167.0437.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959242_331167.0437.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103210_30422.0266.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103242_33122.0266.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST00000393412031_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203210_3040219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203242_3310219.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST00000393413021_1010.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302210_3040.0219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302242_3310.0219.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314210_30427.0271.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314242_33127.0271.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711242_331228.0498.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959210_304167.0437.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959242_331167.0437.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103210_30422.0266.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103242_33122.0266.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026210_30452.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026242_33152.0322.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST00000393412031_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203210_3040219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203242_3310219.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST00000393413021_1010.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302210_3040.0219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302242_3310.0219.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314210_30427.0271.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314242_33127.0271.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711242_331228.0498.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715210_30427.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715242_33127.0297.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979242_331245.0437.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235210_304130.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235242_331130.0322.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113210_30474.0266.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113242_33174.0266.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046210_304130.0322.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046242_331130.0322.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024210_304105.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024242_331105.0297.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213210_30427.0219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213242_33127.0219.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302210_30427.0219.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302242_33127.0219.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324210_30479.0271.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324242_33179.0271.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735210_304105.0297.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735242_331105.0297.0RegionNote=Region II
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959299_328167.0437.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959438_479167.0437.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000029925215438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103299_32822.0266.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000034880103438_47922.0266.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000035629026438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000036043004438_47927.0297.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203299_3280219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341203438_4790219.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302299_3280.0219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000039341302438_4790.0219.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314299_32827.0271.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000042886314438_47927.0271.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711299_328228.0498.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711438_479228.0498.0Zinc fingerRING-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175594chr12:69229608ENST0000054082715438_47927.0297.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959299_328167.0437.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959438_479167.0437.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000029925215438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103299_32822.0266.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000034880103438_47922.0266.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026299_32852.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000035629026438_47952.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000036043004438_47927.0297.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203299_3280219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341203438_4790219.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302299_3280.0219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000039341302438_4790.0219.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314299_32827.0271.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000042886314438_47927.0271.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711299_328228.0498.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711438_479228.0498.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715299_32827.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69229609ENST0000054082715438_47927.0297.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979299_328245.0437.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979438_479245.0437.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235299_328130.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000029925235438_479130.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113299_32874.0266.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000034880113438_47974.0266.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046299_328130.0322.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000035629046438_479130.0322.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024299_328105.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000036043024438_479105.0297.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213299_32827.0219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341213438_47927.0219.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302299_32827.0219.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000039341302438_47927.0219.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324299_32879.0271.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000042886324438_47979.0271.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911438_479306.0498.0Zinc fingerRING-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735299_328105.0297.0Zinc fingerRanBP2-type
TgeneMDM2chr12:117175595chr12:69233054ENST0000054082735438_479105.0297.0Zinc fingerRING-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC12orf49chr12:117175594chr12:69229608ENST00000261318-15103_13537.0206.0Compositional biasNote=Cys-rich
HgeneC12orf49chr12:117175595chr12:69229609ENST00000261318-15103_13537.0206.0Compositional biasNote=Cys-rich
HgeneC12orf49chr12:117175595chr12:69233054ENST00000261318-15103_13537.0206.0Compositional biasNote=Cys-rich
HgeneC12orf49chr12:117175594chr12:69229608ENST00000261318-1536_20537.0206.0Topological domainLumenal
HgeneC12orf49chr12:117175595chr12:69229609ENST00000261318-1536_20537.0206.0Topological domainLumenal
HgeneC12orf49chr12:117175595chr12:69233054ENST00000261318-1536_20537.0206.0Topological domainLumenal
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711210_215228.0498.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711210_215228.0498.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979210_215245.0437.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911210_215306.0498.0Compositional biasNote=Poly-Ser
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911243_301306.0498.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMDM2chr12:117175594chr12:69229608ENST000002581495926_109167.0437.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000002992521526_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST000003562902626_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST0000046228471126_109228.0498.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000002581495926_109167.0437.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000002992521526_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST000003562902626_10952.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69229609ENST0000046228471126_109228.0498.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000002581497926_109245.0437.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000002992523526_109130.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000003488011326_10974.0266.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000003562904626_109130.0322.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000003604302426_109105.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000004288632426_10979.0271.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST0000046228491126_109306.0498.0DomainSWIB/MDM2
TgeneMDM2chr12:117175595chr12:69233054ENST000005408273526_109105.0297.0DomainSWIB/MDM2
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711179_185228.0498.0MotifNuclear localization signal
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711190_202228.0498.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711179_185228.0498.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711190_202228.0498.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979179_185245.0437.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979190_202245.0437.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911179_185306.0498.0MotifNuclear localization signal
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911190_202306.0498.0MotifNote=Nuclear export signal
TgeneMDM2chr12:117175594chr12:69229608ENST00000258149591_101167.0437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000299252151_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000348801031_10122.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000356290261_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000360430041_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000428863141_10127.0271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST000004622847111_101228.0498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711210_304228.0498.0RegionNote=ARF-binding
TgeneMDM2chr12:117175594chr12:69229608ENST00000540827151_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000258149591_101167.0437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000299252151_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000348801031_10122.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000356290261_10152.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000360430041_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000428863141_10127.0271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST000004622847111_101228.0498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711210_304228.0498.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69229609ENST00000540827151_10127.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000258149791_101245.0437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979210_304245.0437.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST00000299252351_101130.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000348801131_10174.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000356290461_101130.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000360430241_101105.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000393412131_10127.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000393413021_10127.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000428863241_10179.0271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST000004622849111_101306.0498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911210_304306.0498.0RegionNote=ARF-binding
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911242_331306.0498.0RegionNote=Region II
TgeneMDM2chr12:117175595chr12:69233054ENST00000540827351_101105.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911299_328306.0498.0Zinc fingerRanBP2-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
C12orf49
MDM2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711170_306228.0498.0MTBP
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711170_306228.0498.0MTBP
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979170_306245.0437.0MTBP
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911170_306306.0498.0MTBP
TgeneMDM2chr12:117175594chr12:69229608ENST0000025814959150_230167.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711150_230228.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175595chr12:69229609ENST0000025814959150_230167.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711150_230228.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979150_230245.0437.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911150_230306.0498.0PYHIN1 and necessary for interaction with RFFL and RNF34
TgeneMDM2chr12:117175594chr12:69229608ENST00000462284711223_232228.0498.0USP7
TgeneMDM2chr12:117175595chr12:69229609ENST00000462284711223_232228.0498.0USP7
TgeneMDM2chr12:117175595chr12:69233054ENST0000025814979223_232245.0437.0USP7
TgeneMDM2chr12:117175595chr12:69233054ENST00000462284911223_232306.0498.0USP7


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Related Drugs to C12orf49-MDM2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to C12orf49-MDM2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource