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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:C1S-HP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: C1S-HP
FusionPDB ID: 11454
FusionGDB2.0 ID: 11454
HgeneTgene
Gene symbol

C1S

HP

Gene ID

716

10395

Gene namecomplement C1sDLC1 Rho GTPase activating protein
SynonymsEDSPD2ARHGAP7|HP|STARD12|p122-RhoGAP
Cytomap

12p13.31

8p22

Type of geneprotein-codingprotein-coding
Descriptioncomplement C1s subcomponentC1 esterasebasic proline-rich peptide IB-1complement component 1 subcomponent scomplement component 1, s subcomponentrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer varia
Modification date2020031320200313
UniProtAcc

P09871

P02790

Ensembl transtripts involved in fusion geneENST idsENST00000495061, ENST00000328916, 
ENST00000360817, ENST00000402681, 
ENST00000406697, 		ENST00000355906, 
ENST00000357763, ENST00000398131, 
ENST00000562526, ENST00000569639, 
ENST00000570083, ENST00000565574, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 10 X 6=66014 X 11 X 3=462
# samples 1113
** MAII scorelog2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/462*10)=-1.8293812283876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: C1S [Title/Abstract] AND HP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)C1S(7175075)-HP(72093013), # samples:1
Anticipated loss of major functional domain due to fusion event.C1S-HP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C1S-HP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C1S-HP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C1S-HP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C1S-HP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHP

GO:0006915

apoptotic process

17292327

TgeneHP

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

TgeneHP

GO:0008285

negative regulation of cell proliferation

12545165|17932950

TgeneHP

GO:0030336

negative regulation of cell migration

17932950|19158340

TgeneHP

GO:0035307

positive regulation of protein dephosphorylation

17292327

TgeneHP

GO:0051497

negative regulation of stress fiber assembly

17932950

TgeneHP

GO:0051895

negative regulation of focal adhesion assembly

19158340

TgeneHP

GO:1900119

positive regulation of execution phase of apoptosis

17888903


check buttonFusion gene breakpoints across C1S (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-FV-A23B-11AC1Schr12

7175075

+HPchr16

72093013

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406697C1Schr127175075+ENST00000570083HPchr1672093013+284218236282676682
ENST00000406697C1Schr127175075+ENST00000355906HPchr1672093013+284118236282676682
ENST00000406697C1Schr127175075+ENST00000398131HPchr1672093013+284118236282676682
ENST00000406697C1Schr127175075+ENST00000357763HPchr1672093013+280318236282676682
ENST00000406697C1Schr127175075+ENST00000562526HPchr1672093013+229118236281911427
ENST00000328916C1Schr127175075+ENST00000570083HPchr1672093013+273817193142572752
ENST00000328916C1Schr127175075+ENST00000355906HPchr1672093013+273717193142572752
ENST00000328916C1Schr127175075+ENST00000398131HPchr1672093013+273717193142572752
ENST00000328916C1Schr127175075+ENST00000357763HPchr1672093013+269917193142572752
ENST00000328916C1Schr127175075+ENST00000562526HPchr1672093013+218717193141807497
ENST00000360817C1Schr127175075+ENST00000570083HPchr1672093013+249014711532324723
ENST00000360817C1Schr127175075+ENST00000355906HPchr1672093013+248914711532324723
ENST00000360817C1Schr127175075+ENST00000398131HPchr1672093013+248914711532324723
ENST00000360817C1Schr127175075+ENST00000357763HPchr1672093013+245114711532324723
ENST00000360817C1Schr127175075+ENST00000562526HPchr1672093013+193914711531559468
ENST00000402681C1Schr127175075+ENST00000570083HPchr1672093013+236013412662194642
ENST00000402681C1Schr127175075+ENST00000355906HPchr1672093013+235913412662194642
ENST00000402681C1Schr127175075+ENST00000398131HPchr1672093013+235913412662194642
ENST00000402681C1Schr127175075+ENST00000357763HPchr1672093013+232113412662194642
ENST00000402681C1Schr127175075+ENST00000562526HPchr1672093013+180913412661429387

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406697ENST00000570083C1Schr127175075+HPchr1672093013+0.0005927650.9994073
ENST00000406697ENST00000355906C1Schr127175075+HPchr1672093013+0.0006026280.9993974
ENST00000406697ENST00000398131C1Schr127175075+HPchr1672093013+0.0006026280.9993974
ENST00000406697ENST00000357763C1Schr127175075+HPchr1672093013+0.000633160.9993668
ENST00000406697ENST00000562526C1Schr127175075+HPchr1672093013+0.0004604820.9995395
ENST00000328916ENST00000570083C1Schr127175075+HPchr1672093013+0.0003755510.9996244
ENST00000328916ENST00000355906C1Schr127175075+HPchr1672093013+0.0003827630.9996172
ENST00000328916ENST00000398131C1Schr127175075+HPchr1672093013+0.0003827630.9996172
ENST00000328916ENST00000357763C1Schr127175075+HPchr1672093013+0.0003973610.9996026
ENST00000328916ENST00000562526C1Schr127175075+HPchr1672093013+0.0003531450.9996469
ENST00000360817ENST00000570083C1Schr127175075+HPchr1672093013+0.0004135070.9995865
ENST00000360817ENST00000355906C1Schr127175075+HPchr1672093013+0.00042210.99957794
ENST00000360817ENST00000398131C1Schr127175075+HPchr1672093013+0.00042210.99957794
ENST00000360817ENST00000357763C1Schr127175075+HPchr1672093013+0.0004402180.9995598
ENST00000360817ENST00000562526C1Schr127175075+HPchr1672093013+0.0003502440.99964976
ENST00000402681ENST00000570083C1Schr127175075+HPchr1672093013+0.0010671810.9989328
ENST00000402681ENST00000355906C1Schr127175075+HPchr1672093013+0.0010853830.9989146
ENST00000402681ENST00000398131C1Schr127175075+HPchr1672093013+0.0010853830.9989146
ENST00000402681ENST00000357763C1Schr127175075+HPchr1672093013+0.0011062090.9988938
ENST00000402681ENST00000562526C1Schr127175075+HPchr1672093013+0.0017904350.9982096

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>11454_11454_1_C1S-HP_C1S_chr12_7175075_ENST00000328916_HP_chr16_72093013_ENST00000355906_length(amino acids)=752AA_BP=468
MAGERELTHLLLPASEGDTEPQVTPHHQRRCLCLSDKYSQACHPLGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMY
GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIF
KSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS
RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGD
PMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGS
VIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINE
QWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGW
GRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGI

--------------------------------------------------------------

>11454_11454_2_C1S-HP_C1S_chr12_7175075_ENST00000328916_HP_chr16_72093013_ENST00000357763_length(amino acids)=752AA_BP=468
MAGERELTHLLLPASEGDTEPQVTPHHQRRCLCLSDKYSQACHPLGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMY
GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIF
KSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS
RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGD
PMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGS
VIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINE
QWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGW
GRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGI

--------------------------------------------------------------

>11454_11454_3_C1S-HP_C1S_chr12_7175075_ENST00000328916_HP_chr16_72093013_ENST00000398131_length(amino acids)=752AA_BP=468
MAGERELTHLLLPASEGDTEPQVTPHHQRRCLCLSDKYSQACHPLGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMY
GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIF
KSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS
RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGD
PMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGS
VIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINE
QWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGW
GRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGI

--------------------------------------------------------------

>11454_11454_4_C1S-HP_C1S_chr12_7175075_ENST00000328916_HP_chr16_72093013_ENST00000562526_length(amino acids)=497AA_BP=468
MAGERELTHLLLPASEGDTEPQVTPHHQRRCLCLSDKYSQACHPLGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMY
GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIF
KSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS
RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGD
PMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGS

--------------------------------------------------------------

>11454_11454_5_C1S-HP_C1S_chr12_7175075_ENST00000328916_HP_chr16_72093013_ENST00000570083_length(amino acids)=752AA_BP=468
MAGERELTHLLLPASEGDTEPQVTPHHQRRCLCLSDKYSQACHPLGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMY
GEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIF
KSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENS
RCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGD
PMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGS
VIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINE
QWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGW
GRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGI

--------------------------------------------------------------

>11454_11454_6_C1S-HP_C1S_chr12_7175075_ENST00000360817_HP_chr16_72093013_ENST00000355906_length(amino acids)=723AA_BP=439
MAGERELTHLLLPASEGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYG
IHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFV
DVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAAD
SAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQI
TCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQW
INKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTL
YVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTI

--------------------------------------------------------------

>11454_11454_7_C1S-HP_C1S_chr12_7175075_ENST00000360817_HP_chr16_72093013_ENST00000357763_length(amino acids)=723AA_BP=439
MAGERELTHLLLPASEGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYG
IHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFV
DVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAAD
SAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQI
TCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQW
INKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTL
YVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTI

--------------------------------------------------------------

>11454_11454_8_C1S-HP_C1S_chr12_7175075_ENST00000360817_HP_chr16_72093013_ENST00000398131_length(amino acids)=723AA_BP=439
MAGERELTHLLLPASEGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYG
IHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFV
DVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAAD
SAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQI
TCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQW
INKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTL
YVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTI

--------------------------------------------------------------

>11454_11454_9_C1S-HP_C1S_chr12_7175075_ENST00000360817_HP_chr16_72093013_ENST00000562526_length(amino acids)=468AA_BP=439
MAGERELTHLLLPASEGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYG
IHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFV
DVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAAD
SAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQI
TCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQW

--------------------------------------------------------------

>11454_11454_10_C1S-HP_C1S_chr12_7175075_ENST00000360817_HP_chr16_72093013_ENST00000570083_length(amino acids)=723AA_BP=439
MAGERELTHLLLPASEGSKVRRCRKPGPRDRQLTRVDKSPEMWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYG
IHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFV
DVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAAD
SAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQI
TCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQW
INKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTL
YVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY
EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTI

--------------------------------------------------------------

>11454_11454_11_C1S-HP_C1S_chr12_7175075_ENST00000402681_HP_chr16_72093013_ENST00000355906_length(amino acids)=642AA_BP=358
MPPLRLQSPEVQKARTKRQAAHQGGQIARDVIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVAT
DINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRR
EDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAK
YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGV
YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATA
KDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVA
DQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTS

--------------------------------------------------------------

>11454_11454_12_C1S-HP_C1S_chr12_7175075_ENST00000402681_HP_chr16_72093013_ENST00000357763_length(amino acids)=642AA_BP=358
MPPLRLQSPEVQKARTKRQAAHQGGQIARDVIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVAT
DINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRR
EDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAK
YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGV
YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATA
KDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVA
DQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTS

--------------------------------------------------------------

>11454_11454_13_C1S-HP_C1S_chr12_7175075_ENST00000402681_HP_chr16_72093013_ENST00000398131_length(amino acids)=642AA_BP=358
MPPLRLQSPEVQKARTKRQAAHQGGQIARDVIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVAT
DINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRR
EDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAK
YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGV
YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATA
KDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVA
DQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTS

--------------------------------------------------------------

>11454_11454_14_C1S-HP_C1S_chr12_7175075_ENST00000402681_HP_chr16_72093013_ENST00000562526_length(amino acids)=387AA_BP=358
MPPLRLQSPEVQKARTKRQAAHQGGQIARDVIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVAT
DINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRR
EDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAK
YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGV

--------------------------------------------------------------

>11454_11454_15_C1S-HP_C1S_chr12_7175075_ENST00000402681_HP_chr16_72093013_ENST00000570083_length(amino acids)=642AA_BP=358
MPPLRLQSPEVQKARTKRQAAHQGGQIARDVIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVAT
DINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRR
EDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAK
YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGV
YTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATA
KDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVA
DQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTS

--------------------------------------------------------------

>11454_11454_16_C1S-HP_C1S_chr12_7175075_ENST00000406697_HP_chr16_72093013_ENST00000355906_length(amino acids)=682AA_BP=398
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNN
PHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDI
IFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFP
WQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMP
ICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGD

--------------------------------------------------------------

>11454_11454_17_C1S-HP_C1S_chr12_7175075_ENST00000406697_HP_chr16_72093013_ENST00000357763_length(amino acids)=682AA_BP=398
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNN
PHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDI
IFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFP
WQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMP
ICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGD

--------------------------------------------------------------

>11454_11454_18_C1S-HP_C1S_chr12_7175075_ENST00000406697_HP_chr16_72093013_ENST00000398131_length(amino acids)=682AA_BP=398
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNN
PHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDI
IFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFP
WQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMP
ICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGD

--------------------------------------------------------------

>11454_11454_19_C1S-HP_C1S_chr12_7175075_ENST00000406697_HP_chr16_72093013_ENST00000562526_length(amino acids)=427AA_BP=398
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNN
PHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDI
IFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG

--------------------------------------------------------------

>11454_11454_20_C1S-HP_C1S_chr12_7175075_ENST00000406697_HP_chr16_72093013_ENST00000570083_length(amino acids)=682AA_BP=398
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQIISGDTEEGRLCGQRSSNN
PHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDI
IFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFP
WQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMP
ICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:7175075/chr16:72093013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C1S

P09871

HP

P02790

FUNCTION: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.FUNCTION: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+1012131_172398.3333333333333689.0DomainNote=EGF-like%3B calcium-binding
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+101216_130398.3333333333333689.0DomainCUB 1
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+1012175_290398.3333333333333689.0DomainCUB 2
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+1012292_356398.3333333333333689.0DomainSushi 1
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+1012131_172398.3333333333333689.0DomainNote=EGF-like%3B calcium-binding
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+101216_130398.3333333333333689.0DomainCUB 1
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+1012175_290398.3333333333333689.0DomainCUB 2
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+1012292_356398.3333333333333689.0DomainSushi 1
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+1315131_172398.3333333333333689.0DomainNote=EGF-like%3B calcium-binding
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+131516_130398.3333333333333689.0DomainCUB 1
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+1315175_290398.3333333333333689.0DomainCUB 2
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+1315292_356398.3333333333333689.0DomainSushi 1
TgeneHPchr12:7175075chr16:72093013ENST0000035590647162_404122.33333333333333407.0DomainPeptidase S1
TgeneHPchr12:7175075chr16:72093013ENST0000039813125162_40463.333333333333336348.0DomainPeptidase S1
TgeneHPchr12:7175075chr16:72093013ENST000003981312590_14763.333333333333336348.0DomainSushi 2
TgeneHPchr12:7175075chr16:72093013ENST0000056557405162_4040348.0DomainPeptidase S1
TgeneHPchr12:7175075chr16:72093013ENST000005655740531_880348.0DomainSushi 1
TgeneHPchr12:7175075chr16:72093013ENST000005655740590_1470348.0DomainSushi 2
TgeneHPchr12:7175075chr16:72093013ENST0000057008325162_40463.333333333333336348.0DomainPeptidase S1
TgeneHPchr12:7175075chr16:72093013ENST000005700832590_14763.333333333333336348.0DomainSushi 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+1012357_423398.3333333333333689.0DomainSushi 2
HgeneC1Schr12:7175075chr16:72093013ENST00000328916+1012438_680398.3333333333333689.0DomainPeptidase S1
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+1012357_423398.3333333333333689.0DomainSushi 2
HgeneC1Schr12:7175075chr16:72093013ENST00000360817+1012438_680398.3333333333333689.0DomainPeptidase S1
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+1315357_423398.3333333333333689.0DomainSushi 2
HgeneC1Schr12:7175075chr16:72093013ENST00000406697+1315438_680398.3333333333333689.0DomainPeptidase S1
TgeneHPchr12:7175075chr16:72093013ENST000003559064731_88122.33333333333333407.0DomainSushi 1
TgeneHPchr12:7175075chr16:72093013ENST000003559064790_147122.33333333333333407.0DomainSushi 2
TgeneHPchr12:7175075chr16:72093013ENST000003981312531_8863.333333333333336348.0DomainSushi 1
TgeneHPchr12:7175075chr16:72093013ENST000005700832531_8863.333333333333336348.0DomainSushi 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
C1S
HP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to C1S-HP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to C1S-HP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource