UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ACACA-GSDMB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACACA-GSDMB
FusionPDB ID: 1154
FusionGDB2.0 ID: 1154
HgeneTgene
Gene symbol

ACACA

GSDMB

Gene ID

31

55876

Gene nameacetyl-CoA carboxylase alphagasdermin B
SynonymsACAC|ACACAD|ACC|ACC1|ACCAGSDMB-1|GSDML|PP4052|PRO2521
Cytomap

17q12

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphagasdermin-Bgasdermin-like proteingasderminB-1
Modification date2020031320200313
UniProtAcc

Q13085

Q8TAX9

Ensembl transtripts involved in fusion geneENST idsENST00000353139, ENST00000360679, 
ENST00000335166, ENST00000394406, 
ENST00000361253, ENST00000416895, 
ENST00000588142, ENST00000589665, 
ENST00000309481, ENST00000360317, 
ENST00000394175, ENST00000394179, 
ENST00000418519, ENST00000520542, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 35 X 17=2618012 X 13 X 9=1404
# samples 5115
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1404*10)=-3.22650852980868
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACACA [Title/Abstract] AND GSDMB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACACA(35627642)-GSDMB(38068750), # samples:3
Anticipated loss of major functional domain due to fusion event.ACACA-GSDMB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-GSDMB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-GSDMB seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACACA-GSDMB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GSDMB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6929-01AACACAchr17

35627642

-GSDMBchr17

38068750

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394406ACACAchr1735627642-ENST00000360317GSDMBchr1738068750-243211991131234373
ENST00000394406ACACAchr1735627642-ENST00000394175GSDMBchr1738068750-236611991131234373
ENST00000394406ACACAchr1735627642-ENST00000309481GSDMBchr1738068750-239311991131234373
ENST00000394406ACACAchr1735627642-ENST00000520542GSDMBchr1738068750-240311991131234373
ENST00000394406ACACAchr1735627642-ENST00000418519GSDMBchr1738068750-243011991131234373
ENST00000394406ACACAchr1735627642-ENST00000394179GSDMBchr1738068750-241511991131234373
ENST00000335166ACACAchr1735627642-ENST00000360317GSDMBchr1738068750-2613138014032395330
ENST00000335166ACACAchr1735627642-ENST00000394175GSDMBchr1738068750-2547138014032329308
ENST00000335166ACACAchr1735627642-ENST00000309481GSDMBchr1738068750-2574138014032356317
ENST00000335166ACACAchr1735627642-ENST00000520542GSDMBchr1738068750-2584138014032368321
ENST00000335166ACACAchr1735627642-ENST00000418519GSDMBchr1738068750-2611138014032395330
ENST00000335166ACACAchr1735627642-ENST00000394179GSDMBchr1738068750-2596138014032380325

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394406ENST00000360317ACACAchr1735627642-GSDMBchr1738068750-0.0037179340.99628204
ENST00000394406ENST00000394175ACACAchr1735627642-GSDMBchr1738068750-0.0039307090.9960693
ENST00000394406ENST00000309481ACACAchr1735627642-GSDMBchr1738068750-0.003726970.99627304
ENST00000394406ENST00000520542ACACAchr1735627642-GSDMBchr1738068750-0.0038719570.996128
ENST00000394406ENST00000418519ACACAchr1735627642-GSDMBchr1738068750-0.0037881380.9962119
ENST00000394406ENST00000394179ACACAchr1735627642-GSDMBchr1738068750-0.0037617220.99623823
ENST00000335166ENST00000360317ACACAchr1735627642-GSDMBchr1738068750-0.0022313430.99776864
ENST00000335166ENST00000394175ACACAchr1735627642-GSDMBchr1738068750-0.0024246330.99757534
ENST00000335166ENST00000309481ACACAchr1735627642-GSDMBchr1738068750-0.0023309720.99766904
ENST00000335166ENST00000520542ACACAchr1735627642-GSDMBchr1738068750-0.0022733620.9977266
ENST00000335166ENST00000418519ACACAchr1735627642-GSDMBchr1738068750-0.0022576080.9977424
ENST00000335166ENST00000394179ACACAchr1735627642-GSDMBchr1738068750-0.0023312390.9976687

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1154_1154_1_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=317AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMKKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNS
LAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKS

--------------------------------------------------------------

>1154_1154_2_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=330AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLK
DLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALE

--------------------------------------------------------------

>1154_1154_3_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=308AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMRKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLNSLAKCLGKED
IRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVKSVMEQNWDEL

--------------------------------------------------------------

>1154_1154_4_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=325AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMSAGLDIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEE
KRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLP

--------------------------------------------------------------

>1154_1154_5_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=330AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLK
DLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALE

--------------------------------------------------------------

>1154_1154_6_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000335166_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=321AA_BP=
MDNVDSTGELIVRLPKEITISGSFQGFHHQKIKISENRISQQYLATLENRKLKRELPFSFRSINTRENLYLVTETLETVKEETLKSDRQY
KFWSQISQGHLSYKHKGQREVTIPPNRVLSYRVKQLVFPNKETMNIHFRGKTKSFPEGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKD
VLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKD

--------------------------------------------------------------

>1154_1154_7_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000309481_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

>1154_1154_8_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000360317_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

>1154_1154_9_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000394175_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

>1154_1154_10_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000394179_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

>1154_1154_11_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000418519_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

>1154_1154_12_ACACA-GSDMB_ACACA_chr17_35627642_ENST00000394406_GSDMB_chr17_38068750_ENST00000520542_length(amino acids)=373AA_BP=
MRSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGI
SSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFV
VMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKI
ASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLF

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35627642/chr17:38068750)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

GSDMB

Q8TAX9

FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). {ECO:0000269|PubMed:32299851}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851). Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28154144, ECO:0000269|PubMed:32299851}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-1056315_320373.02384.0Nucleotide bindingATP
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-1056315_320336.02347.0Nucleotide bindingATP
TgeneGSDMBchr17:35627642chr17:38068750ENST00000309481110243_27178.33333333333333404.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:35627642chr17:38068750ENST00000360317010243_27178.33333333333333417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:35627642chr17:38068750ENST0000039417508243_27178.33333333333333395.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:35627642chr17:38068750ENST00000394179110243_27178.33333333333333412.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:35627642chr17:38068750ENST00000418519111243_27178.33333333333333417.0Coiled coilOntology_term=ECO:0000255
TgeneGSDMBchr17:35627642chr17:38068750ENST00000520542110243_27178.33333333333333408.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-955117_618258.02269.0DomainBiotin carboxylation
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-9551576_1914258.02269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-9551918_2234258.02269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-955275_466258.02269.0DomainATP-grasp
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-955745_819258.02269.0DomainBiotinyl-binding
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-1056117_618373.02384.0DomainBiotin carboxylation
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-10561576_1914373.02384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-10561918_2234373.02384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-1056275_466373.02384.0DomainATP-grasp
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-1056745_819373.02384.0DomainBiotinyl-binding
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-854117_618278.02289.0DomainBiotin carboxylation
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-8541576_1914278.02289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-8541918_2234278.02289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-854275_466278.02289.0DomainATP-grasp
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-854745_819278.02289.0DomainBiotinyl-binding
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-1056117_618336.02347.0DomainBiotin carboxylation
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-10561576_1914336.02347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-10561918_2234336.02347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-1056275_466336.02347.0DomainATP-grasp
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-1056745_819336.02347.0DomainBiotinyl-binding
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-955315_320258.02269.0Nucleotide bindingATP
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-854315_320278.02289.0Nucleotide bindingATP
HgeneACACAchr17:35627642chr17:38068750ENST00000335166-9551576_2234258.02269.0RegionCarboxyltransferase
HgeneACACAchr17:35627642chr17:38068750ENST00000353139-10561576_2234373.02384.0RegionCarboxyltransferase
HgeneACACAchr17:35627642chr17:38068750ENST00000360679-8541576_2234278.02289.0RegionCarboxyltransferase
HgeneACACAchr17:35627642chr17:38068750ENST00000394406-10561576_2234336.02347.0RegionCarboxyltransferase
TgeneGSDMBchr17:35627642chr17:38068750ENST000003094811101_27578.33333333333333404.0RegionTriggers pyroptosis
TgeneGSDMBchr17:35627642chr17:38068750ENST000003603170101_27578.33333333333333417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:35627642chr17:38068750ENST00000394175081_27578.33333333333333395.0RegionTriggers pyroptosis
TgeneGSDMBchr17:35627642chr17:38068750ENST000003941791101_27578.33333333333333412.0RegionTriggers pyroptosis
TgeneGSDMBchr17:35627642chr17:38068750ENST000004185191111_27578.33333333333333417.0RegionTriggers pyroptosis
TgeneGSDMBchr17:35627642chr17:38068750ENST000005205421101_27578.33333333333333408.0RegionTriggers pyroptosis


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACACA
GSDMB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ACACA-GSDMB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ACACA-GSDMB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource