UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ACACA-LASP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACACA-LASP1
FusionPDB ID: 1158
FusionGDB2.0 ID: 1158
HgeneTgene
Gene symbol

ACACA

LASP1

Gene ID

31

3927

Gene nameacetyl-CoA carboxylase alphaLIM and SH3 protein 1
SynonymsACAC|ACACAD|ACC|ACC1|ACCALasp-1|MLN50
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphaLIM and SH3 domain protein 1metastatic lymph node gene 50 protein
Modification date2020031320200313
UniProtAcc

Q13085

Q14847

Ensembl transtripts involved in fusion geneENST idsENST00000335166, ENST00000353139, 
ENST00000360679, ENST00000394406, 
ENST00000361253, ENST00000416895, 
ENST00000588142, ENST00000589665, 
ENST00000433206, ENST00000435347, 
ENST00000318008, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 35 X 17=2618016 X 20 X 9=2880
# samples 5120
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2880*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACACA [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACACA(35536200)-LASP1(37034338), # samples:2
Anticipated loss of major functional domain due to fusion event.ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACACA-LASP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ACACA-LASP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LASP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01AACACAchr17

35536201

-LASP1chr17

37034339

+
ChimerDB4ESCATCGA-L5-A4OQ-01AACACAchr17

35536203

-LASP1chr17

37034337

+
ChimerDB4ESCATCGA-L5-A4OQACACAchr17

35536200

-LASP1chr17

37034338

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353139ACACAchr1735536203-ENST00000318008LASP1chr1737034337+9270556146162771938
ENST00000360679ACACAchr1735536203-ENST00000318008LASP1chr1737034337+8938522929759451882
ENST00000353139ACACAchr1735536200-ENST00000318008LASP1chr1737034338+9270556146162771938
ENST00000360679ACACAchr1735536200-ENST00000318008LASP1chr1737034338+8938522929759451882
ENST00000353139ACACAchr1735536201-ENST00000318008LASP1chr1737034339+9270556146162771938
ENST00000360679ACACAchr1735536201-ENST00000318008LASP1chr1737034339+8938522929759451882

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353139ENST00000318008ACACAchr1735536203-LASP1chr1737034337+0.0008546840.99914527
ENST00000360679ENST00000318008ACACAchr1735536203-LASP1chr1737034337+0.0007991960.99920076
ENST00000353139ENST00000318008ACACAchr1735536200-LASP1chr1737034338+0.0008546840.99914527
ENST00000360679ENST00000318008ACACAchr1735536200-LASP1chr1737034338+0.0007991960.99920076
ENST00000353139ENST00000318008ACACAchr1735536201-LASP1chr1737034339+0.0008546840.99914527
ENST00000360679ENST00000318008ACACAchr1735536201-LASP1chr1737034339+0.0007991960.99920076

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1158_1158_1_ACACA-LASP1_ACACA_chr17_35536200_ENST00000353139_LASP1_chr17_37034338_ENST00000318008_length(amino acids)=1938AA_BP=1700
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS
IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG
IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGG
GGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQ
CAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSA
HVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD
FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIY
EGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYI
VEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYV
LDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILD
SHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTK
KNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILS
ETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVAS
VSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAA
MFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPC
ANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPS
KIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTP
YVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCE
TCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYH
EEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDY

--------------------------------------------------------------

>1158_1158_2_ACACA-LASP1_ACACA_chr17_35536200_ENST00000360679_LASP1_chr17_37034338_ENST00000318008_length(amino acids)=1882AA_BP=1644
MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV
ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP
QELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAIS
LFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL
QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEF
ADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADV
SLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVD
RYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDN
PSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPP
NVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQ
NGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPS
YELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQF
MLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHT
SLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARD
KFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLE
AMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDI
SLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEE
FEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPV

--------------------------------------------------------------

>1158_1158_3_ACACA-LASP1_ACACA_chr17_35536201_ENST00000353139_LASP1_chr17_37034339_ENST00000318008_length(amino acids)=1938AA_BP=1700
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS
IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG
IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGG
GGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQ
CAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSA
HVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD
FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIY
EGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYI
VEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYV
LDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILD
SHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTK
KNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILS
ETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVAS
VSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAA
MFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPC
ANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPS
KIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTP
YVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCE
TCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYH
EEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDY

--------------------------------------------------------------

>1158_1158_4_ACACA-LASP1_ACACA_chr17_35536201_ENST00000360679_LASP1_chr17_37034339_ENST00000318008_length(amino acids)=1882AA_BP=1644
MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV
ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP
QELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAIS
LFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL
QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEF
ADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADV
SLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVD
RYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDN
PSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPP
NVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQ
NGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPS
YELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQF
MLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHT
SLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARD
KFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLE
AMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDI
SLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEE
FEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPV

--------------------------------------------------------------

>1158_1158_5_ACACA-LASP1_ACACA_chr17_35536203_ENST00000353139_LASP1_chr17_37034337_ENST00000318008_length(amino acids)=1938AA_BP=1700
MRRNDERMWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKE
GSLSPASVGSDTLSDLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRS
IRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNG
IAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGG
GGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQ
CAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSA
HVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD
FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIY
EGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYI
VEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYV
LDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILD
SHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTK
KNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILS
ETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVAS
VSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAA
MFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPC
ANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPS
KIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTP
YVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCE
TCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYH
EEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDY

--------------------------------------------------------------

>1158_1158_6_ACACA-LASP1_ACACA_chr17_35536203_ENST00000360679_LASP1_chr17_37034337_ENST00000318008_length(amino acids)=1882AA_BP=1644
MTEARQKAQYLLSSWVLSSCNRRRNCGLCLQGRNLKKKLPFFSHLDMEGSPEENKEMRYYMLQRSSMSGLHLVKQGRDRKKIDSQRDFTV
ASPAEFVTRFGGNKVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
ILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVP
QELYEKGYVKDVDDGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEVQILADQYGNAIS
LFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQL
QIAMGIPLYRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEF
ADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADV
SLRNSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVD
RYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDN
PSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPP
NVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQ
NGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPS
YELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQF
MLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHT
SLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARD
KFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLE
AMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDI
SLYKEVTDSRTAQIMFQAYGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDML
TYTELVLDDQGQLVHMNRLPGGNEFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEE
FEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQPQQQPV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35536200/chr17:37034338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

LASP1

Q14847

FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.FUNCTION: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-4055117_6181578.02269.0DomainBiotin carboxylation
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-4055275_4661578.02269.0DomainATP-grasp
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-4055745_8191578.02269.0DomainBiotinyl-binding
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-4156117_6181693.02384.0DomainBiotin carboxylation
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-4156275_4661693.02384.0DomainATP-grasp
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-4156745_8191693.02384.0DomainBiotinyl-binding
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-3954117_6181598.02289.0DomainBiotin carboxylation
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-3954275_4661598.02289.0DomainATP-grasp
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-3954745_8191598.02289.0DomainBiotinyl-binding
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-4156117_6181656.02347.0DomainBiotin carboxylation
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-4156275_4661656.02347.0DomainATP-grasp
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-4156745_8191656.02347.0DomainBiotinyl-binding
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-4055117_6181578.02269.0DomainBiotin carboxylation
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-4055275_4661578.02269.0DomainATP-grasp
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-4055745_8191578.02269.0DomainBiotinyl-binding
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-4156117_6181693.02384.0DomainBiotin carboxylation
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-4156275_4661693.02384.0DomainATP-grasp
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-4156745_8191693.02384.0DomainBiotinyl-binding
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-3954117_6181598.02289.0DomainBiotin carboxylation
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-3954275_4661598.02289.0DomainATP-grasp
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-3954745_8191598.02289.0DomainBiotinyl-binding
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-4156117_6181656.02347.0DomainBiotin carboxylation
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-4156275_4661656.02347.0DomainATP-grasp
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-4156745_8191656.02347.0DomainBiotinyl-binding
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-4055117_6181578.02269.0DomainBiotin carboxylation
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-4055275_4661578.02269.0DomainATP-grasp
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-4055745_8191578.02269.0DomainBiotinyl-binding
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-4156117_6181693.02384.0DomainBiotin carboxylation
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-4156275_4661693.02384.0DomainATP-grasp
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-4156745_8191693.02384.0DomainBiotinyl-binding
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-3954117_6181598.02289.0DomainBiotin carboxylation
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-3954275_4661598.02289.0DomainATP-grasp
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-3954745_8191598.02289.0DomainBiotinyl-binding
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-4156117_6181656.02347.0DomainBiotin carboxylation
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-4156275_4661656.02347.0DomainATP-grasp
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-4156745_8191656.02347.0DomainBiotinyl-binding
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-4055315_3201578.02269.0Nucleotide bindingATP
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-4156315_3201693.02384.0Nucleotide bindingATP
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-3954315_3201598.02289.0Nucleotide bindingATP
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-4156315_3201656.02347.0Nucleotide bindingATP
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-4055315_3201578.02269.0Nucleotide bindingATP
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-4156315_3201693.02384.0Nucleotide bindingATP
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-3954315_3201598.02289.0Nucleotide bindingATP
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-4156315_3201656.02347.0Nucleotide bindingATP
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-4055315_3201578.02269.0Nucleotide bindingATP
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-4156315_3201693.02384.0Nucleotide bindingATP
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-3954315_3201598.02289.0Nucleotide bindingATP
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-4156315_3201656.02347.0Nucleotide bindingATP
TgeneLASP1chr17:35536200chr17:37034338ENST0000031800807201_20423.0262.0Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536200chr17:37034338ENST0000043534708201_20423.0708.3333333333334Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536201chr17:37034339ENST0000031800807201_20423.0262.0Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536201chr17:37034339ENST0000043534708201_20423.0708.3333333333334Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536203chr17:37034337ENST0000031800807201_20423.0262.0Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536203chr17:37034337ENST0000043534708201_20423.0708.3333333333334Compositional biasNote=Poly-Gly
TgeneLASP1chr17:35536200chr17:37034338ENST0000031800807202_26123.0262.0DomainSH3
TgeneLASP1chr17:35536200chr17:37034338ENST0000043534708202_26123.0708.3333333333334DomainSH3
TgeneLASP1chr17:35536201chr17:37034339ENST0000031800807202_26123.0262.0DomainSH3
TgeneLASP1chr17:35536201chr17:37034339ENST0000043534708202_26123.0708.3333333333334DomainSH3
TgeneLASP1chr17:35536203chr17:37034337ENST0000031800807202_26123.0262.0DomainSH3
TgeneLASP1chr17:35536203chr17:37034337ENST0000043534708202_26123.0708.3333333333334DomainSH3
TgeneLASP1chr17:35536200chr17:37034338ENST000003180080761_9523.0262.0RepeatNote=Nebulin 1
TgeneLASP1chr17:35536200chr17:37034338ENST000003180080797_13123.0262.0RepeatNote=Nebulin 2
TgeneLASP1chr17:35536200chr17:37034338ENST000004353470861_9523.0708.3333333333334RepeatNote=Nebulin 1
TgeneLASP1chr17:35536200chr17:37034338ENST000004353470897_13123.0708.3333333333334RepeatNote=Nebulin 2
TgeneLASP1chr17:35536201chr17:37034339ENST000003180080761_9523.0262.0RepeatNote=Nebulin 1
TgeneLASP1chr17:35536201chr17:37034339ENST000003180080797_13123.0262.0RepeatNote=Nebulin 2
TgeneLASP1chr17:35536201chr17:37034339ENST000004353470861_9523.0708.3333333333334RepeatNote=Nebulin 1
TgeneLASP1chr17:35536201chr17:37034339ENST000004353470897_13123.0708.3333333333334RepeatNote=Nebulin 2
TgeneLASP1chr17:35536203chr17:37034337ENST000003180080761_9523.0262.0RepeatNote=Nebulin 1
TgeneLASP1chr17:35536203chr17:37034337ENST000003180080797_13123.0262.0RepeatNote=Nebulin 2
TgeneLASP1chr17:35536203chr17:37034337ENST000004353470861_9523.0708.3333333333334RepeatNote=Nebulin 1
TgeneLASP1chr17:35536203chr17:37034337ENST000004353470897_13123.0708.3333333333334RepeatNote=Nebulin 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-40551576_19141578.02269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-40551918_22341578.02269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-41561576_19141693.02384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-41561918_22341693.02384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-39541576_19141598.02289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-39541918_22341598.02289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-41561576_19141656.02347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-41561918_22341656.02347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-40551576_19141578.02269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-40551918_22341578.02269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-41561576_19141693.02384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-41561918_22341693.02384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-39541576_19141598.02289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-39541918_22341598.02289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-41561576_19141656.02347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-41561918_22341656.02347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-40551576_19141578.02269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-40551918_22341578.02269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-41561576_19141693.02384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-41561918_22341693.02384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-39541576_19141598.02289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-39541918_22341598.02289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-41561576_19141656.02347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-41561918_22341656.02347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35536200chr17:37034338ENST00000335166-40551576_22341578.02269.0RegionCarboxyltransferase
HgeneACACAchr17:35536200chr17:37034338ENST00000353139-41561576_22341693.02384.0RegionCarboxyltransferase
HgeneACACAchr17:35536200chr17:37034338ENST00000360679-39541576_22341598.02289.0RegionCarboxyltransferase
HgeneACACAchr17:35536200chr17:37034338ENST00000394406-41561576_22341656.02347.0RegionCarboxyltransferase
HgeneACACAchr17:35536201chr17:37034339ENST00000335166-40551576_22341578.02269.0RegionCarboxyltransferase
HgeneACACAchr17:35536201chr17:37034339ENST00000353139-41561576_22341693.02384.0RegionCarboxyltransferase
HgeneACACAchr17:35536201chr17:37034339ENST00000360679-39541576_22341598.02289.0RegionCarboxyltransferase
HgeneACACAchr17:35536201chr17:37034339ENST00000394406-41561576_22341656.02347.0RegionCarboxyltransferase
HgeneACACAchr17:35536203chr17:37034337ENST00000335166-40551576_22341578.02269.0RegionCarboxyltransferase
HgeneACACAchr17:35536203chr17:37034337ENST00000353139-41561576_22341693.02384.0RegionCarboxyltransferase
HgeneACACAchr17:35536203chr17:37034337ENST00000360679-39541576_22341598.02289.0RegionCarboxyltransferase
HgeneACACAchr17:35536203chr17:37034337ENST00000394406-41561576_22341656.02347.0RegionCarboxyltransferase
TgeneLASP1chr17:35536200chr17:37034338ENST00000318008075_5623.0262.0DomainLIM zinc-binding
TgeneLASP1chr17:35536200chr17:37034338ENST00000435347085_5623.0708.3333333333334DomainLIM zinc-binding
TgeneLASP1chr17:35536201chr17:37034339ENST00000318008075_5623.0262.0DomainLIM zinc-binding
TgeneLASP1chr17:35536201chr17:37034339ENST00000435347085_5623.0708.3333333333334DomainLIM zinc-binding
TgeneLASP1chr17:35536203chr17:37034337ENST00000318008075_5623.0262.0DomainLIM zinc-binding
TgeneLASP1chr17:35536203chr17:37034337ENST00000435347085_5623.0708.3333333333334DomainLIM zinc-binding


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
LASP1TRIP13, PLSCR1, FHL3, MDFI, ZYX, Fancc, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, Prkg1, Prkaca, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, Prkcz, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES, PPP6C, EFTUD2, TNIP2, RBPMS, DPF2, COPS5, SFN, MYC, CDK9, CANX, ATG16L1, DCAF15, BICD1, BICD2, BMH1, BMH2, TRIM28, FAM168A, POLD1, DMRT3, POU1F1, ANKS1A, PITX1, CAMK2A, RBFOX1, CHERP, DTX2, NUTF2, VAC14, MED25, HOXA1, CRYBA1, TENC1, TFG, OTX1, GCM2, TEKT3, CPSF3L, ARHGEF16, BHLHE40, ZC3H10, VEZF1, RNF38, SPAG8, GUCD1, BAHD1, GAS8, LMO4, YTHDF1, FAM168B, TEKT5, BAG4, FOXH1, PRR35, PPP1R32, OXER1, TEKT4, CRYBA2, TLX3, RBPMS2, CERCAM, LENG8, MGAT5B, VPS37C, HNRNPF, EVX2, CATSPER1, YES1, UFSP1, CSTF2T, MKRN3, C14orf119, CTNNA3, HGS, WWOX, KRTAP19-6, KRTAP6-2, KRTAP19-4, KRTAP10-8, UBQLN2, C19orf54, NOXA1, ARID5A, CYSRT1, KRTAP26-1, QRICH1, PRR20B, PRR20A, DOK6, VGLL3, KRTAP3-3, KRTAP3-2, KRTAP12-4, PRR20D, PRR20C, PRR20E, KRTAP19-3, FBXO17, PLEKHA4, HCVgp1, PRNP, NUPR1, BRD4, USP15, RIN3, ACTB, PFN1, PRPH, RDX, TJP2, VASP, VIM, NAA40, FAM24B, RPL35A, HSPA1A, BTF3, EP300, STAT1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACACA
LASP1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ACACA-LASP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ACACA-LASP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLASP1C0004352Autistic Disorder1CTD_human
TgeneLASP1C0014170Endometrial Neoplasms1CTD_human
TgeneLASP1C0036341Schizophrenia1PSYGENET
TgeneLASP1C0476089Endometrial Carcinoma1CTD_human