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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CABIN1-CTNNBIP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CABIN1-CTNNBIP1
	FusionPDB ID: 12227
	FusionGDB2.0 ID: 12227
		Hgene	Tgene
	Gene symbol	CABIN1	CTNNBIP1
	Gene ID	23523	56998
	Gene name	calcineurin binding protein 1	catenin beta interacting protein 1
	Synonyms	CAIN\|KB-318B8.7\|PPP3IN	ICAT
	Cytomap	22q11.23	1p36.22
	Type of gene	protein-coding	protein-coding
	Description	calcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitor	beta-catenin-interacting protein 1beta-catenin-interacting protein ICATinhibitor of beta-catenin and Tcf-4
	Modification date	20200313	20200313
	UniProtAcc	Q9Y6J0	Q9NSA3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263119, ENST00000398319, ENST00000405822, ENST00000337989, ENST00000485008,	ENST00000377256, ENST00000377258, ENST00000400904, ENST00000537447, ENST00000377263,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 15 X 8=1920	7 X 7 X 9=441
	# samples	18	13
	** MAII score	log2(18/1920*10)=-3.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/441*10)=-1.76226703252907 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CABIN1 [Title/Abstract] AND CTNNBIP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CABIN1(24509715)-CTNNBIP1(9910834), # samples:1
Anticipated loss of major functional domain due to fusion event.	CABIN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CABIN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CABIN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CABIN1-CTNNBIP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CABIN1	GO:0006336	DNA replication-independent nucleosome assembly	14718166
Tgene	CTNNBIP1	GO:0032091	negative regulation of protein binding	12408825\|18287330

Fusion gene breakpoints across CABIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CTNNBIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0725-01A	CABIN1	chr22	24509715	+	CTNNBIP1	chr1	9910834	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263119	CABIN1	chr22	24509715	+	ENST00000377263	CTNNBIP1	chr1	9910834	-	6928	4427	121	4485	1454
ENST00000405822	CABIN1	chr22	24509715	+	ENST00000377263	CTNNBIP1	chr1	9910834	-	6658	4157	88	4215	1375
ENST00000398319	CABIN1	chr22	24509715	+	ENST00000377263	CTNNBIP1	chr1	9910834	-	7186	4685	379	4743	1454

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263119	ENST00000377263	CABIN1	chr22	24509715	+	CTNNBIP1	chr1	9910834	-	0.002651902	0.99734807
ENST00000405822	ENST00000377263	CABIN1	chr22	24509715	+	CTNNBIP1	chr1	9910834	-	0.001797634	0.9982023
ENST00000398319	ENST00000377263	CABIN1	chr22	24509715	+	CTNNBIP1	chr1	9910834	-	0.003355513	0.9966445

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12227_12227_1_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000263119_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1454AA_BP=1435
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFF
TWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLL
ETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESF
PSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHI
KDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQ
GDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCT
SGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILK
VSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEY
LGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPK
TLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFY
MHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGEL
PPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAM
EALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSP
PYTATPIDHDYVKCKKPHQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGAEDV

--------------------------------------------------------------

>12227_12227_2_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000398319_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1454AA_BP=1435
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFF
TWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLL
ETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESF
PSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHI
KDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQ
GDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCT
SGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILK
VSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEY
LGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPK
TLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFY
MHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGEL
PPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAM
EALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSP
PYTATPIDHDYVKCKKPHQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGAEDV

--------------------------------------------------------------

>12227_12227_3_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000405822_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1375AA_BP=1356
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTP
VNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLLETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKV
DFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESFPSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHK
FLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTH
CLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLE
EIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAV
QQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILKVSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQE
EDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFY
CLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTST
EVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNC
FRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGELPPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEK
QQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTP
KASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24509715/chr1:9910834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CABIN1 Q9Y6J0	CTNNBIP1 Q9NSA3
FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:9655484}.	FUNCTION: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269\|PubMed:12408824}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

1055_1088

1433.3333333333333

2221.0

Repeat

Note=TPR 5

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

1106_1139

1433.3333333333333

2221.0

Repeat

Note=TPR 6

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

125_157

1433.3333333333333

2221.0

Repeat

Note=TPR 3

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

36_69

1433.3333333333333

2221.0

Repeat

Note=TPR 1

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

615_648

1433.3333333333333

2221.0

Repeat

Note=TPR 4

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000263119

90_123

1433.3333333333333

2221.0

Repeat

Note=TPR 2

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

1055_1088

1433.3333333333333

2221.0

Repeat

Note=TPR 5

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

1106_1139

1433.3333333333333

2221.0

Repeat

Note=TPR 6

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

125_157

1433.3333333333333

2221.0

Repeat

Note=TPR 3

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

36_69

1433.3333333333333

2221.0

Repeat

Note=TPR 1

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

615_648

1433.3333333333333

2221.0

Repeat

Note=TPR 4

Hgene

CABIN1

chr22:24509715

chr1:9910834

ENST00000398319

90_123

1433.3333333333333

2221.0

Repeat

Note=TPR 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

CABIN1

MEF2BNB-MEF2B, HDAC1, HDAC2, SIN3A, MEF2D, DNM1, AMPH, AP1B1, PPP3CA, SUV39H1, HIRA, CAMK4, YWHAQ, H3F3A, UBN1, POLR2A, TFAP4, HECW2, MEF2B, EAF1, HIST1H3A, ASF1A, MEF2A, NFATC2, ASF1B, CDX1, XAGE1B, TLK2, SMARCA4, SMARCB1, ESR2, TP53BP1, BRCA1, KIAA1429, HIST1H4A, TCF7L2, GRM1, HIST1H1A, ATRX, KIF14, PYHIN1, UBN2, CDAN1, C15orf41, HAT1, NASP, CALML5, MCM2, CSTA, SPRR1B, S100A14, FABP5, RIF1, RBBP4, ERCC4, HNRNPCL2, ZCCHC10, IFI6, H3F3B, HMGA1, HIST1H3F, HNF1B, HNF4A, MYOD1, PAX6, YY1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CABIN1
CTNNBIP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CABIN1-CTNNBIP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CABIN1-CTNNBIP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CABIN1	C0018800	Cardiomegaly	1	CTD_human
Hgene	CABIN1	C1383860	Cardiac Hypertrophy	1	CTD_human