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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CABLES1-RBBP8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CABLES1-RBBP8
FusionPDB ID: 12252
FusionGDB2.0 ID: 12252
HgeneTgene
Gene symbol

CABLES1

RBBP8

Gene ID

91768

5932

Gene nameCdk5 and Abl enzyme substrate 1RB binding protein 8, endonuclease
SynonymsCABL1|CABLES|HsT2563|IK3-1COM1|CTIP|JWDS|RIM|SAE2|SCKL2
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
DescriptionCDK5 and ABL1 enzyme substrate 1interactor with CDK3 1DNA endonuclease RBBP8CTBP-interacting proteinRBBP-8retinoblastoma binding protein 8sporulation in the absence of SPO11 protein 2 homolog
Modification date2020031320200328
UniProtAcc

Q8TDN4

RBBP8NL,C20orf151

Ensembl transtripts involved in fusion geneENST idsENST00000256925, ENST00000400473, 
ENST00000420687, ENST00000585061, 
ENST00000581687, ENST00000360790, 
ENST00000399725, ENST00000327155, 
ENST00000399722, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 13 X 3=62412 X 12 X 6=864
# samples 2115
** MAII scorelog2(21/624*10)=-1.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/864*10)=-2.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CABLES1 [Title/Abstract] AND RBBP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CABLES1(20716571)-RBBP8(20569184), # samples:3
Anticipated loss of major functional domain due to fusion event.CABLES1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CABLES1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CABLES1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CABLES1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CABLES1-RBBP8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CABLES1-RBBP8 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CABLES1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBBP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01ACABLES1chr18

20716571

-RBBP8chr18

20569184

+
ChimerDB4BRCATCGA-A1-A0SN-01ACABLES1chr18

20716571

+RBBP8chr18

20569184

+
ChimerDB4BRCATCGA-A8-A08R-01ACABLES1chr18

20716571

-RBBP8chr18

20548769

+
ChimerDB4BRCATCGA-A8-A08R-01ACABLES1chr18

20716571

+RBBP8chr18

20548769

+
ChimerDB4BRCATCGA-E9-A1NA-01ACABLES1chr18

20774504

+RBBP8chr18

20548769

+
ChimerDB4BRCATCGA-E9-A1RB-01ACABLES1chr18

20716571

+RBBP8chr18

20596791

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256925CABLES1chr1820716571+ENST00000327155RBBP8chr1820548769+3537845032901096
ENST00000256925CABLES1chr1820716571+ENST00000399722RBBP8chr1820548769+3539845032901096
ENST00000256925CABLES1chr1820716571+ENST00000399725RBBP8chr1820548769+3440845032001066
ENST00000256925CABLES1chr1820716571+ENST00000360790RBBP8chr1820548769+3436845033051101
ENST00000400473CABLES1chr1820774504+ENST00000327155RBBP8chr1820548769+2964272272717896
ENST00000400473CABLES1chr1820774504+ENST00000399722RBBP8chr1820548769+2966272272717896
ENST00000400473CABLES1chr1820774504+ENST00000399725RBBP8chr1820548769+2867272272627866
ENST00000400473CABLES1chr1820774504+ENST00000360790RBBP8chr1820548769+2863272272732901
ENST00000256925CABLES1chr1820774504+ENST00000327155RBBP8chr1820548769+37021010034551151
ENST00000256925CABLES1chr1820774504+ENST00000399722RBBP8chr1820548769+37041010034551151
ENST00000256925CABLES1chr1820774504+ENST00000399725RBBP8chr1820548769+36051010033651121
ENST00000256925CABLES1chr1820774504+ENST00000360790RBBP8chr1820548769+36011010034701156
ENST00000420687CABLES1chr1820774504+ENST00000327155RBBP8chr1820548769+2985293782738886
ENST00000420687CABLES1chr1820774504+ENST00000399722RBBP8chr1820548769+2987293782738886
ENST00000420687CABLES1chr1820774504+ENST00000399725RBBP8chr1820548769+2888293782648856
ENST00000420687CABLES1chr1820774504+ENST00000360790RBBP8chr1820548769+2884293782753891
ENST00000256925CABLES1chr1820716571+ENST00000327155RBBP8chr1820596791+142884501181393
ENST00000256925CABLES1chr1820716571+ENST00000399722RBBP8chr1820596791+143084501181393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256925ENST00000327155CABLES1chr1820716571+RBBP8chr1820548769+0.0006677040.99933225
ENST00000256925ENST00000399722CABLES1chr1820716571+RBBP8chr1820548769+0.0006570740.99934286
ENST00000256925ENST00000399725CABLES1chr1820716571+RBBP8chr1820548769+0.0005507610.9994492
ENST00000256925ENST00000360790CABLES1chr1820716571+RBBP8chr1820548769+0.0006691040.9993309
ENST00000400473ENST00000327155CABLES1chr1820774504+RBBP8chr1820548769+0.0005156990.9994843
ENST00000400473ENST00000399722CABLES1chr1820774504+RBBP8chr1820548769+0.0005069850.999493
ENST00000400473ENST00000399725CABLES1chr1820774504+RBBP8chr1820548769+0.000514130.99948585
ENST00000400473ENST00000360790CABLES1chr1820774504+RBBP8chr1820548769+0.000685760.9993142
ENST00000256925ENST00000327155CABLES1chr1820774504+RBBP8chr1820548769+0.0003976170.9996024
ENST00000256925ENST00000399722CABLES1chr1820774504+RBBP8chr1820548769+0.0003905010.99960953
ENST00000256925ENST00000399725CABLES1chr1820774504+RBBP8chr1820548769+0.0004740650.9995259
ENST00000256925ENST00000360790CABLES1chr1820774504+RBBP8chr1820548769+0.0004578160.99954224
ENST00000420687ENST00000327155CABLES1chr1820774504+RBBP8chr1820548769+0.0003681060.9996319
ENST00000420687ENST00000399722CABLES1chr1820774504+RBBP8chr1820548769+0.0003615190.99963844
ENST00000420687ENST00000399725CABLES1chr1820774504+RBBP8chr1820548769+0.000405040.999595
ENST00000420687ENST00000360790CABLES1chr1820774504+RBBP8chr1820548769+0.0004217470.9995783
ENST00000256925ENST00000327155CABLES1chr1820716571+RBBP8chr1820596791+0.098096620.9019034
ENST00000256925ENST00000399722CABLES1chr1820716571+RBBP8chr1820596791+0.099898550.9001014

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12252_12252_1_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20548769_ENST00000327155_length(amino acids)=1096AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIP
DSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSF
NLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLD
LNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTD
KHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTL
YEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEP
IKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLL
KMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQ
NFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRR

--------------------------------------------------------------

>12252_12252_2_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20548769_ENST00000360790_length(amino acids)=1101AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIP
DSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSF
NLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLD
LNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTD
KHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTL
YEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEP
IKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLL
KMKKQEQKGEKSSMLFYIDEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDER
ETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCP

--------------------------------------------------------------

>12252_12252_3_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20548769_ENST00000399722_length(amino acids)=1096AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIP
DSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSF
NLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLD
LNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTD
KHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTL
YEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEP
IKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLL
KMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQ
NFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRR

--------------------------------------------------------------

>12252_12252_4_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20548769_ENST00000399725_length(amino acids)=1066AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRLRAGLCDRCAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIP
DSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSF
NLATVVAETLGLGVQEESETQGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLD
LNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTD
KHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTL
YEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEP
IKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLL
KMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDESIMQIC

--------------------------------------------------------------

>12252_12252_5_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20596791_ENST00000327155_length(amino acids)=393AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCME

--------------------------------------------------------------

>12252_12252_6_CABLES1-RBBP8_CABLES1_chr18_20716571_ENST00000256925_RBBP8_chr18_20596791_ENST00000399722_length(amino acids)=393AA_BP=281
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCME

--------------------------------------------------------------

>12252_12252_7_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000256925_RBBP8_chr18_20548769_ENST00000327155_length(amino acids)=1151AA_BP=336
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRKKQQEF
ENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEH
SVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCL
EGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTR
SKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFD
KENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQ
ECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQ
DVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEY
ESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAE

--------------------------------------------------------------

>12252_12252_8_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000256925_RBBP8_chr18_20548769_ENST00000360790_length(amino acids)=1156AA_BP=336
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRKKQQEF
ENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEH
SVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCL
EGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTR
SKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFD
KENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQ
ECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQ
DVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSMLFYIDEERKMNDSLEDMFDRT
THEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYA

--------------------------------------------------------------

>12252_12252_9_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000256925_RBBP8_chr18_20548769_ENST00000399722_length(amino acids)=1151AA_BP=336
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRKKQQEF
ENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEH
SVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCL
EGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTR
SKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFD
KENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQ
ECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQ
DVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEY
ESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYADMPAE

--------------------------------------------------------------

>12252_12252_10_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000256925_RBBP8_chr18_20548769_ENST00000399725_length(amino acids)=1121AA_BP=336
MAAAAAAATTAACSSGSAGTDAAGASGLQQPPPQPQPQPAAAAPAQPPPEPPRKPRMDPRRRQAALSFLTNISLDGRLPPQDAEWGGGEE
GGAAKPGAGGACGARTRFSLLAAAERGGCIALAAPGTPAAGLAAGSGPCLPQPSSLPPLIPGGHATVSGPGVARGFASPLGAGRASGEQW
QPPRPAPLAACAQLQLLDGSGAAGQEELEEDDAFISVQVPAAAFLGSGTPGSGSGSRGRLNSFTQGILPIAFSRPTSQNYCSLEQPGQGG
STSAFEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRKKQQEF
ENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTHTKLEH
SVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDELYHCL
EGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISRLEKTR
SKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCPQASFD
KENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPGEPCSQ
ECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKSLQNNQ
DVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRTTHEEY
ESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDESIMQICQQKKEKRNWLPAQDTDSATFHPTHQRIFGKLVFLP

--------------------------------------------------------------

>12252_12252_11_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000400473_RBBP8_chr18_20548769_ENST00000327155_length(amino acids)=896AA_BP=81
MSTLVPVYEGEEIIIYKNLQGDQGKRVRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDR
CAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKEN
PHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESET
QGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKT
LPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTE
EESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDG
NCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQL
NPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMN
DSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGH

--------------------------------------------------------------

>12252_12252_12_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000400473_RBBP8_chr18_20548769_ENST00000360790_length(amino acids)=901AA_BP=81
MSTLVPVYEGEEIIIYKNLQGDQGKRVRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDR
CAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKEN
PHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESET
QGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKT
LPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTE
EESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDG
NCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQL
NPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSMLFYIDE
ERKMNDSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERR
KLLGHTCKECEIYYADMPAEEREKKLASCSRHRFRYIPPNTPENFWEVGFPSTQTCMERGYIKEDLDPCPRPKRRQPYNAIFSPKGKEQK

--------------------------------------------------------------

>12252_12252_13_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000400473_RBBP8_chr18_20548769_ENST00000399722_length(amino acids)=896AA_BP=81
MSTLVPVYEGEEIIIYKNLQGDQGKRVRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDR
CAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKEN
PHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESET
QGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKT
LPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTE
EESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDG
NCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQL
NPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMN
DSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGH

--------------------------------------------------------------

>12252_12252_14_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000400473_RBBP8_chr18_20548769_ENST00000399725_length(amino acids)=866AA_BP=81
MSTLVPVYEGEEIIIYKNLQGDQGKRVRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDR
CAVTEEHMRKKQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKEN
PHVRYIEQTHTKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESET
QGPMSPLGDELYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKT
LPFSNTCISRLEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTE
EESEHEVSCPQASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDG
NCTLPKDSPGEPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQL
NPCRTGKIKSLQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMN
DSLEDMFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDESIMQICQQKKEKRNWLPAQDTDSATF

--------------------------------------------------------------

>12252_12252_15_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000420687_RBBP8_chr18_20548769_ENST00000327155_length(amino acids)=886AA_BP=71
MLSKRGCHARIYADFPIRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRK
KQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH
TKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDE
LYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISR
LEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCP
QASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPG
EPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKS
LQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRT
THEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYA

--------------------------------------------------------------

>12252_12252_16_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000420687_RBBP8_chr18_20548769_ENST00000360790_length(amino acids)=891AA_BP=71
MLSKRGCHARIYADFPIRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRK
KQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH
TKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDE
LYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISR
LEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCP
QASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPG
EPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKS
LQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSMLFYIDEERKMNDSLED
MFDRTTHEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKEC

--------------------------------------------------------------

>12252_12252_17_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000420687_RBBP8_chr18_20548769_ENST00000399722_length(amino acids)=886AA_BP=71
MLSKRGCHARIYADFPIRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRK
KQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH
TKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDE
LYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISR
LEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCP
QASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPG
EPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKS
LQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRT
THEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDERETSLQNFPHIEVVRKKEERRKLLGHTCKECEIYYA

--------------------------------------------------------------

>12252_12252_18_CABLES1-RBBP8_CABLES1_chr18_20774504_ENST00000420687_RBBP8_chr18_20548769_ENST00000399725_length(amino acids)=856AA_BP=71
MLSKRGCHARIYADFPIRRLISQRSSLETLEDIEENAPLRRCRTLSGSPRPKNFKKIHFIKNMRQHDTRNGRLRAGLCDRCAVTEEHMRK
KQQEFENIRQQNLKLITELMNERNTLQEENKKLSEQLQQKIENDQQHQAAELECEEDVIPDSPITAFSFSGVNRLRRKENPHVRYIEQTH
TKLEHSVCANEMRKVSKSSTHPQHNPNENEILVADTYDQSQSPMAKAHGTSSYTPDKSSFNLATVVAETLGLGVQEESETQGPMSPLGDE
LYHCLEGNHKKQPFEESTRNTEDSLRFSDSTSKTPPQEELPTRVSSPVFGATSSIKSGLDLNTSLSPSLLQPGKKKHLKTLPFSNTCISR
LEKTRSKSEDSALFTHHSLGSEVNKIIIQSSNKQILINKNISESLGEQNRTEYGKDSNTDKHLEPLKSLGGRTSKRKKTEEESEHEVSCP
QASFDKENAFPFPMDNQFSMNGDCVMDKPLDLSDRFSAIQRQEKSQGSETSKNKFRQVTLYEALKTIPKGFSSSRKASDGNCTLPKDSPG
EPCSQECIILQPLNKCSPDNKPSLQIKEENAVFKIPLRPRESLETENVLDDIKSAGSHEPIKIQTRSDHGGCELASVLQLNPCRTGKIKS
LQNNQDVSFENIQWSIDPGADLSQYKMDVTVIDTKDGSQSKLGGETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLEDMFDRT
THEEYESCLADSFSQAADEEEELSTATKKLHTHGDKQDKVKQKAFVEPYFKGDESIMQICQQKKEKRNWLPAQDTDSATFHPTHQRIFGK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:20716571/chr18:20569184)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CABLES1

Q8TDN4

RBBP8

RBBP8NL,C20orf151

FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.664

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCABLES1chr18:20716571chr18:20548769ENST00000256925+1102_134281.6666666666667634.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20716571chr18:20596791ENST00000256925+1102_134281.6666666666667634.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20774504chr18:20548769ENST00000256925+3102_134336.6666666666667634.0Compositional biasNote=Ala-rich
TgeneRBBP8chr18:20716571chr18:20596791ENST0000039972501828_1570868.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20548769ENST00000327155319490_49482.66666666666667898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20548769ENST00000327155319840_84282.66666666666667898.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399722319490_49482.66666666666667898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399722319840_84282.66666666666667898.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399725318490_49482.66666666666667868.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399725318840_84282.66666666666667868.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20596791ENST000003271551519840_842785.6666666666666898.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20596791ENST000003997221519840_842785.6666666666666898.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20596791ENST00000399725018490_4940868.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20596791ENST00000399725018840_8420868.0MotifKLHL15-binding
TgeneRBBP8chr18:20774504chr18:20548769ENST00000327155319490_49482.66666666666667898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000327155319840_84282.66666666666667898.0MotifKLHL15-binding
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399722319490_49482.66666666666667898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399722319840_84282.66666666666667898.0MotifKLHL15-binding
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399725318490_49482.66666666666667868.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399725318840_84282.66666666666667868.0MotifKLHL15-binding
TgeneRBBP8chr18:20716571chr18:20548769ENST00000327155319509_55782.66666666666667898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399722319509_55782.66666666666667898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20716571chr18:20548769ENST00000399725318509_55782.66666666666667868.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20716571chr18:20596791ENST0000039972501822_450868.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20596791ENST00000399725018509_5570868.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000327155319509_55782.66666666666667898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399722319509_55782.66666666666667898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20774504chr18:20548769ENST00000399725318509_55782.66666666666667868.0RegionNote=Damage-recruitment motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCABLES1chr18:20716571chr18:20548769ENST00000400473+1102_1340307.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20716571chr18:20548769ENST00000420687+1102_1340369.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20716571chr18:20596791ENST00000400473+1102_1340307.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20716571chr18:20596791ENST00000420687+1102_1340369.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20774504chr18:20548769ENST00000400473+3102_1349.666666666666666307.0Compositional biasNote=Ala-rich
HgeneCABLES1chr18:20774504chr18:20548769ENST00000420687+3102_13471.66666666666667369.0Compositional biasNote=Ala-rich
TgeneRBBP8chr18:20716571chr18:20548769ENST0000032715531928_15782.66666666666667898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20548769ENST0000039972231928_15782.66666666666667898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20548769ENST0000039972531828_15782.66666666666667868.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20596791ENST00000327155151928_157785.6666666666666898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20596791ENST00000399722151928_157785.6666666666666898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20774504chr18:20548769ENST0000032715531928_15782.66666666666667898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20774504chr18:20548769ENST0000039972231928_15782.66666666666667898.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20774504chr18:20548769ENST0000039972531828_15782.66666666666667868.0Coiled coilOntology_term=ECO:0000255
TgeneRBBP8chr18:20716571chr18:20596791ENST000003271551519490_494785.6666666666666898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20596791ENST000003997221519490_494785.6666666666666898.0MotifNote=PXDLS motif
TgeneRBBP8chr18:20716571chr18:20548769ENST0000032715531922_4582.66666666666667898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20548769ENST0000039972231922_4582.66666666666667898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20548769ENST0000039972531822_4582.66666666666667868.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20596791ENST00000327155151922_45785.6666666666666898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20596791ENST000003271551519509_557785.6666666666666898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20716571chr18:20596791ENST00000399722151922_45785.6666666666666898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20716571chr18:20596791ENST000003997221519509_557785.6666666666666898.0RegionNote=Damage-recruitment motif
TgeneRBBP8chr18:20774504chr18:20548769ENST0000032715531922_4582.66666666666667898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20774504chr18:20548769ENST0000039972231922_4582.66666666666667898.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage
TgeneRBBP8chr18:20774504chr18:20548769ENST0000039972531822_4582.66666666666667868.0RegionNote=Essential for binding to the MRN complex and for RPA focus formation on DNA damage


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CABLES1
RBBP8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCABLES1chr18:20716571chr18:20548769ENST00000256925+110179_492281.6666666666667634.0CDK3
HgeneCABLES1chr18:20716571chr18:20548769ENST00000400473+110179_4920307.0CDK3
HgeneCABLES1chr18:20716571chr18:20548769ENST00000420687+110179_4920369.0CDK3
HgeneCABLES1chr18:20716571chr18:20596791ENST00000256925+110179_492281.6666666666667634.0CDK3
HgeneCABLES1chr18:20716571chr18:20596791ENST00000400473+110179_4920307.0CDK3
HgeneCABLES1chr18:20716571chr18:20596791ENST00000420687+110179_4920369.0CDK3
HgeneCABLES1chr18:20774504chr18:20548769ENST00000256925+310179_492336.6666666666667634.0CDK3
HgeneCABLES1chr18:20774504chr18:20548769ENST00000400473+310179_4929.666666666666666307.0CDK3
HgeneCABLES1chr18:20774504chr18:20548769ENST00000420687+310179_49271.66666666666667369.0CDK3
HgeneCABLES1chr18:20716571chr18:20548769ENST00000400473+1101_1090307.0TDRD7
HgeneCABLES1chr18:20716571chr18:20548769ENST00000420687+1101_1090369.0TDRD7
HgeneCABLES1chr18:20716571chr18:20596791ENST00000400473+1101_1090307.0TDRD7
HgeneCABLES1chr18:20716571chr18:20596791ENST00000420687+1101_1090369.0TDRD7
HgeneCABLES1chr18:20774504chr18:20548769ENST00000400473+3101_1099.666666666666666307.0TDRD7
HgeneCABLES1chr18:20774504chr18:20548769ENST00000420687+3101_10971.66666666666667369.0TDRD7


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Related Drugs to CABLES1-RBBP8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CABLES1-RBBP8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource