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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CACNA2D3-TEX264

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CACNA2D3-TEX264
FusionPDB ID: 12374
FusionGDB2.0 ID: 12374
HgeneTgene
Gene symbol

CACNA2D3

TEX264

Gene ID

55799

51368

Gene namecalcium voltage-gated channel auxiliary subunit alpha2delta 3testis expressed 264, ER-phagy receptor
SynonymsHSA272268ZSIG11
Cytomap

3p21.1-p14.3

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit atestis-expressed protein 264testis expressed 264testis expressed gene 264testis-expressed sequence 264 protein
Modification date2020031320200313
UniProtAcc

Q8IZS8

.
Ensembl transtripts involved in fusion geneENST idsENST00000288197, ENST00000415676, 
ENST00000474759, ENST00000490478, 
ENST00000478261, 
ENST00000463857, 
ENST00000341333, ENST00000395057, 
ENST00000415259, ENST00000416589, 
ENST00000457573, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 6=10085 X 7 X 5=175
# samples 156
** MAII scorelog2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CACNA2D3 [Title/Abstract] AND TEX264 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CACNA2D3(54798378)-TEX264(51718428), # samples:1
Anticipated loss of major functional domain due to fusion event.CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CACNA2D3-TEX264 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CACNA2D3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TEX264 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-20-0987CACNA2D3chr3

54798378

+TEX264chr3

51718428

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000415676CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+248814981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+248914981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+244914981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+248714981182181687
ENST00000415676CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+248314981182181687
ENST00000288197CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+24181428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+24191428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+23791428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+24171428482111687
ENST00000288197CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+24131428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+24181428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+24191428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+23791428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+24171428482111687
ENST00000474759CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+24131428482111687
ENST00000490478CACNA2D3chr354798378+ENST00000457573TEX264chr351718428+230013101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000341333TEX264chr351718428+230113101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000415259TEX264chr351718428+226113101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000395057TEX264chr351718428+229913101251993622
ENST00000490478CACNA2D3chr354798378+ENST00000416589TEX264chr351718428+229513101251993622

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415676ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0051662160.9948338
ENST00000415676ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.0051873310.9948127
ENST00000415676ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0057610660.994239
ENST00000415676ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0052011040.9947989
ENST00000415676ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0052445720.9947554
ENST00000288197ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0049858340.99501413
ENST00000288197ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.005017390.9949826
ENST00000288197ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0053314290.99466854
ENST00000288197ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0050195710.9949804
ENST00000288197ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0049926580.9950073
ENST00000474759ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0049858340.99501413
ENST00000474759ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.005017390.9949826
ENST00000474759ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0053314290.99466854
ENST00000474759ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0050195710.9949804
ENST00000474759ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0049926580.9950073
ENST00000490478ENST00000457573CACNA2D3chr354798378+TEX264chr351718428+0.0045703510.99542964
ENST00000490478ENST00000341333CACNA2D3chr354798378+TEX264chr351718428+0.0045878850.9954122
ENST00000490478ENST00000415259CACNA2D3chr354798378+TEX264chr351718428+0.0048720130.9951279
ENST00000490478ENST00000395057CACNA2D3chr354798378+TEX264chr351718428+0.0046018680.9953981
ENST00000490478ENST00000416589CACNA2D3chr354798378+TEX264chr351718428+0.0045797990.9954202

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12374_12374_1_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000288197_TEX264_chr3_51718428_ENST00000341333_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_2_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000288197_TEX264_chr3_51718428_ENST00000395057_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_3_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000288197_TEX264_chr3_51718428_ENST00000415259_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_4_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000288197_TEX264_chr3_51718428_ENST00000416589_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_5_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000288197_TEX264_chr3_51718428_ENST00000457573_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_6_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000415676_TEX264_chr3_51718428_ENST00000341333_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_7_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000415676_TEX264_chr3_51718428_ENST00000395057_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_8_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000415676_TEX264_chr3_51718428_ENST00000415259_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_9_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000415676_TEX264_chr3_51718428_ENST00000416589_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_10_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000415676_TEX264_chr3_51718428_ENST00000457573_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_11_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000474759_TEX264_chr3_51718428_ENST00000341333_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_12_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000474759_TEX264_chr3_51718428_ENST00000395057_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_13_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000474759_TEX264_chr3_51718428_ENST00000415259_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_14_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000474759_TEX264_chr3_51718428_ENST00000416589_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_15_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000474759_TEX264_chr3_51718428_ENST00000457573_length(amino acids)=687AA_BP=460
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKK
LAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYN
KDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGL
RLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSI
CSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
VWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCA
YPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGD

--------------------------------------------------------------

>12374_12374_16_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000490478_TEX264_chr3_51718428_ENST00000341333_length(amino acids)=622AA_BP=395
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLA
DVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTI
LSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEV

--------------------------------------------------------------

>12374_12374_17_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000490478_TEX264_chr3_51718428_ENST00000395057_length(amino acids)=622AA_BP=395
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLA
DVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTI
LSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEV

--------------------------------------------------------------

>12374_12374_18_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000490478_TEX264_chr3_51718428_ENST00000415259_length(amino acids)=622AA_BP=395
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLA
DVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTI
LSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEV

--------------------------------------------------------------

>12374_12374_19_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000490478_TEX264_chr3_51718428_ENST00000416589_length(amino acids)=622AA_BP=395
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLA
DVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTI
LSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEV

--------------------------------------------------------------

>12374_12374_20_CACNA2D3-TEX264_CACNA2D3_chr3_54798378_ENST00000490478_TEX264_chr3_51718428_ENST00000457573_length(amino acids)=622AA_BP=395
MQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILA
PNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRK
WYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGI
GMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLA
DVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTI
LSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:54798378/chr3:51718428)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACNA2D3

Q8IZS8

.
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+1338256_438460.01092.0DomainVWFA
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+1439256_438460.01092.0DomainVWFA
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+1338256_438460.01092.0DomainVWFA
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+1338262_266460.01092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+1439262_266460.01092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+1338262_266460.01092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+1237262_266366.0998.0MotifNote=MIDAS-like motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000034133315273_27686.0314.0MotifLIR motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000039505715273_27686.0314.0MotifLIR motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000041525915273_27686.0314.0MotifLIR motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000041658915273_27686.0314.0MotifLIR motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000045757326273_27686.0314.0MotifLIR motif
TgeneTEX264chr3:54798378chr3:51718428ENST0000034133315193_31386.0314.0RegionIntrinsically disordered region (IDR)
TgeneTEX264chr3:54798378chr3:51718428ENST0000039505715193_31386.0314.0RegionIntrinsically disordered region (IDR)
TgeneTEX264chr3:54798378chr3:51718428ENST0000041525915193_31386.0314.0RegionIntrinsically disordered region (IDR)
TgeneTEX264chr3:54798378chr3:51718428ENST0000041658915193_31386.0314.0RegionIntrinsically disordered region (IDR)
TgeneTEX264chr3:54798378chr3:51718428ENST0000045757326193_31386.0314.0RegionIntrinsically disordered region (IDR)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+1338452_549460.01092.0DomainNote=Cache
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+1439452_549460.01092.0DomainNote=Cache
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+1338452_549460.01092.0DomainNote=Cache
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+1237256_438366.0998.0DomainVWFA
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+1237452_549366.0998.0DomainNote=Cache
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+13381090_1091460.01092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+133829_1068460.01092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+14391090_1091460.01092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+143929_1068460.01092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+13381090_1091460.01092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+133829_1068460.01092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+12371090_1091366.0998.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+123729_1068366.0998.0Topological domainExtracellular
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000288197+13381069_1089460.01092.0TransmembraneHelical
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000415676+14391069_1089460.01092.0TransmembraneHelical
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000474759+13381069_1089460.01092.0TransmembraneHelical
HgeneCACNA2D3chr3:54798378chr3:51718428ENST00000490478+12371069_1089366.0998.0TransmembraneHelical
TgeneTEX264chr3:54798378chr3:51718428ENST00000341333151_686.0314.0Topological domainLumenal
TgeneTEX264chr3:54798378chr3:51718428ENST000003413331532_31386.0314.0Topological domainCytoplasmic
TgeneTEX264chr3:54798378chr3:51718428ENST00000395057151_686.0314.0Topological domainLumenal
TgeneTEX264chr3:54798378chr3:51718428ENST000003950571532_31386.0314.0Topological domainCytoplasmic
TgeneTEX264chr3:54798378chr3:51718428ENST00000415259151_686.0314.0Topological domainLumenal
TgeneTEX264chr3:54798378chr3:51718428ENST000004152591532_31386.0314.0Topological domainCytoplasmic
TgeneTEX264chr3:54798378chr3:51718428ENST00000416589151_686.0314.0Topological domainLumenal
TgeneTEX264chr3:54798378chr3:51718428ENST000004165891532_31386.0314.0Topological domainCytoplasmic
TgeneTEX264chr3:54798378chr3:51718428ENST00000457573261_686.0314.0Topological domainLumenal
TgeneTEX264chr3:54798378chr3:51718428ENST000004575732632_31386.0314.0Topological domainCytoplasmic
TgeneTEX264chr3:54798378chr3:51718428ENST00000341333157_3186.0314.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneTEX264chr3:54798378chr3:51718428ENST00000395057157_3186.0314.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneTEX264chr3:54798378chr3:51718428ENST00000415259157_3186.0314.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneTEX264chr3:54798378chr3:51718428ENST00000416589157_3186.0314.0TransmembraneHelical%3B Signal-anchor for type III membrane protein
TgeneTEX264chr3:54798378chr3:51718428ENST00000457573267_3186.0314.0TransmembraneHelical%3B Signal-anchor for type III membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CACNA2D3
TEX264


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CACNA2D3-TEX264


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CACNA2D3-TEX264


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource