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Fusion Protein:CADM1-PARD6G |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CADM1-PARD6G | FusionPDB ID: 12445 | FusionGDB2.0 ID: 12445 | Hgene | Tgene | Gene symbol | CADM1 | PARD6G | Gene ID | 23705 | 84552 |
| Gene name | cell adhesion molecule 1 | par-6 family cell polarity regulator gamma | |
| Synonyms | BL2|IGSF4|IGSF4A|NECL2|Necl-2|RA175|ST17|SYNCAM|TSLC1|sTSLC-1|sgIGSF|synCAM1 | PAR-6G|PAR6gamma | |
| Cytomap | 11q23.3 | 18q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell adhesion molecule 1TSLC-1TSLC1/Nectin-like 2/IGSF4immunoglobulin superfamily member 4immunoglobulin superfamily, member 4D variant 1immunoglobulin superfamily, member 4D variant 2nectin-like 2nectin-like protein 2spermatogenic immunoglobulin | partitioning defective 6 homolog gammaPAR-6 gamma proteinPAR6Dpar-6 partitioning defective 6 homolog gamma | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q9BY67 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000537140, ENST00000331581, ENST00000452722, ENST00000536727, ENST00000537058, ENST00000542447, | ENST00000353265, ENST00000470488, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 7 X 5 X 4=140 | 10 X 3 X 8=240 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CADM1 [Title/Abstract] AND PARD6G [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CADM1(115374988)-PARD6G(77960815), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CADM1-PARD6G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CADM1-PARD6G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CADM1-PARD6G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CADM1-PARD6G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CADM1 | GO:0001913 | T cell mediated cytotoxicity | 15811952 |
| Hgene | CADM1 | GO:0008037 | cell recognition | 15811952 |
| Hgene | CADM1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity | 15811952 |
| Hgene | CADM1 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 15811952 |
| Hgene | CADM1 | GO:0050715 | positive regulation of cytokine secretion | 15811952 |
| Hgene | CADM1 | GO:0050798 | activated T cell proliferation | 15811952 |
| Hgene | CADM1 | GO:0051606 | detection of stimulus | 15811952 |
| Fusion gene breakpoints across CADM1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PARD6G (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-61-1910 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000452722 | CADM1 | chr11 | 115374988 | - | ENST00000353265 | PARD6G | chr18 | 77960815 | - | 3743 | 145 | 172 | 1203 | 343 |
| ENST00000452722 | CADM1 | chr11 | 115374988 | - | ENST00000470488 | PARD6G | chr18 | 77960815 | - | 669 | 145 | 393 | 647 | 84 |
| ENST00000542447 | CADM1 | chr11 | 115374988 | - | ENST00000353265 | PARD6G | chr18 | 77960815 | - | 3851 | 253 | 280 | 1311 | 343 |
| ENST00000542447 | CADM1 | chr11 | 115374988 | - | ENST00000470488 | PARD6G | chr18 | 77960815 | - | 777 | 253 | 2 | 361 | 119 |
| ENST00000537058 | CADM1 | chr11 | 115374988 | - | ENST00000353265 | PARD6G | chr18 | 77960815 | - | 3743 | 145 | 172 | 1203 | 343 |
| ENST00000537058 | CADM1 | chr11 | 115374988 | - | ENST00000470488 | PARD6G | chr18 | 77960815 | - | 669 | 145 | 393 | 647 | 84 |
| ENST00000536727 | CADM1 | chr11 | 115374988 | - | ENST00000353265 | PARD6G | chr18 | 77960815 | - | 3743 | 145 | 172 | 1203 | 343 |
| ENST00000536727 | CADM1 | chr11 | 115374988 | - | ENST00000470488 | PARD6G | chr18 | 77960815 | - | 669 | 145 | 393 | 647 | 84 |
| ENST00000331581 | CADM1 | chr11 | 115374988 | - | ENST00000353265 | PARD6G | chr18 | 77960815 | - | 3893 | 295 | 322 | 1353 | 343 |
| ENST00000331581 | CADM1 | chr11 | 115374988 | - | ENST00000470488 | PARD6G | chr18 | 77960815 | - | 819 | 295 | 44 | 403 | 119 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000452722 | ENST00000353265 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.004610159 | 0.9953898 |
| ENST00000452722 | ENST00000470488 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.16987911 | 0.83012086 |
| ENST00000542447 | ENST00000353265 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.004698597 | 0.99530137 |
| ENST00000542447 | ENST00000470488 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.26564896 | 0.73435104 |
| ENST00000537058 | ENST00000353265 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.004610159 | 0.9953898 |
| ENST00000537058 | ENST00000470488 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.16987911 | 0.83012086 |
| ENST00000536727 | ENST00000353265 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.004610159 | 0.9953898 |
| ENST00000536727 | ENST00000470488 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.16987911 | 0.83012086 |
| ENST00000331581 | ENST00000353265 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.004724399 | 0.9952756 |
| ENST00000331581 | ENST00000470488 | CADM1 | chr11 | 115374988 | - | PARD6G | chr18 | 77960815 | - | 0.26985663 | 0.7301433 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >12445_12445_1_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000331581_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=343AA_BP= MDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRD EGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVN DEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVI -------------------------------------------------------------- >12445_12445_2_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000331581_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=119AA_BP=83 MGSRRCDWSARTPPPAHVISISLAVRSGSGGSQRRQSEAGARHGECSAAERIPVCGGSGGGGASRAPAPASAVALLRRGTDPHSLGRNSE -------------------------------------------------------------- >12445_12445_3_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000452722_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=343AA_BP= MDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRD EGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVN DEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVI -------------------------------------------------------------- >12445_12445_4_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000452722_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=84AA_BP= -------------------------------------------------------------- >12445_12445_5_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000536727_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=343AA_BP= MDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRD EGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVN DEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVI -------------------------------------------------------------- >12445_12445_6_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000536727_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=84AA_BP= -------------------------------------------------------------- >12445_12445_7_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000537058_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=343AA_BP= MDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRD EGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVN DEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVI -------------------------------------------------------------- >12445_12445_8_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000537058_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=84AA_BP= -------------------------------------------------------------- >12445_12445_9_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000542447_PARD6G_chr18_77960815_ENST00000353265_length(amino acids)=343AA_BP= MDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRD EGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVN DEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVI -------------------------------------------------------------- >12445_12445_10_CADM1-PARD6G_CADM1_chr11_115374988_ENST00000542447_PARD6G_chr18_77960815_ENST00000470488_length(amino acids)=119AA_BP=83 LGSRRCDWSARTPPPAHVISISLAVRSGSGGSQRRQSEAGARHGECSAAERIPVCGGSGGGGASRAPAPASAVALLRRGTDPHSLGRNSE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:115374988/chr18:77960815) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CADM1 | . |
| FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:22438059, PubMed:12050160). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed:15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed:11279526, PubMed:12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed:12920246). {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000269|PubMed:11279526, ECO:0000269|PubMed:12050160, ECO:0000269|PubMed:12234973, ECO:0000269|PubMed:12920246, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:15905536, ECO:0000269|PubMed:22438059}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000353265 | 0 | 3 | 134_151 | 24.0 | 377.0 | Domain | Note=Pseudo-CRIB | |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000353265 | 0 | 3 | 158_251 | 24.0 | 377.0 | Domain | PDZ | |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000470488 | 0 | 3 | 134_151 | 24.0 | 108.0 | Domain | Note=Pseudo-CRIB | |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000470488 | 0 | 3 | 158_251 | 24.0 | 108.0 | Domain | PDZ |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 144_238 | 41.333333333333336 | 472.0 | Domain | Ig-like C2-type 1 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 243_329 | 41.333333333333336 | 472.0 | Domain | Ig-like C2-type 2 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 45_139 | 41.333333333333336 | 472.0 | Domain | Ig-like V-type |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 144_238 | 41.333333333333336 | 443.0 | Domain | Ig-like C2-type 1 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 243_329 | 41.333333333333336 | 443.0 | Domain | Ig-like C2-type 2 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 45_139 | 41.333333333333336 | 443.0 | Domain | Ig-like V-type |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 144_238 | 41.333333333333336 | 454.0 | Domain | Ig-like C2-type 1 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 243_329 | 41.333333333333336 | 454.0 | Domain | Ig-like C2-type 2 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 45_139 | 41.333333333333336 | 454.0 | Domain | Ig-like V-type |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 144_238 | 41.333333333333336 | 415.0 | Domain | Ig-like C2-type 1 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 243_329 | 41.333333333333336 | 415.0 | Domain | Ig-like C2-type 2 |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 45_139 | 41.333333333333336 | 415.0 | Domain | Ig-like V-type |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 396_442 | 41.333333333333336 | 472.0 | Topological domain | Cytoplasmic |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 45_374 | 41.333333333333336 | 472.0 | Topological domain | Extracellular |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 396_442 | 41.333333333333336 | 443.0 | Topological domain | Cytoplasmic |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 45_374 | 41.333333333333336 | 443.0 | Topological domain | Extracellular |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 396_442 | 41.333333333333336 | 454.0 | Topological domain | Cytoplasmic |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 45_374 | 41.333333333333336 | 454.0 | Topological domain | Extracellular |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 396_442 | 41.333333333333336 | 415.0 | Topological domain | Cytoplasmic |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 45_374 | 41.333333333333336 | 415.0 | Topological domain | Extracellular |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000331581 | - | 1 | 12 | 375_395 | 41.333333333333336 | 472.0 | Transmembrane | Helical |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000452722 | - | 1 | 10 | 375_395 | 41.333333333333336 | 443.0 | Transmembrane | Helical |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000537058 | - | 1 | 11 | 375_395 | 41.333333333333336 | 454.0 | Transmembrane | Helical |
| Hgene | CADM1 | chr11:115374988 | chr18:77960815 | ENST00000542447 | - | 1 | 9 | 375_395 | 41.333333333333336 | 415.0 | Transmembrane | Helical |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000353265 | 0 | 3 | 18_98 | 24.0 | 377.0 | Domain | PB1 | |
| Tgene | PARD6G | chr11:115374988 | chr18:77960815 | ENST00000470488 | 0 | 3 | 18_98 | 24.0 | 108.0 | Domain | PB1 |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CADM1 | |
| PARD6G |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to CADM1-PARD6G |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CADM1-PARD6G |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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