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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CAMK2B-SPIDR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAMK2B-SPIDR
FusionPDB ID: 12663
FusionGDB2.0 ID: 12663
HgeneTgene
Gene symbol

CAMK2B

SPIDR

Gene ID

816

23514

Gene namecalcium/calmodulin dependent protein kinase II betascaffold protein involved in DNA repair
SynonymsCAM2|CAMK2|CAMKB|CaMKIIbeta|MRD54KIAA0146
Cytomap

7p13

8q11.21

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type II subunit betaCaM kinase II beta subunitCaM-kinase II beta chaincaMK-II subunit betaproline rich calmodulin-dependent protein kinaseDNA repair-scaffolding proteinscaffolding protein involved in DNA repair
Modification date2020031320200320
UniProtAcc

Q13554

Q14159

Ensembl transtripts involved in fusion geneENST idsENST00000258682, ENST00000346990, 
ENST00000347193, ENST00000350811, 
ENST00000353625, ENST00000358707, 
ENST00000395747, ENST00000395749, 
ENST00000440254, ENST00000457475, 
ENST00000502837, ENST00000489429, 
ENST00000521214, ENST00000517693, 
ENST00000518060, ENST00000297423, 
ENST00000518074, ENST00000541342, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 4=6419 X 18 X 7=2394
# samples 422
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2394*10)=-3.44384772341884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CAMK2B [Title/Abstract] AND SPIDR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAMK2B(44364956)-SPIDR(48308936), # samples:1
Anticipated loss of major functional domain due to fusion event.CAMK2B-SPIDR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMK2B-SPIDR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK2B

GO:0046777

protein autophosphorylation

18817731

TgeneSPIDR

GO:0006974

cellular response to DNA damage stimulus

23509288

TgeneSPIDR

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneSPIDR

GO:0031334

positive regulation of protein complex assembly

23509288

TgeneSPIDR

GO:0070202

regulation of establishment of protein localization to chromosome

23509288

TgeneSPIDR

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneSPIDR

GO:0072711

cellular response to hydroxyurea

23509288

TgeneSPIDR

GO:0072757

cellular response to camptothecin

23509288


check buttonFusion gene breakpoints across CAMK2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPIDR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-69-7760-01ACAMK2Bchr7

44364956

-SPIDRchr8

48308936

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350811CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+3219140922362756
ENST00000350811CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+2443140922425777
ENST00000350811CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+2424140922362756
ENST00000457475CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+3354275172497826
ENST00000457475CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+2578275172560847
ENST00000457475CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+2559275172497826
ENST00000395749CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+3221142942364756
ENST00000395749CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+2445142942427777
ENST00000395749CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+2426142942364756
ENST00000440254CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+3379300422522826
ENST00000440254CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+2603300422585847
ENST00000440254CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+2584300422522826
ENST00000358707CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+3348269112491826
ENST00000358707CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+2572269112554847
ENST00000358707CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+2553269112491826
ENST00000353625CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+315475272297756
ENST00000353625CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+237875272360777
ENST00000353625CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+235975272297756
ENST00000258682CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+314768202290756
ENST00000258682CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+237168202353777
ENST00000258682CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+235268202290756
ENST00000347193CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+314768202290756
ENST00000347193CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+237168202353777
ENST00000347193CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+235268202290756
ENST00000346990CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+314768202290756
ENST00000346990CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+237168202353777
ENST00000346990CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+235268202290756
ENST00000395747CAMK2Bchr744364956-ENST00000297423SPIDRchr848308936+314465172287756
ENST00000395747CAMK2Bchr744364956-ENST00000518074SPIDRchr848308936+236865172350777
ENST00000395747CAMK2Bchr744364956-ENST00000541342SPIDRchr848308936+234965172287756

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350811ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0049796510.9950204
ENST00000350811ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0106745550.9893254
ENST00000350811ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0087107180.99128926
ENST00000457475ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0056032680.9943968
ENST00000457475ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0115232650.98847675
ENST00000457475ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0094750430.99052495
ENST00000395749ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0050063730.9949936
ENST00000395749ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0107311630.98926884
ENST00000395749ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0087661050.9912339
ENST00000440254ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0055301980.99446976
ENST00000440254ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0112757130.9887243
ENST00000440254ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0093319320.9906681
ENST00000358707ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0055704880.9944296
ENST00000358707ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0116706090.9883294
ENST00000358707ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0096075470.99039245
ENST00000353625ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0043286050.9956714
ENST00000353625ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0092645630.9907354
ENST00000353625ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0075363950.9924636
ENST00000258682ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0043354750.99566454
ENST00000258682ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0090729090.9909271
ENST00000258682ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0073831030.99261683
ENST00000347193ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0043354750.99566454
ENST00000347193ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0090729090.9909271
ENST00000347193ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0073831030.99261683
ENST00000346990ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.0043354750.99566454
ENST00000346990ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.0090729090.9909271
ENST00000346990ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0073831030.99261683
ENST00000395747ENST00000297423CAMK2Bchr744364956-SPIDRchr848308936+0.004357690.9956423
ENST00000395747ENST00000518074CAMK2Bchr744364956-SPIDRchr848308936+0.009052830.99094725
ENST00000395747ENST00000541342CAMK2Bchr744364956-SPIDRchr848308936+0.0073645220.99263555

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12663_12663_1_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000258682_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_2_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000258682_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_3_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000258682_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_4_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000346990_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_5_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000346990_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_6_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000346990_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_7_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000347193_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_8_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000347193_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_9_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000347193_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_10_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000350811_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_11_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000350811_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_12_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000350811_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_13_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000353625_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_14_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000353625_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_15_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000353625_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_16_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000358707_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

>12663_12663_17_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000358707_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=847AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKGSGVVKLFCPVRNRPPDQLHW

--------------------------------------------------------------

>12663_12663_18_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000358707_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

>12663_12663_19_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395747_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_20_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395747_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_21_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395747_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_22_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395749_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_23_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395749_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=777AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKG

--------------------------------------------------------------

>12663_12663_24_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000395749_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=756AA_BP=15
MHPLHRRVPALRGYWQPSSIEILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTP
ENSAKKKLLRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAG
LKVLFTKETAGYLRGRPQDTVRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPE
IQVVCSGVATTGTAWTHGHKEAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLL
VQDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHP
NLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVA
PLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDES
TAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKE

--------------------------------------------------------------

>12663_12663_25_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000440254_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

>12663_12663_26_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000440254_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=847AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKGSGVVKLFCPVRNRPPDQLHW

--------------------------------------------------------------

>12663_12663_27_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000440254_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

>12663_12663_28_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000457475_SPIDR_chr8_48308936_ENST00000297423_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

>12663_12663_29_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000457475_SPIDR_chr8_48308936_ENST00000518074_length(amino acids)=847AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKVGARPEHARTPSSLQHSEELRSEECPRKGSGVVKLFCPVRNRPPDQLHW

--------------------------------------------------------------

>12663_12663_30_CAMK2B-SPIDR_CAMK2B_chr7_44364956_ENST00000457475_SPIDR_chr8_48308936_ENST00000541342_length(amino acids)=826AA_BP=85
MARTERADLACARRPAQPSPAPAWRREPRCLPRPRPCRRRAREREPESPPPERSRAHAEPVRRRHGHHGDLHPLHRRVPALRGYWQPSSI
EILEYSSDSEKEDDLENVLLIDSESPHKYHVQFASDARQIMERLIDPRTKSTETILHTPQKPTAKFPRTPENSAKKKLLRGGLAERLNGL
QNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAPRPGAGLKVLFTKETAGYLRGRPQDT
VRIFPPWQKLIIPSGSCPVILNTYFCEKVVAKEDSEKTCEVYCPDIPLPRRSISLAQMFVIKGLTNNSPEIQVVCSGVATTGTAWTHGHK
EAKQRIPTSTPLRDSLLDVVESQGAASWPGAGVRVVVQRVYSLPSRDSTRGQQGASSGHTDPAGTRACLLVQDACGMFGEVHLEFTMSKA
RQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPALCYILTAHPNLGQIDIIDEDPIYKLYQPP
VTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHS
LFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPGPVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRP
EDRGAFSCGDCSRVVTSPVLKRHLQVFLDCRSRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:44364956/chr8:48308936)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMK2B

Q13554

SPIDR

Q14159

FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:29100089}.FUNCTION: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000258682-12014_27221.666666666666668573.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000346990-11614_27221.666666666666668505.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000347193-12014_27221.666666666666668548.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000350811-12114_27221.666666666666668738.3333333333334DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000353625-11814_27221.666666666666668559.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000358707-11914_27221.666666666666668520.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395747-11914_27221.666666666666668519.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395749-12414_27221.6666666666666681455.3333333333333DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000440254-12114_27221.666666666666668566.6666666666666DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000457475-12014_27221.6666666666666681265.0DomainProtein kinase
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000258682-12020_2821.666666666666668573.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000346990-11620_2821.666666666666668505.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000347193-12020_2821.666666666666668548.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000350811-12120_2821.666666666666668738.3333333333334Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000353625-11820_2821.666666666666668559.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000358707-11920_2821.666666666666668520.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395747-11920_2821.666666666666668519.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395749-12420_2821.6666666666666681455.3333333333333Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000440254-12120_2821.666666666666668566.6666666666666Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000457475-12020_2821.6666666666666681265.0Nucleotide bindingATP
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000258682-120283_29221.666666666666668573.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000258682-120291_30121.666666666666668573.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000346990-116283_29221.666666666666668505.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000346990-116291_30121.666666666666668505.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000347193-120283_29221.666666666666668548.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000347193-120291_30121.666666666666668548.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000350811-121283_29221.666666666666668738.3333333333334RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000350811-121291_30121.666666666666668738.3333333333334RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000353625-118283_29221.666666666666668559.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000353625-118291_30121.666666666666668559.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000358707-119283_29221.666666666666668520.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000358707-119291_30121.666666666666668520.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395747-119283_29221.666666666666668519.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395747-119291_30121.666666666666668519.0RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395749-124283_29221.6666666666666681455.3333333333333RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000395749-124291_30121.6666666666666681455.3333333333333RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000440254-121283_29221.666666666666668566.6666666666666RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000440254-121291_30121.666666666666668566.6666666666666RegionNote=Calmodulin-binding
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000457475-120283_29221.6666666666666681265.0RegionAutoinhibitory domain
HgeneCAMK2Bchr7:44364956chr8:48308936ENST00000457475-120291_30121.6666666666666681265.0RegionNote=Calmodulin-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CAMK2B
SPIDR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CAMK2B-SPIDR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAMK2B-SPIDR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource