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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CAMK2D-TLL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAMK2D-TLL2
FusionPDB ID: 12674
FusionGDB2.0 ID: 12674
HgeneTgene
Gene symbol

CAMK2D

TLL2

Gene ID

817

7093

Gene namecalcium/calmodulin dependent protein kinase II deltatolloid like 2
SynonymsCAMKD-
Cytomap

4q26

10q24.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium/calmodulin-dependent protein kinase type II subunit deltaCaM kinase II delta subunitCaM-kinase II delta chainCaMK-II delta subunitcalcium/calmodulin-dependent protein kinase (CaM kinase) II deltacalcium/calmodulin-dependent protein kinase typtolloid-like protein 2
Modification date2020032720200313
UniProtAcc

Q13557

.
Ensembl transtripts involved in fusion geneENST idsENST00000296402, ENST00000342666, 
ENST00000379773, ENST00000394522, 
ENST00000394524, ENST00000394526, 
ENST00000418639, ENST00000429180, 
ENST00000454265, ENST00000505990, 
ENST00000508738, ENST00000511664, 
ENST00000514328, ENST00000515496, 
ENST00000509907, 		ENST00000469598, 
ENST00000357947, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 12 X 8=9604 X 5 X 5=100
# samples 136
** MAII scorelog2(13/960*10)=-2.88452278258006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CAMK2D [Title/Abstract] AND TLL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAMK2D(114421619)-TLL2(98192719), # samples:3
Anticipated loss of major functional domain due to fusion event.CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CAMK2D-TLL2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAMK2D

GO:0003254

regulation of membrane depolarization

22514276

HgeneCAMK2D

GO:0006468

protein phosphorylation

17179159|23283722

HgeneCAMK2D

GO:0018105

peptidyl-serine phosphorylation

22514276|23283722

HgeneCAMK2D

GO:0018107

peptidyl-threonine phosphorylation

22514276|23283722

HgeneCAMK2D

GO:0046777

protein autophosphorylation

22514276

HgeneCAMK2D

GO:1901897

regulation of relaxation of cardiac muscle

23283722

HgeneCAMK2D

GO:1902306

negative regulation of sodium ion transmembrane transport

22514276

HgeneCAMK2D

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

22514276


check buttonFusion gene breakpoints across CAMK2D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TLL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6864-01ACAMK2Dchr4

114421619

-TLL2chr10

98192719

-
ChimerDB4READTCGA-F5-6864CAMK2Dchr4

114421619

-TLL2chr10

98188505

-
ChimerDB4READTCGA-F5-6864CAMK2Dchr4

114421619

-TLL2chr10

98192719

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394524CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-7576141037740931238
ENST00000515496CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-72321066037491249
ENST00000514328CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-71961030037131237
ENST00000394522CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-7736157049542531252
ENST00000505990CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-7416125011539331272
ENST00000379773CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-726110956237781238
ENST00000508738CAMK2Dchr4114421619-ENST00000357947TLL2chr1098192719-72321066037491249
ENST00000394524CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-7420141037739371186
ENST00000515496CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-70761066035931197
ENST00000514328CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-70401030035571185
ENST00000394522CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-7580157049540971200
ENST00000505990CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-7260125011537771220
ENST00000379773CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-710510956236221186
ENST00000508738CAMK2Dchr4114421619-ENST00000357947TLL2chr1098188505-70761066035931197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394524ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0004354390.9995646
ENST00000515496ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0003869680.9996131
ENST00000514328ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0003728170.9996271
ENST00000394522ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0004497110.9995503
ENST00000505990ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0005475760.9994524
ENST00000379773ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0003252250.9996748
ENST00000508738ENST00000357947CAMK2Dchr4114421619-TLL2chr1098192719-0.0003869680.9996131
ENST00000394524ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0002884240.9997116
ENST00000515496ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0003680420.999632
ENST00000514328ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0001672540.99983275
ENST00000394522ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0005036820.99949634
ENST00000505990ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0004370610.9995629
ENST00000379773ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0002147450.99978524
ENST00000508738ENST00000357947CAMK2Dchr4114421619-TLL2chr1098188505-0.0003680420.999632

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12674_12674_1_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000379773_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1186AA_BP=342
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKGSQRAIFKQAMRHWEK
HTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFL
KMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPN
GYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAA
YEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKS
SSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKE
YPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF
FSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFN
EFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFG
DNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFH

--------------------------------------------------------------

>12674_12674_2_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000379773_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1238AA_BP=342
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKDGRENTTLLHSPGTLH
AAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQA
ISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILP
RQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD
YVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVS
EGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGG
CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDF
VEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHEN
GHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPD
PTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCG

--------------------------------------------------------------

>12674_12674_3_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000394522_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1200AA_BP=356
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDEDVKGS
QRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTI
IRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETL
QDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEF
RSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALI
GHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFIT
KLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFK
SDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWN
ISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKA
EVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMI

--------------------------------------------------------------

>12674_12674_4_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000394522_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1252AA_BP=356
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKEPQTTVIHNPDGNKESTESSNTTIEDEDVKDG
RENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCG
CCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYAR
NTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNF
TSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDD
YRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF
FKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFE
VFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGS
YLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSL
APILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVEL

--------------------------------------------------------------

>12674_12674_5_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000394524_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1186AA_BP=342
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKGSQRAIFKQAMRHWEK
HTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFL
KMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPN
GYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAA
YEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKS
SSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKE
YPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHF
FSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFN
EFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFG
DNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFH

--------------------------------------------------------------

>12674_12674_6_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000394524_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1238AA_BP=342
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKDGRENTTLLHSPGTLH
AAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQA
ISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILP
RQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYD
YVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVS
EGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGG
CEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDF
VEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHEN
GHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPD
PTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCG

--------------------------------------------------------------

>12674_12674_7_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000505990_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1220AA_BP=376
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIHNPDG
NKESTESSNTTIEDEDVKGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELG
HVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLS
QGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRF
CGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHD
SCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDP
GYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFC
GSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEG
TLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDAS
VQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLG

--------------------------------------------------------------

>12674_12674_8_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000505990_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1272AA_BP=376
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIHNPDG
NKESTESSNTTIEDEDVKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCV
TFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEA
GEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPS
YSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT
CGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNR
LWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN
KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDK
DECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEI
EQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNY
PSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYT

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>12674_12674_9_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000508738_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1197AA_BP=353
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKGSQRA
IFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRE
NIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDT
TGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSS
SNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHF
CGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLN
GTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDN
TVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISS
TAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQ
TKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFR

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>12674_12674_10_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000508738_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1249AA_BP=353
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKDGREN
TTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCS
YVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTF
SRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSM
DLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRP
SKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKE
VDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFE
LEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLC
RCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPI
LGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFR

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>12674_12674_11_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000514328_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1185AA_BP=341
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAKSLLKKPDGVKESTESSNTTIEDEDVKGSQRAIFKQAMRHWEKH
TCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLK
MEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNG
YPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY
EATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSS
SNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEY
PTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFF
SDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNE
FEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGD
NNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHA

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>12674_12674_12_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000514328_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1237AA_BP=341
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAKSLLKKPDGVKESTESSNTTIEDEDVKDGRENTTLLHSPGTLHA
AAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAI
SIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPR
QDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDY
VEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSE
GFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGC
EHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFV
EVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENG
HDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDP
TVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGY

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>12674_12674_13_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000515496_TLL2_chr10_98188505_ENST00000357947_length(amino acids)=1197AA_BP=353
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKGSQRA
IFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRE
NIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDT
TGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSS
SNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHF
CGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLN
GTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDN
TVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISS
TAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQ
TKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFR

--------------------------------------------------------------

>12674_12674_14_CAMK2D-TLL2_CAMK2D_chr4_114421619_ENST00000515496_TLL2_chr10_98192719_ENST00000357947_length(amino acids)=1249AA_BP=353
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVF
DLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP
WICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKKRKSSSSVQMMESTESSNTTIEDEDVKDGREN
TTLLHSPGTLHAAAKTFSPRVRRATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCS
YVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTF
SRGVFLDTILPRQDDNGVRPTIGQRVRLSQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSM
DLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGGDMNKDAGQIQSPNYPDDYRP
SKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKE
VDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFE
LEGNDVCKYDFVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSYLC
RCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDSLAPI
LGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:114421619/chr10:98192719)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAMK2D

Q13557

.
FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000296402-141814_272344.33333333333331391.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000342666-141914_272344.3333333333333615.6666666666666DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000379773-141714_272344.3333333333333479.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394522-151814_272358.3333333333333493.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394524-141814_272344.3333333333333479.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394526-152014_272355.33333333333331364.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000418639-152014_272358.33333333333331367.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000429180-152014_272364.33333333333331373.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000454265-162114_272369.33333333333331378.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000508738-151814_272355.3333333333333490.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000515496-151914_272355.3333333333333511.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000296402-141814_272344.33333333333331391.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000342666-141914_272344.3333333333333615.6666666666666DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000379773-141714_272344.3333333333333479.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394522-151814_272358.3333333333333493.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394524-141814_272344.3333333333333479.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394526-152014_272355.33333333333331364.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000418639-152014_272358.33333333333331367.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000429180-152014_272364.33333333333331373.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000454265-162114_272369.33333333333331378.6666666666667DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000508738-151814_272355.3333333333333490.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000515496-151914_272355.3333333333333511.0DomainProtein kinase
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000296402-141820_28344.33333333333331391.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000342666-141920_28344.3333333333333615.6666666666666Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000379773-141720_28344.3333333333333479.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394522-151820_28358.3333333333333493.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394524-141820_28344.3333333333333479.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394526-152020_28355.33333333333331364.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000418639-152020_28358.33333333333331367.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000429180-152020_28364.33333333333331373.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000454265-162120_28369.33333333333331378.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000508738-151820_28355.3333333333333490.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000515496-151920_28355.3333333333333511.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000296402-141820_28344.33333333333331391.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000342666-141920_28344.3333333333333615.6666666666666Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000379773-141720_28344.3333333333333479.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394522-151820_28358.3333333333333493.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394524-141820_28344.3333333333333479.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394526-152020_28355.33333333333331364.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000418639-152020_28358.33333333333331367.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000429180-152020_28364.33333333333331373.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000454265-162120_28369.33333333333331378.6666666666667Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000508738-151820_28355.3333333333333490.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000515496-151920_28355.3333333333333511.0Nucleotide bindingATP
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000296402-1418283_292344.33333333333331391.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000296402-1418291_301344.33333333333331391.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000342666-1419283_292344.3333333333333615.6666666666666RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000342666-1419291_301344.3333333333333615.6666666666666RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000379773-1417283_292344.3333333333333479.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000379773-1417291_301344.3333333333333479.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394522-1518283_292358.3333333333333493.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394522-1518291_301358.3333333333333493.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394524-1418283_292344.3333333333333479.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394524-1418291_301344.3333333333333479.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394526-1520283_292355.33333333333331364.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000394526-1520291_301355.33333333333331364.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000418639-1520283_292358.33333333333331367.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000418639-1520291_301358.33333333333331367.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000429180-1520283_292364.33333333333331373.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000429180-1520291_301364.33333333333331373.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000454265-1621283_292369.33333333333331378.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000454265-1621291_301369.33333333333331378.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000508738-1518283_292355.3333333333333490.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000508738-1518291_301355.3333333333333490.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000515496-1519283_292355.3333333333333511.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98188505ENST00000515496-1519291_301355.3333333333333511.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000296402-1418283_292344.33333333333331391.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000296402-1418291_301344.33333333333331391.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000342666-1419283_292344.3333333333333615.6666666666666RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000342666-1419291_301344.3333333333333615.6666666666666RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000379773-1417283_292344.3333333333333479.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000379773-1417291_301344.3333333333333479.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394522-1518283_292358.3333333333333493.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394522-1518291_301358.3333333333333493.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394524-1418283_292344.3333333333333479.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394524-1418291_301344.3333333333333479.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394526-1520283_292355.33333333333331364.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000394526-1520291_301355.33333333333331364.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000418639-1520283_292358.33333333333331367.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000418639-1520291_301358.33333333333331367.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000429180-1520283_292364.33333333333331373.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000429180-1520291_301364.33333333333331373.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000454265-1621283_292369.33333333333331378.6666666666667RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000454265-1621291_301369.33333333333331378.6666666666667RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000508738-1518283_292355.3333333333333490.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000508738-1518291_301355.3333333333333490.0RegionCalmodulin-binding
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000515496-1519283_292355.3333333333333511.0RegionAutoinhibitory domain
HgeneCAMK2Dchr4:114421619chr10:98192719ENST00000515496-1519291_301355.3333333333333511.0RegionCalmodulin-binding
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321351_463173.333333333333341016.0DomainCUB 1
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321464_576173.333333333333341016.0DomainCUB 2
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321576_617173.333333333333341016.0DomainEGF-like 1%3B calcium-binding
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321620_732173.333333333333341016.0DomainCUB 3
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321732_772173.333333333333341016.0DomainEGF-like 2%3B calcium-binding
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321776_888173.333333333333341016.0DomainCUB 4
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321889_1005173.333333333333341016.0DomainCUB 5
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221149_349121.333333333333331016.0DomainPeptidase M12A
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221351_463121.333333333333331016.0DomainCUB 1
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221464_576121.333333333333331016.0DomainCUB 2
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221576_617121.333333333333331016.0DomainEGF-like 1%3B calcium-binding
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221620_732121.333333333333331016.0DomainCUB 3
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221732_772121.333333333333331016.0DomainEGF-like 2%3B calcium-binding
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221776_888121.333333333333331016.0DomainCUB 4
TgeneTLL2chr4:114421619chr10:98192719ENST00000357947221889_1005121.333333333333331016.0DomainCUB 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTLL2chr4:114421619chr10:98188505ENST00000357947321149_349173.333333333333341016.0DomainPeptidase M12A


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CAMK2D_pLDDT.png
all structure
all structure
TLL2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CAMK2D
TLL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CAMK2D-TLL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAMK2D-TLL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource