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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CAPN1-PFDN5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CAPN1-PFDN5
FusionPDB ID: 12866
FusionGDB2.0 ID: 12866
HgeneTgene
Gene symbol

CAPN1

PFDN5

Gene ID

823

5204

Gene namecalpain 1prefoldin subunit 5
SynonymsCANP|CANP1|CANPL1|SPG76|muCANP|muCLMM-1|MM1|PFD5
Cytomap

11q13.1

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioncalpain-1 catalytic subunitCANP 1calcium-activated neutral proteinase 1calpain 1, (mu/I) large subunitcalpain mu-typecalpain, large polypeptide L1calpain-1 large subunitcell proliferation-inducing gene 30 proteincell proliferation-inducing proteinprefoldin subunit 5c-myc binding proteinmyc modulator-1
Modification date2020032220200313
UniProtAcc

O75808

.
Ensembl transtripts involved in fusion geneENST idsENST00000279247, ENST00000524773, 
ENST00000527323, ENST00000533129, 
ENST00000533820, ENST00000527469, 
ENST00000334478, ENST00000550846, 
ENST00000351500, ENST00000551018, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 11 X 8=11447 X 6 X 3=126
# samples 138
** MAII scorelog2(13/1144*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/126*10)=-0.655351828612554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CAPN1 [Title/Abstract] AND PFDN5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAPN1(64976858)-PFDN5(53691634), # samples:1
Anticipated loss of major functional domain due to fusion event.CAPN1-PFDN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN1-PFDN5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN1-PFDN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CAPN1-PFDN5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPN1

GO:0006508

proteolysis

2400579|2407243|16411745|21531719

HgeneCAPN1

GO:0050790

regulation of catalytic activity

8954105|9271093

HgeneCAPN1

GO:0097264

self proteolysis

8769305|8954105


check buttonFusion gene breakpoints across CAPN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PFDN5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ACAPN1chr11

64976858

+PFDN5chr12

53691634

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000533820CAPN1chr1164976858+ENST00000551018PFDN5chr1253691634+237520121672269700
ENST00000533820CAPN1chr1164976858+ENST00000351500PFDN5chr1253691634+237520121672269700
ENST00000533129CAPN1chr1164976858+ENST00000551018PFDN5chr1253691634+22321869752126683
ENST00000533129CAPN1chr1164976858+ENST00000351500PFDN5chr1253691634+22321869752126683
ENST00000524773CAPN1chr1164976858+ENST00000551018PFDN5chr1253691634+225718941002151683
ENST00000524773CAPN1chr1164976858+ENST00000351500PFDN5chr1253691634+225718941002151683
ENST00000279247CAPN1chr1164976858+ENST00000551018PFDN5chr1253691634+230019371432194683
ENST00000279247CAPN1chr1164976858+ENST00000351500PFDN5chr1253691634+230019371432194683
ENST00000527323CAPN1chr1164976858+ENST00000551018PFDN5chr1253691634+239720342072291694
ENST00000527323CAPN1chr1164976858+ENST00000351500PFDN5chr1253691634+239720342072291694

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000533820ENST00000551018CAPN1chr1164976858+PFDN5chr1253691634+0.014819330.98518074
ENST00000533820ENST00000351500CAPN1chr1164976858+PFDN5chr1253691634+0.014819330.98518074
ENST00000533129ENST00000551018CAPN1chr1164976858+PFDN5chr1253691634+0.0141504180.9858496
ENST00000533129ENST00000351500CAPN1chr1164976858+PFDN5chr1253691634+0.0141504180.9858496
ENST00000524773ENST00000551018CAPN1chr1164976858+PFDN5chr1253691634+0.0137628760.98623717
ENST00000524773ENST00000351500CAPN1chr1164976858+PFDN5chr1253691634+0.0137628760.98623717
ENST00000279247ENST00000551018CAPN1chr1164976858+PFDN5chr1253691634+0.0139488950.98605114
ENST00000279247ENST00000351500CAPN1chr1164976858+PFDN5chr1253691634+0.0139488950.98605114
ENST00000527323ENST00000551018CAPN1chr1164976858+PFDN5chr1253691634+0.0137047780.9862953
ENST00000527323ENST00000351500CAPN1chr1164976858+PFDN5chr1253691634+0.0137047780.9862953

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12866_12866_1_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000279247_PFDN5_chr12_53691634_ENST00000351500_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_2_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000279247_PFDN5_chr12_53691634_ENST00000551018_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_3_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000524773_PFDN5_chr12_53691634_ENST00000351500_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_4_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000524773_PFDN5_chr12_53691634_ENST00000551018_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_5_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000527323_PFDN5_chr12_53691634_ENST00000351500_length(amino acids)=694AA_BP=609
MGSEQAHLSGRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSK
TYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLP
IKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLD
MEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLE
ICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDME
TIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQ
ANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGY

--------------------------------------------------------------

>12866_12866_6_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000527323_PFDN5_chr12_53691634_ENST00000551018_length(amino acids)=694AA_BP=609
MGSEQAHLSGRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSK
TYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLP
IKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLD
MEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLE
ICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDME
TIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQ
ANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGY

--------------------------------------------------------------

>12866_12866_7_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000533129_PFDN5_chr12_53691634_ENST00000351500_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_8_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000533129_PFDN5_chr12_53691634_ENST00000551018_length(amino acids)=683AA_BP=598
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVK
GHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPP
ELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKD

--------------------------------------------------------------

>12866_12866_9_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000533820_PFDN5_chr12_53691634_ENST00000351500_length(amino acids)=700AA_BP=615
MLAASPAPPQSSCRSPRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDL
GPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVV
VDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSID
ISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMR
EFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERR
FGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVE
LDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLI

--------------------------------------------------------------

>12866_12866_10_CAPN1-PFDN5_CAPN1_chr11_64976858_ENST00000533820_PFDN5_chr12_53691634_ENST00000551018_length(amino acids)=700AA_BP=615
MLAASPAPPQSSCRSPRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDL
GPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVV
VDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSID
ISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMR
EFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERR
FGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVE
LDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDMYVPGKLHDVEHVLI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64976858/chr12:53691634)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPN1

O75808

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722302_333598.0715.0Calcium bindingNote=2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+172299_106598.0715.0Calcium bindingNote=1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722302_333598.0715.0Calcium bindingNote=2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+172299_106598.0715.0Calcium bindingNote=1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621302_333598.0715.0Calcium bindingNote=2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+162199_106598.0715.0Calcium bindingNote=1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722302_333598.0715.0Calcium bindingNote=2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+172299_106598.0715.0Calcium bindingNote=1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722302_333598.0715.0Calcium bindingNote=2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+172299_106598.0715.0Calcium bindingNote=1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722541_576598.0715.0DomainEF-hand 1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+172255_354598.0715.0DomainCalpain catalytic
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722541_576598.0715.0DomainEF-hand 1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+172255_354598.0715.0DomainCalpain catalytic
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621541_576598.0715.0DomainEF-hand 1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+162155_354598.0715.0DomainCalpain catalytic
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722541_576598.0715.0DomainEF-hand 1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+172255_354598.0715.0DomainCalpain catalytic
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722541_576598.0715.0DomainEF-hand 1
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+172255_354598.0715.0DomainCalpain catalytic
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722355_526598.0715.0RegionNote=Domain III
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722527_542598.0715.0RegionNote=Linker
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722355_526598.0715.0RegionNote=Domain III
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722527_542598.0715.0RegionNote=Linker
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621355_526598.0715.0RegionNote=Domain III
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621527_542598.0715.0RegionNote=Linker
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722355_526598.0715.0RegionNote=Domain III
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722527_542598.0715.0RegionNote=Linker
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722355_526598.0715.0RegionNote=Domain III
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722527_542598.0715.0RegionNote=Linker

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722598_609598.0715.0Calcium bindingNote=3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722628_639598.0715.0Calcium bindingNote=4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722598_609598.0715.0Calcium bindingNote=3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722628_639598.0715.0Calcium bindingNote=4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621598_609598.0715.0Calcium bindingNote=3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621628_639598.0715.0Calcium bindingNote=4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722598_609598.0715.0Calcium bindingNote=3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722628_639598.0715.0Calcium bindingNote=4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722598_609598.0715.0Calcium bindingNote=3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722628_639598.0715.0Calcium bindingNote=4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722585_618598.0715.0DomainEF-hand 2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722615_650598.0715.0DomainEF-hand 3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722680_714598.0715.0DomainEF-hand 4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722585_618598.0715.0DomainEF-hand 2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722615_650598.0715.0DomainEF-hand 3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722680_714598.0715.0DomainEF-hand 4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621585_618598.0715.0DomainEF-hand 2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621615_650598.0715.0DomainEF-hand 3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621680_714598.0715.0DomainEF-hand 4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722585_618598.0715.0DomainEF-hand 2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722615_650598.0715.0DomainEF-hand 3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722680_714598.0715.0DomainEF-hand 4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722585_618598.0715.0DomainEF-hand 2
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722615_650598.0715.0DomainEF-hand 3
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722680_714598.0715.0DomainEF-hand 4
HgeneCAPN1chr11:64976858chr12:53691634ENST00000279247+1722543_713598.0715.0RegionNote=Domain IV
HgeneCAPN1chr11:64976858chr12:53691634ENST00000524773+1722543_713598.0715.0RegionNote=Domain IV
HgeneCAPN1chr11:64976858chr12:53691634ENST00000527323+1621543_713598.0715.0RegionNote=Domain IV
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533129+1722543_713598.0715.0RegionNote=Domain IV
HgeneCAPN1chr11:64976858chr12:53691634ENST00000533820+1722543_713598.0715.0RegionNote=Domain IV


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CAPN1
PFDN5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CAPN1-PFDN5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CAPN1-PFDN5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource