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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CAPRIN1-C11orf84

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CAPRIN1-C11orf84
	FusionPDB ID: 12935
	FusionGDB2.0 ID: 12935
		Hgene	Tgene
	Gene symbol	CAPRIN1	C11orf84
	Gene ID	4076	144097
	Gene name	cell cycle associated protein 1	spindlin interactor and repressor of chromatin binding
	Synonyms	GPIAP1\|GPIP137\|GRIP137\|M11S1\|RNG105\|p137GPI	C11orf84\|SPIN-DOC
	Cytomap	11p13	11q13.1
	Type of gene	protein-coding	protein-coding
	Description	caprin-1GPI-anchored membrane protein 1GPI-anchored protein p137GPI-p137RNA granule protein 105activation/proliferation-associated protein 1caprin 1cytoplasmic activation- and proliferation-associated protein 1cytoplasmic activation/proliferation-	spindlin interactor and repressor of chromatin-binding proteinSPIN1 docking proteinhypothetical protein BC007540uncharacterized protein C11orf84
	Modification date	20200313	20200313
	UniProtAcc	Q14444	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000533657, ENST00000341394, ENST00000389645, ENST00000529307, ENST00000530820, ENST00000532820,	ENST00000294244,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 11 X 7=847	6 X 3 X 8=144
	# samples	13	9
	** MAII score	log2(13/847*10)=-2.70385034630374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CAPRIN1 [Title/Abstract] AND C11orf84 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CAPRIN1(34113603)-C11orf84(63585277), # samples:3
Anticipated loss of major functional domain due to fusion event.	CAPRIN1-C11orf84 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CAPRIN1-C11orf84 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	C11orf84	GO:0045892	negative regulation of transcription, DNA-templated	29061846

Fusion gene breakpoints across CAPRIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C11orf84 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-A7T6-01A	CAPRIN1	chr11	34113603	-	C11orf84	chr11	63585277	+
ChimerDB4	LGG	TCGA-DU-A7T6-01A	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+
ChimerDB4	LGG	TCGA-DU-A7T6	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000341394

CAPRIN1

chr11

34113603

ENST00000294244

C11orf84

chr11

63585277

3492

1894

114

2912

932

ENST00000389645

CAPRIN1

chr11

34113603

ENST00000294244

C11orf84

chr11

63585277

3443

1845

2863

932

ENST00000532820

CAPRIN1

chr11

34113603

ENST00000294244

C11orf84

chr11

63585277

3514

1916

2934

969

ENST00000530820

CAPRIN1

chr11

34113603

ENST00000294244

C11orf84

chr11

63585277

3395

1797

2815

936

ENST00000529307

CAPRIN1

chr11

34113603

ENST00000294244

C11orf84

chr11

63585277

3292

1694

232

2712

826

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341394	ENST00000294244	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+	0.003624831	0.99637514
ENST00000389645	ENST00000294244	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+	0.003659431	0.9963406
ENST00000532820	ENST00000294244	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+	0.002985869	0.99701416
ENST00000530820	ENST00000294244	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+	0.00322202	0.99677795
ENST00000529307	ENST00000294244	CAPRIN1	chr11	34113603	+	C11orf84	chr11	63585277	+	0.003435283	0.9965647

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>12935_12935_1_CAPRIN1-C11orf84_CAPRIN1_chr11_34113603_ENST00000341394_C11orf84_chr11_63585277_ENST00000294244_length(amino acids)=932AA_BP=593
MPGRDHHPCPLSCPLVISSGLRARTMPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKL
RNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYV
LDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNY
FDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAAS
PSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPV
QPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQS
MQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLV
GSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAA
RMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAP
AEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRHPQGT

--------------------------------------------------------------

>12935_12935_2_CAPRIN1-C11orf84_CAPRIN1_chr11_34113603_ENST00000389645_C11orf84_chr11_63585277_ENST00000294244_length(amino acids)=932AA_BP=593
MPGRDHHPCPLSCPLVISSGLRARTMPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKL
RNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYV
LDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNY
FDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAAS
PSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPV
QPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQS
MQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLV
GSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAA
RMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAP
AEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRHPQGT

--------------------------------------------------------------

>12935_12935_3_CAPRIN1-C11orf84_CAPRIN1_chr11_34113603_ENST00000529307_C11orf84_chr11_63585277_ENST00000294244_length(amino acids)=826AA_BP=487
MNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQG
LNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEE
AASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQAD
PLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEG
YTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNE
PETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCG
AEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAARMPAEIVVLLDSEDNP
SLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFV
LQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRHPQGTKRVGAGDTSDWPTVLS

--------------------------------------------------------------

>12935_12935_4_CAPRIN1-C11orf84_CAPRIN1_chr11_34113603_ENST00000530820_C11orf84_chr11_63585277_ENST00000294244_length(amino acids)=936AA_BP=597
MSRVSPRPSPDWPLLSFLPLFLLSPCGLKMPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVI
DKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLE
LQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKVLKEIVERVF
QSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQP
QAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPN
QVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAA
PFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQTVTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQ
EFLVGSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEQPSPPNSDSGQDAHPDPDAN
PDAARMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEPPGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTET
FAAPAEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSRH

--------------------------------------------------------------

>12935_12935_5_CAPRIN1-C11orf84_CAPRIN1_chr11_34113603_ENST00000532820_C11orf84_chr11_63585277_ENST00000294244_length(amino acids)=969AA_BP=630
MAGRARARALFLPSRRAAPPPPPARVGYRSLRVLSRVSPRPSPDWPLLSFLPLFLLSPCGLKMPSATSHSGSGSKSSGPPPPSGSSGSEA
AAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMA
LSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYE
HASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQ
FMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPA
IVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQT
TASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQT
VTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAW
SEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAARMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEP
PGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:34113603/chr11:63585277)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAPRIN1 Q14444	.
FUNCTION: May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. {ECO:0000269\|PubMed:17210633}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000341394

125_153

568.3333333333334

710.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000341394

60_94

568.3333333333334

710.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000389645

125_153

568.3333333333334

695.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000389645

60_94

568.3333333333334

695.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000530820

125_153

568.3333333333334

695.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000530820

60_94

568.3333333333334

695.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000532820

125_153

568.3333333333334

710.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000532820

60_94

568.3333333333334

710.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000341394

360_381

568.3333333333334

710.0

Region

Note=G3BP1-binding

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000389645

360_381

568.3333333333334

695.0

Region

Note=G3BP1-binding

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000530820

360_381

568.3333333333334

695.0

Region

Note=G3BP1-binding

Hgene

CAPRIN1

chr11:34113603

chr11:63585277

ENST00000532820

360_381

568.3333333333334

710.0

Region

Note=G3BP1-binding

Tgene

C11orf84

chr11:34113603

chr11:63585277

ENST00000294244

147_252

42.333333333333336

382.0

Compositional bias

Note=Pro-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1770_CAPRIN1_34113603_C11orf84_63585277_ranked_0.pdb	CAPRIN1	34113603	34113603	ENST00000294244	C11orf84	chr11	63585277	+	MAGRARARALFLPSRRAAPPPPPARVGYRSLRVLSRVSPRPSPDWPLLSFLPLFLLSPCGLKMPSATSHSGSGSKSSGPPPPSGSSGSEA AAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMA LSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYE HASIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPAEEYTEQSEVESTEYVNRQ FMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPA IVSAQPMNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQT TASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTELQQEQLQT VTQQEKTPPPRPSPLEAGSDGCEEPKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIRAPSADTARSHILEQHPHTLDLSPSEKSNILEAW SEGVALLQDVRAEQPSPPNSDSGQDAHPDPDANPDAARMPAEIVVLLDSEDNPSLPKRSRPRGLRPLELPAVPATEPGNKKPRGQRWKEP PGEEPVRKKRGRPMTKNLDPDPEPPSPDSPTETFAAPAEVRHFTDGSFPAGFVLQLFSHTQLRGPDSKDSPKDREVAEGGLPRAESPSPA	969

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CAPRIN1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CAPRIN1
C11orf84

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CAPRIN1-C11orf84

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CAPRIN1-C11orf84

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source