UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CARM1-NDUFS1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CARM1-NDUFS1
	FusionPDB ID: 13057
	FusionGDB2.0 ID: 13057
		Hgene	Tgene
	Gene symbol	CARM1	NDUFS1
	Gene ID	10498	4719
	Gene name	coactivator associated arginine methyltransferase 1	NADH:ubiquinone oxidoreductase core subunit S1
	Synonyms	PRMT4	CI-75Kd\|CI-75k\|MC1DN5\|PRO1304
	Cytomap	19p13.2	2q33.3
	Type of gene	protein-coding	protein-coding
	Description	histone-arginine methyltransferase CARM1protein arginine N-methyltransferase 4	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)complex I 75kDa subunitcomplex I, mitochondrial respiratory chain, 75-kD subunitmitochondrial NADH-ubiquinone
	Modification date	20200313	20200313
	UniProtAcc	Q86X55	P28331
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000327064, ENST00000344150,	ENST00000233190, ENST00000423725, ENST00000432169, ENST00000440274, ENST00000449699, ENST00000455934, ENST00000457011,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 10 X 10=1400	7 X 7 X 6=294
	# samples	20	7
	** MAII score	log2(20/1400*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CARM1 [Title/Abstract] AND NDUFS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CARM1(11019883)-NDUFS1(207007555), # samples:1
Anticipated loss of major functional domain due to fusion event.	CARM1-NDUFS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CARM1-NDUFS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CARM1-NDUFS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CARM1-NDUFS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CARM1	GO:0016571	histone methylation	19405910
Tgene	NDUFS1	GO:0008637	apoptotic mitochondrial changes	15186778

Fusion gene breakpoints across CARM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-JY-A93F	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000327064	CARM1	chr19	11019883	+	ENST00000233190	NDUFS1	chr2	207007555	-	11313	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000423725	NDUFS1	chr2	207007555	-	2311	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000457011	NDUFS1	chr2	207007555	-	2185	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000440274	NDUFS1	chr2	207007555	-	2174	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000455934	NDUFS1	chr2	207007555	-	2031	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000449699	NDUFS1	chr2	207007555	-	2029	748	46	1944	632
ENST00000327064	CARM1	chr19	11019883	+	ENST00000432169	NDUFS1	chr2	207007555	-	2029	748	46	1944	632
ENST00000344150	CARM1	chr19	11019883	+	ENST00000233190	NDUFS1	chr2	207007555	-	11123	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000423725	NDUFS1	chr2	207007555	-	2121	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000457011	NDUFS1	chr2	207007555	-	1995	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000440274	NDUFS1	chr2	207007555	-	1984	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000455934	NDUFS1	chr2	207007555	-	1841	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000449699	NDUFS1	chr2	207007555	-	1839	558	0	1754	584
ENST00000344150	CARM1	chr19	11019883	+	ENST00000432169	NDUFS1	chr2	207007555	-	1839	558	0	1754	584

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000327064	ENST00000233190	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.000547684	0.9994523
ENST00000327064	ENST00000423725	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.002164218	0.9978358
ENST00000327064	ENST00000457011	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.002909654	0.99709034
ENST00000327064	ENST00000440274	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.002945814	0.9970542
ENST00000327064	ENST00000455934	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.00462303	0.99537694
ENST00000327064	ENST00000449699	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.004705091	0.99529487
ENST00000327064	ENST00000432169	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.004705091	0.99529487
ENST00000344150	ENST00000233190	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.000472588	0.99952745
ENST00000344150	ENST00000423725	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.001617535	0.99838245
ENST00000344150	ENST00000457011	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.002199118	0.9978009
ENST00000344150	ENST00000440274	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.002206436	0.99779356
ENST00000344150	ENST00000455934	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.003503812	0.99649626
ENST00000344150	ENST00000449699	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.003567459	0.99643254
ENST00000344150	ENST00000432169	CARM1	chr19	11019883	+	NDUFS1	chr2	207007555	-	0.003567459	0.99643254

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13057_13057_1_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000233190_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_2_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000423725_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_3_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000432169_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_4_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000440274_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_5_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000449699_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_6_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000455934_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_7_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000327064_NDUFS1_chr2_207007555_ENST00000457011_length(amino acids)=632AA_BP=234
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTL
ERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDT
LCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDI
ASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVL
FLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP
YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPS

--------------------------------------------------------------

>13057_13057_8_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000233190_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_9_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000423725_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_10_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000432169_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_11_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000440274_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_12_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000449699_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_13_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000455934_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

>13057_13057_14_CARM1-NDUFS1_CARM1_chr19_11019883_ENST00000344150_NDUFS1_chr2_207007555_ENST00000457011_length(amino acids)=584AA_BP=186
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETEC
SRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPL
FNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMT
SGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKS
ATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADP

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11019883/chr2:207007555)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CARM1 Q86X55	NDUFS1 P28331
FUNCTION: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. {ECO:0000269\|PubMed:16497732, ECO:0000269\|PubMed:19405910}.	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30879903, PubMed:31557978). Essential for catalysing the entry and efficient transfer of electrons within complex I (PubMed:31557978). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:30879903, PubMed:31557978). {ECO:0000269\|PubMed:30879903, ECO:0000269\|PubMed:31557978}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000432169

245_301

218.0

617.0

Domain

4Fe-4S Mo/W bis-MGD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CARM1

chr19:11019883

chr2:207007555

ENST00000327064

146_453

186.0

609.0

Domain

SAM-dependent MTase PRMT-type

Hgene

CARM1

chr19:11019883

chr2:207007555

ENST00000344150

146_453

186.0

586.0

Domain

SAM-dependent MTase PRMT-type

Hgene

CARM1

chr19:11019883

chr2:207007555

ENST00000327064

499_608

186.0

609.0

Region

Transactivation domain

Hgene

CARM1

chr19:11019883

chr2:207007555

ENST00000344150

499_608

186.0

586.0

Region

Transactivation domain

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000233190

108_147

329.0

728.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000233190

245_301

329.0

728.0

Domain

4Fe-4S Mo/W bis-MGD-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000233190

30_108

329.0

728.0

Domain

2Fe-2S ferredoxin-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000423725

108_147

272.0

671.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000423725

245_301

272.0

671.0

Domain

4Fe-4S Mo/W bis-MGD-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000423725

30_108

272.0

671.0

Domain

2Fe-2S ferredoxin-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000432169

108_147

218.0

617.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000432169

30_108

218.0

617.0

Domain

2Fe-2S ferredoxin-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000440274

108_147

293.0

692.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000440274

245_301

293.0

692.0

Domain

4Fe-4S Mo/W bis-MGD-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000440274

30_108

293.0

692.0

Domain

2Fe-2S ferredoxin-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000449699

108_147

329.0

728.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000449699

245_301

329.0

728.0

Domain

4Fe-4S Mo/W bis-MGD-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000449699

30_108

329.0

728.0

Domain

2Fe-2S ferredoxin-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000455934

108_147

343.0

742.0

Domain

4Fe-4S His(Cys)3-ligated-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000455934

245_301

343.0

742.0

Domain

4Fe-4S Mo/W bis-MGD-type

Tgene

NDUFS1

chr19:11019883

chr2:207007555

ENST00000455934

30_108

343.0

742.0

Domain

2Fe-2S ferredoxin-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CARM1
NDUFS1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CARM1-NDUFS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CARM1-NDUFS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source