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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ACIN1-NUTM1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACIN1-NUTM1
FusionPDB ID: 1310
FusionGDB2.0 ID: 1310
HgeneTgene
Gene symbol

ACIN1

NUTM1

Gene ID

22985

256646

Gene nameapoptotic chromatin condensation inducer 1NUT midline carcinoma family member 1
SynonymsACINUS|ACN|fSAP152C15orf55|FAM22H|NUT
Cytomap

14q11.2

15q14

Type of geneprotein-codingprotein-coding
Descriptionapoptotic chromatin condensation inducer in the nucleusfunctional spliceosome-associated protein 152NUT family member 1nuclear protein in testis
Modification date2020031320200313
UniProtAcc

Q9UKV3

Q86Y26

Ensembl transtripts involved in fusion geneENST idsENST00000262710, ENST00000457657, 
ENST00000555053, ENST00000605057, 
ENST00000338631, ENST00000357481, 
ENST00000397341, ENST00000555352, 
ENST00000557515, 		ENST00000333756, 
ENST00000438749, ENST00000537011, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 11 X 4=5286 X 5 X 4=120
# samples 135
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/120*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACIN1 [Title/Abstract] AND NUTM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACIN1

GO:0030263

apoptotic chromosome condensation

10490026


check buttonFusion gene breakpoints across ACIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..ACIN1chr14

23559191

-NUTM1chr

34640170

+
ChimerKB3..ACIN1chr14

23559731

-NUTM1chr

34640168

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000605057ACIN1chr1423559191-ENST00000537011NUTM1chr34640170+1470477411468476
ENST00000605057ACIN1chr1423559191-ENST00000438749NUTM1chr34640170+1470477411468476
ENST00000605057ACIN1chr1423559191-ENST00000333756NUTM1chr34640170+1470477411468476
ENST00000262710ACIN1chr1423559191-ENST00000537011NUTM1chr34640170+19319383191929537
ENST00000262710ACIN1chr1423559191-ENST00000438749NUTM1chr34640170+19319383191929537
ENST00000262710ACIN1chr1423559191-ENST00000333756NUTM1chr34640170+19319383191929537
ENST00000555053ACIN1chr1423559191-ENST00000537011NUTM1chr34640170+1700707881698537
ENST00000555053ACIN1chr1423559191-ENST00000438749NUTM1chr34640170+1700707881698537
ENST00000555053ACIN1chr1423559191-ENST00000333756NUTM1chr34640170+1700707881698537
ENST00000605057ACIN1chr1423559731-ENST00000537011NUTM1chr34640168+1350357411348436
ENST00000605057ACIN1chr1423559731-ENST00000438749NUTM1chr34640168+1350357411348436
ENST00000605057ACIN1chr1423559731-ENST00000333756NUTM1chr34640168+1350357411348436
ENST00000457657ACIN1chr1423559731-ENST00000537011NUTM1chr34640168+18118183191809497
ENST00000457657ACIN1chr1423559731-ENST00000438749NUTM1chr34640168+18118183191809497
ENST00000457657ACIN1chr1423559731-ENST00000333756NUTM1chr34640168+18118183191809497
ENST00000262710ACIN1chr1423559731-ENST00000537011NUTM1chr34640168+18118183191809497
ENST00000262710ACIN1chr1423559731-ENST00000438749NUTM1chr34640168+18118183191809497
ENST00000262710ACIN1chr1423559731-ENST00000333756NUTM1chr34640168+18118183191809497
ENST00000555053ACIN1chr1423559731-ENST00000537011NUTM1chr34640168+1580587881578497
ENST00000555053ACIN1chr1423559731-ENST00000438749NUTM1chr34640168+1580587881578497
ENST00000555053ACIN1chr1423559731-ENST00000333756NUTM1chr34640168+1580587881578497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1310_1310_1_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000262710_NUTM1_chr_34640170_ENST00000333756_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_2_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000262710_NUTM1_chr_34640170_ENST00000438749_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_3_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000262710_NUTM1_chr_34640170_ENST00000537011_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_4_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000555053_NUTM1_chr_34640170_ENST00000333756_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_5_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000555053_NUTM1_chr_34640170_ENST00000438749_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_6_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000555053_NUTM1_chr_34640170_ENST00000537011_length(amino acids)=537AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYT
CHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS
SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG

--------------------------------------------------------------

>1310_1310_7_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000605057_NUTM1_chr_34640170_ENST00000333756_length(amino acids)=476AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDK
SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEV
GELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRIC
TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR

--------------------------------------------------------------

>1310_1310_8_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000605057_NUTM1_chr_34640170_ENST00000438749_length(amino acids)=476AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDK
SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEV
GELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRIC
TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR

--------------------------------------------------------------

>1310_1310_9_ACIN1-NUTM1_ACIN1_chr14_23559191_ENST00000605057_NUTM1_chr_34640170_ENST00000537011_length(amino acids)=476AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDK
SSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEV
GELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRIC
TRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR

--------------------------------------------------------------

>1310_1310_10_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000262710_NUTM1_chr_34640168_ENST00000333756_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_11_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000262710_NUTM1_chr_34640168_ENST00000438749_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_12_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000262710_NUTM1_chr_34640168_ENST00000537011_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_13_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000457657_NUTM1_chr_34640168_ENST00000333756_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_14_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000457657_NUTM1_chr_34640168_ENST00000438749_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_15_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000457657_NUTM1_chr_34640168_ENST00000537011_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_16_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000555053_NUTM1_chr_34640168_ENST00000333756_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_17_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000555053_NUTM1_chr_34640168_ENST00000438749_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_18_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000555053_NUTM1_chr_34640168_ENST00000537011_length(amino acids)=497AA_BP=
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEAIETQSSSSEEIVP
SPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRN
KKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE

--------------------------------------------------------------

>1310_1310_19_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000605057_NUTM1_chr_34640168_ENST00000333756_length(amino acids)=436AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINK
VTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDL
WDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAN

--------------------------------------------------------------

>1310_1310_20_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000605057_NUTM1_chr_34640168_ENST00000438749_length(amino acids)=436AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINK
VTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDL
WDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAN

--------------------------------------------------------------

>1310_1310_21_ACIN1-NUTM1_ACIN1_chr14_23559731_ENST00000605057_NUTM1_chr_34640168_ENST00000537011_length(amino acids)=436AA_BP=
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINK
VTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDL
WDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:/chr:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACIN1

Q9UKV3

NUTM1

Q86Y26

FUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.FUNCTION: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. {ECO:0000269|PubMed:30447097}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (200) >>>200.pdbFusion protein BP residue:
CIF file (200) >>>200.cif		ACIN1chr1423559731-NUTM1chr34640168+
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALML
ENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREARE
AAELEAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSA
CEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMS
KESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQ
LGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTI
ADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGP
LTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP
436
3D view using mol* of 200 (AA BP:)
PDB file (255) >>>255.pdbFusion protein BP residue:
CIF file (255) >>>255.cif		ACIN1chr1423559191-NUTM1chr34640170+
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALML
ENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREARE
AAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPTIETQ
SSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR
SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNK
KKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSS
EQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAA
CLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAN
QLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVR
476
3D view using mol* of 255 (AA BP:)
PDB file (293) >>>293.pdbFusion protein BP residue:
CIF file (293) >>>293.cif		ACIN1chr1423559731-NUTM1chr34640168+
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPE
AVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSA
LVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQEL
LRQRLEREAREAAELEAIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQD
KSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYC
RLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRK
AHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFA
KQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLN
RTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLE
497
3D view using mol* of 293 (AA BP:)
PDB file (368) >>>368.pdbFusion protein BP residue:
CIF file (368) >>>368.cif		ACIN1chr1423559191-NUTM1chr34640170+
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPE
AVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSA
LVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQEL
LRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELE
LSRHSPTIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVS
ACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGM
SKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALC
QLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLT
IADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG
PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQE
537
3D view using mol* of 368 (AA BP:)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ACIN1_pLDDT.png
all structure
all structure
NUTM1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ACIN1_NUTM1_200_PAE.png (AA BP:)
all structure
ACIN1_NUTM1_200_pLDDT.png (AA BP:)
all structure
ACIN1_NUTM1_200_pLDDT_and_active_sites.png (AA BP:)
all structure
ACIN1_NUTM1_200_violinplot.png (AA BP:)
all structure
ACIN1_NUTM1_255_PAE.png (AA BP:)
all structure
ACIN1_NUTM1_255_pLDDT.png (AA BP:)
all structure
ACIN1_NUTM1_255_pLDDT_and_active_sites.png (AA BP:)
all structure
ACIN1_NUTM1_255_violinplot.png (AA BP:)
all structure
ACIN1_NUTM1_293_pLDDT.png (AA BP:)
all structure
ACIN1_NUTM1_293_pLDDT_and_active_sites.png (AA BP:)
all structure
ACIN1_NUTM1_293_violinplot.png (AA BP:)
all structure
ACIN1_NUTM1_368_pLDDT.png (AA BP:)
all structure
ACIN1_NUTM1_368_pLDDT_and_active_sites.png (AA BP:)
all structure
ACIN1_NUTM1_368_violinplot.png (AA BP:)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
ACIN1_NUTM1_200.png
all structure
ACIN1_NUTM1_255.png
all structure
ACIN1_NUTM1_293.png
all structure
ACIN1_NUTM1_368.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
2001.1191751.148405.0830.4170.8351.1071.440.8991.6020.722Chain A: 82,83,86,89,90,92,93,96,245,265,266,271,2
74,275,277,278,280,281,312,315,316,318,319,322,332
,333,344,347,348,349,350,351,354,436
2001.1491011.229216.4330.5020.7771.0772.4950.5434.5921.483Chain A: 244,245,246,274,277,278,280,281,284,312,3
15,316,318,319,322,332,333,334,347,348,351,355
2551.1432631.228646.2120.4460.7621.0192.5680.5194.9481.159Chain A: 73,78,79,82,83,90,93,94,97,285,305,306,30
8,311,314,317,318,319,321,322,323,324,325,326,327,
330,335,340,343,344,347,348,349,350,351,352,353,35
5,356,358,359,362,371,372,373,384,387,388,389,391,
395
2930.991691.012477.1130.5250.680.9040.491.0330.4751.057Chain A: 3,4,5,6,7,8,41,42,43,44,45,46,47,48,329,3
32,333,336,337,340,341,343,344,369
3680.911210671.0225526.1620.71640.41010.36480.27250.50150.54330.9119Chain A: 1,2,3,4,5,6,7,8,9,10,11,12,355,357,358,35
9,366,367,370,371,372,373,374,375,376,377,378,380,
381,383,384,387,388,391,396,397,401,402,403,404,40
5,406,408,409,410,412,413,414,416,417,420,433,435,
437,445,448,449,450,451,452,456,485,486,487,488,48
9,490,532,535,536,537

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
200ZINC000006467621DB11115Ensulizole-8.53108-8.94198
200ZINC000001530886DB00966Telmisartan-6.91402-8.78602
200ZINC000003775644DB01123Proflavine-8.38021-8.41101
200ZINC000012414057DB08167Methylthioninium-8.34226-8.34526
200ZINC000000643153DB01026Ketoconazole-8.00171-8.32641
200ZINC000003784182DB00210Adapalene-8.15412-8.15462
200ZINC000003871541DB00261Anagrelide-7.96023-7.96023
200ZINC000019632614DB00317Gefitinib-7.54063-7.95563
200ZINC000000020243DB00861Diflunisal-7.93043-7.93043
200ZINC000007997897DB00735Naftifine-7.78599-7.86549
200NetarsudilDB00735-5.41883-7.78113
200ZINC000000020221DB00461Nabumetone-7.77018-7.77018
200ZINC000005733652DB11259Diosmetin-7.67373-7.70973
200ZINC000000403010DB00598Labetalol-7.64109-7.66869
200ZINC000003873371DB06820Sulconazole-7.28918-7.62058
200ZINC000000018635DB00998Frovatriptan-7.61229-7.61279
200ZINC000004676424DB00213Pantoprazole-5.50102-7.58682
200ZINC000002568036DB01219Dantrolene-7.49747-7.56987
200ZINC000252679615DB01219Dantrolene-7.49747-7.56987
200ZINC000000896740DB01110Miconazole-7.35821-7.56541

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000006467621DB11115EnsulizoleSmall moleculeOS(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C1=CC=CC=C1Approved
ZINC000001530886DB00966TelmisartanSmall moleculeCCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=OApproved|Investigational
ZINC000003775644DB01123ProflavineSmall moleculeNC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1Approved
ZINC000012414057DB08167MethylthioniniumSmall moleculeCN(C)C1=CC2=[S+]C3=CC(=CC=C3N=C2C=C1)N(C)CExperimental|Investigational
ZINC000000643153DB01026KetoconazoleSmall moleculeCC(=O)N1CCN(CC1)C1=CC=C(OCC2COC(CN3C=CN=C3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1Approved|Investigational
ZINC000003784182DB00210AdapaleneSmall moleculeCOC1=C(C=C(C=C1)C1=CC2=C(C=C1)C=C(C=C2)C(O)=O)C12CC3CC(CC(C3)C1)C2Approved
ZINC000003871541DB00261AnagrelideSmall moleculeClC1=CC=C2N=C3NC(=O)CN3CC2=C1ClApproved
ZINC000019632614DB00317GefitinibSmall moleculeCOC1=C(OCCCN2CCOCC2)C=C2C(NC3=CC(Cl)=C(F)C=C3)=NC=NC2=C1Approved|Investigational
ZINC000000020243DB00861DiflunisalSmall moleculeOC(=O)C1=C(O)C=CC(=C1)C1=C(F)C=C(F)C=C1Approved|Investigational
ZINC000007997897DB00735NaftifineSmall moleculeCN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12Approved
ZINC000000020221DB00461NabumetoneSmall moleculeCOC1=CC2=C(C=C1)C=C(CCC(C)=O)C=C2Approved
ZINC000005733652DB11259DiosmetinSmall moleculeCOC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2OExperimental
ZINC000000018635DB00998FrovatriptanSmall moleculeCN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=OApproved|Investigational
ZINC000004676424DB00213PantoprazoleSmall moleculeCOC1=C(OC)C(CS(=O)C2=NC3=C(N2)C=C(OC(F)F)C=C3)=NC=C1Approved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000006467621274.2949.514495.1790165.642327.0772.46816.85725.59.09370.24100
ZINC000006467621274.2945.937496.1670165.586328.1242.456817.80525.59.121370.28800
ZINC000006467621274.2949.57496.8940166.022328.3772.495819.64625.58.954370.26400
ZINC000001530886514.6267.48850.985294.329111.948444.70901601.819158.498186.97921
ZINC000001530886514.6263.392898.781323.212100.491475.07801648.918158.623191.31421
ZINC000001530886514.6266.83830.587285.837116.397428.35301580.24158.44185.14421
ZINC000001530886514.6268.764825.335324.05451.458449.82301592.388158.537110021
ZINC000003775644209.250.181433.0810137.936295.1440706.541337.603383.63700
ZINC000003775644209.250.371432.1120138.151293.9610705.014337.627383.53500
ZINC000000643153531.4384.384839.249315.21579.661325.769118.6051545.90708.258.127392.68210
ZINC000000643153531.4386.93833.589316.34779.801318.588118.8531539.92208.258.129392.7210
ZINC000000643153531.4387.908857.901337.475.081326.963118.4571564.78608.259.251393.85910
ZINC000000643153531.4387.932859.065337.49975.339327.516118.7111562.19208.259.243393.79110
ZINC000003784182412.5274.577711.883341.679105.692264.51301306.99912.758.652194.64811
ZINC000003871541256.0915.713431.01683.331115.582113.587118.517708.29214.59.009388.69400
ZINC000019632614446.9085.605766.017373.78438.968243.44109.8241351.7317.78.493310000
ZINC000019632614446.9085.389803.125411.61339.025242.679109.8061392.00817.78.484310001
ZINC000000020243250.2018.261459.0810144.436231.00583.64751.87911.759.879386.60100
ZINC000007997897287.4040.789607.9141.9030.103465.89501056.595028.523310010
ZINC000007997897287.4040.718598.565138.9570459.60801048.049028.531310010
ZINC000007997897287.4040.791521.98157.9712.38361.6280973.251028.498310000
ZINC000000020221228.293.885504.783246.1447.874210.7680841.57502.758.539310000
ZINC000005733652300.2674.88528.85593.31204.424231.120896.84124.58.9373.98200
ZINC000005733652300.2676.652527.11893.294202.511231.3130894.00524.58.908374.28700
ZINC000000403010328.415.633665.048169.772199.786295.4901141.27145.459.068270.57200
ZINC000000403010328.418.153662.671168.348200.011294.31201140.63345.459.267270.52100
ZINC000003873371397.7494.24592.99855.47928.414315.842193.2641087.32702.59.366110011
ZINC000003873371397.7495.797597.3971.09830.348301.939194.0061088.01302.59.324110011
ZINC000000018635243.3087.2492.762217.467154.534120.7610833.223448.296366.4100
ZINC000004676424383.3698.251592.117212.64584.97180.573113.9291072.52189.002374.59500
ZINC000004676424383.3697.215561.053186.6484.216176.622113.5751038.795189.168373.69800
ZINC000004676424383.3694.727588.455213.53385.064183.201106.6561066.712188.895374.24100
ZINC000004676424383.3695.371591.248214.44486.708182.582107.5151072.188188.894374.09700
ZINC000002568036314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000002568036314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2573.867548.75854.323243.185251.250924.46159.205367.05800
ZINC000252679615314.2572.557527.99664.383238.233225.380905.494159.686367.50600
ZINC000252679615314.2574.186547.354.729241.127251.4440922.097159.191367.40800
ZINC000252679615314.2572.845525.88465.15235.939224.7950902.055159.671367.87500
ZINC000000896740416.1336.333627.14457.1430.582311.804227.6171129.9303.79.196310011
ZINC000000896740416.1336.395627.23857.06531.054311.648227.4711127.91703.79.189310011


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000006467621O=S(=O)(O)c1ccc2[nH]c(-c3ccccc3)nc2c10.385041040.405031793
ZINC000001530886CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc10.2177627810.303280041
ZINC000003775644Nc1ccc2cc3ccc(N)cc3nc2c10.3467620850.473171062
ZINC000012414057CN(C)c1ccc2nc3ccc(=[N+](C)C)cc-3sc2c10.175812350.481215426
ZINC000000643153CC(=O)N1CCN(c2ccc(OC[C@@H]3CO[C@@](Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC10.0873932720.387082142
ZINC000003784182COc1ccc(-c2ccc3cc(C(=O)O)ccc3c2)cc1C12CC3CC(CC(C3)C1)C20.086406850.326661019
ZINC000003871541O=C1CN2Cc3c(ccc(Cl)c3Cl)NC2=N10.1545114710.436231104
ZINC000019632614COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC10.2625384980.113127421
ZINC000000020243O=C(O)c1cc(-c2ccc(F)cc2F)ccc1O0.4404093730.371648269
ZINC000007997897CN(C/C=Cc1ccccc1)Cc1cccc2ccccc120.3947728360.303491673
ZINC000000020221COc1ccc2cc(CCC(C)=O)ccc2c10.4885719630.340637585
ZINC000005733652COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1O0.2601990860.67867566
ZINC000000403010C[C@@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c10.1638887930.349082082
ZINC000003873371Clc1ccc(CS[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)cc10.1585046540.345558409
ZINC000000018635CN[C@@H]1CCc2[nH]c3ccc(C(N)=O)cc3c2C10.156787310.476568578
ZINC000004676424COc1ccnc(C[S@@](=O)c2nc3ccc(OC(F)F)cc3[nH]2)c1OC0.1146673540.321842622
ZINC000002568036O=C1CN(/N=C/c2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(=O)N10.2040708230.461176527
ZINC000252679615O=C1CN(N=Cc2ccc(-c3ccc([N+](=O)[O-])cc3)o2)C(O)=N10.1491321090.500589886
ZINC000000896740Clc1ccc(CO[C@@H](Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c10.1551456160.325725199


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ACIN1ABCF3, PAFAH1B2, BANF1, SAP18, SRRM1, tat, RBM39, ELAVL1, SF3A2, SIRT7, HNRNPA1, RNPS1, CUL3, ALYREF, GRK5, BCAS2, SMU1, DHX9, DHX15, DDX17, PRPF6, SF3A1, WIBG, CSGALNACT1, SEPT7, SRP14, RHOT2, BET1, FUT8, DHRS7B, TRMT112, UTP14A, RRP7A, ATP7A, SEPT2, SNAP91, ARMCX3, CAV1, EVPL, S100A9, PRKCA, SMC1A, BOP1, PTCD3, THRAP3, LGMN, NFIA, SUPT16H, RCC1, SNRPGP15, SAFB, SON, RRS1, NDUFAF4, EIF4A3, MAGOH, SRPK2, CSNK2A1, HDAC6, HDAC11, PCBD1, SRPK1, CLK2, rev, WWOX, LGR4, CUL7, OBSL1, SUZ12, EED, RNF2, BMI1, LUZP4, PRPF40A, VTI1B, LUC7L, LUC7L2, SNIP1, EPB41L3, NTRK1, RPL7, RPS13, SLC3A2, SRRM2, SSRP1, SUB1, ZC3H18, IFI16, HIST1H3E, SGTB, Lgals3bp, Rab5c, Esrrb, Ccdc9, SNW1, SENP3, U2AF2, CAMKV, C11orf57, EPB41L2, PIP4K2A, WSB2, KLHL2, PNN, U2AF1, SARNP, TMEM184B, INSL6, ARRB1, ELAVL2, DENND2D, SNRPA1, COX15, DLD, DLST, DNM1L, PDHA1, LMNA, API5, DDX39B, PPIE, GSK3A, IQGAP1, KRAS, PCBP1, TNIP2, CHD3, CHD4, ESR2, EZH2, MYC, CDK9, ACTC1, TPT1, NR2C2, PPP1CC, XRCC6, YAP1, HIST1H4A, SNRNP70, FUS, TAF15, SBF1, HMGB1, BIRC3, STAU1, PLEKHA4, RAD18, PINK1, ENG, LINC01554, CIT, ANLN, CHMP4C, ECT2, KIF14, KIF23, PRC1, MKI67, HNRNPH1, SUMO2, EGFR, NUPR1, CIC, BRD4, Apc2, vpr, CFAP20, ZRANB2, PHRF1, RBBP6, DDX58, UFL1, DDX23, WDR5, NAA40, ZBTB2, SULF2, ARGLU1, HNRNPUL2, NKAP, NFKBIL1, ZC3H11A, SRPK3, RNF151, EPB41L1, SRSF6, SRSF4, PABPC5, SRSF11, C1orf35, TECTB, GOLGA7, SRSF7, MAPKAPK2, CLK3, CUL9, NRP1, TOP3B, CTSL, FURIN, ACE2, E, ORF10, ORF7b, ORF8, BRD2, BRD3,
NUTM1EP300, ALOX5, IFIT2, KPNA2, LMO1, LMO2, PRKAA2, TP53BP2, NEBL, ZNF277, SAMD4A, PSME4, ZMYND10, CCHCR1, LMO3, RIC8A, SH2D4A, HSPBAP1, FAM161A, MORN4, P4HA3, KANSL1, LHX8, AXIN1, SMARCD1, MBD3, TXN2, TTC23, AES, CHCHD3, CDK18, RCOR3, ENKD1, ARHGEF6, PRKAB2, OSTF1, SOGA1, ALS2CR11, CCDC116, SCNM1, CDC20B, PRPF18, METTL17, TBC1D21, LRRC8E, TSGA10IP, PLEKHF2, CCDC185, SAMD4B, GADD45GIP1, KANK2, TEAD4, SH2D1B, GPANK1, AQP1, E7, nsp8,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACIN1all structure
NUTM1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ACIN1-NUTM1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ACIN1-NUTM1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACIN1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneNUTM1C1707291NUT midline carcinoma1ORPHANET