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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CASP8-VMP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CASP8-VMP1
FusionPDB ID: 13251
FusionGDB2.0 ID: 13251
HgeneTgene
Gene symbol

CASP8

VMP1

Gene ID

841

81671

Gene namecaspase 8vacuole membrane protein 1
SynonymsALPS2B|CAP4|Casp-8|FLICE|MACH|MCH5EPG3|TANGO5|TMEM49
Cytomap

2q33.1

17q23.1

Type of geneprotein-codingprotein-coding
Descriptioncaspase-8FADD-homologous ICE/CED-3-like proteaseFADD-like ICEICE-like apoptotic protease 5MACH-alpha-1/2/3 proteinMACH-beta-1/2/3/4 proteinMORT1-associated ced-3 homologapoptotic cysteine proteaseapoptotic protease Mch-5caspase 8, apoptosis-relatvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog
Modification date2020032220200327
UniProtAcc

Q9UKL3

.
Ensembl transtripts involved in fusion geneENST idsENST00000392259, ENST00000392266, 
ENST00000264274, ENST00000264275, 
ENST00000323492, ENST00000358485, 
ENST00000432109, ENST00000392258, 
ENST00000490682, 		ENST00000262291, 
ENST00000536180, ENST00000537567, 
ENST00000539763, ENST00000545362, 
ENST00000588617, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 7 X 10=70042 X 34 X 19=27132
# samples 12151
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(151/27132*10)=-4.16737494326024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CASP8 [Title/Abstract] AND VMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CASP8(202150040)-VMP1(57915656), # samples:3
Anticipated loss of major functional domain due to fusion event.CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CASP8-VMP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CASP8-VMP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASP8

GO:0006508

proteolysis

12888622

HgeneCASP8

GO:0036462

TRAIL-activated apoptotic signaling pathway

21785459

HgeneCASP8

GO:0045862

positive regulation of proteolysis

18387192

HgeneCASP8

GO:0097191

extrinsic apoptotic signaling pathway

21785459

HgeneCASP8

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across CASP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A3KW-01ACASP8chr2

202150040

-VMP1chr17

57915656

+
ChimerDB4UCECTCGA-EO-A3KW-01ACASP8chr2

202150040

+VMP1chr17

57915656

+
ChimerDB4UCECTCGA-EO-A3KW-01ACASP8chr2

202151224

+VMP1chr17

57915656

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264274CASP8chr2202150040+ENST00000262291VMP1chr1757915656+271512872201533437
ENST00000264274CASP8chr2202150040+ENST00000537567VMP1chr1757915656+179412872201533437
ENST00000264274CASP8chr2202150040+ENST00000539763VMP1chr1757915656+175412872201533437
ENST00000264274CASP8chr2202150040+ENST00000536180VMP1chr1757915656+162612872201533437
ENST00000264274CASP8chr2202150040+ENST00000545362VMP1chr1757915656+178612872201533437
ENST00000432109CASP8chr2202150040+ENST00000262291VMP1chr1757915656+292114931681739523
ENST00000432109CASP8chr2202150040+ENST00000537567VMP1chr1757915656+200014931681739523
ENST00000432109CASP8chr2202150040+ENST00000539763VMP1chr1757915656+196014931681739523
ENST00000432109CASP8chr2202150040+ENST00000536180VMP1chr1757915656+183214931681739523
ENST00000432109CASP8chr2202150040+ENST00000545362VMP1chr1757915656+199214931681739523
ENST00000264275CASP8chr2202150040+ENST00000262291VMP1chr1757915656+306316352651881538
ENST00000264275CASP8chr2202150040+ENST00000537567VMP1chr1757915656+214216352651881538
ENST00000264275CASP8chr2202150040+ENST00000539763VMP1chr1757915656+210216352651881538
ENST00000264275CASP8chr2202150040+ENST00000536180VMP1chr1757915656+197416352651881538
ENST00000264275CASP8chr2202150040+ENST00000545362VMP1chr1757915656+213416352651881538
ENST00000358485CASP8chr2202150040+ENST00000262291VMP1chr1757915656+31051677941923609
ENST00000358485CASP8chr2202150040+ENST00000537567VMP1chr1757915656+21841677941923609
ENST00000358485CASP8chr2202150040+ENST00000539763VMP1chr1757915656+21441677941923609
ENST00000358485CASP8chr2202150040+ENST00000536180VMP1chr1757915656+20161677941923609
ENST00000358485CASP8chr2202150040+ENST00000545362VMP1chr1757915656+21761677941923609
ENST00000323492CASP8chr2202150040+ENST00000262291VMP1chr1757915656+282713991251645506
ENST00000323492CASP8chr2202150040+ENST00000537567VMP1chr1757915656+190613991251645506
ENST00000323492CASP8chr2202150040+ENST00000539763VMP1chr1757915656+186613991251645506
ENST00000323492CASP8chr2202150040+ENST00000536180VMP1chr1757915656+173813991251645506
ENST00000323492CASP8chr2202150040+ENST00000545362VMP1chr1757915656+189813991251645506
ENST00000323492CASP8chr2202151224+ENST00000262291VMP1chr1757915656+403526071251402425
ENST00000323492CASP8chr2202151224+ENST00000537567VMP1chr1757915656+311426071251402425
ENST00000323492CASP8chr2202151224+ENST00000539763VMP1chr1757915656+307426071251402425
ENST00000323492CASP8chr2202151224+ENST00000536180VMP1chr1757915656+294626071251402425
ENST00000323492CASP8chr2202151224+ENST00000545362VMP1chr1757915656+310626071251402425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264274ENST00000262291CASP8chr2202150040+VMP1chr1757915656+0.0004765770.9995234
ENST00000264274ENST00000537567CASP8chr2202150040+VMP1chr1757915656+0.0021390650.99786097
ENST00000264274ENST00000539763CASP8chr2202150040+VMP1chr1757915656+0.0022243860.9977756
ENST00000264274ENST00000536180CASP8chr2202150040+VMP1chr1757915656+0.0029233590.99707663
ENST00000264274ENST00000545362CASP8chr2202150040+VMP1chr1757915656+0.0021640.99783605
ENST00000432109ENST00000262291CASP8chr2202150040+VMP1chr1757915656+0.0003922810.99960774
ENST00000432109ENST00000537567CASP8chr2202150040+VMP1chr1757915656+0.0020596490.99794036
ENST00000432109ENST00000539763CASP8chr2202150040+VMP1chr1757915656+0.0021519020.99784815
ENST00000432109ENST00000536180CASP8chr2202150040+VMP1chr1757915656+0.0026534360.9973465
ENST00000432109ENST00000545362CASP8chr2202150040+VMP1chr1757915656+0.0020872550.9979127
ENST00000264275ENST00000262291CASP8chr2202150040+VMP1chr1757915656+0.0006519050.9993481
ENST00000264275ENST00000537567CASP8chr2202150040+VMP1chr1757915656+0.0031966450.9968034
ENST00000264275ENST00000539763CASP8chr2202150040+VMP1chr1757915656+0.0032763850.9967236
ENST00000264275ENST00000536180CASP8chr2202150040+VMP1chr1757915656+0.0037756450.9962244
ENST00000264275ENST00000545362CASP8chr2202150040+VMP1chr1757915656+0.0032097170.99679023
ENST00000358485ENST00000262291CASP8chr2202150040+VMP1chr1757915656+0.0004034210.99959654
ENST00000358485ENST00000537567CASP8chr2202150040+VMP1chr1757915656+0.001588720.9984113
ENST00000358485ENST00000539763CASP8chr2202150040+VMP1chr1757915656+0.001579350.9984206
ENST00000358485ENST00000536180CASP8chr2202150040+VMP1chr1757915656+0.0019318870.99806815
ENST00000358485ENST00000545362CASP8chr2202150040+VMP1chr1757915656+0.001591790.99840826
ENST00000323492ENST00000262291CASP8chr2202150040+VMP1chr1757915656+0.0003158820.9996841
ENST00000323492ENST00000537567CASP8chr2202150040+VMP1chr1757915656+0.0013680740.9986319
ENST00000323492ENST00000539763CASP8chr2202150040+VMP1chr1757915656+0.0013857270.9986143
ENST00000323492ENST00000536180CASP8chr2202150040+VMP1chr1757915656+0.0017586090.9982414
ENST00000323492ENST00000545362CASP8chr2202150040+VMP1chr1757915656+0.001379750.9986203
ENST00000323492ENST00000262291CASP8chr2202151224+VMP1chr1757915656+0.0002286330.9997714
ENST00000323492ENST00000537567CASP8chr2202151224+VMP1chr1757915656+0.0004601430.99953985
ENST00000323492ENST00000539763CASP8chr2202151224+VMP1chr1757915656+0.0004641710.9995358
ENST00000323492ENST00000536180CASP8chr2202151224+VMP1chr1757915656+0.0004843260.99951565
ENST00000323492ENST00000545362CASP8chr2202151224+VMP1chr1757915656+0.0004609520.999539

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13251_13251_1_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264274_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=437AA_BP=356
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA
GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPG

--------------------------------------------------------------

>13251_13251_2_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264274_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=437AA_BP=356
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA
GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPG

--------------------------------------------------------------

>13251_13251_3_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264274_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=437AA_BP=356
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA
GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPG

--------------------------------------------------------------

>13251_13251_4_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264274_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=437AA_BP=356
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA
GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPG

--------------------------------------------------------------

>13251_13251_5_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264274_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=437AA_BP=356
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLA
GKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPG

--------------------------------------------------------------

>13251_13251_6_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264275_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=538AA_BP=457
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIF
IEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAR
EKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTS
QFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS

--------------------------------------------------------------

>13251_13251_7_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264275_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=538AA_BP=457
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIF
IEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAR
EKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTS
QFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS

--------------------------------------------------------------

>13251_13251_8_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264275_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=538AA_BP=457
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIF
IEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAR
EKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTS
QFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS

--------------------------------------------------------------

>13251_13251_9_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264275_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=538AA_BP=457
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIF
IEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAR
EKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTS
QFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS

--------------------------------------------------------------

>13251_13251_10_CASP8-VMP1_CASP8_chr2_202150040_ENST00000264275_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=538AA_BP=457
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIF
IEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAR
EKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTS
QFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQS

--------------------------------------------------------------

>13251_13251_11_CASP8-VMP1_CASP8_chr2_202150040_ENST00000323492_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=506AA_BP=425
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP
VETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKPFQEYLEAQRQKLH

--------------------------------------------------------------

>13251_13251_12_CASP8-VMP1_CASP8_chr2_202150040_ENST00000323492_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=506AA_BP=425
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP
VETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKPFQEYLEAQRQKLH

--------------------------------------------------------------

>13251_13251_13_CASP8-VMP1_CASP8_chr2_202150040_ENST00000323492_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=506AA_BP=425
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP
VETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKPFQEYLEAQRQKLH

--------------------------------------------------------------

>13251_13251_14_CASP8-VMP1_CASP8_chr2_202150040_ENST00000323492_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=506AA_BP=425
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP
VETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKPFQEYLEAQRQKLH

--------------------------------------------------------------

>13251_13251_15_CASP8-VMP1_CASP8_chr2_202150040_ENST00000323492_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=506AA_BP=425
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP
VETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKPFQEYLEAQRQKLH

--------------------------------------------------------------

>13251_13251_16_CASP8-VMP1_CASP8_chr2_202150040_ENST00000358485_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=609AA_BP=528
MLEGSVFTGSPPFIFCVFFQALLNLLVNSTGSEAMEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLP
FKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEME
RELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIND
YEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA
GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI
QACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKP

--------------------------------------------------------------

>13251_13251_17_CASP8-VMP1_CASP8_chr2_202150040_ENST00000358485_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=609AA_BP=528
MLEGSVFTGSPPFIFCVFFQALLNLLVNSTGSEAMEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLP
FKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEME
RELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIND
YEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA
GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI
QACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKP

--------------------------------------------------------------

>13251_13251_18_CASP8-VMP1_CASP8_chr2_202150040_ENST00000358485_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=609AA_BP=528
MLEGSVFTGSPPFIFCVFFQALLNLLVNSTGSEAMEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLP
FKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEME
RELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIND
YEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA
GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI
QACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKP

--------------------------------------------------------------

>13251_13251_19_CASP8-VMP1_CASP8_chr2_202150040_ENST00000358485_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=609AA_BP=528
MLEGSVFTGSPPFIFCVFFQALLNLLVNSTGSEAMEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLP
FKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEME
RELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIND
YEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA
GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI
QACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKP

--------------------------------------------------------------

>13251_13251_20_CASP8-VMP1_CASP8_chr2_202150040_ENST00000358485_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=609AA_BP=528
MLEGSVFTGSPPFIFCVFFQALLNLLVNSTGSEAMEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLP
FKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEME
RELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIIND
YEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDA
GALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFI
QACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPSLQKP

--------------------------------------------------------------

>13251_13251_21_CASP8-VMP1_CASP8_chr2_202150040_ENST00000432109_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=523AA_BP=442
MNLGNIEMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRK
EEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK
IINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT
HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK
VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPS

--------------------------------------------------------------

>13251_13251_22_CASP8-VMP1_CASP8_chr2_202150040_ENST00000432109_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=523AA_BP=442
MNLGNIEMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRK
EEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK
IINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT
HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK
VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPS

--------------------------------------------------------------

>13251_13251_23_CASP8-VMP1_CASP8_chr2_202150040_ENST00000432109_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=523AA_BP=442
MNLGNIEMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRK
EEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK
IINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT
HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK
VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPS

--------------------------------------------------------------

>13251_13251_24_CASP8-VMP1_CASP8_chr2_202150040_ENST00000432109_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=523AA_BP=442
MNLGNIEMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRK
EEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK
IINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT
HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK
VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPS

--------------------------------------------------------------

>13251_13251_25_CASP8-VMP1_CASP8_chr2_202150040_ENST00000432109_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=523AA_BP=442
MNLGNIEMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRK
EEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLK
IINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGT
HLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPK
VFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRAVPGIGPS

--------------------------------------------------------------

>13251_13251_26_CASP8-VMP1_CASP8_chr2_202151224_ENST00000323492_VMP1_chr17_57915656_ENST00000262291_length(amino acids)=425AA_BP=
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP

--------------------------------------------------------------

>13251_13251_27_CASP8-VMP1_CASP8_chr2_202151224_ENST00000323492_VMP1_chr17_57915656_ENST00000536180_length(amino acids)=425AA_BP=
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP

--------------------------------------------------------------

>13251_13251_28_CASP8-VMP1_CASP8_chr2_202151224_ENST00000323492_VMP1_chr17_57915656_ENST00000537567_length(amino acids)=425AA_BP=
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP

--------------------------------------------------------------

>13251_13251_29_CASP8-VMP1_CASP8_chr2_202151224_ENST00000323492_VMP1_chr17_57915656_ENST00000539763_length(amino acids)=425AA_BP=
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP

--------------------------------------------------------------

>13251_13251_30_CASP8-VMP1_CASP8_chr2_202151224_ENST00000323492_VMP1_chr17_57915656_ENST00000545362_length(amino acids)=425AA_BP=
MPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEE
MERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKII
NDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE
IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:202150040/chr17:57915656)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASP8

Q9UKL3

.
FUNCTION: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. {ECO:0000269|PubMed:12477726, ECO:0000269|PubMed:15698540, ECO:0000269|PubMed:17003125, ECO:0000269|PubMed:17245429}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASP8chr2:202150040chr17:57915656ENST00000264274+67100_177350.6666666666667396.0DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000264274+672_80350.6666666666667396.0DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000264275+910100_177451.6666666666667497.0DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000264275+9102_80451.6666666666667497.0DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000323492+78100_177419.6666666666667465.0DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000323492+782_80419.6666666666667465.0DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000358485+89100_177493.6666666666667539.0DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000358485+892_80493.6666666666667539.0DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000392259+89100_177413.0751.3333333333334DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000392259+892_80413.0751.3333333333334DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000392266+78100_177398.0736.3333333333334DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000392266+782_80398.0736.3333333333334DomainDED 1
HgeneCASP8chr2:202150040chr17:57915656ENST00000432109+910100_177434.6666666666667480.0DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000432109+9102_80434.6666666666667480.0DomainDED 1
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912327_363324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912385_406324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912327_363324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912385_406324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912364_384324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912364_384324.6666666666667407.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASP8chr2:202150040chr17:57915656ENST00000392258+18100_1770224.66666666666666DomainDED 2
HgeneCASP8chr2:202150040chr17:57915656ENST00000392258+182_800224.66666666666666DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000264274+17100_1770396.0DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000264274+172_800396.0DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000264275+110100_1770497.0DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000264275+1102_800497.0DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000323492+18100_1770465.0DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000323492+182_800465.0DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000358485+19100_1770539.0DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000358485+192_800539.0DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000392258+18100_1770224.66666666666666DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000392258+182_800224.66666666666666DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000392259+19100_1770751.3333333333334DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000392259+192_800751.3333333333334DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000392266+18100_1770736.3333333333334DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000392266+182_800736.3333333333334DomainDED 1
HgeneCASP8chr2:202151224chr17:57915656ENST00000432109+110100_1770480.0DomainDED 2
HgeneCASP8chr2:202151224chr17:57915656ENST00000432109+1102_800480.0DomainDED 1
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912173_316324.6666666666667407.0RegionVTT domain
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912173_316324.6666666666667407.0RegionVTT domain
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912131_250324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912272_273324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912295_305324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202150040chr17:57915656ENST000002622919122_43324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202150040chr17:57915656ENST0000026229191265_77324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202150040chr17:57915656ENST0000026229191299_109324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912131_250324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912272_273324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912295_305324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202151224chr17:57915656ENST000002622919122_43324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202151224chr17:57915656ENST0000026229191265_77324.6666666666667407.0Topological domainExtracellular
TgeneVMP1chr2:202151224chr17:57915656ENST0000026229191299_109324.6666666666667407.0Topological domainCytoplasmic
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912110_130324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912251_271324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912274_294324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202150040chr17:57915656ENST00000262291912306_326324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202150040chr17:57915656ENST0000026229191244_64324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202150040chr17:57915656ENST0000026229191278_98324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912110_130324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912251_271324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912274_294324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST00000262291912306_326324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST0000026229191244_64324.6666666666667407.0TransmembraneHelical
TgeneVMP1chr2:202151224chr17:57915656ENST0000026229191278_98324.6666666666667407.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CASP8
VMP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CASP8-VMP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CASP8-VMP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource