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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CBFB-MYH11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CBFB-MYH11
FusionPDB ID: 13372
FusionGDB2.0 ID: 13372
HgeneTgene
Gene symbol

CBFB

MYH11

Gene ID

865

4629

Gene namecore-binding factor subunit betamyosin heavy chain 11
SynonymsPEBP2BAAT4|FAA4|SMHC|SMMHC
Cytomap

16q22.1

16p13.11

Type of geneprotein-codingprotein-coding
Descriptioncore-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, betmyosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth muscle
Modification date2020032020200322
UniProtAcc

Q13951

P35749

Ensembl transtripts involved in fusion geneENST idsENST00000290858, ENST00000412916, 
ENST00000561924, ENST00000568858, 
ENST00000573908, ENST00000300036, 
ENST00000396324, ENST00000452625, 
ENST00000576790, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 18 X 12=367244 X 55 X 10=24200
# samples 3362
** MAII scorelog2(33/3672*10)=-3.47602812916799
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(62/24200*10)=-5.28659502177508
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CBFB [Title/Abstract] AND MYH11 [Title/Abstract] AND fusion [Title/Abstract]

Acute myeloid leukemia with t(16;16) (p13;q22) showing a new CBFB-MYH11 fusion transcript associated with an atypical leukemic blasts morphology (pmid: 24342433)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CBFB(67116211)-MYH11(15814908), # samples:34
Anticipated loss of major functional domain due to fusion event.CBFB-MYH11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFB-MYH11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFB-MYH11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFB-MYH11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFB-MYH11 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CBFB-MYH11 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CBFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYH11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2815-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2815-03ACBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2815_61660AAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2815_6166WAAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2815CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2828-03ACBFBchr16

67116211

-MYH11chr16

15820911

-
ChimerDB4LAMLTCGA-AB-2828-03ACBFBchr16

67116242

+MYH11chr16

15820911

-
ChimerDB4LAMLTCGA-AB-2828_61673AAXX_4CBFBchr16

67116211

+MYH11chr16

15820911

-
ChimerDB4LAMLTCGA-AB-2828_61J4GAAXX_4CBFBchr16

67116211

+MYH11chr16

15820911

-
ChimerDB4LAMLTCGA-AB-2846-03ACBFBchr16

67063342

+MYH11chr16

15811013

-
ChimerDB4LAMLTCGA-AB-2846-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2846_700GJAAXX_7CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2846_700J3AAXX_8CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2846_700J3AAXX_8CBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2846CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2870-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2870_61HMEAAXX_6CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2870_700F8AAXX_6CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2870CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2881-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2881-03ACBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2881_61GABAAXX_3CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2881_700FEAAXX_3CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2881CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2888-03BCBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2888-03BCBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2888_61TV6AAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2888_624YPAAXX_1CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2889-03ACBFBchr16

67070555

+MYH11chr16

15814832

-
ChimerDB4LAMLTCGA-AB-2889-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2889_61HNFAAXX_3CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2889_61LMEAAXX_3CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2892-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2892_613RTAAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2892_6162NAAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2892CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2914-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2914-03ACBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2914_61646AAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2914_6164HAAXX_2CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2914_6164HAAXX_2CBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2942-03ACBFBchr16

67116208

+MYH11chr16

15814910

-
ChimerDB4LAMLTCGA-AB-2942-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2942_61GAJAAXX_6CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2942_61LP1AAXX_6CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2954-03ACBFBchr16

67116211

-MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2954-03ACBFBchr16

67116242

+MYH11chr16

15814908

-
ChimerDB4LAMLTCGA-AB-2954_616EAAAXX_7CBFBchr16

67116211

+MYH11chr16

15814908

-
ChimerKB3..CBFBchr16

67116211

+MYH11chr16

15818656

-
ChimerKB4..CBFBchr16

67116115

+MYH11chr16

67116115

-
ChimerKB4..CBFBchr16

67116211

+MYH11chr16

15818656

-
ChiTaRS5.0N/AAF202996CBFBchr16

67116231

+MYH11chr16

15818658

-
ChiTaRS5.0N/AAF249897CBFBchr16

67116211

+MYH11chr16

15818851

-
ChiTaRS5.0N/AAF249898CBFBchr16

67116213

+MYH11chr16

15814910

-
ChiTaRS5.0N/AAF390859CBFBchr16

67120259

+MYH11chr16

15815070

-
ChiTaRS5.0N/AAF390860CBFBchr16

67130867

+MYH11chr16

15865977

-
ChiTaRS5.0N/AX87833CBFBchr16

67126325

+MYH11chr16

15820911

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412916CBFBchr1667116211+ENST00000396324MYH11chr1615818656-34336581632613816
ENST00000412916CBFBchr1667116211+ENST00000452625MYH11chr1615818656-34726581632511782
ENST00000412916CBFBchr1667116211+ENST00000576790MYH11chr1615818656-28576581632511782
ENST00000412916CBFBchr1667116211+ENST00000300036MYH11chr1615818656-26146581632613817
ENST00000290858CBFBchr1667063342+ENST00000396324MYH11chr1615811013-129746807391138
ENST00000290858CBFBchr1667063342+ENST00000452625MYH11chr1615811013-133646807391138
ENST00000290858CBFBchr1667063342+ENST00000576790MYH11chr1615811013-72146720187177
ENST00000290858CBFBchr1667063342+ENST00000300036MYH11chr1615811013-478464771159
ENST00000412916CBFBchr1667063342+ENST00000396324MYH11chr1615811013-129746807391138
ENST00000412916CBFBchr1667063342+ENST00000452625MYH11chr1615811013-133646807391138
ENST00000412916CBFBchr1667063342+ENST00000576790MYH11chr1615811013-72146720187177
ENST00000412916CBFBchr1667063342+ENST00000300036MYH11chr1615811013-478464771159
ENST00000290858CBFBchr1667070555+ENST00000396324MYH11chr1615814832-261352922931403296
ENST00000290858CBFBchr1667070555+ENST00000452625MYH11chr1615814832-265252923321403309
ENST00000290858CBFBchr1667070555+ENST00000576790MYH11chr1615814832-20375291728670352
ENST00000290858CBFBchr1667070555+ENST00000300036MYH11chr1615814832-17945291474488328
ENST00000412916CBFBchr1667070555+ENST00000396324MYH11chr1615814832-251543121951305296
ENST00000412916CBFBchr1667070555+ENST00000452625MYH11chr1615814832-255443122341305309
ENST00000412916CBFBchr1667070555+ENST00000576790MYH11chr1615814832-19394311630572352
ENST00000412916CBFBchr1667070555+ENST00000300036MYH11chr1615814832-16964311376390328
ENST00000412916CBFBchr1667116208+ENST00000396324MYH11chr1615814910-28186581631998611
ENST00000412916CBFBchr1667116208+ENST00000452625MYH11chr1615814910-28576581631896577
ENST00000412916CBFBchr1667116208+ENST00000576790MYH11chr1615814910-22426581631896577
ENST00000412916CBFBchr1667116208+ENST00000300036MYH11chr1615814910-19996581631998612
ENST00000412916CBFBchr1667116211+ENST00000396324MYH11chr1615814908-28186581631998611
ENST00000412916CBFBchr1667116211+ENST00000452625MYH11chr1615814908-28576581631896577
ENST00000412916CBFBchr1667116211+ENST00000576790MYH11chr1615814908-22426581631896577
ENST00000412916CBFBchr1667116211+ENST00000300036MYH11chr1615814908-19996581631998612
ENST00000412916CBFBchr1667116211+ENST00000396324MYH11chr1615820911-37456581632925920
ENST00000412916CBFBchr1667116211+ENST00000452625MYH11chr1615820911-37846581632823886
ENST00000412916CBFBchr1667116211+ENST00000576790MYH11chr1615820911-31696581632823886
ENST00000412916CBFBchr1667116211+ENST00000300036MYH11chr1615820911-29266581632925921
ENST00000412916CBFBchr1667116211+ENST00000396324MYH11chr1615818851-35386581632718851
ENST00000412916CBFBchr1667116211+ENST00000452625MYH11chr1615818851-35776581632616817
ENST00000412916CBFBchr1667116211+ENST00000576790MYH11chr1615818851-29626581632616817
ENST00000412916CBFBchr1667116211+ENST00000300036MYH11chr1615818851-27196581632718852
ENST00000412916CBFBchr1667116213+ENST00000396324MYH11chr1615814910-28186581631998611
ENST00000412916CBFBchr1667116213+ENST00000452625MYH11chr1615814910-28576581631896577
ENST00000412916CBFBchr1667116213+ENST00000576790MYH11chr1615814910-22426581631896577
ENST00000412916CBFBchr1667116213+ENST00000300036MYH11chr1615814910-19996581631998612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290858ENST00000396324CBFBchr1667063342+MYH11chr1615811013-0.357936470.6420635
ENST00000290858ENST00000452625CBFBchr1667063342+MYH11chr1615811013-0.364598930.63540107
ENST00000290858ENST00000576790CBFBchr1667063342+MYH11chr1615811013-0.157896920.84210306
ENST00000290858ENST00000300036CBFBchr1667063342+MYH11chr1615811013-0.107839750.89216024
ENST00000412916ENST00000396324CBFBchr1667063342+MYH11chr1615811013-0.357936470.6420635
ENST00000412916ENST00000452625CBFBchr1667063342+MYH11chr1615811013-0.364598930.63540107
ENST00000412916ENST00000576790CBFBchr1667063342+MYH11chr1615811013-0.157896920.84210306
ENST00000412916ENST00000300036CBFBchr1667063342+MYH11chr1615811013-0.107839750.89216024
ENST00000290858ENST00000396324CBFBchr1667070555+MYH11chr1615814832-0.0011574570.99884254
ENST00000290858ENST00000452625CBFBchr1667070555+MYH11chr1615814832-0.0017503830.9982496
ENST00000290858ENST00000576790CBFBchr1667070555+MYH11chr1615814832-0.0011933050.9988067
ENST00000290858ENST00000300036CBFBchr1667070555+MYH11chr1615814832-0.0005152220.9994848
ENST00000412916ENST00000396324CBFBchr1667070555+MYH11chr1615814832-0.0012246040.9987754
ENST00000412916ENST00000452625CBFBchr1667070555+MYH11chr1615814832-0.0018305390.9981694
ENST00000412916ENST00000576790CBFBchr1667070555+MYH11chr1615814832-0.0010466860.99895334
ENST00000412916ENST00000300036CBFBchr1667070555+MYH11chr1615814832-0.0004051380.99959487
ENST00000412916ENST00000396324CBFBchr1667116208+MYH11chr1615814910-0.0091229820.990877
ENST00000412916ENST00000452625CBFBchr1667116208+MYH11chr1615814910-0.0081568080.99184316
ENST00000412916ENST00000576790CBFBchr1667116208+MYH11chr1615814910-0.0059881050.99401194
ENST00000412916ENST00000300036CBFBchr1667116208+MYH11chr1615814910-0.004542070.995458
ENST00000412916ENST00000396324CBFBchr1667116211+MYH11chr1615814908-0.0091229820.990877
ENST00000412916ENST00000452625CBFBchr1667116211+MYH11chr1615814908-0.0081568080.99184316
ENST00000412916ENST00000576790CBFBchr1667116211+MYH11chr1615814908-0.0059881050.99401194
ENST00000412916ENST00000300036CBFBchr1667116211+MYH11chr1615814908-0.004542070.995458
ENST00000412916ENST00000396324CBFBchr1667116211+MYH11chr1615818851-0.0159051210.9840949
ENST00000412916ENST00000452625CBFBchr1667116211+MYH11chr1615818851-0.0158291740.98417085
ENST00000412916ENST00000576790CBFBchr1667116211+MYH11chr1615818851-0.0156866180.98431337
ENST00000412916ENST00000300036CBFBchr1667116211+MYH11chr1615818851-0.012713620.9872864
ENST00000412916ENST00000396324CBFBchr1667116213+MYH11chr1615814910-0.0091229820.990877
ENST00000412916ENST00000452625CBFBchr1667116213+MYH11chr1615814910-0.0081568080.99184316
ENST00000412916ENST00000576790CBFBchr1667116213+MYH11chr1615814910-0.0059881050.99401194
ENST00000412916ENST00000300036CBFBchr1667116213+MYH11chr1615814910-0.004542070.995458

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13372_13372_1_CBFB-MYH11_CBFB_chr16_67063342_ENST00000290858_MYH11_chr16_15811013_ENST00000300036_length(amino acids)=159AA_BP=
LASCSTCSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLS

--------------------------------------------------------------

>13372_13372_2_CBFB-MYH11_CBFB_chr16_67063342_ENST00000290858_MYH11_chr16_15811013_ENST00000396324_length(amino acids)=138AA_BP=
MNWEWGPAAPISVTFSPFHVNRIARDRLPWICFSKNSVSAQSIDRTGGCVCVSCWVFLISYIIQTSIFTLNTGVVGVVVVVVVETGSLLP

--------------------------------------------------------------

>13372_13372_3_CBFB-MYH11_CBFB_chr16_67063342_ENST00000290858_MYH11_chr16_15811013_ENST00000452625_length(amino acids)=138AA_BP=
MNWEWGPAAPISVTFSPFHVNRIARDRLPWICFSKNSVSAQSIDRTGGCVCVSCWVFLISYIIQTSIFTLNTGVVGVVVVVVVETGSLLP

--------------------------------------------------------------

>13372_13372_4_CBFB-MYH11_CBFB_chr16_67063342_ENST00000290858_MYH11_chr16_15811013_ENST00000576790_length(amino acids)=177AA_BP=42
LASCSTCSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLS

--------------------------------------------------------------

>13372_13372_5_CBFB-MYH11_CBFB_chr16_67063342_ENST00000412916_MYH11_chr16_15811013_ENST00000300036_length(amino acids)=159AA_BP=
LASCSTCSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLS

--------------------------------------------------------------

>13372_13372_6_CBFB-MYH11_CBFB_chr16_67063342_ENST00000412916_MYH11_chr16_15811013_ENST00000396324_length(amino acids)=138AA_BP=
MNWEWGPAAPISVTFSPFHVNRIARDRLPWICFSKNSVSAQSIDRTGGCVCVSCWVFLISYIIQTSIFTLNTGVVGVVVVVVVETGSLLP

--------------------------------------------------------------

>13372_13372_7_CBFB-MYH11_CBFB_chr16_67063342_ENST00000412916_MYH11_chr16_15811013_ENST00000452625_length(amino acids)=138AA_BP=
MNWEWGPAAPISVTFSPFHVNRIARDRLPWICFSKNSVSAQSIDRTGGCVCVSCWVFLISYIIQTSIFTLNTGVVGVVVVVVVETGSLLP

--------------------------------------------------------------

>13372_13372_8_CBFB-MYH11_CBFB_chr16_67063342_ENST00000412916_MYH11_chr16_15811013_ENST00000576790_length(amino acids)=177AA_BP=42
LASCSTCSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLS

--------------------------------------------------------------

>13372_13372_9_CBFB-MYH11_CBFB_chr16_67070555_ENST00000290858_MYH11_chr16_15814832_ENST00000300036_length(amino acids)=328AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_10_CBFB-MYH11_CBFB_chr16_67070555_ENST00000290858_MYH11_chr16_15814832_ENST00000396324_length(amino acids)=296AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_11_CBFB-MYH11_CBFB_chr16_67070555_ENST00000290858_MYH11_chr16_15814832_ENST00000452625_length(amino acids)=309AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_12_CBFB-MYH11_CBFB_chr16_67070555_ENST00000290858_MYH11_chr16_15814832_ENST00000576790_length(amino acids)=352AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------

>13372_13372_13_CBFB-MYH11_CBFB_chr16_67070555_ENST00000412916_MYH11_chr16_15814832_ENST00000300036_length(amino acids)=328AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_14_CBFB-MYH11_CBFB_chr16_67070555_ENST00000412916_MYH11_chr16_15814832_ENST00000396324_length(amino acids)=296AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_15_CBFB-MYH11_CBFB_chr16_67070555_ENST00000412916_MYH11_chr16_15814832_ENST00000452625_length(amino acids)=309AA_BP=36
MLPSSWLSSHSLWLWQRSHLWRHGHLPALFESPSSEPSRQATGQLLCQFLLLEVRLFASPLSGGEVLLCGFADPVAHGLHVALLLLQLLL
QLGDPGLQAALLVLECVPGLLLDLLLQLCNLGLQRRDGGLELGLDGPLHLVELAPELLVLPLELLPGTLILLGRAALCGQLVAELLGLLL
VLLGHLALVLHLQQDFLQLLVFLLQRLGGRLFLSELALECVHLAAHGLVALRGLIQLPLQLPAVGVDALGLLLCLLQLPLELLDPGIAFL

--------------------------------------------------------------

>13372_13372_16_CBFB-MYH11_CBFB_chr16_67070555_ENST00000412916_MYH11_chr16_15814832_ENST00000576790_length(amino acids)=352AA_BP=
MHEVCFQALGFLLILFGCGKDLISGGTGIFQLSLKVLHLSLPDRLLASSSASSSFSRSACLRALSAAARSCCVALRTRSLMASMLPCSSS
SSSSSWAIRASRRRFSSWSAFLASCSTCSSSCAILASSAAMVDLNLDLTAPSISWSLLRSSLFCRSSCCRALSFFWAVLRSVASSLLSCS
ACSLYCSAILRSSSTCSKISFSFLSFCFSDLVAACFSLSLLLSAFTSRPMASLLSVASSSSRCSFLRLALMRWDSSSASSSCLLSCLTLA

--------------------------------------------------------------

>13372_13372_17_CBFB-MYH11_CBFB_chr16_67116208_ENST00000412916_MYH11_chr16_15814910_ENST00000300036_length(amino acids)=612AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_18_CBFB-MYH11_CBFB_chr16_67116208_ENST00000412916_MYH11_chr16_15814910_ENST00000396324_length(amino acids)=611AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_19_CBFB-MYH11_CBFB_chr16_67116208_ENST00000412916_MYH11_chr16_15814910_ENST00000452625_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_20_CBFB-MYH11_CBFB_chr16_67116208_ENST00000412916_MYH11_chr16_15814910_ENST00000576790_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_21_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15814908_ENST00000300036_length(amino acids)=612AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_22_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15814908_ENST00000396324_length(amino acids)=611AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_23_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15814908_ENST00000452625_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_24_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15814908_ENST00000576790_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_25_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818656_ENST00000300036_length(amino acids)=817AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEELLQEETRQKLNVST
KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ
QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL
VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL
AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA
RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN
ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFN

--------------------------------------------------------------

>13372_13372_26_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818656_ENST00000396324_length(amino acids)=816AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEELLQEETRQKLNVST
KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ
QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL
VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL
AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA
RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN
ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFN

--------------------------------------------------------------

>13372_13372_27_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818656_ENST00000452625_length(amino acids)=782AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEELLQEETRQKLNVST
KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ
QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL
VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL
AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA
RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN

--------------------------------------------------------------

>13372_13372_28_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818656_ENST00000576790_length(amino acids)=782AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEELLQEETRQKLNVST
KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ
QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL
VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL
AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA
RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN

--------------------------------------------------------------

>13372_13372_29_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818851_ENST00000300036_length(amino acids)=852AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMENEVESVTGMLNEAEG
KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE
EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK
ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA
LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL
EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN
MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT
KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRG

--------------------------------------------------------------

>13372_13372_30_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818851_ENST00000396324_length(amino acids)=851AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMENEVESVTGMLNEAEG
KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE
EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK
ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA
LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL
EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN
MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT
KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRG

--------------------------------------------------------------

>13372_13372_31_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818851_ENST00000452625_length(amino acids)=817AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMENEVESVTGMLNEAEG
KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE
EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK
ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA
LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL
EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN
MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT
KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGP

--------------------------------------------------------------

>13372_13372_32_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15818851_ENST00000576790_length(amino acids)=817AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMENEVESVTGMLNEAEG
KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE
EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK
ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA
LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL
EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN
MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT
KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGP

--------------------------------------------------------------

>13372_13372_33_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15820911_ENST00000300036_length(amino acids)=921AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEAKANLDKNKQTLEKE
NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE
LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA
AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL
ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR
QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA
KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE
LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER
KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD

--------------------------------------------------------------

>13372_13372_34_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15820911_ENST00000396324_length(amino acids)=920AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEAKANLDKNKQTLEKE
NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE
LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA
AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL
ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR
QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA
KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE
LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER
KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD

--------------------------------------------------------------

>13372_13372_35_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15820911_ENST00000452625_length(amino acids)=886AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEAKANLDKNKQTLEKE
NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE
LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA
AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL
ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR
QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA
KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE
LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER

--------------------------------------------------------------

>13372_13372_36_CBFB-MYH11_CBFB_chr16_67116211_ENST00000412916_MYH11_chr16_15820911_ENST00000576790_length(amino acids)=886AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEAKANLDKNKQTLEKE
NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE
LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA
AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL
ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR
QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA
KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE
LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER

--------------------------------------------------------------

>13372_13372_37_CBFB-MYH11_CBFB_chr16_67116213_ENST00000412916_MYH11_chr16_15814910_ENST00000300036_length(amino acids)=612AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_38_CBFB-MYH11_CBFB_chr16_67116213_ENST00000412916_MYH11_chr16_15814910_ENST00000396324_length(amino acids)=611AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_39_CBFB-MYH11_CBFB_chr16_67116213_ENST00000412916_MYH11_chr16_15814910_ENST00000452625_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

>13372_13372_40_CBFB-MYH11_CBFB_chr16_67116213_ENST00000412916_MYH11_chr16_15814910_ENST00000576790_length(amino acids)=577AA_BP=165
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVHELEKSKRALETQM
EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL
QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL
SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK
FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67116211/chr16:15814908)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBFB

Q13951

MYH11

P35749

FUNCTION: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. {ECO:0000250|UniProtKB:Q08024}.FUNCTION: Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYH11chr16:67063342chr16:15811013ENST00000300036041844_193401973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67063342chr16:15811013ENST00000396324042844_193401980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67063342chr16:15811013ENST00000452625043844_193402132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67063342chr16:15811013ENST00000576790042844_193401912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67070555chr16:15814832ENST00000300036041844_193401973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67070555chr16:15814832ENST00000396324042844_193401980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67070555chr16:15814832ENST00000452625043844_193402132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67070555chr16:15814832ENST00000576790042844_193401912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67063342chr16:15811013ENST0000030003604131_8101973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67063342chr16:15811013ENST00000300036041786_81501973.0DomainIQ
TgeneMYH11chr16:67063342chr16:15811013ENST0000030003604185_78301973.0DomainMyosin motor
TgeneMYH11chr16:67063342chr16:15811013ENST0000039632404231_8101980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67063342chr16:15811013ENST00000396324042786_81501980.0DomainIQ
TgeneMYH11chr16:67063342chr16:15811013ENST0000039632404285_78301980.0DomainMyosin motor
TgeneMYH11chr16:67063342chr16:15811013ENST0000045262504331_8102132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67063342chr16:15811013ENST00000452625043786_81502132.0DomainIQ
TgeneMYH11chr16:67063342chr16:15811013ENST0000045262504385_78302132.0DomainMyosin motor
TgeneMYH11chr16:67063342chr16:15811013ENST0000057679004231_8101912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67063342chr16:15811013ENST00000576790042786_81501912.6666666666667DomainIQ
TgeneMYH11chr16:67063342chr16:15811013ENST0000057679004285_78301912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67070555chr16:15814832ENST0000030003604131_8101973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67070555chr16:15814832ENST00000300036041786_81501973.0DomainIQ
TgeneMYH11chr16:67070555chr16:15814832ENST0000030003604185_78301973.0DomainMyosin motor
TgeneMYH11chr16:67070555chr16:15814832ENST0000039632404231_8101980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67070555chr16:15814832ENST00000396324042786_81501980.0DomainIQ
TgeneMYH11chr16:67070555chr16:15814832ENST0000039632404285_78301980.0DomainMyosin motor
TgeneMYH11chr16:67070555chr16:15814832ENST0000045262504331_8102132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67070555chr16:15814832ENST00000452625043786_81502132.0DomainIQ
TgeneMYH11chr16:67070555chr16:15814832ENST0000045262504385_78302132.0DomainMyosin motor
TgeneMYH11chr16:67070555chr16:15814832ENST0000057679004231_8101912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67070555chr16:15814832ENST00000576790042786_81501912.6666666666667DomainIQ
TgeneMYH11chr16:67070555chr16:15814832ENST0000057679004285_78301912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67063342chr16:15811013ENST00000300036041178_18501973.0Nucleotide bindingATP
TgeneMYH11chr16:67063342chr16:15811013ENST00000396324042178_18501980.0Nucleotide bindingATP
TgeneMYH11chr16:67063342chr16:15811013ENST00000452625043178_18502132.0Nucleotide bindingATP
TgeneMYH11chr16:67063342chr16:15811013ENST00000576790042178_18501912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67070555chr16:15814832ENST00000300036041178_18501973.0Nucleotide bindingATP
TgeneMYH11chr16:67070555chr16:15814832ENST00000396324042178_18501980.0Nucleotide bindingATP
TgeneMYH11chr16:67070555chr16:15814832ENST00000452625043178_18502132.0Nucleotide bindingATP
TgeneMYH11chr16:67070555chr16:15814832ENST00000576790042178_18501912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67063342chr16:15811013ENST000003000360411935_197201973.0RegionNote=C-terminal
TgeneMYH11chr16:67063342chr16:15811013ENST00000300036041661_68301973.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST00000300036041762_77601973.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST000003963240421935_197201980.0RegionNote=C-terminal
TgeneMYH11chr16:67063342chr16:15811013ENST00000396324042661_68301980.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST00000396324042762_77601980.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST000004526250431935_197202132.0RegionNote=C-terminal
TgeneMYH11chr16:67063342chr16:15811013ENST00000452625043661_68302132.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST00000452625043762_77602132.0RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST000005767900421935_197201912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67063342chr16:15811013ENST00000576790042661_68301912.6666666666667RegionActin-binding
TgeneMYH11chr16:67063342chr16:15811013ENST00000576790042762_77601912.6666666666667RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST000003000360411935_197201973.0RegionNote=C-terminal
TgeneMYH11chr16:67070555chr16:15814832ENST00000300036041661_68301973.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST00000300036041762_77601973.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST000003963240421935_197201980.0RegionNote=C-terminal
TgeneMYH11chr16:67070555chr16:15814832ENST00000396324042661_68301980.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST00000396324042762_77601980.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST000004526250431935_197202132.0RegionNote=C-terminal
TgeneMYH11chr16:67070555chr16:15814832ENST00000452625043661_68302132.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST00000452625043762_77602132.0RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST000005767900421935_197201912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67070555chr16:15814832ENST00000576790042661_68301912.6666666666667RegionActin-binding
TgeneMYH11chr16:67070555chr16:15814832ENST00000576790042762_77601912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST0000030003631411935_19721526.01973.0RegionNote=C-terminal
TgeneMYH11chr16:67116208chr16:15814910ENST0000039632432421935_19721533.01980.0RegionNote=C-terminal
TgeneMYH11chr16:67116208chr16:15814910ENST0000045262532431935_19721533.02132.0RegionNote=C-terminal
TgeneMYH11chr16:67116208chr16:15814910ENST0000057679031421935_19721526.01912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15814908ENST0000030003631411935_19721526.01973.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15814908ENST0000039632432421935_19721533.01980.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15814908ENST0000045262532431935_19721533.02132.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15814908ENST0000057679031421935_19721526.01912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15818851ENST0000030003627411935_19721286.01973.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15818851ENST0000039632428421935_19721293.01980.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15818851ENST0000045262528431935_19721293.02132.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15818851ENST0000057679027421935_19721286.01912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15820911ENST0000030003626411935_19721217.01973.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15820911ENST0000039632427421935_19721224.01980.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15820911ENST0000045262527431935_19721224.02132.0RegionNote=C-terminal
TgeneMYH11chr16:67116211chr16:15820911ENST0000057679026421935_19721217.01912.6666666666667RegionNote=C-terminal
TgeneMYH11chr16:67116213chr16:15814910ENST0000030003631411935_19721526.01973.0RegionNote=C-terminal
TgeneMYH11chr16:67116213chr16:15814910ENST0000039632432421935_19721533.01980.0RegionNote=C-terminal
TgeneMYH11chr16:67116213chr16:15814910ENST0000045262532431935_19721533.02132.0RegionNote=C-terminal
TgeneMYH11chr16:67116213chr16:15814910ENST0000057679031421935_19721526.01912.6666666666667RegionNote=C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYH11chr16:67116208chr16:15814910ENST000003000363141844_19341526.01973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116208chr16:15814910ENST000003963243242844_19341533.01980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116208chr16:15814910ENST000004526253243844_19341533.02132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116208chr16:15814910ENST000005767903142844_19341526.01912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15814908ENST000003000363141844_19341526.01973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15814908ENST000003963243242844_19341533.01980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15814908ENST000004526253243844_19341533.02132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15814908ENST000005767903142844_19341526.01912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15818851ENST000003000362741844_19341286.01973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15818851ENST000003963242842844_19341293.01980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15818851ENST000004526252843844_19341293.02132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15818851ENST000005767902742844_19341286.01912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15820911ENST000003000362641844_19341217.01973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15820911ENST000003963242742844_19341224.01980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15820911ENST000004526252743844_19341224.02132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116211chr16:15820911ENST000005767902642844_19341217.01912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116213chr16:15814910ENST000003000363141844_19341526.01973.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116213chr16:15814910ENST000003963243242844_19341533.01980.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116213chr16:15814910ENST000004526253243844_19341533.02132.0Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116213chr16:15814910ENST000005767903142844_19341526.01912.6666666666667Coiled coilOntology_term=ECO:0000255
TgeneMYH11chr16:67116208chr16:15814910ENST00000300036314131_811526.01973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116208chr16:15814910ENST000003000363141786_8151526.01973.0DomainIQ
TgeneMYH11chr16:67116208chr16:15814910ENST00000300036314185_7831526.01973.0DomainMyosin motor
TgeneMYH11chr16:67116208chr16:15814910ENST00000396324324231_811533.01980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116208chr16:15814910ENST000003963243242786_8151533.01980.0DomainIQ
TgeneMYH11chr16:67116208chr16:15814910ENST00000396324324285_7831533.01980.0DomainMyosin motor
TgeneMYH11chr16:67116208chr16:15814910ENST00000452625324331_811533.02132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116208chr16:15814910ENST000004526253243786_8151533.02132.0DomainIQ
TgeneMYH11chr16:67116208chr16:15814910ENST00000452625324385_7831533.02132.0DomainMyosin motor
TgeneMYH11chr16:67116208chr16:15814910ENST00000576790314231_811526.01912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116208chr16:15814910ENST000005767903142786_8151526.01912.6666666666667DomainIQ
TgeneMYH11chr16:67116208chr16:15814910ENST00000576790314285_7831526.01912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15814908ENST00000300036314131_811526.01973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15814908ENST000003000363141786_8151526.01973.0DomainIQ
TgeneMYH11chr16:67116211chr16:15814908ENST00000300036314185_7831526.01973.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15814908ENST00000396324324231_811533.01980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15814908ENST000003963243242786_8151533.01980.0DomainIQ
TgeneMYH11chr16:67116211chr16:15814908ENST00000396324324285_7831533.01980.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15814908ENST00000452625324331_811533.02132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15814908ENST000004526253243786_8151533.02132.0DomainIQ
TgeneMYH11chr16:67116211chr16:15814908ENST00000452625324385_7831533.02132.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15814908ENST00000576790314231_811526.01912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15814908ENST000005767903142786_8151526.01912.6666666666667DomainIQ
TgeneMYH11chr16:67116211chr16:15814908ENST00000576790314285_7831526.01912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15818851ENST00000300036274131_811286.01973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15818851ENST000003000362741786_8151286.01973.0DomainIQ
TgeneMYH11chr16:67116211chr16:15818851ENST00000300036274185_7831286.01973.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15818851ENST00000396324284231_811293.01980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15818851ENST000003963242842786_8151293.01980.0DomainIQ
TgeneMYH11chr16:67116211chr16:15818851ENST00000396324284285_7831293.01980.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15818851ENST00000452625284331_811293.02132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15818851ENST000004526252843786_8151293.02132.0DomainIQ
TgeneMYH11chr16:67116211chr16:15818851ENST00000452625284385_7831293.02132.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15818851ENST00000576790274231_811286.01912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15818851ENST000005767902742786_8151286.01912.6666666666667DomainIQ
TgeneMYH11chr16:67116211chr16:15818851ENST00000576790274285_7831286.01912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15820911ENST00000300036264131_811217.01973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15820911ENST000003000362641786_8151217.01973.0DomainIQ
TgeneMYH11chr16:67116211chr16:15820911ENST00000300036264185_7831217.01973.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15820911ENST00000396324274231_811224.01980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15820911ENST000003963242742786_8151224.01980.0DomainIQ
TgeneMYH11chr16:67116211chr16:15820911ENST00000396324274285_7831224.01980.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15820911ENST00000452625274331_811224.02132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15820911ENST000004526252743786_8151224.02132.0DomainIQ
TgeneMYH11chr16:67116211chr16:15820911ENST00000452625274385_7831224.02132.0DomainMyosin motor
TgeneMYH11chr16:67116211chr16:15820911ENST00000576790264231_811217.01912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116211chr16:15820911ENST000005767902642786_8151217.01912.6666666666667DomainIQ
TgeneMYH11chr16:67116211chr16:15820911ENST00000576790264285_7831217.01912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67116213chr16:15814910ENST00000300036314131_811526.01973.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116213chr16:15814910ENST000003000363141786_8151526.01973.0DomainIQ
TgeneMYH11chr16:67116213chr16:15814910ENST00000300036314185_7831526.01973.0DomainMyosin motor
TgeneMYH11chr16:67116213chr16:15814910ENST00000396324324231_811533.01980.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116213chr16:15814910ENST000003963243242786_8151533.01980.0DomainIQ
TgeneMYH11chr16:67116213chr16:15814910ENST00000396324324285_7831533.01980.0DomainMyosin motor
TgeneMYH11chr16:67116213chr16:15814910ENST00000452625324331_811533.02132.0DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116213chr16:15814910ENST000004526253243786_8151533.02132.0DomainIQ
TgeneMYH11chr16:67116213chr16:15814910ENST00000452625324385_7831533.02132.0DomainMyosin motor
TgeneMYH11chr16:67116213chr16:15814910ENST00000576790314231_811526.01912.6666666666667DomainMyosin N-terminal SH3-like
TgeneMYH11chr16:67116213chr16:15814910ENST000005767903142786_8151526.01912.6666666666667DomainIQ
TgeneMYH11chr16:67116213chr16:15814910ENST00000576790314285_7831526.01912.6666666666667DomainMyosin motor
TgeneMYH11chr16:67116208chr16:15814910ENST000003000363141178_1851526.01973.0Nucleotide bindingATP
TgeneMYH11chr16:67116208chr16:15814910ENST000003963243242178_1851533.01980.0Nucleotide bindingATP
TgeneMYH11chr16:67116208chr16:15814910ENST000004526253243178_1851533.02132.0Nucleotide bindingATP
TgeneMYH11chr16:67116208chr16:15814910ENST000005767903142178_1851526.01912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15814908ENST000003000363141178_1851526.01973.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15814908ENST000003963243242178_1851533.01980.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15814908ENST000004526253243178_1851533.02132.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15814908ENST000005767903142178_1851526.01912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15818851ENST000003000362741178_1851286.01973.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15818851ENST000003963242842178_1851293.01980.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15818851ENST000004526252843178_1851293.02132.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15818851ENST000005767902742178_1851286.01912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15820911ENST000003000362641178_1851217.01973.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15820911ENST000003963242742178_1851224.01980.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15820911ENST000004526252743178_1851224.02132.0Nucleotide bindingATP
TgeneMYH11chr16:67116211chr16:15820911ENST000005767902642178_1851217.01912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67116213chr16:15814910ENST000003000363141178_1851526.01973.0Nucleotide bindingATP
TgeneMYH11chr16:67116213chr16:15814910ENST000003963243242178_1851533.01980.0Nucleotide bindingATP
TgeneMYH11chr16:67116213chr16:15814910ENST000004526253243178_1851533.02132.0Nucleotide bindingATP
TgeneMYH11chr16:67116213chr16:15814910ENST000005767903142178_1851526.01912.6666666666667Nucleotide bindingATP
TgeneMYH11chr16:67116208chr16:15814910ENST000003000363141661_6831526.01973.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000003000363141762_7761526.01973.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000003963243242661_6831533.01980.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000003963243242762_7761533.01980.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000004526253243661_6831533.02132.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000004526253243762_7761533.02132.0RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000005767903142661_6831526.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116208chr16:15814910ENST000005767903142762_7761526.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000003000363141661_6831526.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000003000363141762_7761526.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000003963243242661_6831533.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000003963243242762_7761533.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000004526253243661_6831533.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000004526253243762_7761533.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000005767903142661_6831526.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15814908ENST000005767903142762_7761526.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000003000362741661_6831286.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000003000362741762_7761286.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000003963242842661_6831293.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000003963242842762_7761293.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000004526252843661_6831293.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000004526252843762_7761293.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000005767902742661_6831286.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15818851ENST000005767902742762_7761286.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000003000362641661_6831217.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000003000362641762_7761217.01973.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000003963242742661_6831224.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000003963242742762_7761224.01980.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000004526252743661_6831224.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000004526252743762_7761224.02132.0RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000005767902642661_6831217.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116211chr16:15820911ENST000005767902642762_7761217.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000003000363141661_6831526.01973.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000003000363141762_7761526.01973.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000003963243242661_6831533.01980.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000003963243242762_7761533.01980.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000004526253243661_6831533.02132.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000004526253243762_7761533.02132.0RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000005767903142661_6831526.01912.6666666666667RegionActin-binding
TgeneMYH11chr16:67116213chr16:15814910ENST000005767903142762_7761526.01912.6666666666667RegionActin-binding


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (640) >>>640.pdbFusion protein BP residue: 165
CIF file (640) >>>640.cif		CBFBchr1667116211+MYH11chr1615818656-
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRD
GRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAP
MILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRT
REFEDRDRSHREEMEELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM
EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ
QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL
LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN
KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ
ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD
FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA
DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS
DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG
AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL
QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE
782
3D view using mol* of 640 (AA BP:165)
PDB file (662) >>>662.pdbFusion protein BP residue: 165
CIF file (662) >>>662.cif		CBFBchr1667116211+MYH11chr1615818656-
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRD
GRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAP
MILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRT
REFEDRDRSHREEMEELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM
EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ
QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL
LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN
KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ
ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD
FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA
DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS
DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG
AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL
QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE
LDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE
816
3D view using mol* of 662 (AA BP:165)
PDB file (664)CBFBchr1667116211+MYH11chr1615818656-
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRD
GRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAP
MILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRT
REFEDRDRSHREEMEELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM
EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ
QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQL
LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN
KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ
ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE
DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD
FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA
DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS
DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG
AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL
QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE
LDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE
817


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CBFB_pLDDT.png
all structure
all structure
MYH11_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CBFB_MYH11_640_pLDDT.png (AA BP:165)
all structure
CBFB_MYH11_662_pLDDT.png (AA BP:165)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
CBFB_MYH11_640.png
all structure
CBFB_MYH11_662.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CBFBCHGB, RUNX1, MYOD1, RUNX3, COPRS, KMT2A, ELAVL1, CUL5, vif, nef, APOBEC3G, MYC, RAB2A, TCEB1, RNF7, TCEB2, RUNX2, ARL6IP6, SERPINB5, SLC25A32, TAS2R41, CRIP1, GALK1, PPIA, SOD1, NFATC1, GCHFR, G3BP1, CTNNB1, CBFA2T3, NKX2-1, IKZF3, IKZF1, AMBRA1, TRIM28, BAG3, BCL11B, CBFB, EMD, ETS1, HAX1, HLTF, HNRNPM, HSPBP1, PML, RBM14, TCF12, TCF7, TSC2, TUBA4A, ZBTB1, AKAP8L, ANXA1, HDAC3, IKZF2, SEC16A, TAF4, PDCD6IP, ARIH1, ARIH2, CUL2, DCAF11, NCOR1, NEDD8, RBX1, YTHDF2, PLEKHA4, CHRM5, BRD4, DDX58, ATG7, FBXW12, NIP7, HSPA1A, FCN3, FAM109A, LHFPL4, FOXF2, LRRC32, DUOXA2, VPS28, SMPDL3B, RP2, AQP12B, BTF3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CBFBall structure
MYH11all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CBFB-MYH11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
CBFBMYH11High-Dose Cytarabine ConsolidationPubMed30726835

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Related Diseases to CBFB-MYH11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
CBFBMYH11Aml And Mesentery Granulocytic SarcomaPubMed30726835
CBFBMYH11Breast Invasive Lobular CarcinomaMyCancerGenome
CBFBMYH11Acute Myeloid LeukemiaMyCancerGenome
CBFBMYH11Acute Myeloid Leukemia With Inv(16)(P13.1q22) Or T(16;16)(P13.1;Q22); Cbfb-Myh11MyCancerGenome
CBFBMYH11Esophagogastric CarcinomaMyCancerGenome
CBFBMYH11Malignant Ovarian Clear Cell TumorMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCBFBC0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneCBFBC0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
HgeneCBFBC0026998Acute Myeloid Leukemia, M12CTD_human
HgeneCBFBC1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneCBFBC0005941Bone Diseases, Developmental1CTD_human
HgeneCBFBC0008925Cleft Palate1CTD_human
HgeneCBFBC0018798Congenital Heart Defects1CTD_human
HgeneCBFBC0029396Heterotopic Ossification1CTD_human
HgeneCBFBC1837218Cleft palate, isolated1CTD_human
TgeneMYH11C4707243Familial thoracic aortic aneurysm and aortic dissection10CLINGEN;GENOMICS_ENGLAND
TgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneMYH11C0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
TgeneMYH11C0026998Acute Myeloid Leukemia, M12CTD_human
TgeneMYH11C1851504Aortic aneurysm, familial thoracic 42CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMYH11C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneMYH11C1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET