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Fusion Protein:CCAR1-CAAP1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CCAR1-CAAP1 | FusionPDB ID: 13515 | FusionGDB2.0 ID: 13515 | Hgene | Tgene | Gene symbol | CCAR1 | CAAP1 | Gene ID | 55749 | 79886 |
| Gene name | cell division cycle and apoptosis regulator 1 | caspase activity and apoptosis inhibitor 1 | |
| Synonyms | - | C9orf82|CAAP | |
| Cytomap | 10q21.3 | 9p21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cell division cycle and apoptosis regulator protein 1cell cycle and apoptosis regulatory protein 1death inducer with SAP domain | caspase activity and apoptosis inhibitor 1conserved anti-apoptotic protein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q8IX12 | Q9H8G2 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265872, ENST00000535016, ENST00000543719, ENST00000483264, | ENST00000495958, ENST00000535437, ENST00000520187, ENST00000333916, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 11 X 8=1144 | 3 X 2 X 3=18 |
| # samples | 17 | 4 | |
| ** MAII score | log2(17/1144*10)=-2.75048040064069 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CCAR1 [Title/Abstract] AND CAAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CCAR1(70514584)-CAAP1(26887511), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CCAR1-CAAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CCAR1 | GO:0043065 | positive regulation of apoptotic process | 12816952 |
| Fusion gene breakpoints across CCAR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CAAP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCS | TCGA-N8-A4PL | CCAR1 | chr10 | 70514584 | + | CAAP1 | chr9 | 26887511 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000535016 | CCAR1 | chr10 | 70514584 | + | ENST00000333916 | CAAP1 | chr9 | 26887511 | - | 3931 | 1532 | 119 | 2314 | 731 |
| ENST00000265872 | CCAR1 | chr10 | 70514584 | + | ENST00000333916 | CAAP1 | chr9 | 26887511 | - | 3976 | 1577 | 119 | 2359 | 746 |
| ENST00000543719 | CCAR1 | chr10 | 70514584 | + | ENST00000333916 | CAAP1 | chr9 | 26887511 | - | 3925 | 1526 | 113 | 2308 | 731 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000535016 | ENST00000333916 | CCAR1 | chr10 | 70514584 | + | CAAP1 | chr9 | 26887511 | - | 0.000848914 | 0.9991511 |
| ENST00000265872 | ENST00000333916 | CCAR1 | chr10 | 70514584 | + | CAAP1 | chr9 | 26887511 | - | 0.001050107 | 0.99894994 |
| ENST00000543719 | ENST00000333916 | CCAR1 | chr10 | 70514584 | + | CAAP1 | chr9 | 26887511 | - | 0.000830184 | 0.9991698 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >13515_13515_1_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000265872_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=746AA_BP=486 MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQQYSQPQQA LYSVQQQLQQPQQTLLTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQ QPQQKAGLLQPPVRIVSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVM LMASPSMEDLYHKSCALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIG EKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELK QGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQ -------------------------------------------------------------- >13515_13515_2_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000535016_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471 MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA -------------------------------------------------------------- >13515_13515_3_CCAR1-CAAP1_CCAR1_chr10_70514584_ENST00000543719_CAAP1_chr9_26887511_ENST00000333916_length(amino acids)=731AA_BP=471 MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPANYQLTQTAALQQQAAAAAAALQQLQQPQQTL LTQPAVALPTSLSLSTPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTPQVGDRVLVEATYNPN MPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQTQPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRI VSQPQPARRLDPPSRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVPRYTVQFSKFSLDCPS CDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFYVMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSC ALAEDPQELRDGFQHPARLVKETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNC SIEEIKKLCQEQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINAD AYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:70514584/chr9:26887511) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CCAR1 | CAAP1 |
| FUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952). In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938). {ECO:0000250|UniProtKB:Q8CH18, ECO:0000269|PubMed:12816952, ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}. | FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 293_361 | 486.0 | 1151.0 | Compositional bias | Note=Arg-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 73_79 | 486.0 | 1151.0 | Compositional bias | Note=Poly-Ala |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 293_361 | 471.0 | 1136.0 | Compositional bias | Note=Arg-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 73_79 | 471.0 | 1136.0 | Compositional bias | Note=Poly-Ala |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 293_361 | 471.0 | 1136.0 | Compositional bias | Note=Arg-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 73_79 | 471.0 | 1136.0 | Compositional bias | Note=Poly-Ala |
| Tgene | CAAP1 | chr10:70514584 | chr9:26887511 | ENST00000333916 | 0 | 6 | 281_311 | 101.0 | 362.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CAAP1 | chr10:70514584 | chr9:26887511 | ENST00000535437 | 0 | 6 | 281_311 | 0 | 217.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | CAAP1 | chr10:70514584 | chr9:26887511 | ENST00000535437 | 0 | 6 | 19_25 | 0 | 217.0 | Compositional bias | Note=Poly-Ala |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 1033_1114 | 486.0 | 1151.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 594_618 | 486.0 | 1151.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 1033_1114 | 471.0 | 1136.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 594_618 | 471.0 | 1136.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 1033_1114 | 471.0 | 1136.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 594_618 | 471.0 | 1136.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 673_889 | 486.0 | 1151.0 | Compositional bias | Note=Glu-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 673_889 | 471.0 | 1136.0 | Compositional bias | Note=Glu-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 673_889 | 471.0 | 1136.0 | Compositional bias | Note=Glu-rich |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 636_670 | 486.0 | 1151.0 | Domain | SAP |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 636_670 | 471.0 | 1136.0 | Domain | SAP |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 636_670 | 471.0 | 1136.0 | Domain | SAP |
| Tgene | CAAP1 | chr10:70514584 | chr9:26887511 | ENST00000333916 | 0 | 6 | 19_25 | 101.0 | 362.0 | Compositional bias | Note=Poly-Ala |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CCAR1 | |
| CAAP1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 643_1150 | 486.0 | 1151.0 | GATA1 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 643_1150 | 471.0 | 1136.0 | GATA1 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 643_1150 | 471.0 | 1136.0 | GATA1 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000265872 | + | 12 | 25 | 203_660 | 486.0 | 1151.0 | GATA2 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000535016 | + | 11 | 24 | 203_660 | 471.0 | 1136.0 | GATA2 |
| Hgene | CCAR1 | chr10:70514584 | chr9:26887511 | ENST00000543719 | + | 11 | 24 | 203_660 | 471.0 | 1136.0 | GATA2 |
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Related Drugs to CCAR1-CAAP1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to CCAR1-CAAP1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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