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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CCDC132-CDH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CCDC132-CDH1
FusionPDB ID: 13625
FusionGDB2.0 ID: 98460
HgeneTgene
Gene symbol

CCDC132

CDH1

Gene ID

55610

51343

Gene nameVPS50 subunit of EARP/GARPII complexfizzy and cell division cycle 20 related 1
SynonymsCCDC132|VPS54LCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1
Cytomap

7q21.2-q21.3

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionsyndetinEARP/GARPII complex subunit VPS50VPS50, EARP/GARPII complex subunitcoiled-coil domain containing 132coiled-coil domain-containing protein 132fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1
Modification date2020031320200313
UniProtAcc.

Q9H159

Ensembl transtripts involved in fusion geneENST idsENST00000305866, ENST00000317751, 
ENST00000535481, ENST00000541136, 
ENST00000544910, ENST00000251739, 
ENST00000474412, 
ENST00000562836, 
ENST00000261769, ENST00000422392, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=819 X 20 X 5=1900
# samples 323
** MAII scorelog2(3/8*10)=1.90689059560852log2(23/1900*10)=-3.04629365227394
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CCDC132 [Title/Abstract] AND CDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CCDC132(92940584)-CDH1(68862077), # samples:2
CDH1(68857529)-CCDC132(92952923), # samples:2
Anticipated loss of major functional domain due to fusion event.CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCDC132

GO:0032456

endocytic recycling

25799061

TgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

TgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

TgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check buttonFusion gene breakpoints across CCDC132 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A12E-01ACCDC132chr7

92940584

-CDH1chr16

68862077

+
ChimerDB4BRCATCGA-AO-A12E-01ACCDC132chr7

92940584

+CDH1chr16

68862077

+
ChimerDB4BRCATCGA-AO-A12ECCDC132chr7

92940584

+CDH1chr16

68862076

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000305866CCDC132chr792940584+ENST00000261769CDH1chr1668862076+451719831282467779
ENST00000305866CCDC132chr792940584+ENST00000422392CDH1chr1668862076+250519831282467779
ENST00000541136CCDC132chr792940584+ENST00000261769CDH1chr1668862076+438418502412334697
ENST00000541136CCDC132chr792940584+ENST00000422392CDH1chr1668862076+237218502412334697
ENST00000544910CCDC132chr792940584+ENST00000261769CDH1chr1668862076+451919852202469749
ENST00000544910CCDC132chr792940584+ENST00000422392CDH1chr1668862076+250719852202469749
ENST00000535481CCDC132chr792940584+ENST00000261769CDH1chr1668862076+36381104891588499
ENST00000535481CCDC132chr792940584+ENST00000422392CDH1chr1668862076+16261104891588499
ENST00000317751CCDC132chr792940584+ENST00000261769CDH1chr1668862076+44741940852424779
ENST00000317751CCDC132chr792940584+ENST00000422392CDH1chr1668862076+24621940852424779
ENST00000305866CCDC132chr792940584+ENST00000261769CDH1chr1668862077+451719831282467779
ENST00000305866CCDC132chr792940584+ENST00000422392CDH1chr1668862077+250519831282467779
ENST00000541136CCDC132chr792940584+ENST00000261769CDH1chr1668862077+438418502412334697
ENST00000541136CCDC132chr792940584+ENST00000422392CDH1chr1668862077+237218502412334697
ENST00000544910CCDC132chr792940584+ENST00000261769CDH1chr1668862077+451919852202469749
ENST00000544910CCDC132chr792940584+ENST00000422392CDH1chr1668862077+250719852202469749
ENST00000535481CCDC132chr792940584+ENST00000261769CDH1chr1668862077+36381104891588499
ENST00000535481CCDC132chr792940584+ENST00000422392CDH1chr1668862077+16261104891588499
ENST00000317751CCDC132chr792940584+ENST00000261769CDH1chr1668862077+44741940852424779
ENST00000317751CCDC132chr792940584+ENST00000422392CDH1chr1668862077+24621940852424779

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305866ENST00000261769CCDC132chr792940584+CDH1chr1668862076+0.0005274440.99947256
ENST00000305866ENST00000422392CCDC132chr792940584+CDH1chr1668862076+0.0013695690.9986304
ENST00000541136ENST00000261769CCDC132chr792940584+CDH1chr1668862076+0.0005646810.99943525
ENST00000541136ENST00000422392CCDC132chr792940584+CDH1chr1668862076+0.0010344490.9989655
ENST00000544910ENST00000261769CCDC132chr792940584+CDH1chr1668862076+0.0008498580.99915016
ENST00000544910ENST00000422392CCDC132chr792940584+CDH1chr1668862076+0.0018844380.99811554
ENST00000535481ENST00000261769CCDC132chr792940584+CDH1chr1668862076+0.0005606590.9994393
ENST00000535481ENST00000422392CCDC132chr792940584+CDH1chr1668862076+0.0009372220.99906284
ENST00000317751ENST00000261769CCDC132chr792940584+CDH1chr1668862076+0.0005214990.9994785
ENST00000317751ENST00000422392CCDC132chr792940584+CDH1chr1668862076+0.0013338070.99866617
ENST00000305866ENST00000261769CCDC132chr792940584+CDH1chr1668862077+0.0005274440.99947256
ENST00000305866ENST00000422392CCDC132chr792940584+CDH1chr1668862077+0.0013695690.9986304
ENST00000541136ENST00000261769CCDC132chr792940584+CDH1chr1668862077+0.0005646810.99943525
ENST00000541136ENST00000422392CCDC132chr792940584+CDH1chr1668862077+0.0010344490.9989655
ENST00000544910ENST00000261769CCDC132chr792940584+CDH1chr1668862077+0.0008498580.99915016
ENST00000544910ENST00000422392CCDC132chr792940584+CDH1chr1668862077+0.0018844380.99811554
ENST00000535481ENST00000261769CCDC132chr792940584+CDH1chr1668862077+0.0005606590.9994393
ENST00000535481ENST00000422392CCDC132chr792940584+CDH1chr1668862077+0.0009372220.99906284
ENST00000317751ENST00000261769CCDC132chr792940584+CDH1chr1668862077+0.0005214990.9994785
ENST00000317751ENST00000422392CCDC132chr792940584+CDH1chr1668862077+0.0013338070.99866617

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13625_13625_1_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000305866_CDH1_chr16_68862076_ENST00000261769_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_2_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000305866_CDH1_chr16_68862076_ENST00000422392_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_3_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000305866_CDH1_chr16_68862077_ENST00000261769_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_4_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000305866_CDH1_chr16_68862077_ENST00000422392_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_5_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000317751_CDH1_chr16_68862076_ENST00000261769_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_6_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000317751_CDH1_chr16_68862076_ENST00000422392_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_7_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000317751_CDH1_chr16_68862077_ENST00000261769_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_8_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000317751_CDH1_chr16_68862077_ENST00000422392_length(amino acids)=779AA_BP=618
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYR
DKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTL
QRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAM
DQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEG
SNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFK
NYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLA
SNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRR
RAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPT

--------------------------------------------------------------

>13625_13625_9_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000535481_CDH1_chr16_68862076_ENST00000261769_length(amino acids)=499AA_BP=338
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETN
FDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDEL
RMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQE
KSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLP
PEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVF

--------------------------------------------------------------

>13625_13625_10_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000535481_CDH1_chr16_68862076_ENST00000422392_length(amino acids)=499AA_BP=338
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETN
FDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDEL
RMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQE
KSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLP
PEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVF

--------------------------------------------------------------

>13625_13625_11_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000535481_CDH1_chr16_68862077_ENST00000261769_length(amino acids)=499AA_BP=338
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETN
FDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDEL
RMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQE
KSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLP
PEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVF

--------------------------------------------------------------

>13625_13625_12_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000535481_CDH1_chr16_68862077_ENST00000422392_length(amino acids)=499AA_BP=338
MQKIKSLMTRQGLKSPQESLSDLGAIESLRVPGKHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETN
FDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDEL
RMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQE
KSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLP
PEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVF

--------------------------------------------------------------

>13625_13625_13_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000541136_CDH1_chr16_68862076_ENST00000261769_length(amino acids)=697AA_BP=536
MQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLK
SLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRL
LGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNE
DTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIR
KQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKD
EETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLIL
LLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENL

--------------------------------------------------------------

>13625_13625_14_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000541136_CDH1_chr16_68862076_ENST00000422392_length(amino acids)=697AA_BP=536
MQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLK
SLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRL
LGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNE
DTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIR
KQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKD
EETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLIL
LLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENL

--------------------------------------------------------------

>13625_13625_15_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000541136_CDH1_chr16_68862077_ENST00000261769_length(amino acids)=697AA_BP=536
MQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLK
SLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRL
LGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNE
DTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIR
KQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKD
EETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLIL
LLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENL

--------------------------------------------------------------

>13625_13625_16_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000541136_CDH1_chr16_68862077_ENST00000422392_length(amino acids)=697AA_BP=536
MQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELERVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLK
SLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAASTFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRL
LGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNTDTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNE
DTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQDVQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIR
KQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSILQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKD
EETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRDYVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLIL
LLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENL

--------------------------------------------------------------

>13625_13625_17_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000544910_CDH1_chr16_68862076_ENST00000261769_length(amino acids)=749AA_BP=588
MLTLEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELE
RVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAA
STFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNT
DTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQD
VQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSI
LQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRD
YVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEE
DQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSES

--------------------------------------------------------------

>13625_13625_18_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000544910_CDH1_chr16_68862076_ENST00000422392_length(amino acids)=749AA_BP=588
MLTLEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELE
RVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAA
STFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNT
DTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQD
VQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSI
LQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRD
YVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEE
DQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSES

--------------------------------------------------------------

>13625_13625_19_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000544910_CDH1_chr16_68862077_ENST00000261769_length(amino acids)=749AA_BP=588
MLTLEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELE
RVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAA
STFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNT
DTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQD
VQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSI
LQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRD
YVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEE
DQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSES

--------------------------------------------------------------

>13625_13625_20_CCDC132-CDH1_CCDC132_chr7_92940584_ENST00000544910_CDH1_chr16_68862077_ENST00000422392_length(amino acids)=749AA_BP=588
MLTLEEFRELREQPSDPQAEQELINSIEQVYFSVDSFDIVKYELEKLPPVLNLQELEAYRDKLKQQQAAVSKKVADLILEKQPAYVKELE
RVTSLQTGLQLAAVICTNGRRHLNIAKEGFTQASLGLLANQRKRQLLIGLLKSLRTIKTLQRTDVRLSEMLEEEDYPGAIQLCLECQKAA
STFKHYSCISELNSKLQDTLEQIEEQLDVALSKICKNFDINHYTKVQQAYRLLGKTQTAMDQLHMHFTQAIHNTVFQVVLGYVELCAGNT
DTKFQKLQYKDLCTHVTPDSYIPCLADLCKALWEVMLSYYRTMEWHEKHDNEDTASASEGSNMIGTEETNFDRGYIKKKLEHGLTRIWQD
VQLKVKTYLLGTDLSIFKYDDFIFVLDIISRLMQVGEEFCGSKSEVLQESIRKQSVNYFKNYHRTRLDELRMFLENETWELCPVKSNFSI
LQLHEFKFMEQSRSPSVSPSKQPVSTSSKTVTLFEQYCSGGNPFEIQANHKDEETEDVLASNGYESDEQEKSAYQEYDSDSDVPEELKRD
YVDEQTGDGPVKSVSRETLKSRKKSDYSLNKVNAPILTNTTLNVIRLVVLILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEE
DQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSES

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:92940584/chr16:68862077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDH1

Q9H159

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC132chr7:92940584chr16:68862076ENST00000305866+2028216_244618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862076ENST00000305866+202882_105618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862076ENST00000544910+2129216_244588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862076ENST00000544910+212982_105588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000305866+2028216_244618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000305866+202882_105618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000544910+2129216_244588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000544910+212982_105588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216838_851721.3333333333334883.0Compositional biasNote=Ser-rich
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216838_851721.3333333333334883.0Compositional biasNote=Ser-rich
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216758_769721.3333333333334883.0RegionNote=Required for binding CTNND1 and PSEN1
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216811_882721.3333333333334883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216758_769721.3333333333334883.0RegionNote=Required for binding CTNND1 and PSEN1
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216811_882721.3333333333334883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216731_882721.3333333333334883.0Topological domainCytoplasmic
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216731_882721.3333333333334883.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC132chr7:92940584chr16:68862076ENST00000251739+112216_2440328.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862076ENST00000251739+11282_1050328.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000251739+112216_2440328.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC132chr7:92940584chr16:68862077ENST00000251739+11282_1050328.0Coiled coilOntology_term=ECO:0000255
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216155_262721.3333333333334883.0DomainCadherin 1
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216263_375721.3333333333334883.0DomainCadherin 2
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216376_486721.3333333333334883.0DomainCadherin 3
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216487_593721.3333333333334883.0DomainCadherin 4
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216594_697721.3333333333334883.0DomainCadherin 5
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216155_262721.3333333333334883.0DomainCadherin 1
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216263_375721.3333333333334883.0DomainCadherin 2
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216376_486721.3333333333334883.0DomainCadherin 3
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216487_593721.3333333333334883.0DomainCadherin 4
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216594_697721.3333333333334883.0DomainCadherin 5
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216155_709721.3333333333334883.0Topological domainExtracellular
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216155_709721.3333333333334883.0Topological domainExtracellular
TgeneCDH1chr7:92940584chr16:68862076ENST000002617691216710_730721.3333333333334883.0TransmembraneHelical
TgeneCDH1chr7:92940584chr16:68862077ENST000002617691216710_730721.3333333333334883.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CCDC132
CDH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CCDC132-CDH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CCDC132-CDH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource