UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:CCNY-PTPRD

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CCNY-PTPRD
FusionPDB ID: 14227
FusionGDB2.0 ID: 14227
HgeneTgene
Gene symbol

CCNY

PTPRD

Gene ID

219771

5789

Gene namecyclin Yprotein tyrosine phosphatase receptor type D
SynonymsC10orf9|CBCP1|CCNX|CFP1HPTP|HPTPD|HPTPDELTA|PTPD|R-PTP-delta|RPTPDELTA
Cytomap

10p11.21

9p24.1-p23

Type of geneprotein-codingprotein-coding
Descriptioncyclin-Ycyc-Ycyclin box protein 1cyclin fold protein 1cyclin-Xcyclin-box carrying protein 1receptor-type tyrosine-protein phosphatase deltaprotein tyrosine phosphatase, receptor type, delta polypeptiderceptor-type tyrosine-protein phosphatase delta
Modification date2020031320200320
UniProtAcc

P0C7X3

.
Ensembl transtripts involved in fusion geneENST idsENST00000492478, ENST00000265375, 
ENST00000339497, ENST00000374704, 
ENST00000374706, 		ENST00000381196, 
ENST00000463477, ENST00000355233, 
ENST00000356435, ENST00000358503, 
ENST00000360074, ENST00000397606, 
ENST00000397611, ENST00000397617, 
ENST00000471274, ENST00000486161, 
ENST00000537002, ENST00000540109, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 14 X 12=386427 X 25 X 10=6750
# samples 2728
** MAII scorelog2(27/3864*10)=-3.83906378178494
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/6750*10)=-4.59138876988059
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CCNY [Title/Abstract] AND PTPRD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CCNY(35819171)-PTPRD(10033790), # samples:3
Anticipated loss of major functional domain due to fusion event.CCNY-PTPRD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCNY-PTPRD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCNY-PTPRD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CCNY-PTPRD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCNY

GO:0000086

G2/M transition of mitotic cell cycle

20059949

HgeneCCNY

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

19524571|20059949

HgeneCCNY

GO:0060828

regulation of canonical Wnt signaling pathway

20059949

TgenePTPRD

GO:0099545

trans-synaptic signaling by trans-synaptic complex

21926414

TgenePTPRD

GO:0099560

synaptic membrane adhesion

23345436

TgenePTPRD

GO:1905606

regulation of presynapse assembly

21926414


check buttonFusion gene breakpoints across CCNY (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-B0-4688-01ACCNYchr10

35819171

-PTPRDchr9

10033790

-
ChimerDB4KIRCTCGA-B0-4688-01ACCNYchr10

35819171

+PTPRDchr9

10033790

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374706CCNYchr1035819171+ENST00000381196PTPRDchr910033790-10650739126570211918
ENST00000265375CCNYchr1035819171+ENST00000381196PTPRDchr910033790-10670759128570411918
ENST00000339497CCNYchr1035819171+ENST00000381196PTPRDchr910033790-10595684121069661918
ENST00000374704CCNYchr1035819171+ENST00000381196PTPRDchr910033790-10670759128570411918

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374706ENST00000381196CCNYchr1035819171+PTPRDchr910033790-0.0009197850.9990802
ENST00000265375ENST00000381196CCNYchr1035819171+PTPRDchr910033790-0.0009271010.9990729
ENST00000339497ENST00000381196CCNYchr1035819171+PTPRDchr910033790-0.0008231550.9991768
ENST00000374704ENST00000381196CCNYchr1035819171+PTPRDchr910033790-0.0009271010.9990729

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14227_14227_1_CCNY-PTPRD_CCNY_chr10_35819171_ENST00000265375_PTPRD_chr9_10033790_ENST00000381196_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

--------------------------------------------------------------

>14227_14227_2_CCNY-PTPRD_CCNY_chr10_35819171_ENST00000339497_PTPRD_chr9_10033790_ENST00000381196_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

--------------------------------------------------------------

>14227_14227_3_CCNY-PTPRD_CCNY_chr10_35819171_ENST00000374704_PTPRD_chr9_10033790_ENST00000381196_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

--------------------------------------------------------------

>14227_14227_4_CCNY-PTPRD_CCNY_chr10_35819171_ENST00000374706_PTPRD_chr9_10033790_ENST00000381196_length(amino acids)=1918AA_BP=
MLPSCRMVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRI
QPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGR
IKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM
PYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYY
IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEP
NGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL
SWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSST
SILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGP
PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYT
TKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR
LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGL
KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN
LKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEM
ELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMD
LDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELAD
HIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPE
TFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGV
PEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVT
CGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
IDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:35819171/chr9:10033790)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCNY

P0C7X3

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311020_110601507.0DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031126_22401507.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311357_161201507.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311644_190301507.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031236_31801507.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST0000035523303124_11401507.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031325_41501507.0DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031420_51601507.0DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031518_60701507.0DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031612_70901507.0DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031714_82201507.0DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031823_91601507.0DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000355233031921_101601507.0DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351020_110601913.0DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035126_22401913.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351357_161201913.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351644_190301913.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035236_31801913.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST0000035643503524_11401913.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035325_41501913.0DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035420_51601913.0DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035518_60701913.0DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035612_70901913.0DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035714_82201913.0DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035823_91601913.0DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000356435035921_101601913.0DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431020_110601913.0DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143126_22401913.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431357_161201913.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431644_190301913.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143236_31801913.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-14324_11401913.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143325_41501913.0DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143420_51601913.0DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143518_60701913.0DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143612_70901913.0DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143714_82201913.0DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143823_91601913.0DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-143921_101601913.0DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291020_110601506.0DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029126_22401506.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291357_161201506.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291644_190301506.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029236_31801506.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST0000039760602924_11401506.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029325_41501506.0DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029420_51601506.0DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029518_60701506.0DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029612_70901506.0DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029714_82201506.0DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029823_91601506.0DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000397606029921_101601506.0DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311020_110601506.0DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031126_22401506.0DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311357_161201506.0DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311644_190301506.0DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031236_31801506.0DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST0000048616103124_11401506.0DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031325_41501506.0DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031420_51601506.0DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031518_60701506.0DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031612_70901506.0DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031714_82201506.0DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031823_91601506.0DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000486161031921_101601506.0DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361020_110601952.3333333333333DomainFibronectin type-III 8
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036126_22401952.3333333333333DomainNote=Ig-like C2-type 2
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361357_161201952.3333333333333DomainTyrosine-protein phosphatase 1
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361644_190301952.3333333333333DomainTyrosine-protein phosphatase 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036236_31801952.3333333333333DomainNote=Ig-like C2-type 3
TgenePTPRDchr10:35819171chr9:10033790ENST0000054010903624_11401952.3333333333333DomainNote=Ig-like C2-type 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036325_41501952.3333333333333DomainFibronectin type-III 1
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036420_51601952.3333333333333DomainFibronectin type-III 2
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036518_60701952.3333333333333DomainFibronectin type-III 3
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036612_70901952.3333333333333DomainFibronectin type-III 4
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036714_82201952.3333333333333DomainFibronectin type-III 5
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036823_91601952.3333333333333DomainFibronectin type-III 6
TgenePTPRDchr10:35819171chr9:10033790ENST00000540109036921_101601952.3333333333333DomainFibronectin type-III 7
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311553_155901507.0RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351553_155901913.0RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431553_155901913.0RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291553_155901506.0RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311553_155901506.0RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361553_155901952.3333333333333RegionSubstrate binding
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311291_191201507.0Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST0000035523303121_126501507.0Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351291_191201913.0Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST0000035643503521_126501913.0Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431291_191201913.0Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-14321_126501913.0Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291291_191201506.0Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST0000039760602921_126501506.0Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311291_191201506.0Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST0000048616103121_126501506.0Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361291_191201952.3333333333333Topological domainCytoplasmic
TgenePTPRDchr10:35819171chr9:10033790ENST0000054010903621_126501952.3333333333333Topological domainExtracellular
TgenePTPRDchr10:35819171chr9:10033790ENST000003552330311266_129001507.0TransmembraneHelical
TgenePTPRDchr10:35819171chr9:10033790ENST000003564350351266_129001913.0TransmembraneHelical
TgenePTPRDchr10:35819171chr9:10033790ENST00000381196-1431266_129001913.0TransmembraneHelical
TgenePTPRDchr10:35819171chr9:10033790ENST000003976060291266_129001506.0TransmembraneHelical
TgenePTPRDchr10:35819171chr9:10033790ENST000004861610311266_129001506.0TransmembraneHelical
TgenePTPRDchr10:35819171chr9:10033790ENST000005401090361266_129001952.3333333333333TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCNYchr10:35819171chr9:10033790ENST00000265375+710143_265139.0288.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35819171chr9:10033790ENST00000339497+69143_265168.0317.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35819171chr9:10033790ENST00000374704+710143_265193.0342.0DomainNote=Cyclin N-terminal
HgeneCCNYchr10:35819171chr9:10033790ENST00000374706+912143_265139.0288.0DomainNote=Cyclin N-terminal


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CCNY
PTPRD


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to CCNY-PTPRD


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to CCNY-PTPRD


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource