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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CD22-CADPS

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CD22-CADPS
FusionPDB ID: 14412
FusionGDB2.0 ID: 14412
HgeneTgene
Gene symbol

CD22

CADPS

Gene ID

933

8618

Gene nameCD22 moleculecalcium dependent secretion activator
SynonymsSIGLEC-2|SIGLEC2CADPS1|CAPS|CAPS1|UNC-31
Cytomap

19q13.12

3p14.2

Type of geneprotein-codingprotein-coding
DescriptionB-cell receptor CD22B-lymphocyte cell adhesion moleculeBL-CAMCD22 antigenT-cell surface antigen Leu-14sialic acid-binding Ig-like lectin 2calcium-dependent secretion activator 1CAPS-1Ca++-dependent secretion activatorCa2+ dependent secretion activatorCa2+-dependent activator protein for secretionCa2+-regulated cytoskeletal proteincalcium-dependent activator protein for secretion 1
Modification date2020031320200313
UniProtAcc

Q15762

Q86UW7

Ensembl transtripts involved in fusion geneENST idsENST00000595419, ENST00000085219, 
ENST00000270311, ENST00000341773, 
ENST00000419549, ENST00000536635, 
ENST00000544992, ENST00000594250, 
ENST00000283269, ENST00000357948, 
ENST00000383710, ENST00000490353, 
ENST00000462768, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 2 X 2=126 X 5 X 5=150
# samples 47
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CD22 [Title/Abstract] AND CADPS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CD22(35820133)-CADPS(62751659), # samples:3
Anticipated loss of major functional domain due to fusion event.CD22-CADPS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD22-CADPS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD22-CADPS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD22-CADPS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD22-CADPS seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD22

GO:0030100

regulation of endocytosis

17562860

HgeneCD22

GO:0042113

B cell activation

26017478

HgeneCD22

GO:0050859

negative regulation of B cell receptor signaling pathway

26017478


check buttonFusion gene breakpoints across CD22 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CADPS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1870-01ACD22chr19

35820133

+CADPSchr3

62751659

-
ChimerDB4OVTCGA-25-1870-01ACD22chr19

35823827

+CADPSchr3

62751659

-
ChimerDB4OVTCGA-25-1870CD22chr19

35820133

+CADPSchr3

62751659

-
ChimerDB4OVTCGA-25-1870CD22chr19

35823827

+CADPSchr3

62751659

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000419549CD22chr1935823827+ENST00000383710CADPSchr362751659-507139135240111219
ENST00000419549CD22chr1935823827+ENST00000357948CADPSchr362751659-483139135237741140
ENST00000419549CD22chr1935823827+ENST00000283269CADPSchr362751659-432939135238941180
ENST00000419549CD22chr1935823827+ENST00000490353CADPSchr362751659-26193913521323323

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000419549ENST00000383710CD22chr1935823827+CADPSchr362751659-0.0003557860.99964416
ENST00000419549ENST00000357948CD22chr1935823827+CADPSchr362751659-0.0005102640.99948967
ENST00000419549ENST00000283269CD22chr1935823827+CADPSchr362751659-0.0009925220.9990075
ENST00000419549ENST00000490353CD22chr1935823827+CADPSchr362751659-0.0012398520.9987601

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14412_14412_1_CD22-CADPS_CD22_chr19_35823827_ENST00000419549_CADPS_chr3_62751659_ENST00000283269_length(amino acids)=1180AA_BP=13
MRNGWNEYTSMSLISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPE
IDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGR
LQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVI
MEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEW
HKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQP
GLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPC
NFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNR
PDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLS
EYAKIEGKKREMYEHPVFCLASQVMDLTIQNVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMD
AALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDA
LQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYH
SKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMY
IERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMK

--------------------------------------------------------------

>14412_14412_2_CD22-CADPS_CD22_chr19_35823827_ENST00000419549_CADPS_chr3_62751659_ENST00000357948_length(amino acids)=1140AA_BP=13
MRNGWNEYTSMSLISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPE
IDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGR
LQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVI
MEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEW
HKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQP
GLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPC
NFDHASLFEMGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEE
IKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENVGRLITPAK
KLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQ
DLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRI
AFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGT
LFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMV

--------------------------------------------------------------

>14412_14412_3_CD22-CADPS_CD22_chr19_35823827_ENST00000419549_CADPS_chr3_62751659_ENST00000383710_length(amino acids)=1219AA_BP=13
MRNGWNEYTSMSLISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPE
IDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGR
LQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVI
MEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEW
HKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQP
GLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPC
NFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNR
PDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLS
EYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDT
WDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVN
IPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSR
STDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVK
AASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQG

--------------------------------------------------------------

>14412_14412_4_CD22-CADPS_CD22_chr19_35823827_ENST00000419549_CADPS_chr3_62751659_ENST00000490353_length(amino acids)=323AA_BP=13
MRNGWNEYTSMSLISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPE
IDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGR
LQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:35820133/chr3:62751659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD22

Q15762

CADPS

Q86UW7

FUNCTION: Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:8673704}.FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+31420_138137.33333333333334848.0DomainNote=Ig-like V-type
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+31220_138137.33333333333334671.0DomainNote=Ig-like V-type
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+31320_138137.33333333333334760.0DomainNote=Ig-like V-type
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+31320_138137.33333333333334867.0DomainNote=Ig-like V-type
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+21120_138137.33333333333334671.0DomainNote=Ig-like V-type
TgeneCADPSchr19:35823827chr3:62751659ENST00000283269028380_495147.01315.0DomainC2
TgeneCADPSchr19:35823827chr3:62751659ENST00000283269028521_624147.01315.0DomainPH
TgeneCADPSchr19:35823827chr3:62751659ENST00000283269028931_1111147.01315.0DomainMHD1
TgeneCADPSchr19:35823827chr3:62751659ENST00000357948027380_495147.01275.0DomainC2
TgeneCADPSchr19:35823827chr3:62751659ENST00000357948027521_624147.01275.0DomainPH
TgeneCADPSchr19:35823827chr3:62751659ENST00000357948027931_1111147.01275.0DomainMHD1
TgeneCADPSchr19:35823827chr3:62751659ENST00000383710030380_495147.01354.0DomainC2
TgeneCADPSchr19:35823827chr3:62751659ENST00000383710030521_624147.01354.0DomainPH
TgeneCADPSchr19:35823827chr3:62751659ENST00000383710030931_1111147.01354.0DomainMHD1
TgeneCADPSchr19:35823827chr3:62751659ENST0000049035307380_495147.0458.0DomainC2
TgeneCADPSchr19:35823827chr3:62751659ENST0000049035307521_624147.0458.0DomainPH
TgeneCADPSchr19:35823827chr3:62751659ENST0000049035307931_1111147.0458.0DomainMHD1
TgeneCADPSchr19:35823827chr3:62751659ENST000002832690281177_1353147.01315.0RegionMediates targeting and association with DCVs
TgeneCADPSchr19:35823827chr3:62751659ENST000003579480271177_1353147.01275.0RegionMediates targeting and association with DCVs
TgeneCADPSchr19:35823827chr3:62751659ENST000003837100301177_1353147.01354.0RegionMediates targeting and association with DCVs
TgeneCADPSchr19:35823827chr3:62751659ENST00000490353071177_1353147.0458.0RegionMediates targeting and association with DCVs

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314143_235137.33333333333334848.0DomainNote=Ig-like C2-type 1
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314242_326137.33333333333334848.0DomainNote=Ig-like C2-type 2
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314331_416137.33333333333334848.0DomainNote=Ig-like C2-type 3
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314419_500137.33333333333334848.0DomainNote=Ig-like C2-type 4
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314505_582137.33333333333334848.0DomainNote=Ig-like C2-type 5
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314593_676137.33333333333334848.0DomainNote=Ig-like C2-type 6
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312143_235137.33333333333334671.0DomainNote=Ig-like C2-type 1
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312242_326137.33333333333334671.0DomainNote=Ig-like C2-type 2
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312331_416137.33333333333334671.0DomainNote=Ig-like C2-type 3
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312419_500137.33333333333334671.0DomainNote=Ig-like C2-type 4
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312505_582137.33333333333334671.0DomainNote=Ig-like C2-type 5
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312593_676137.33333333333334671.0DomainNote=Ig-like C2-type 6
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313143_235137.33333333333334760.0DomainNote=Ig-like C2-type 1
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313242_326137.33333333333334760.0DomainNote=Ig-like C2-type 2
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313331_416137.33333333333334760.0DomainNote=Ig-like C2-type 3
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313419_500137.33333333333334760.0DomainNote=Ig-like C2-type 4
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313505_582137.33333333333334760.0DomainNote=Ig-like C2-type 5
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313593_676137.33333333333334760.0DomainNote=Ig-like C2-type 6
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313143_235137.33333333333334867.0DomainNote=Ig-like C2-type 1
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313242_326137.33333333333334867.0DomainNote=Ig-like C2-type 2
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313331_416137.33333333333334867.0DomainNote=Ig-like C2-type 3
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313419_500137.33333333333334867.0DomainNote=Ig-like C2-type 4
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313505_582137.33333333333334867.0DomainNote=Ig-like C2-type 5
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313593_676137.33333333333334867.0DomainNote=Ig-like C2-type 6
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211143_235137.33333333333334671.0DomainNote=Ig-like C2-type 1
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211242_326137.33333333333334671.0DomainNote=Ig-like C2-type 2
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211331_416137.33333333333334671.0DomainNote=Ig-like C2-type 3
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211419_500137.33333333333334671.0DomainNote=Ig-like C2-type 4
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211505_582137.33333333333334671.0DomainNote=Ig-like C2-type 5
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211593_676137.33333333333334671.0DomainNote=Ig-like C2-type 6
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314760_765137.33333333333334848.0MotifNote=ITIM motif 1
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314794_799137.33333333333334848.0MotifNote=ITIM motif 2
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314820_825137.33333333333334848.0MotifNote=ITIM motif 3
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314840_845137.33333333333334848.0MotifNote=ITIM motif 4
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312760_765137.33333333333334671.0MotifNote=ITIM motif 1
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312794_799137.33333333333334671.0MotifNote=ITIM motif 2
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312820_825137.33333333333334671.0MotifNote=ITIM motif 3
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312840_845137.33333333333334671.0MotifNote=ITIM motif 4
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313760_765137.33333333333334760.0MotifNote=ITIM motif 1
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313794_799137.33333333333334760.0MotifNote=ITIM motif 2
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313820_825137.33333333333334760.0MotifNote=ITIM motif 3
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313840_845137.33333333333334760.0MotifNote=ITIM motif 4
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313760_765137.33333333333334867.0MotifNote=ITIM motif 1
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313794_799137.33333333333334867.0MotifNote=ITIM motif 2
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313820_825137.33333333333334867.0MotifNote=ITIM motif 3
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313840_845137.33333333333334867.0MotifNote=ITIM motif 4
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211760_765137.33333333333334671.0MotifNote=ITIM motif 1
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211794_799137.33333333333334671.0MotifNote=ITIM motif 2
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211820_825137.33333333333334671.0MotifNote=ITIM motif 3
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211840_845137.33333333333334671.0MotifNote=ITIM motif 4
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+31420_687137.33333333333334848.0Topological domainExtracellular
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314707_847137.33333333333334848.0Topological domainCytoplasmic
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+31220_687137.33333333333334671.0Topological domainExtracellular
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312707_847137.33333333333334671.0Topological domainCytoplasmic
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+31320_687137.33333333333334760.0Topological domainExtracellular
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313707_847137.33333333333334760.0Topological domainCytoplasmic
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+31320_687137.33333333333334867.0Topological domainExtracellular
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313707_847137.33333333333334867.0Topological domainCytoplasmic
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+21120_687137.33333333333334671.0Topological domainExtracellular
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211707_847137.33333333333334671.0Topological domainCytoplasmic
HgeneCD22chr19:35823827chr3:62751659ENST00000085219+314688_706137.33333333333334848.0TransmembraneHelical
HgeneCD22chr19:35823827chr3:62751659ENST00000341773+312688_706137.33333333333334671.0TransmembraneHelical
HgeneCD22chr19:35823827chr3:62751659ENST00000536635+313688_706137.33333333333334760.0TransmembraneHelical
HgeneCD22chr19:35823827chr3:62751659ENST00000544992+313688_706137.33333333333334867.0TransmembraneHelical
HgeneCD22chr19:35823827chr3:62751659ENST00000594250+211688_706137.33333333333334671.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1938_CD22_35823827_CADPS_62751659_ranked_0.pdbCD223582382735823827ENST00000490353CADPSchr362751659-
MRNGWNEYTSMSLISKQQLQTVKDRFQAFLNGETQIMADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPE
IDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGR
LQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVI
MEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEW
HKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQP
GLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRAQKHGMDEFISSNPC
NFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNR
PDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLS
EYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDT
WDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVN
IPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSR
STDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVK
AASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQG
1219


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CD22_pLDDT.png
all structure
all structure
CADPS_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CD22
CADPS


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CD22-CADPS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CD22-CADPS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource