UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CD55-MPC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CD55-MPC2
	FusionPDB ID: 14554
	FusionGDB2.0 ID: 14554
		Hgene	Tgene
	Gene symbol	CD55	MPC2
	Gene ID	1604	25874
	Gene name	CD55 molecule (Cromer blood group)	mitochondrial pyruvate carrier 2
	Synonyms	CHAPLE\|CR\|CROM\|DAF\|TC	BRP44\|SLC54A2
	Cytomap	1q32.2	1q24.2
	Type of gene	protein-coding	protein-coding
	Description	complement decay-accelerating factorCD55 antigenCD55 molecule, decay accelerating factor for complement (Cromer blood group)Cromer blood group antigen	mitochondrial pyruvate carrier 2brain protein 44
	Modification date	20200313	20200313
	UniProtAcc	P08174	O95563
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367067, ENST00000465534, ENST00000314754, ENST00000367062, ENST00000367063, ENST00000367064, ENST00000367065, ENST00000391920, ENST00000391921,	ENST00000271373, ENST00000367846,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 5 X 7=280	7 X 5 X 6=210
	# samples	9	7
	** MAII score	log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CD55 [Title/Abstract] AND MPC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CD55(207500182)-MPC2(167889328), # samples:1
Anticipated loss of major functional domain due to fusion event.	CD55-MPC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD55-MPC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD55-MPC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CD55-MPC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD55	GO:0007204	positive regulation of cytosolic calcium ion concentration	8223854
Hgene	CD55	GO:0030449	regulation of complement activation	25284781
Hgene	CD55	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	12731067
Hgene	CD55	GO:0035743	CD4-positive, alpha-beta T cell cytokine production	16818763
Hgene	CD55	GO:0045916	negative regulation of complement activation	6211481
Hgene	CD55	GO:1903659	regulation of complement-dependent cytotoxicity	25284781
Hgene	CD55	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	16818763
Hgene	CD55	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	16818763

Fusion gene breakpoints across CD55 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MPC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GH-01A	CD55	chr1	207500182	+	MPC2	chr1	167889328	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367064	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2665	922	81	1070	329
ENST00000367064	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1326	922	81	1070	329
ENST00000367063	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2641	898	57	1046	329
ENST00000367063	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1302	898	57	1046	329
ENST00000391921	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2338	595	42	743	233
ENST00000391921	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	999	595	42	743	233
ENST00000314754	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2472	729	65	877	270
ENST00000314754	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1133	729	65	877	270
ENST00000391920	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2425	682	18	830	270
ENST00000391920	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1086	682	18	830	270
ENST00000367062	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2425	682	18	830	270
ENST00000367062	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1086	682	18	830	270
ENST00000367065	CD55	chr1	207500182	+	ENST00000367846	MPC2	chr1	167889328	-	2425	682	18	830	270
ENST00000367065	CD55	chr1	207500182	+	ENST00000271373	MPC2	chr1	167889328	-	1086	682	18	830	270

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367064	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003323711	0.9966763
ENST00000367064	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.004987376	0.9950126
ENST00000367063	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003318719	0.9966813
ENST00000367063	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.005525873	0.9944741
ENST00000391921	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.01472357	0.9852764
ENST00000391921	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.021463605	0.9785364
ENST00000314754	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.002886269	0.9971137
ENST00000314754	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003508338	0.9964916
ENST00000391920	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.002786429	0.99721354
ENST00000391920	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003619621	0.9963804
ENST00000367062	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.002786429	0.99721354
ENST00000367062	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003619621	0.9963804
ENST00000367065	ENST00000367846	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.002786429	0.99721354
ENST00000367065	ENST00000271373	CD55	chr1	207500182	+	MPC2	chr1	167889328	-	0.003619621	0.9963804

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14554_14554_1_CD55-MPC2_CD55_chr1_207500182_ENST00000314754_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_2_CD55-MPC2_CD55_chr1_207500182_ENST00000314754_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_3_CD55-MPC2_CD55_chr1_207500182_ENST00000367062_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_4_CD55-MPC2_CD55_chr1_207500182_ENST00000367062_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_5_CD55-MPC2_CD55_chr1_207500182_ENST00000367063_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=329AA_BP=280
MFVPPLVTQSPSPDPAQSTHLTGIAEPRGFCLLQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPA
VWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPV
GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSV

--------------------------------------------------------------

>14554_14554_6_CD55-MPC2_CD55_chr1_207500182_ENST00000367063_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=329AA_BP=280
MFVPPLVTQSPSPDPAQSTHLTGIAEPRGFCLLQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPA
VWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPV
GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSV

--------------------------------------------------------------

>14554_14554_7_CD55-MPC2_CD55_chr1_207500182_ENST00000367064_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=329AA_BP=280
MFVPPLVTQSPSPDPAQSTHLTGIAEPRGFCLLQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPA
VWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPV
GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSV

--------------------------------------------------------------

>14554_14554_8_CD55-MPC2_CD55_chr1_207500182_ENST00000367064_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=329AA_BP=280
MFVPPLVTQSPSPDPAQSTHLTGIAEPRGFCLLQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPA
VWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPV
GTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSV

--------------------------------------------------------------

>14554_14554_9_CD55-MPC2_CD55_chr1_207500182_ENST00000367065_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_10_CD55-MPC2_CD55_chr1_207500182_ENST00000367065_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_11_CD55-MPC2_CD55_chr1_207500182_ENST00000391920_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_12_CD55-MPC2_CD55_chr1_207500182_ENST00000391920_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=270AA_BP=221
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDI
EEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGI
LFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECRGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK

--------------------------------------------------------------

>14554_14554_13_CD55-MPC2_CD55_chr1_207500182_ENST00000391921_MPC2_chr1_167889328_ENST00000271373_length(amino acids)=233AA_BP=184
MQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITY
KCEESFVKIPGEKDSVICLKGSQWSDIEEFCNQKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL

--------------------------------------------------------------

>14554_14554_14_CD55-MPC2_CD55_chr1_207500182_ENST00000391921_MPC2_chr1_167889328_ENST00000367846_length(amino acids)=233AA_BP=184
MQLAPAAGRSCDSAESRRRVLVLTRRAMTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITY
KCEESFVKIPGEKDSVICLKGSQWSDIEEFCNQKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:207500182/chr1:167889328)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD55 P08174	MPC2 O95563
FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269\|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269\|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269\|PubMed:7525274, ECO:0000305\|PubMed:12409401}.	FUNCTION: Mediates the uptake of pyruvate into mitochondria. {ECO:0000269\|PubMed:22628558}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000314754

161_222

221.33333333333334

441.0

Domain

Sushi 3

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000314754

35_96

221.33333333333334

441.0

Domain

Sushi 1

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000314754

96_160

221.33333333333334

441.0

Domain

Sushi 2

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367062

161_222

221.33333333333334

436.0

Domain

Sushi 3

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367062

35_96

221.33333333333334

436.0

Domain

Sushi 1

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367062

96_160

221.33333333333334

436.0

Domain

Sushi 2

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367064

161_222

221.33333333333334

382.0

Domain

Sushi 3

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367064

35_96

221.33333333333334

382.0

Domain

Sushi 1

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367064

96_160

221.33333333333334

382.0

Domain

Sushi 2

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367065

161_222

221.33333333333334

440.0

Domain

Sushi 3

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367065

35_96

221.33333333333334

440.0

Domain

Sushi 1

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367065

96_160

221.33333333333334

440.0

Domain

Sushi 2

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000391920

161_222

221.33333333333334

456.0

Domain

Sushi 3

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000391920

35_96

221.33333333333334

456.0

Domain

Sushi 1

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000391920

96_160

221.33333333333334

456.0

Domain

Sushi 2

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000271373

96_115

78.33333333333333

128.0

Transmembrane

Helical

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000367846

96_115

78.33333333333333

128.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000314754

287_356

221.33333333333334

441.0

Compositional bias

Note=Ser/Thr-rich

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367062

287_356

221.33333333333334

436.0

Compositional bias

Note=Ser/Thr-rich

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367064

287_356

221.33333333333334

382.0

Compositional bias

Note=Ser/Thr-rich

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367065

287_356

221.33333333333334

440.0

Compositional bias

Note=Ser/Thr-rich

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000391920

287_356

221.33333333333334

456.0

Compositional bias

Note=Ser/Thr-rich

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000314754

223_285

221.33333333333334

441.0

Domain

Sushi 4

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367062

223_285

221.33333333333334

436.0

Domain

Sushi 4

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367064

223_285

221.33333333333334

382.0

Domain

Sushi 4

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000367065

223_285

221.33333333333334

440.0

Domain

Sushi 4

Hgene

CD55

chr1:207500182

chr1:167889328

ENST00000391920

223_285

221.33333333333334

456.0

Domain

Sushi 4

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000271373

41_61

78.33333333333333

128.0

Transmembrane

Helical

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000271373

73_90

78.33333333333333

128.0

Transmembrane

Helical

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000367846

41_61

78.33333333333333

128.0

Transmembrane

Helical

Tgene

MPC2

chr1:207500182

chr1:167889328

ENST00000367846

73_90

78.33333333333333

128.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CD55
MPC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CD55-MPC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CD55-MPC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source