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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CD63-CAPN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CD63-CAPN2
FusionPDB ID: 14581
FusionGDB2.0 ID: 14581
HgeneTgene
Gene symbol

CD63

CAPN2

Gene ID

967

824

Gene nameCD63 moleculecalpain 2
SynonymsLAMP-3|ME491|MLA1|OMA81H|TSPAN30CANP2|CANPL2|CANPml|mCANP
Cytomap

12q13.2

1q41

Type of geneprotein-codingprotein-coding
DescriptionCD63 antigenCD63 antigen (melanoma 1 antigen)granulophysinlysosomal-associated membrane protein 3lysosome-associated membrane glycoprotein 3melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspacalpain-2 catalytic subunitCANP 2M-calpaincalcium-activated neutral proteinase 2calpain 2, (m/II) large subunitcalpain 2, large [catalytic] subunitcalpain 2, large subunitcalpain M-typecalpain, large polypeptide L2millimolar-calpain
Modification date2020032720200313
UniProtAcc

P08962

P17655

Ensembl transtripts involved in fusion geneENST idsENST00000257857, ENST00000420846, 
ENST00000546939, ENST00000548160, 
ENST00000548898, ENST00000549117, 
ENST00000550776, ENST00000552067, 
ENST00000552692, ENST00000552754, 
ENST00000474026, ENST00000295006, 
ENST00000433674, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 19 X 9=393311 X 7 X 7=539
# samples 2311
** MAII scorelog2(23/3933*10)=-4.09592441999854
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/539*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CD63 [Title/Abstract] AND CAPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CD63(56120484)-CAPN2(223946972), # samples:1
Anticipated loss of major functional domain due to fusion event.CD63-CAPN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD63-CAPN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD63-CAPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD63-CAPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD63-CAPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CD63-CAPN2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD63

GO:0034613

cellular protein localization

15647390

HgeneCD63

GO:1901379

regulation of potassium ion transmembrane transport

15647390

TgeneCAPN2

GO:0051603

proteolysis involved in cellular protein catabolic process

12150984


check buttonFusion gene breakpoints across CD63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8059-01ACD63chr12

56120484

-CAPN2chr1

223946972

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000548898CD63chr1256120484-ENST00000433674CAPN2chr1223946972+214319839983314
ENST00000548898CD63chr1256120484-ENST00000295006CAPN2chr1223946972+214519839983314
ENST00000420846CD63chr1256120484-ENST00000433674CAPN2chr1223946972+25566111611396411
ENST00000420846CD63chr1256120484-ENST00000295006CAPN2chr1223946972+25586111611396411
ENST00000548160CD63chr1256120484-ENST00000433674CAPN2chr1223946972+2211266831051322
ENST00000548160CD63chr1256120484-ENST00000295006CAPN2chr1223946972+2213266831051322
ENST00000552692CD63chr1256120484-ENST00000433674CAPN2chr1223946972+25125671411352403
ENST00000552692CD63chr1256120484-ENST00000295006CAPN2chr1223946972+25145671411352403
ENST00000257857CD63chr1256120484-ENST00000433674CAPN2chr1223946972+26507052551490411
ENST00000257857CD63chr1256120484-ENST00000295006CAPN2chr1223946972+26527052551490411
ENST00000552754CD63chr1256120484-ENST00000433674CAPN2chr1223946972+231036581150380
ENST00000552754CD63chr1256120484-ENST00000295006CAPN2chr1223946972+231236581150380

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000548898ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0006785060.99932146
ENST00000548898ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0006812240.99931884
ENST00000420846ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0004463590.9995536
ENST00000420846ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0004471580.9995528
ENST00000548160ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0006014210.9993986
ENST00000548160ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0006046310.9993954
ENST00000552692ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0003939240.9996061
ENST00000552692ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0003939410.9996061
ENST00000257857ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0004356970.99956435
ENST00000257857ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0004361080.9995639
ENST00000552754ENST00000433674CD63chr1256120484-CAPN2chr1223946972+0.0002789730.999721
ENST00000552754ENST00000295006CD63chr1256120484-CAPN2chr1223946972+0.0002814920.9997185

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14581_14581_1_CD63-CAPN2_CD63_chr12_56120484_ENST00000257857_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=411AA_BP=150
MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL
MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLR
EVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVAR

--------------------------------------------------------------

>14581_14581_2_CD63-CAPN2_CD63_chr12_56120484_ENST00000257857_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=411AA_BP=150
MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL
MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLR
EVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVAR

--------------------------------------------------------------

>14581_14581_3_CD63-CAPN2_CD63_chr12_56120484_ENST00000420846_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=411AA_BP=150
MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL
MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLR
EVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVAR

--------------------------------------------------------------

>14581_14581_4_CD63-CAPN2_CD63_chr12_56120484_ENST00000420846_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=411AA_BP=150
MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL
MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLR
EVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRR
VLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVAR

--------------------------------------------------------------

>14581_14581_5_CD63-CAPN2_CD63_chr12_56120484_ENST00000548160_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=322AA_BP=61
MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINL
REVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR
RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVA

--------------------------------------------------------------

>14581_14581_6_CD63-CAPN2_CD63_chr12_56120484_ENST00000548160_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=322AA_BP=61
MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINL
REVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILR
RVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVA

--------------------------------------------------------------

>14581_14581_7_CD63-CAPN2_CD63_chr12_56120484_ENST00000548898_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=314AA_BP=53
MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK
LPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD
IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLI

--------------------------------------------------------------

>14581_14581_8_CD63-CAPN2_CD63_chr12_56120484_ENST00000548898_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=314AA_BP=53
MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFK
LPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQD
IKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLI

--------------------------------------------------------------

>14581_14581_9_CD63-CAPN2_CD63_chr12_56120484_ENST00000552692_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=403AA_BP=142
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL
SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKL
PPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDI
KSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLII

--------------------------------------------------------------

>14581_14581_10_CD63-CAPN2_CD63_chr12_56120484_ENST00000552692_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=403AA_BP=142
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL
SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKL
PPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDI
KSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLII

--------------------------------------------------------------

>14581_14581_11_CD63-CAPN2_CD63_chr12_56120484_ENST00000552754_CAPN2_chr1_223946972_ENST00000295006_length(amino acids)=380AA_BP=119
MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS
EFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIR
VFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSG
KLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLD

--------------------------------------------------------------

>14581_14581_12_CD63-CAPN2_CD63_chr12_56120484_ENST00000552754_CAPN2_chr1_223946972_ENST00000433674_length(amino acids)=380AA_BP=119
MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS
EFNNNFRQQMENYPKNNHTASILDRMQADLSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIR
VFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSG
KLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56120484/chr1:223946972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD63

P08962

CAPN2

P17655

FUNCTION: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-582_11142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-5833_51142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-5873_81142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-472_1160.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-4733_5160.0157.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-582_11142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-5833_51142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-5873_81142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-472_1160.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-4733_5160.0157.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-472_11142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-4733_51142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-4773_81142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-472_11119.0216.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-4733_51119.0216.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-4773_81119.0216.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-5812_32142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-5852_72142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-5882_102142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-4712_3260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-5812_32142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-5852_72142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-5882_102142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-4712_3260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-4712_32142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-4752_72142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-4782_102142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-4712_32119.0216.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-4752_72119.0216.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-4782_102119.0216.0TransmembraneHelical
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021585_596439.0701.0Calcium bindingNote=1
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021615_626439.0701.0Calcium bindingNote=2
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021585_596361.0623.0Calcium bindingNote=1
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021615_626361.0623.0Calcium bindingNote=2
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021572_605439.0701.0DomainEF-hand 1
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021602_637439.0701.0DomainEF-hand 2
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021667_700439.0701.0DomainEF-hand 3
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021572_605361.0623.0DomainEF-hand 1
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021602_637361.0623.0DomainEF-hand 2
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021667_700361.0623.0DomainEF-hand 3
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021515_529439.0701.0RegionNote=Linker
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021530_700439.0701.0RegionNote=Domain IV
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021515_529361.0623.0RegionNote=Linker
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021530_700361.0623.0RegionNote=Domain IV

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-58234_238142.0239.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-47234_23860.0157.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-58234_238142.0239.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-47234_23860.0157.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-47234_238142.0239.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-47234_238119.0216.0MotifLysosomal targeting motif
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-58103_203142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-58225_238142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-47103_20360.0157.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-47225_23860.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-4773_8160.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-58103_203142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-58225_238142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-47103_20360.0157.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-47225_23860.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-4773_8160.0157.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-47103_203142.0239.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-47225_238142.0239.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-47103_203119.0216.0Topological domainExtracellular
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-47225_238119.0216.0Topological domainCytoplasmic
HgeneCD63chr12:56120484chr1:223946972ENST00000257857-58204_224142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-47204_22460.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-4752_7260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000546939-4782_10260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000549117-58204_224142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-47204_22460.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-4752_7260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000550776-4782_10260.0157.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552692-47204_224142.0239.0TransmembraneHelical
HgeneCD63chr12:56120484chr1:223946972ENST00000552754-47204_224119.0216.0TransmembraneHelical
TgeneCAPN2chr12:56120484chr1:223946972ENST00000295006102145_344439.0701.0DomainCalpain catalytic
TgeneCAPN2chr12:56120484chr1:223946972ENST00000433674102145_344361.0623.0DomainCalpain catalytic
TgeneCAPN2chr12:56120484chr1:223946972ENST000002950061021345_514439.0701.0RegionNote=Domain III
TgeneCAPN2chr12:56120484chr1:223946972ENST000004336741021345_514361.0623.0RegionNote=Domain III


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CD63
CAPN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CD63-CAPN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CD63-CAPN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource