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Fusion Protein:CD63-OS9 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CD63-OS9 | FusionPDB ID: 14591 | FusionGDB2.0 ID: 14591 | Hgene | Tgene | Gene symbol | CD63 | OS9 | Gene ID | 967 | 10956 |
| Gene name | CD63 molecule | OS9 endoplasmic reticulum lectin | |
| Synonyms | LAMP-3|ME491|MLA1|OMA81H|TSPAN30 | ERLEC2|OS-9 | |
| Cytomap | 12q13.2 | 12q13.3-q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD63 antigenCD63 antigen (melanoma 1 antigen)granulophysinlysosomal-associated membrane protein 3lysosome-associated membrane glycoprotein 3melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspa | protein OS-9amplified in osteosarcoma 9endoplasmic reticulum lectin 2erlectin 2osteosarcoma amplified 9, endoplasmic reticulum associated proteinosteosarcoma amplified 9, endoplasmic reticulum lectin | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | P08962 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000257857, ENST00000420846, ENST00000546939, ENST00000548160, ENST00000548898, ENST00000549117, ENST00000550776, ENST00000552067, ENST00000552692, ENST00000552754, | ENST00000257966, ENST00000389142, ENST00000413095, ENST00000435406, ENST00000551035, ENST00000315970, ENST00000389146, ENST00000439210, ENST00000552285, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 23 X 19 X 9=3933 | 28 X 16 X 12=5376 |
| # samples | 23 | 38 | |
| ** MAII score | log2(23/3933*10)=-4.09592441999854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/5376*10)=-3.82246181444781 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CD63 [Title/Abstract] AND OS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CD63(56119597)-OS9(58109543), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | CD63-OS9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD63-OS9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD63-OS9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CD63-OS9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CD63-OS9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD63 | GO:0034613 | cellular protein localization | 15647390 |
| Hgene | CD63 | GO:1901379 | regulation of potassium ion transmembrane transport | 15647390 |
| Tgene | OS9 | GO:0006621 | protein retention in ER lumen | 18417469 |
| Tgene | OS9 | GO:0034976 | response to endoplasmic reticulum stress | 19084021 |
| Fusion gene breakpoints across CD63 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across OS9 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-4Z-AA7S-01A | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + |
| ChimerDB4 | BLCA | TCGA-4Z-AA7S | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000548898 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 1772 | 423 | 39 | 1682 | 547 |
| ENST00000548898 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 2494 | 423 | 39 | 1847 | 602 |
| ENST00000548898 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 1948 | 423 | 39 | 1637 | 532 |
| ENST00000548898 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 1918 | 423 | 39 | 1802 | 587 |
| ENST00000420846 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 2179 | 830 | 161 | 2089 | 642 |
| ENST00000420846 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 2901 | 830 | 161 | 2254 | 697 |
| ENST00000420846 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 2355 | 830 | 161 | 2044 | 627 |
| ENST00000420846 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 2325 | 830 | 161 | 2209 | 682 |
| ENST00000548160 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 1840 | 491 | 83 | 1750 | 555 |
| ENST00000548160 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 2562 | 491 | 83 | 1915 | 610 |
| ENST00000548160 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 2016 | 491 | 83 | 1705 | 540 |
| ENST00000548160 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 1986 | 491 | 83 | 1870 | 595 |
| ENST00000552692 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 2141 | 792 | 141 | 2051 | 636 |
| ENST00000552692 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 2863 | 792 | 141 | 2216 | 691 |
| ENST00000552692 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 2317 | 792 | 141 | 2006 | 621 |
| ENST00000552692 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 2287 | 792 | 141 | 2171 | 676 |
| ENST00000257857 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 2279 | 930 | 255 | 2189 | 644 |
| ENST00000257857 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 3001 | 930 | 255 | 2354 | 699 |
| ENST00000257857 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 2455 | 930 | 255 | 2144 | 629 |
| ENST00000257857 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 2425 | 930 | 255 | 2309 | 684 |
| ENST00000552754 | CD63 | chr12 | 56119597 | - | ENST00000552285 | OS9 | chr12 | 58109543 | + | 1939 | 590 | 8 | 1849 | 613 |
| ENST00000552754 | CD63 | chr12 | 56119597 | - | ENST00000315970 | OS9 | chr12 | 58109543 | + | 2661 | 590 | 8 | 2014 | 668 |
| ENST00000552754 | CD63 | chr12 | 56119597 | - | ENST00000439210 | OS9 | chr12 | 58109543 | + | 2115 | 590 | 8 | 1804 | 598 |
| ENST00000552754 | CD63 | chr12 | 56119597 | - | ENST00000389146 | OS9 | chr12 | 58109543 | + | 2085 | 590 | 8 | 1969 | 653 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000548898 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002948667 | 0.99705136 |
| ENST00000548898 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002705126 | 0.99729484 |
| ENST00000548898 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003054847 | 0.9969452 |
| ENST00000548898 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003626496 | 0.9963735 |
| ENST00000420846 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003303505 | 0.9966965 |
| ENST00000420846 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002805534 | 0.9971944 |
| ENST00000420846 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002861047 | 0.997139 |
| ENST00000420846 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003137324 | 0.99686265 |
| ENST00000548160 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002502818 | 0.99749714 |
| ENST00000548160 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002422718 | 0.99757725 |
| ENST00000548160 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002812846 | 0.9971872 |
| ENST00000548160 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003045003 | 0.99695504 |
| ENST00000552692 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002902221 | 0.99709785 |
| ENST00000552692 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002512326 | 0.99748766 |
| ENST00000552692 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002810741 | 0.9971892 |
| ENST00000552692 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.0025204 | 0.9974796 |
| ENST00000257857 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003613992 | 0.99638605 |
| ENST00000257857 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003007411 | 0.9969926 |
| ENST00000257857 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.003274734 | 0.99672526 |
| ENST00000257857 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002963959 | 0.9970361 |
| ENST00000552754 | ENST00000552285 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002177037 | 0.997823 |
| ENST00000552754 | ENST00000315970 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002168335 | 0.99783164 |
| ENST00000552754 | ENST00000439210 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.00176915 | 0.9982309 |
| ENST00000552754 | ENST00000389146 | CD63 | chr12 | 56119597 | - | OS9 | chr12 | 58109543 | + | 0.002126879 | 0.99787307 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >14591_14591_1_CD63-OS9_CD63_chr12_56119597_ENST00000257857_OS9_chr12_58109543_ENST00000315970_length(amino acids)=699AA_BP=225 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPS AAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEV PAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEED EDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQ SPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRP -------------------------------------------------------------- >14591_14591_2_CD63-OS9_CD63_chr12_56119597_ENST00000257857_OS9_chr12_58109543_ENST00000389146_length(amino acids)=684AA_BP=225 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPS AAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEV PAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEED EDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVP KKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDE -------------------------------------------------------------- >14591_14591_3_CD63-OS9_CD63_chr12_56119597_ENST00000257857_OS9_chr12_58109543_ENST00000439210_length(amino acids)=629AA_BP=225 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPS AAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEV PAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEED EDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVP -------------------------------------------------------------- >14591_14591_4_CD63-OS9_CD63_chr12_56119597_ENST00000257857_OS9_chr12_58109543_ENST00000552285_length(amino acids)=644AA_BP=225 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPS AAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEV PAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEED EDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQ SPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGS -------------------------------------------------------------- >14591_14591_5_CD63-OS9_CD63_chr12_56119597_ENST00000420846_OS9_chr12_58109543_ENST00000315970_length(amino acids)=697AA_BP=223 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPA EEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSP ELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWA -------------------------------------------------------------- >14591_14591_6_CD63-OS9_CD63_chr12_56119597_ENST00000420846_OS9_chr12_58109543_ENST00000389146_length(amino acids)=682AA_BP=223 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPA EEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKK PPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDT -------------------------------------------------------------- >14591_14591_7_CD63-OS9_CD63_chr12_56119597_ENST00000420846_OS9_chr12_58109543_ENST00000439210_length(amino acids)=627AA_BP=223 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPA EEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKK -------------------------------------------------------------- >14591_14591_8_CD63-OS9_CD63_chr12_56119597_ENST00000420846_OS9_chr12_58109543_ENST00000552285_length(amino acids)=642AA_BP=223 MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAA PQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPA EEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDED EDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSP ELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPG -------------------------------------------------------------- >14591_14591_9_CD63-OS9_CD63_chr12_56119597_ENST00000548160_OS9_chr12_58109543_ENST00000315970_length(amino acids)=610AA_BP=136 MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCI NVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPP SAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEE VPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEE DEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEK QSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVR -------------------------------------------------------------- >14591_14591_10_CD63-OS9_CD63_chr12_56119597_ENST00000548160_OS9_chr12_58109543_ENST00000389146_length(amino acids)=595AA_BP=136 MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCI NVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPP SAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEE VPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEE DEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVV PKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTD -------------------------------------------------------------- >14591_14591_11_CD63-OS9_CD63_chr12_56119597_ENST00000548160_OS9_chr12_58109543_ENST00000439210_length(amino acids)=540AA_BP=136 MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCI NVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPP SAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEE VPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEE DEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVV PKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF -------------------------------------------------------------- >14591_14591_12_CD63-OS9_CD63_chr12_56119597_ENST00000548160_OS9_chr12_58109543_ENST00000552285_length(amino acids)=555AA_BP=136 MLLQFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCI NVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPP SAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEE VPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEE DEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEK QSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWG -------------------------------------------------------------- >14591_14591_13_CD63-OS9_CD63_chr12_56119597_ENST00000548898_OS9_chr12_58109543_ENST00000315970_length(amino acids)=602AA_BP=128 MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGI NFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAIL CHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDP SPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDE DEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKK HKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEE -------------------------------------------------------------- >14591_14591_14_CD63-OS9_CD63_chr12_56119597_ENST00000548898_OS9_chr12_58109543_ENST00000389146_length(amino acids)=587AA_BP=128 MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGI NFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAIL CHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDP SPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDE DEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSP QPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKE -------------------------------------------------------------- >14591_14591_15_CD63-OS9_CD63_chr12_56119597_ENST00000548898_OS9_chr12_58109543_ENST00000439210_length(amino acids)=532AA_BP=128 MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGI NFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAIL CHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDP SPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDE DEDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSP -------------------------------------------------------------- >14591_14591_16_CD63-OS9_CD63_chr12_56119597_ENST00000548898_OS9_chr12_58109543_ENST00000552285_length(amino acids)=547AA_BP=128 MSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGI NFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAIL CHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDP SPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDE DEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKK HKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTG -------------------------------------------------------------- >14591_14591_17_CD63-OS9_CD63_chr12_56119597_ENST00000552692_OS9_chr12_58109543_ENST00000315970_length(amino acids)=691AA_BP=217 MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGIN FNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILC HPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPS PEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDED EDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKH KKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEG -------------------------------------------------------------- >14591_14591_18_CD63-OS9_CD63_chr12_56119597_ENST00000552692_OS9_chr12_58109543_ENST00000389146_length(amino acids)=676AA_BP=217 MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGIN FNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILC HPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPS PEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDED EDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQ PTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEI -------------------------------------------------------------- >14591_14591_19_CD63-OS9_CD63_chr12_56119597_ENST00000552692_OS9_chr12_58109543_ENST00000439210_length(amino acids)=621AA_BP=217 MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGIN FNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILC HPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPS PEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDED EDERQLLGEFEKELEGILLPSDRDRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQ -------------------------------------------------------------- >14591_14591_20_CD63-OS9_CD63_chr12_56119597_ENST00000552692_OS9_chr12_58109543_ENST00000552285_length(amino acids)=636AA_BP=217 MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFL SLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGIN FNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILC HPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPS PEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDED EDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKH KKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGD -------------------------------------------------------------- >14591_14591_21_CD63-OS9_CD63_chr12_56119597_ENST00000552754_OS9_chr12_58109543_ENST00000315970_length(amino acids)=668AA_BP=194 MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS EFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNV LVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYG DKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDR DRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEH RVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPG -------------------------------------------------------------- >14591_14591_22_CD63-OS9_CD63_chr12_56119597_ENST00000552754_OS9_chr12_58109543_ENST00000389146_length(amino acids)=653AA_BP=194 MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS EFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNV LVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYG DKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDR DRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPN QDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELE -------------------------------------------------------------- >14591_14591_23_CD63-OS9_CD63_chr12_56119597_ENST00000552754_OS9_chr12_58109543_ENST00000439210_length(amino acids)=598AA_BP=194 MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS EFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNV LVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYG DKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDR DRLRSETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKIVRPWAEGTEEGARW -------------------------------------------------------------- >14591_14591_24_CD63-OS9_CD63_chr12_56119597_ENST00000552754_OS9_chr12_58109543_ENST00000552285_length(amino acids)=613AA_BP=194 MAVEGGMKCVKFLLYVLLLAFCGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMS EFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNV LVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYG DKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVI RSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDR DRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIK -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:56119597/chr12:58109543) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD63 | . |
| FUNCTION: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 103_203 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 2_11 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 33_51 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 73_81 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 2_11 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 33_51 | 135.0 | 157.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 73_81 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 103_203 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 2_11 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 33_51 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 73_81 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 2_11 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 33_51 | 135.0 | 157.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 73_81 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 103_203 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 2_11 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 33_51 | 217.0 | 239.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 73_81 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 2_11 | 194.0 | 216.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 33_51 | 194.0 | 216.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 73_81 | 194.0 | 216.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 12_32 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 52_72 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 82_102 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 12_32 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 52_72 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 82_102 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 12_32 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 52_72 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 82_102 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 12_32 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 52_72 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 82_102 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 12_32 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 52_72 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 82_102 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 12_32 | 194.0 | 216.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 52_72 | 194.0 | 216.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 82_102 | 194.0 | 216.0 | Transmembrane | Helical |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000257966 | 4 | 14 | 414_429 | 193.0 | 614.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000315970 | 4 | 15 | 414_429 | 193.0 | 668.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000389142 | 4 | 14 | 414_429 | 193.0 | 598.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000389146 | 4 | 15 | 414_429 | 193.0 | 653.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000435406 | 3 | 13 | 414_429 | 141.0 | 561.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000439210 | 3 | 13 | 414_429 | 134.0 | 539.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000551035 | 3 | 13 | 414_429 | 160.0 | 581.0 | Compositional bias | Note=Asp/Glu-rich (acidic) | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000552285 | 4 | 14 | 414_429 | 193.0 | 613.0 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 234_238 | 217.0 | 239.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 234_238 | 135.0 | 157.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 234_238 | 217.0 | 239.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 234_238 | 135.0 | 157.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 234_238 | 217.0 | 239.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 234_238 | 194.0 | 216.0 | Motif | Lysosomal targeting motif |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 225_238 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 103_203 | 135.0 | 157.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 225_238 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 225_238 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 103_203 | 135.0 | 157.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 225_238 | 135.0 | 157.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 225_238 | 217.0 | 239.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 103_203 | 194.0 | 216.0 | Topological domain | Extracellular |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 225_238 | 194.0 | 216.0 | Topological domain | Cytoplasmic |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000257857 | - | 7 | 8 | 204_224 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000546939 | - | 6 | 7 | 204_224 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000549117 | - | 7 | 8 | 204_224 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000550776 | - | 6 | 7 | 204_224 | 135.0 | 157.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552692 | - | 6 | 7 | 204_224 | 217.0 | 239.0 | Transmembrane | Helical |
| Hgene | CD63 | chr12:56119597 | chr12:58109543 | ENST00000552754 | - | 6 | 7 | 204_224 | 194.0 | 216.0 | Transmembrane | Helical |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000257966 | 4 | 14 | 108_230 | 193.0 | 614.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000315970 | 4 | 15 | 108_230 | 193.0 | 668.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000389142 | 4 | 14 | 108_230 | 193.0 | 598.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000389146 | 4 | 15 | 108_230 | 193.0 | 653.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000435406 | 3 | 13 | 108_230 | 141.0 | 561.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000439210 | 3 | 13 | 108_230 | 134.0 | 539.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000551035 | 3 | 13 | 108_230 | 160.0 | 581.0 | Domain | MRH | |
| Tgene | OS9 | chr12:56119597 | chr12:58109543 | ENST00000552285 | 4 | 14 | 108_230 | 193.0 | 613.0 | Domain | MRH |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
| PDB file >>>1436_CD63_56119597_OS9_58109543_ranked_0.pdb | CD63 | 56119597 | 56119597 | ENST00000389146 | OS9 | chr12 | 58109543 | + | MGSPGPAAMAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCL MITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCIN VTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPS AAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEV PAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEED EDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQ SPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRP | 699 |
Top |
pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
CD63_pLDDT.png  |
OS9_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
 |
Top |
Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CD63 | |
| OS9 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to CD63-OS9 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CD63-OS9 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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