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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CD99L2-PICALM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CD99L2-PICALM
FusionPDB ID: 14732
FusionGDB2.0 ID: 14732
HgeneTgene
Gene symbol

CD99L2

PICALM

Gene ID

83692

8301

Gene nameCD99 molecule like 2phosphatidylinositol binding clathrin assembly protein
SynonymsCD99B|MIC2L1CALM|CLTH|LAP
Cytomap

Xq28

11q14.2

Type of geneprotein-codingprotein-coding
DescriptionCD99 antigen-like protein 2MIC2 like 1MIC2-like protein 1phosphatidylinositol-binding clathrin assembly proteinclathrin assembly lymphoid myeloid leukemia protein
Modification date2020031320200322
UniProtAcc

Q8TCZ2

Q13492

Ensembl transtripts involved in fusion geneENST idsENST00000370377, ENST00000437787, 
ENST00000346693, ENST00000320893, 
ENST00000355149, ENST00000466436, 
ENST00000356360, ENST00000528398, 
ENST00000528411, ENST00000393346, 
ENST00000526033, ENST00000532317, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 14 X 6=134435 X 26 X 12=10920
# samples 1844
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(44/10920*10)=-4.63332552228256
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CD99L2 [Title/Abstract] AND PICALM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CD99L2(149983335)-PICALM(85742653), # samples:1
Anticipated loss of major functional domain due to fusion event.CD99L2-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD99L2-PICALM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD99L2-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD99L2-PICALM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePICALM

GO:0006897

endocytosis

22118466

TgenePICALM

GO:0006898

receptor-mediated endocytosis

10436022

TgenePICALM

GO:0032880

regulation of protein localization

10436022

TgenePICALM

GO:0045893

positive regulation of transcription, DNA-templated

11425879

TgenePICALM

GO:0048261

negative regulation of receptor-mediated endocytosis

10436022

TgenePICALM

GO:1905224

clathrin-coated pit assembly

16262731


check buttonFusion gene breakpoints across CD99L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PICALM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315353CD99L2chrX

149983335

-PICALMchr11

85742653

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370377CD99L2chrX149983335-ENST00000532317PICALMchr1185742653-3460395822097671
ENST00000370377CD99L2chrX149983335-ENST00000526033PICALMchr1185742653-3561395822202706
ENST00000370377CD99L2chrX149983335-ENST00000393346PICALMchr1185742653-2456395822223713
ENST00000437787CD99L2chrX149983335-ENST00000532317PICALMchr1185742653-35705051922207671
ENST00000437787CD99L2chrX149983335-ENST00000526033PICALMchr1185742653-36715051922312706
ENST00000437787CD99L2chrX149983335-ENST00000393346PICALMchr1185742653-25665051922333713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370377ENST00000532317CD99L2chrX149983335-PICALMchr1185742653-0.0003516740.99964833
ENST00000370377ENST00000526033CD99L2chrX149983335-PICALMchr1185742653-0.0003540210.99964595
ENST00000370377ENST00000393346CD99L2chrX149983335-PICALMchr1185742653-0.0009701120.9990299
ENST00000437787ENST00000532317CD99L2chrX149983335-PICALMchr1185742653-0.0003704010.9996296
ENST00000437787ENST00000526033CD99L2chrX149983335-PICALMchr1185742653-0.0003704030.9996296
ENST00000437787ENST00000393346CD99L2chrX149983335-PICALMchr1185742653-0.0010272430.9989728

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14732_14732_1_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000370377_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=713AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQP
HPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGE

--------------------------------------------------------------

>14732_14732_2_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000370377_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=706AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLN
VDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGS

--------------------------------------------------------------

>14732_14732_3_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000370377_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=671AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAK
LPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTPTGMIGY

--------------------------------------------------------------

>14732_14732_4_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000437787_PICALM_chr11_85742653_ENST00000393346_length(amino acids)=713AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQP
HPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGE

--------------------------------------------------------------

>14732_14732_5_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000437787_PICALM_chr11_85742653_ENST00000526033_length(amino acids)=706AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLN
VDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGS

--------------------------------------------------------------

>14732_14732_6_CD99L2-PICALM_CD99L2_chrX_149983335_ENST00000437787_PICALM_chr11_85742653_ENST00000532317_length(amino acids)=671AA_BP=104
MCSSGALRLLPAMVAWRSAFLVCLAFSLATLVQRGSGDFDDFNLEDAVKETSSVKQPWDHTTTTTTNRPGTTRAPAKPPGSGLDLADALD
DQDDGRRKPGIGGRDLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYD
MSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFA
AYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRA
TTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKL
PNDLLDLQQPTFHPSVHPMSTASQVASTWGGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAK
LPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMNGMHFPQYAPPVMAYPATTPTGMIGY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:149983335/chr11:85742653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD99L2

Q8TCZ2

PICALM

Q13492

FUNCTION: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}.FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly (PubMed:10436022, PubMed:16262731, PubMed:27574975). Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature (PubMed:25898166). In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8 (PubMed:22118466, PubMed:21808019, PubMed:23741335). In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors (PubMed:25241929). Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF) (PubMed:25241929, PubMed:24067654). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16262731, ECO:0000269|PubMed:21808019, ECO:0000269|PubMed:22118466, ECO:0000269|PubMed:23741335, ECO:0000269|PubMed:24067654, ECO:0000269|PubMed:25241929, ECO:0000269|PubMed:25898166, ECO:0000269|PubMed:27574975}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-41149_5492.33333333333333263.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-4849_5492.33333333333333190.0Compositional biasNote=Poly-Thr
TgenePICALMchrX:149983335chr11:85742653ENST0000052839801914_1450552.0DomainENTH

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-13141_1440146.0Compositional biasNote=Poly-Gly
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-13253_2590146.0Compositional biasNote=Poly-Pro
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-1349_540146.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-1399_1020146.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-18141_1440191.0Compositional biasNote=Poly-Gly
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-18253_2590191.0Compositional biasNote=Poly-Pro
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-1849_540191.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-1899_1020191.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-411141_14492.33333333333333263.0Compositional biasNote=Poly-Gly
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-411253_25992.33333333333333263.0Compositional biasNote=Poly-Pro
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-41199_10292.33333333333333263.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-48141_14492.33333333333333190.0Compositional biasNote=Poly-Gly
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-48253_25992.33333333333333190.0Compositional biasNote=Poly-Pro
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-4899_10292.33333333333333190.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-19141_1440214.0Compositional biasNote=Poly-Gly
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-19253_2590214.0Compositional biasNote=Poly-Pro
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-1949_540214.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-1999_1020214.0Compositional biasNote=Poly-Thr
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-13207_2620146.0Topological domainCytoplasmic
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-1326_1850146.0Topological domainExtracellular
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-18207_2620191.0Topological domainCytoplasmic
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-1826_1850191.0Topological domainExtracellular
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-411207_26292.33333333333333263.0Topological domainCytoplasmic
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-41126_18592.33333333333333263.0Topological domainExtracellular
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-48207_26292.33333333333333190.0Topological domainCytoplasmic
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-4826_18592.33333333333333190.0Topological domainExtracellular
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-19207_2620214.0Topological domainCytoplasmic
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-1926_1850214.0Topological domainExtracellular
HgeneCD99L2chrX:149983335chr11:85742653ENST00000320893-13186_2060146.0TransmembraneHelical
HgeneCD99L2chrX:149983335chr11:85742653ENST00000355149-18186_2060191.0TransmembraneHelical
HgeneCD99L2chrX:149983335chr11:85742653ENST00000370377-411186_20692.33333333333333263.0TransmembraneHelical
HgeneCD99L2chrX:149983335chr11:85742653ENST00000437787-48186_20692.33333333333333190.0TransmembraneHelical
HgeneCD99L2chrX:149983335chr11:85742653ENST00000466436-19186_2060214.0TransmembraneHelical
TgenePICALMchrX:149983335chr11:85742653ENST0000035636001914_14543.333333333333336633.0DomainENTH
TgenePICALMchrX:149983335chr11:85742653ENST0000039334602014_14543.333333333333336653.0DomainENTH
TgenePICALMchrX:149983335chr11:85742653ENST0000052603302014_14543.333333333333336646.0DomainENTH
TgenePICALMchrX:149983335chr11:85742653ENST0000053231702014_14543.333333333333336611.0DomainENTH


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PICALMPLCG1, CLTC, ITSN1, AP2A1, HIP1R, LAMTOR3, EEF1A1, SEC24D, DNM2, EGFR, FLOT1, SEC24C, ATP6V1E1, ILF3, HNRNPDL, SH3GLB2, ABCC2, ATP6V1F, CD55, SIRT1, FN1, VCAM1, ITGA4, PELI2, KLHL20, SLC25A41, ITLN1, ATF6B, SLC25A32, SOX2, FAM64A, CYP1A1, HNRNPA1, UNK, NTRK1, C14orf166, CARS, CPPED1, HNRNPD, ILVBL, ITGB1, LPP, PAPOLA, DDX1, EWSR1, FERMT2, FUS, ILK, NPLOC4, PFKM, PTPRF, VCL, PXN, STXBP1, TRIM25, UNC13D, XPO1, AP2B1, AP2M1, CLTA, CLTB, DAB2, EPS15, GAK, MYO6, PIK3C2A, SEC13, CLTCL1, CAPZA2, DBN1, MYH9, LIMA1, GTSE1, ANLN, MYO19, MYO18A, CLINT1, SEC16A, TNRC6A, BMP2K, MICAL3, DENND1A, WNK1, PRRC2B, STON2, FCHO2, Actb, Myh9, Myo1c, Tpm1, Lima1, Calml3, Sec24c, MCM2, SNW1, CDC5L, SMURF1, CDH1, STAMBPL1, RALBP1, SNRNP27, DLST, FCHO1, RBPMS, CRX, AGR2, CDK9, TGOLN2, ATG16L1, MAP1LC3A, DYRK1A, APEX1, SCARB2, VMP1, MTMR4, TENM1, ATXN1, ZC3H10, ATXN1L, PLEKHA4, ORF6, ORF3a, SMAP2, CIT, ECT2, KIF14, KIF20A, MKI67, HNRNPH1, CDC42, Rnf183, E, WDR76, GGA2, FAM20C, OGT, ISG15, ARF6, B3GAT1, C11orf52, DIRAS3, GJA1, KRAS, LAMP2, LAMP3, LAMTOR1, MARCKS, OCLN, RAB35, RHOB, STX6, STX7, SYNE3, ZFPL1, NAA40, PIP, SNAP91, MTSS1L, BAG2, DDX3Y, ZBTB2, DNAJB6, PINK1, WIF1, ZNF444, CCR1, CENPQ, DOK4, ST3GAL5, BBS1, RBM47, C10orf88, NTNG1, C11orf49, DNAJC6, MBNL1, RDH11, MED17, POGZ, SERBP1, RBM38, FSCN1, IFITM1, IFITM3, ACE2, M, nsp14, DDX3X,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CD99L2
PICALMall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CD99L2-PICALM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CD99L2-PICALM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePICALMC0002395Alzheimer's Disease2CTD_human
TgenePICALMC0011265Presenile dementia2CTD_human
TgenePICALMC0276496Familial Alzheimer Disease (FAD)2CTD_human
TgenePICALMC0494463Alzheimer Disease, Late Onset2CTD_human
TgenePICALMC0546126Acute Confusional Senile Dementia2CTD_human
TgenePICALMC0750900Alzheimer's Disease, Focal Onset2CTD_human
TgenePICALMC0750901Alzheimer Disease, Early Onset2CTD_human
TgenePICALMC0234985Mental deterioration1CTD_human
TgenePICALMC0338656Impaired cognition1CTD_human
TgenePICALMC1270972Mild cognitive disorder1CTD_human