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Fusion Protein:CD9-ADAMTS12 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: CD9-ADAMTS12 | FusionPDB ID: 14742 | FusionGDB2.0 ID: 14742 | Hgene | Tgene | Gene symbol | CD9 | ADAMTS12 | Gene ID | 928 | 81792 |
| Gene name | CD9 molecule | ADAM metallopeptidase with thrombospondin type 1 motif 12 | |
| Synonyms | BTCC-1|DRAP-27|MIC3|MRP-1|TSPAN-29|TSPAN29 | PRO4389 | |
| Cytomap | 12p13.31 | 5p13.3-p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CD9 antigen5H9 antigenBA-2/p24 antigenCD9 antigen (p24)antigen CD9cell growth-inhibiting gene 2 proteinleukocyte antigen MIC3motility related protein-1tetraspanin-29 | A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q8TCZ2 | P58397 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000481267, ENST00000009180, ENST00000382518, ENST00000382515, | ENST00000352040, ENST00000504830, ENST00000504582, ENST00000515401, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 13 X 11 X 7=1001 | 9 X 7 X 7=441 |
| # samples | 14 | 9 | |
| ** MAII score | log2(14/1001*10)=-2.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/441*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: CD9 [Title/Abstract] AND ADAMTS12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CD9(6334700)-ADAMTS12(33684160), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | CD9-ADAMTS12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD9-ADAMTS12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CD9-ADAMTS12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CD9-ADAMTS12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CD9 | GO:0007155 | cell adhesion | 7511626 |
| Hgene | CD9 | GO:0007342 | fusion of sperm to egg plasma membrane involved in single fertilization | 14575715 |
| Hgene | CD9 | GO:0051271 | negative regulation of cellular component movement | 8478605 |
| Hgene | CD9 | GO:0090331 | negative regulation of platelet aggregation | 18541721 |
| Tgene | ADAMTS12 | GO:0030167 | proteoglycan catabolic process | 17895370 |
| Tgene | ADAMTS12 | GO:0032331 | negative regulation of chondrocyte differentiation | 22247065 |
| Tgene | ADAMTS12 | GO:0050727 | regulation of inflammatory response | 23019333 |
| Tgene | ADAMTS12 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 16611630 |
| Tgene | ADAMTS12 | GO:0071773 | cellular response to BMP stimulus | 22247065 |
| Tgene | ADAMTS12 | GO:1901509 | regulation of endothelial tube morphogenesis | 17895370 |
| Tgene | ADAMTS12 | GO:1902203 | negative regulation of hepatocyte growth factor receptor signaling pathway | 17895370 |
| Tgene | ADAMTS12 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus | 17895370 |
| Tgene | ADAMTS12 | GO:2001113 | negative regulation of cellular response to hepatocyte growth factor stimulus | 17895370 |
| Fusion gene breakpoints across CD9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ADAMTS12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A7-A4SD-01A | CD9 | chr12 | 6334699 | + | ADAMTS12 | chr5 | 33729891 | - |
| ChimerDB4 | BRCA | TCGA-A7-A4SD-01A | CD9 | chr12 | 6334700 | + | ADAMTS12 | chr5 | 33684160 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000382518 | CD9 | chr12 | 6334700 | + | ENST00000504830 | ADAMTS12 | chr5 | 33684160 | - | 8415 | 611 | 247 | 4761 | 1504 |
| ENST00000382518 | CD9 | chr12 | 6334700 | + | ENST00000352040 | ADAMTS12 | chr5 | 33684160 | - | 4514 | 611 | 247 | 4506 | 1419 |
| ENST00000009180 | CD9 | chr12 | 6334700 | + | ENST00000504830 | ADAMTS12 | chr5 | 33684160 | - | 8030 | 226 | 51 | 4376 | 1441 |
| ENST00000009180 | CD9 | chr12 | 6334700 | + | ENST00000352040 | ADAMTS12 | chr5 | 33684160 | - | 4129 | 226 | 51 | 4121 | 1356 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000382518 | ENST00000504830 | CD9 | chr12 | 6334700 | + | ADAMTS12 | chr5 | 33684160 | - | 0.000410829 | 0.99958915 |
| ENST00000382518 | ENST00000352040 | CD9 | chr12 | 6334700 | + | ADAMTS12 | chr5 | 33684160 | - | 0.001437847 | 0.99856216 |
| ENST00000009180 | ENST00000504830 | CD9 | chr12 | 6334700 | + | ADAMTS12 | chr5 | 33684160 | - | 0.000261411 | 0.99973863 |
| ENST00000009180 | ENST00000352040 | CD9 | chr12 | 6334700 | + | ADAMTS12 | chr5 | 33684160 | - | 0.000999132 | 0.99900085 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >14742_14742_1_CD9-ADAMTS12_CD9_chr12_6334700_ENST00000009180_ADAMTS12_chr5_33684160_ENST00000352040_length(amino acids)=1356AA_BP=58 MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTDSVNISQKQELWREKWERHNLPSRSLSRRSIS KERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSD LNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQL QYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDA AADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTF RQMQCSEFDTVPYKNELYHWFPIFNPGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKG DLEKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPET QPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSV SCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAI SSPSPTTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITW PVTPFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTT SETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWI VGNWSECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFL AGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQC VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHITHTQRQRRQRLL -------------------------------------------------------------- >14742_14742_2_CD9-ADAMTS12_CD9_chr12_6334700_ENST00000009180_ADAMTS12_chr5_33684160_ENST00000504830_length(amino acids)=1441AA_BP=58 MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTDSVNISQKQELWREKWERHNLPSRSLSRRSIS KERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSD LNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQL QYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDA AADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTF RQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGV CLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKL MATGPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR QKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGG VRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSP TTASKEGDLGGKQWQDSSTQPELSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPF YNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSETGT PRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWS ECSTTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPP PLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEG NKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHITHTQRQRRQRLLQKSKE -------------------------------------------------------------- >14742_14742_3_CD9-ADAMTS12_CD9_chr12_6334700_ENST00000382518_ADAMTS12_chr5_33684160_ENST00000352040_length(amino acids)=1419AA_BP=121 MAKGPLALTTRGRVSQSRTPGPAPRPNAGEPEGRGLHRQVPPVPAARAPQSRTRSAQAKLALTMPVKGGTKCIKYLLFGFNFIFWLAGIA VLAIGLWLRFDSQTKSIFEQETNNNNSSFYTDSVNISQKQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESY ILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCET LGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGF CLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES IPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPG YVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPG IKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACS ATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKP NSRALCGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPE LSSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQ PEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDH QPEPSGKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMD SDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQC SRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKK -------------------------------------------------------------- >14742_14742_4_CD9-ADAMTS12_CD9_chr12_6334700_ENST00000382518_ADAMTS12_chr5_33684160_ENST00000504830_length(amino acids)=1504AA_BP=121 MAKGPLALTTRGRVSQSRTPGPAPRPNAGEPEGRGLHRQVPPVPAARAPQSRTRSAQAKLALTMPVKGGTKCIKYLLFGFNFIFWLAGIA VLAIGLWLRFDSQTKSIFEQETNNNNSSFYTDSVNISQKQELWREKWERHNLPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESY ILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCET LGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGF CLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPES IPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPA HPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIG LIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQLLFQVTNPGIKYEY TIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGP HGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRAL CGLQQCPSSRRVLKPNKGTISNGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPELSSRY LISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVTPFYNTLTKGPEMEIHSGSGEEREQPEDKD ESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSRESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPS GKTANRNHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSDCAA IQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCG GGVQERGVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6334700/chr5:33684160) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CD9 | ADAMTS12 |
| FUNCTION: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity). {ECO:0000250}. | FUNCTION: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. {ECO:0000269|PubMed:16611630, ECO:0000269|PubMed:17895370, ECO:0000269|PubMed:18485748}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 2_12 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 34_55 | 58.333333333333336 | 229.0 | Topological domain | Extracellular |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 2_12 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 34_55 | 58.333333333333336 | 229.0 | Topological domain | Extracellular |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 13_33 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 13_33 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 302_305 | 211.33333333333334 | 1510.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 597_700 | 211.33333333333334 | 1510.0 | Compositional bias | Note=Cys-rich | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 302_305 | 211.33333333333334 | 1595.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 597_700 | 211.33333333333334 | 1595.0 | Compositional bias | Note=Cys-rich | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 1313_1366 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 5 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 1368_1422 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 6 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 1423_1471 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 7 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 1472_1532 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 8 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 1535_1575 | 211.33333333333334 | 1510.0 | Domain | PLAC | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 246_456 | 211.33333333333334 | 1510.0 | Domain | Peptidase M12B | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 465_544 | 211.33333333333334 | 1510.0 | Domain | Note=Disintegrin | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 542_597 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 1 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 823_883 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 2 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 887_943 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 3 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 944_997 | 211.33333333333334 | 1510.0 | Domain | TSP type-1 4 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 1313_1366 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 5 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 1368_1422 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 6 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 1423_1471 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 7 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 1472_1532 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 8 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 1535_1575 | 211.33333333333334 | 1595.0 | Domain | PLAC | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 246_456 | 211.33333333333334 | 1595.0 | Domain | Peptidase M12B | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 465_544 | 211.33333333333334 | 1595.0 | Domain | Note=Disintegrin | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 542_597 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 1 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 823_883 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 2 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 887_943 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 3 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 944_997 | 211.33333333333334 | 1595.0 | Domain | TSP type-1 4 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 701_827 | 211.33333333333334 | 1510.0 | Region | Note=Spacer 1 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 997_1316 | 211.33333333333334 | 1510.0 | Region | Note=Spacer 2 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 701_827 | 211.33333333333334 | 1595.0 | Region | Note=Spacer 1 | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 997_1316 | 211.33333333333334 | 1595.0 | Region | Note=Spacer 2 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 112_195 | 58.333333333333336 | 229.0 | Topological domain | Extracellular |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 222_228 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 77_87 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 112_195 | 58.333333333333336 | 229.0 | Topological domain | Extracellular |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 222_228 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 77_87 | 58.333333333333336 | 229.0 | Topological domain | Cytoplasmic |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 196_221 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 56_76 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000009180 | + | 2 | 8 | 88_111 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 196_221 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 56_76 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Hgene | CD9 | chr12:6334700 | chr5:33684160 | ENST00000382518 | + | 3 | 9 | 88_111 | 58.333333333333336 | 229.0 | Transmembrane | Helical |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000352040 | 2 | 22 | 208_213 | 211.33333333333334 | 1510.0 | Motif | Cysteine switch | |
| Tgene | ADAMTS12 | chr12:6334700 | chr5:33684160 | ENST00000504830 | 2 | 24 | 208_213 | 211.33333333333334 | 1595.0 | Motif | Cysteine switch |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| CD9 | |
| ADAMTS12 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to CD9-ADAMTS12 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to CD9-ADAMTS12 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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