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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDC37-KMT2C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDC37-KMT2C
FusionPDB ID: 14819
FusionGDB2.0 ID: 14822
HgeneTgene
Gene symbol

CDC37

KMT2C

Gene ID

11140

58508

Gene namecell division cycle 37, HSP90 cochaperonelysine methyltransferase 2C
SynonymsP50CDC37HALR|KLEFS2|MLL3
Cytomap

19p13.2

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionhsp90 co-chaperone Cdc37CDC37 (cell division cycle 37, S. cerevisiae, homolog)CDC37 cell division cycle 37 homologcell division cycle 37 homologhsp90 chaperone protein kinase-targeting subunithistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le
Modification date2020032720200320
UniProtAcc

Q7L3B6

Q8NEZ4

Ensembl transtripts involved in fusion geneENST idsENST00000222005, ENST00000485655, 
ENST00000485241, ENST00000262189, 
ENST00000355193, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 5=18012 X 17 X 8=1632
# samples 917
** MAII scorelog2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1632*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDC37 [Title/Abstract] AND KMT2C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDC37(10514054)-KMT2C(151836876), # samples:1
Anticipated loss of major functional domain due to fusion event.CDC37-KMT2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC37-KMT2C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC37-KMT2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC37-KMT2C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across CDC37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KMT2C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-67-6217-01ACDC37chr19

10514054

-KMT2Cchr7

151836876

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222005CDC37chr1910514054-ENST00000262189KMT2Cchr7151836876-245615636548170
ENST00000222005CDC37chr1910514054-ENST00000355193KMT2Cchr7151836876-245215636548170

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222005ENST00000262189CDC37chr1910514054-KMT2Cchr7151836876-0.0016081990.9983918
ENST00000222005ENST00000355193CDC37chr1910514054-KMT2Cchr7151836876-0.001583850.9984162

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14819_14819_1_CDC37-KMT2C_CDC37_chr19_10514054_ENST00000222005_KMT2C_chr7_151836876_ENST00000262189_length(amino acids)=170AA_BP=40
MGRQGKMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDN

--------------------------------------------------------------

>14819_14819_2_CDC37-KMT2C_CDC37_chr19_10514054_ENST00000222005_KMT2C_chr7_151836876_ENST00000355193_length(amino acids)=170AA_BP=40
MGRQGKMVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10514054/chr7:151836876)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC37

Q7L3B6

KMT2C

Q8NEZ4

FUNCTION: Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. {ECO:0000250}.FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594895_49114781.04912.0DomainPost-SET
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604895_49114838.04969.0DomainPost-SET
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594848_48494781.04912.0RegionS-adenosyl-L-methionine binding
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604848_48494838.04969.0RegionS-adenosyl-L-methionine binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591338_13664781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591754_17874781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954593054_30814781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954593173_32724781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954593391_34334781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459644_6724781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189545992_1124781.04912.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601338_13664838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601754_17874838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355603054_30814838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355603173_32724838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355603391_34334838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560644_6724838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193556092_1124838.04969.0Coiled coilOntology_term=ECO:0000255
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591719_17964781.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591834_22814781.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954592412_26304781.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954592690_27864781.04912.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954593012_35094781.04912.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954593277_33814781.04912.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601719_17964838.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601834_22814838.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355602412_26304838.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355602690_27864838.04969.0Compositional biasNote=Asp-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355603012_35094838.04969.0Compositional biasNote=Gln-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355603277_33814838.04969.0Compositional biasNote=Pro-rich
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000262189545934_464781.04912.0DNA bindingNote=A.T hook
TgeneKMT2Cchr19:10514054chr7:151836876ENST00000355193556034_464838.04969.0DNA bindingNote=A.T hook
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459436_4894781.04912.0DomainDHHC
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594545_46054781.04912.0DomainFYR N-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594606_46914781.04912.0DomainFYR C-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594771_48874781.04912.0DomainSET
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560436_4894838.04969.0DomainDHHC
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604545_46054838.04969.0DomainFYR N-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604606_46914838.04969.0DomainFYR C-terminal
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604771_48874838.04969.0DomainSET
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591007_10574781.04912.0Zinc fingerPHD-type 6
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954591084_11394781.04912.0Zinc fingerPHD-type 7
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459227_2624781.04912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459283_3314781.04912.0Zinc fingerPHD-type 1
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459341_3914781.04912.0Zinc fingerPHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459344_3894781.04912.0Zinc fingerRING-type
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459388_4384781.04912.0Zinc fingerPHD-type 3
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594399_44394781.04912.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000026218954594460_45074781.04912.0Zinc fingerPHD-type 8
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459464_5204781.04912.0Zinc fingerPHD-type 4
TgeneKMT2Cchr19:10514054chr7:151836876ENST000002621895459957_10104781.04912.0Zinc fingerPHD-type 5
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601007_10574838.04969.0Zinc fingerPHD-type 6
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355601084_11394838.04969.0Zinc fingerPHD-type 7
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560227_2624838.04969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560283_3314838.04969.0Zinc fingerPHD-type 1
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560341_3914838.04969.0Zinc fingerPHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560344_3894838.04969.0Zinc fingerRING-type
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560388_4384838.04969.0Zinc fingerPHD-type 3
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604399_44394838.04969.0Zinc fingerC2HC pre-PHD-type 2
TgeneKMT2Cchr19:10514054chr7:151836876ENST0000035519355604460_45074838.04969.0Zinc fingerPHD-type 8
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560464_5204838.04969.0Zinc fingerPHD-type 4
TgeneKMT2Cchr19:10514054chr7:151836876ENST000003551935560957_10104838.04969.0Zinc fingerPHD-type 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDC37
KMT2C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDC37-KMT2C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDC37-KMT2C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource