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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ACSF2-SPAG9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ACSF2-SPAG9
	FusionPDB ID: 1486
	FusionGDB2.0 ID: 1486
		Hgene	Tgene
	Gene symbol	ACSF2	SPAG9
	Gene ID	80221	9043
	Gene name	acyl-CoA synthetase family member 2	sperm associated antigen 9
	Synonyms	ACSMW\|AVYV493	CT89\|HLC-6\|HLC4\|HLC6\|JIP-4\|JIP4\|JLP\|PHET\|PIG6
	Cytomap	17q21.33	17q21.33
	Type of gene	protein-coding	protein-coding
	Description	medium-chain acyl-CoA ligase ACSF2, mitochondrialPPARG binding, long chain fatty acid acyl Co-A ligase likeacyl-CoA synthetase family member 2, mitochondrial	C-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancer
	Modification date	20200313	20200315
	UniProtAcc	Q96CM8	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000300441, ENST00000427954, ENST00000502667, ENST00000504392, ENST00000541920, ENST00000506085,	ENST00000509724, ENST00000510283, ENST00000262013, ENST00000357122, ENST00000505279,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 4 X 4=96	15 X 14 X 6=1260
	# samples	6	16
	** MAII score	log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ACSF2 [Title/Abstract] AND SPAG9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ACSF2(48503750)-SPAG9(49091714), # samples:4
Anticipated loss of major functional domain due to fusion event.	ACSF2-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSF2-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSF2-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACSF2-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPAG9	GO:0042147	retrograde transport, endosome to Golgi	19056739

Fusion gene breakpoints across ACSF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPAG9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A07I-01A	ACSF2	chr17	48503750	-	SPAG9	chr17	49091714	-
ChimerDB4	BRCA	TCGA-A8-A07I-01A	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-
ChimerDB4	BRCA	TCGA-A8-A07I	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000300441	ACSF2	chr17	48503750	+	ENST00000262013	SPAG9	chr17	49091714	-	7205	232	35	3106	1023
ENST00000300441	ACSF2	chr17	48503750	+	ENST00000505279	SPAG9	chr17	49091714	-	3764	232	35	3118	1027
ENST00000300441	ACSF2	chr17	48503750	+	ENST00000357122	SPAG9	chr17	49091714	-	3735	232	35	3106	1023
ENST00000504392	ACSF2	chr17	48503750	+	ENST00000262013	SPAG9	chr17	49091714	-	7145	172	44	3046	1000
ENST00000504392	ACSF2	chr17	48503750	+	ENST00000505279	SPAG9	chr17	49091714	-	3704	172	44	3058	1004
ENST00000504392	ACSF2	chr17	48503750	+	ENST00000357122	SPAG9	chr17	49091714	-	3675	172	44	3046	1000
ENST00000427954	ACSF2	chr17	48503750	+	ENST00000262013	SPAG9	chr17	49091714	-	7144	171	43	3045	1000
ENST00000427954	ACSF2	chr17	48503750	+	ENST00000505279	SPAG9	chr17	49091714	-	3703	171	43	3057	1004
ENST00000427954	ACSF2	chr17	48503750	+	ENST00000357122	SPAG9	chr17	49091714	-	3674	171	43	3045	1000
ENST00000502667	ACSF2	chr17	48503750	+	ENST00000262013	SPAG9	chr17	49091714	-	7111	138	10	3012	1000
ENST00000502667	ACSF2	chr17	48503750	+	ENST00000505279	SPAG9	chr17	49091714	-	3670	138	10	3024	1004
ENST00000502667	ACSF2	chr17	48503750	+	ENST00000357122	SPAG9	chr17	49091714	-	3641	138	10	3012	1000

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000300441	ENST00000262013	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	7.77E-05	0.9999223
ENST00000300441	ENST00000505279	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000239959	0.9997601
ENST00000300441	ENST00000357122	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000153998	0.999846
ENST00000504392	ENST00000262013	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	7.22E-05	0.99992776
ENST00000504392	ENST00000505279	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.00021676	0.9997832
ENST00000504392	ENST00000357122	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000138993	0.999861
ENST00000427954	ENST00000262013	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	7.22E-05	0.99992776
ENST00000427954	ENST00000505279	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000216586	0.99978346
ENST00000427954	ENST00000357122	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000138724	0.99986124
ENST00000502667	ENST00000262013	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	6.99E-05	0.99993
ENST00000502667	ENST00000505279	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000216461	0.9997836
ENST00000502667	ENST00000357122	ACSF2	chr17	48503750	+	SPAG9	chr17	49091714	-	0.000140397	0.9998596

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1486_1486_1_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000300441_SPAG9_chr17_49091714_ENST00000262013_length(amino acids)=1023AA_BP=65
MRARPAPAHFKSLLGPGRRAKRAMAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSS
AGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA
EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTK
KPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVT
NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKEL
KNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSL
LGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIP
EDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALA
DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRL
DSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS
DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG

--------------------------------------------------------------

>1486_1486_2_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000300441_SPAG9_chr17_49091714_ENST00000357122_length(amino acids)=1023AA_BP=65
MRARPAPAHFKSLLGPGRRAKRAMAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSS
AGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA
EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTK
KPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVT
NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKEL
KNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSL
LGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIP
EDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALA
DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRL
DSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS
DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG

--------------------------------------------------------------

>1486_1486_3_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000300441_SPAG9_chr17_49091714_ENST00000505279_length(amino acids)=1027AA_BP=65
MRARPAPAHFKSLLGPGRRAKRAMAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSS
AGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA
EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSS
NTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY
KQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQ
QKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAE
TDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLG
VQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVL
VALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWV
SIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYG
DENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMG

--------------------------------------------------------------

>1486_1486_4_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000427954_SPAG9_chr17_49091714_ENST00000262013_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_5_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000427954_SPAG9_chr17_49091714_ENST00000357122_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_6_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000427954_SPAG9_chr17_49091714_ENST00000505279_length(amino acids)=1004AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTP
SVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRP
LDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSA
TKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAAT
SPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQ
ISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSN
YHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVD
IEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQL
CFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAE

--------------------------------------------------------------

>1486_1486_7_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000502667_SPAG9_chr17_49091714_ENST00000262013_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_8_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000502667_SPAG9_chr17_49091714_ENST00000357122_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_9_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000502667_SPAG9_chr17_49091714_ENST00000505279_length(amino acids)=1004AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTP
SVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRP
LDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSA
TKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAAT
SPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQ
ISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSN
YHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVD
IEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQL
CFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAE

--------------------------------------------------------------

>1486_1486_10_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000504392_SPAG9_chr17_49091714_ENST00000262013_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_11_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000504392_SPAG9_chr17_49091714_ENST00000357122_length(amino acids)=1000AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKK
RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEK
DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVL
IIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPST
NGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVL
PNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLL
DLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPY
VSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHG
HRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHL

--------------------------------------------------------------

>1486_1486_12_ACSF2-SPAG9_ACSF2_chr17_48503750_ENST00000504392_SPAG9_chr17_49091714_ENST00000505279_length(amino acids)=1004AA_BP=42
MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE
NLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRK
RFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTP
SVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRP
LDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSA
TKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAAT
SPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQ
ISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSN
YHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVD
IEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQL
CFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:48503750/chr17:49091714)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACSF2 Q96CM8	.
FUNCTION: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219). {ECO:0000269\|PubMed:16380219, ECO:0000269\|PubMed:17762044}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000262013

408_534

363.6666666666667

1322.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000262013

724_758

363.6666666666667

1322.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000357122

408_534

349.6666666666667

1308.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000357122

724_758

349.6666666666667

1308.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000505279

408_534

349.6666666666667

1312.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000505279

724_758

349.6666666666667

1312.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000510283

408_534

206.66666666666666

1178.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000510283

724_758

206.66666666666666

1178.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000262013

500_571

363.6666666666667

1322.0

Domain

RH2

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000357122

500_571

349.6666666666667

1308.0

Domain

RH2

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000505279

500_571

349.6666666666667

1312.0

Domain

RH2

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000510283

500_571

206.66666666666666

1178.0

Domain

RH2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACSF2

chr17:48503750

chr17:49091714

ENST00000300441

263_271

42.666666666666664

616.0

Nucleotide binding

ATP

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000262013

66_166

363.6666666666667

1322.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000357122

66_166

349.6666666666667

1308.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000505279

66_166

349.6666666666667

1312.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000510283

66_166

206.66666666666666

1178.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000262013

7_95

363.6666666666667

1322.0

Domain

RH1

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000357122

7_95

349.6666666666667

1308.0

Domain

RH1

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000505279

7_95

349.6666666666667

1312.0

Domain

RH1

Tgene

SPAG9

chr17:48503750

chr17:49091714

ENST00000510283

7_95

206.66666666666666

1178.0

Domain

RH1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1810_ACSF2_48503750_SPAG9_49091714_ranked_0.pdb	ACSF2	48503750	48503750	ENST00000357122	SPAG9	chr17	49091714	-	MRARPAPAHFKSLLGPGRRAKRAMAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSTPTKGIENKAFDRNTESLFEELSS AGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFVPTRFSRLFSSSS NTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKY KQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQ QKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAE TDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLG VQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVL VALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWV SIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYG DENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMG	1027

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ACSF2_pLDDT.png

SPAG9_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ACSF2
SPAG9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ACSF2-SPAG9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ACSF2-SPAG9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source