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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDC42BPB-ZFYVE1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDC42BPB-ZFYVE1
	FusionPDB ID: 14864
	FusionGDB2.0 ID: 14864
		Hgene	Tgene
	Gene symbol	CDC42BPB	ZFYVE1
	Gene ID	9578	53349
	Gene name	CDC42 binding protein kinase beta	zinc finger FYVE-type containing 1
	Synonyms	MRCKB	DFCP1\|PPP1R172\|SR3\|TAFF1\|ZNFN2A1
	Cytomap	14q32.32	14q24.2
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase MRCK betaCDC42 binding protein kinase beta (DMPK-like)CDC42BP-betaDMPK-like betaMRCK betamyotonic dystrophy kinase-related CDC42-binding kinase betamyotonic dystrophy protein kinase-like beta	zinc finger FYVE domain-containing protein 1double FYVE-containing protein 1phosphoinositide-binding protein SR3protein phosphatase 1, regulatory subunit 172tandem FYVE fingers-1 proteinzinc finger protein, subfamily 2A, member 1zinc finger, FYVE do
	Modification date	20200313	20200327
	UniProtAcc	Q9Y5S2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000361246,	ENST00000394207, ENST00000554145, ENST00000555072, ENST00000318876, ENST00000553891, ENST00000556143,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 16 X 10=2720	6 X 5 X 3=90
	# samples	19	7
	** MAII score	log2(19/2720*10)=-3.83953532780675 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDC42BPB [Title/Abstract] AND ZFYVE1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDC42BPB(103452824)-ZFYVE1(73465023), # samples:3
Anticipated loss of major functional domain due to fusion event.	CDC42BPB-ZFYVE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDC42BPB-ZFYVE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDC42BPB-ZFYVE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDC42BPB-ZFYVE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDC42BPB	GO:0006468	protein phosphorylation	21949762
Tgene	ZFYVE1	GO:0009267	cellular response to starvation	25578879
Tgene	ZFYVE1	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	ZFYVE1	GO:0016236	macroautophagy	25578879

Fusion gene breakpoints across CDC42BPB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZFYVE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-NC-A5HI-01A	CDC42BPB	chr14	103452824	-	ZFYVE1	chr14	73465023	-
ChimerDB4	LUSC	TCGA-NC-A5HI	CDC42BPB	chr14	103452823	-	ZFYVE1	chr14	73465023	-
ChimerDB4	LUSC	TCGA-NC-A5HI	CDC42BPB	chr14	103452824	-	ZFYVE1	chr14	73465023	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361246	CDC42BPB	chr14	103452824	-	ENST00000553891	ZFYVE1	chr14	73465023	-	3125	979	184	2865	893
ENST00000361246	CDC42BPB	chr14	103452824	-	ENST00000318876	ZFYVE1	chr14	73465023	-	4218	979	184	2787	867
ENST00000361246	CDC42BPB	chr14	103452824	-	ENST00000556143	ZFYVE1	chr14	73465023	-	4260	979	184	2829	881
ENST00000361246	CDC42BPB	chr14	103452823	-	ENST00000553891	ZFYVE1	chr14	73465023	-	3125	979	184	2865	893
ENST00000361246	CDC42BPB	chr14	103452823	-	ENST00000318876	ZFYVE1	chr14	73465023	-	4218	979	184	2787	867
ENST00000361246	CDC42BPB	chr14	103452823	-	ENST00000556143	ZFYVE1	chr14	73465023	-	4260	979	184	2829	881

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361246	ENST00000553891	CDC42BPB	chr14	103452824	-	ZFYVE1	chr14	73465023	-	0.001990376	0.9980096
ENST00000361246	ENST00000318876	CDC42BPB	chr14	103452824	-	ZFYVE1	chr14	73465023	-	0.001360229	0.99863976
ENST00000361246	ENST00000556143	CDC42BPB	chr14	103452824	-	ZFYVE1	chr14	73465023	-	0.001213174	0.99878687
ENST00000361246	ENST00000553891	CDC42BPB	chr14	103452823	-	ZFYVE1	chr14	73465023	-	0.001990376	0.9980096
ENST00000361246	ENST00000318876	CDC42BPB	chr14	103452823	-	ZFYVE1	chr14	73465023	-	0.001360229	0.99863976
ENST00000361246	ENST00000556143	CDC42BPB	chr14	103452823	-	ZFYVE1	chr14	73465023	-	0.001213174	0.99878687

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14864_14864_1_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452823_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000318876_length(amino acids)=867AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGRQYWFGNQDPVDTVVRTEIV
HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEGFCDS
CSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH

--------------------------------------------------------------

>14864_14864_2_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452823_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000553891_length(amino acids)=893AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFG
NQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDT
KHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDA

--------------------------------------------------------------

>14864_14864_3_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452823_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000556143_length(amino acids)=881AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFG
NQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDT
KHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDA

--------------------------------------------------------------

>14864_14864_4_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452824_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000318876_length(amino acids)=867AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGRQYWFGNQDPVDTVVRTEIV
HVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEGFCDS
CSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDAARPAYWVPDHEILH

--------------------------------------------------------------

>14864_14864_5_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452824_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000553891_length(amino acids)=893AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFG
NQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDT
KHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDA

--------------------------------------------------------------

>14864_14864_6_CDC42BPB-ZFYVE1_CDC42BPB_chr14_103452824_ENST00000361246_ZFYVE1_chr14_73465023_ENST00000556143_length(amino acids)=881AA_BP=265
MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF
LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD
ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE
DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV
LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK
LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC
GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFG
NQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDT
KHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103452824/chr14:73465023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDC42BPB Q9Y5S2	.
FUNCTION: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). {ECO:0000250\|UniProtKB:Q7TT50, ECO:0000269\|PubMed:18854160, ECO:0000269\|PubMed:21457715, ECO:0000269\|PubMed:21949762}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

82_90

230.0

1712.0

Nucleotide binding

ATP

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

82_90

230.0

1712.0

Nucleotide binding

ATP

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000394207

416_777

363.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000555072

416_777

363.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000556143

416_777

161.0

778.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000394207

416_777

363.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000555072

416_777

363.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000556143

416_777

161.0

778.0

Region

Required for localization in the lipid droplets

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000394207

598_659

363.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000394207

715_775

363.0

Zinc finger

FYVE-type 2

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000555072

598_659

363.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000555072

715_775

363.0

Zinc finger

FYVE-type 2

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000556143

598_659

161.0

778.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452823

chr14:73465023

ENST00000556143

715_775

161.0

778.0

Zinc finger

FYVE-type 2

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000394207

598_659

363.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000394207

715_775

363.0

Zinc finger

FYVE-type 2

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000555072

598_659

363.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000555072

715_775

363.0

Zinc finger

FYVE-type 2

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000556143

598_659

161.0

778.0

Zinc finger

FYVE-type 1

Tgene

ZFYVE1

chr14:103452824

chr14:73465023

ENST00000556143

715_775

161.0

778.0

Zinc finger

FYVE-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

431_815

230.0

1712.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

878_939

230.0

1712.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

431_815

230.0

1712.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

878_939

230.0

1712.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

1095_1214

230.0

1712.0

Domain

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

1240_1513

230.0

1712.0

Domain

CNH

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

1583_1596

230.0

1712.0

Domain

CRIB

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

343_413

230.0

1712.0

Domain

AGC-kinase C-terminal

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

76_342

230.0

1712.0

Domain

Protein kinase

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

1095_1214

230.0

1712.0

Domain

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

1240_1513

230.0

1712.0

Domain

CNH

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

1583_1596

230.0

1712.0

Domain

CRIB

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

343_413

230.0

1712.0

Domain

AGC-kinase C-terminal

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

76_342

230.0

1712.0

Domain

Protein kinase

Hgene

CDC42BPB

chr14:103452823

chr14:73465023

ENST00000361246

1025_1075

230.0

1712.0

Zinc finger

Phorbol-ester/DAG-type

Hgene

CDC42BPB

chr14:103452824

chr14:73465023

ENST00000361246

1025_1075

230.0

1712.0

Zinc finger

Phorbol-ester/DAG-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1683_CDC42BPB_103452824_ZFYVE1_73465023_ranked_0.pdb	CDC42BPB	103452823	103452824	ENST00000556143	ZFYVE1	chr14	73465023	-	MLPGLAAAEPPRARPDGLAEPAVRGRRVGSGPRGTMSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEF LEWAKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQD ENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVTNEE DFIRKLDCKPDQHLKVVSIFGNTGDGKSHTLNHTFFYGREVFKTSPTQESCTVGVWAAYDPVHKVAVIDTEGLLGATVNLSQRTRLLLKV LAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELKATTARCGLDVPLSTLGPAVIIFHETVHTQLLGSDHPSEVPEKLIQDRFRK LGRFPEAFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFG NQDPVDTVVRTEIVHVWPGTDGFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDT KHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYEARNVQLAVTEAQVDDEGGTLIARKVGEAVQNTLGAVVTAIDIPLGLVKDA	893

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CDC42BPB_pLDDT.png

ZFYVE1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDC42BPB
ZFYVE1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CDC42BPB-ZFYVE1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CDC42BPB-ZFYVE1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source