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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDH11-KIFC3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDH11-KIFC3
FusionPDB ID: 14978
FusionGDB2.0 ID: 14978
HgeneTgene
Gene symbol

CDH11

KIFC3

Gene ID

1009

3801

Gene namecadherin 11kinesin family member C3
SynonymsCAD11|CDHOB|ESWS|OB|OSF-4-
Cytomap

16q21

16q21

Type of geneprotein-codingprotein-coding
Descriptioncadherin-11cadherin 11, type 2, OB-cadherin (osteoblast)kinesin-like protein KIFC3
Modification date2020031320200327
UniProtAcc

P55287

Q9BVG8

Ensembl transtripts involved in fusion geneENST idsENST00000394156, ENST00000268603, 
ENST00000566827, ENST00000569624, 
ENST00000566975, ENST00000379655, 
ENST00000421376, ENST00000445690, 
ENST00000465878, ENST00000539578, 
ENST00000540079, ENST00000541240, 
ENST00000543930, ENST00000562903, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 9 X 5=3156 X 6 X 3=108
# samples 135
** MAII scorelog2(13/315*10)=-1.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/108*10)=-1.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDH11 [Title/Abstract] AND KIFC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDH11(64982512)-KIFC3(57795448), # samples:2
Anticipated loss of major functional domain due to fusion event.CDH11-KIFC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH11-KIFC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH11-KIFC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH11-KIFC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIFC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A2MN-06ACDH11chr16

64982512

-KIFC3chr16

57795448

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394156CDH11chr1664982512-ENST00000465878KIFC3chr1657795448-397725274542616720
ENST00000394156CDH11chr1664982512-ENST00000379655KIFC3chr1657795448-394825274542616720
ENST00000394156CDH11chr1664982512-ENST00000445690KIFC3chr1657795448-397525274542616720
ENST00000394156CDH11chr1664982512-ENST00000421376KIFC3chr1657795448-376625274542616720
ENST00000394156CDH11chr1664982512-ENST00000541240KIFC3chr1657795448-374925274542616720
ENST00000394156CDH11chr1664982512-ENST00000540079KIFC3chr1657795448-373525274542616720
ENST00000394156CDH11chr1664982512-ENST00000543930KIFC3chr1657795448-366225274542616720
ENST00000394156CDH11chr1664982512-ENST00000562903KIFC3chr1657795448-347425274542616720
ENST00000394156CDH11chr1664982512-ENST00000539578KIFC3chr1657795448-336925274542616720

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394156ENST00000465878CDH11chr1664982512-KIFC3chr1657795448-0.0026794740.9973206
ENST00000394156ENST00000379655CDH11chr1664982512-KIFC3chr1657795448-0.0025824510.99741757
ENST00000394156ENST00000445690CDH11chr1664982512-KIFC3chr1657795448-0.002669990.99733007
ENST00000394156ENST00000421376CDH11chr1664982512-KIFC3chr1657795448-0.0030622080.99693775
ENST00000394156ENST00000541240CDH11chr1664982512-KIFC3chr1657795448-0.0031157820.99688417
ENST00000394156ENST00000540079CDH11chr1664982512-KIFC3chr1657795448-0.0030422780.9969578
ENST00000394156ENST00000543930CDH11chr1664982512-KIFC3chr1657795448-0.0030346080.99696535
ENST00000394156ENST00000562903CDH11chr1664982512-KIFC3chr1657795448-0.0028742310.9971258
ENST00000394156ENST00000539578CDH11chr1664982512-KIFC3chr1657795448-0.00290680.9970932

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14978_14978_1_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000379655_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_2_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000421376_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_3_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000445690_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_4_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000465878_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_5_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000539578_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_6_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000540079_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_7_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000541240_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_8_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000543930_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

>14978_14978_9_CDH11-KIFC3_CDH11_chr16_64982512_ENST00000394156_KIFC3_chr16_57795448_ENST00000562903_length(amino acids)=720AA_BP=689
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVIL
LGCPSLMEPPSPREDMRLLYLGFQLMLFSYVKVNRRFCLLGVFIKLPFLYVVATESPTTLTGPARERASGKTGDPAVPRRQWAAVCTRAD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:64982512/chr16:57795448)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH11

P55287

KIFC3

Q9BVG8

FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.FUNCTION: Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269|PubMed:19041755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314160_268691.0694.0DomainCadherin 2
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314269_383691.0694.0DomainCadherin 3
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314384_486691.0694.0DomainCadherin 4
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314487_612691.0694.0DomainCadherin 5
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-131454_159691.0694.0DomainCadherin 1
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-131454_617691.0694.0Topological domainExtracellular
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314618_640691.0694.0TransmembraneHelical
TgeneKIFC3chr16:64982512chr16:57795448ENST000004213761119445_768443.6666666666667706.3333333333334DomainKinesin motor
TgeneKIFC3chr16:64982512chr16:57795448ENST000004658781220445_768443.6666666666667861.0DomainKinesin motor
TgeneKIFC3chr16:64982512chr16:57795448ENST000005629031321445_768443.6666666666667579.0DomainKinesin motor
TgeneKIFC3chr16:64982512chr16:57795448ENST000004213761119528_535443.6666666666667706.3333333333334Nucleotide bindingNote=ATP
TgeneKIFC3chr16:64982512chr16:57795448ENST000004658781220528_535443.6666666666667861.0Nucleotide bindingNote=ATP
TgeneKIFC3chr16:64982512chr16:57795448ENST000005629031321528_535443.6666666666667579.0Nucleotide bindingNote=ATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113160_2680797.0DomainCadherin 2
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113269_3830797.0DomainCadherin 3
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113384_4860797.0DomainCadherin 4
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113487_6120797.0DomainCadherin 5
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-11354_1590797.0DomainCadherin 1
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-11354_6170797.0Topological domainExtracellular
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113641_7960797.0Topological domainCytoplasmic
HgeneCDH11chr16:64982512chr16:57795448ENST00000394156-1314641_796691.0694.0Topological domainCytoplasmic
HgeneCDH11chr16:64982512chr16:57795448ENST00000268603-113618_6400797.0TransmembraneHelical
TgeneKIFC3chr16:64982512chr16:57795448ENST000003796551219102_362582.6666666666666834.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000003796551219395_432582.6666666666666834.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004213761119102_362443.6666666666667706.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004213761119395_432443.6666666666667706.3333333333334Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004456901220102_362582.6666666666666948.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004456901220395_432582.6666666666666948.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004658781220102_362443.6666666666667861.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000004658781220395_432443.6666666666667861.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000005629031321102_362443.6666666666667579.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000005629031321395_432443.6666666666667579.0Coiled coilOntology_term=ECO:0000255
TgeneKIFC3chr16:64982512chr16:57795448ENST000003796551219445_768582.6666666666666834.0DomainKinesin motor
TgeneKIFC3chr16:64982512chr16:57795448ENST000004456901220445_768582.6666666666666948.6666666666666DomainKinesin motor
TgeneKIFC3chr16:64982512chr16:57795448ENST000003796551219528_535582.6666666666666834.0Nucleotide bindingNote=ATP
TgeneKIFC3chr16:64982512chr16:57795448ENST000004456901220528_535582.6666666666666948.6666666666666Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDH11
KIFC3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDH11-KIFC3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDH11-KIFC3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource