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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDH11-PRC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDH11-PRC1
	FusionPDB ID: 14981
	FusionGDB2.0 ID: 14981
		Hgene	Tgene
	Gene symbol	CDH11	PRC1
	Gene ID	1009	9055
	Gene name	cadherin 11	protein regulator of cytokinesis 1
	Synonyms	CAD11\|CDHOB\|ESWS\|OB\|OSF-4	ASE1
	Cytomap	16q21	15q26.1
	Type of gene	protein-coding	protein-coding
	Description	cadherin-11cadherin 11, type 2, OB-cadherin (osteoblast)	protein regulator of cytokinesis 1anaphase spindle elongation 1 homologprotein regulating cytokinesis 1
	Modification date	20200313	20200313
	UniProtAcc	P55287	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000268603, ENST00000394156, ENST00000566827, ENST00000569624,	ENST00000556129, ENST00000361188, ENST00000361919, ENST00000394249, ENST00000442656,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 9 X 5=315	3 X 4 X 2=24
	# samples	13	4
	** MAII score	log2(13/315*10)=-1.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDH11 [Title/Abstract] AND PRC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDH11(65005482)-PRC1(91512853), # samples:3
Anticipated loss of major functional domain due to fusion event.	CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CDH11-PRC1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CDH11-PRC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PRC1	GO:0032465	regulation of cytokinesis	17351640

Fusion gene breakpoints across CDH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A4S1-01A	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-
ChimerDB4	BRCA	TCGA-A2-A4S1-01A	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-
ChimerDB4	BRCA	TCGA-A2-A4S1	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394156	CDH11	chr16	65005482	-	ENST00000394249	PRC1	chr15	91512853	-	3478	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005482	-	ENST00000361919	PRC1	chr15	91512853	-	3354	2096	454	2277	607
ENST00000394156	CDH11	chr16	65005482	-	ENST00000361188	PRC1	chr15	91512853	-	3399	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005482	-	ENST00000442656	PRC1	chr15	91512853	-	2599	2096	454	2277	607
ENST00000268603	CDH11	chr16	65005482	-	ENST00000394249	PRC1	chr15	91512853	-	3640	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005482	-	ENST00000361919	PRC1	chr15	91512853	-	3516	2258	616	2439	607
ENST00000268603	CDH11	chr16	65005482	-	ENST00000361188	PRC1	chr15	91512853	-	3561	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005482	-	ENST00000442656	PRC1	chr15	91512853	-	2761	2258	616	2439	607
ENST00000394156	CDH11	chr16	65005481	-	ENST00000394249	PRC1	chr15	91512853	-	3478	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005481	-	ENST00000361919	PRC1	chr15	91512853	-	3354	2096	454	2277	607
ENST00000394156	CDH11	chr16	65005481	-	ENST00000361188	PRC1	chr15	91512853	-	3399	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005481	-	ENST00000442656	PRC1	chr15	91512853	-	2599	2096	454	2277	607
ENST00000268603	CDH11	chr16	65005481	-	ENST00000394249	PRC1	chr15	91512853	-	3640	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005481	-	ENST00000361919	PRC1	chr15	91512853	-	3516	2258	616	2439	607
ENST00000268603	CDH11	chr16	65005481	-	ENST00000361188	PRC1	chr15	91512853	-	3561	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005481	-	ENST00000442656	PRC1	chr15	91512853	-	2761	2258	616	2439	607
ENST00000394156	CDH11	chr16	65005481	-	ENST00000394249	PRC1	chr15	91512852	-	3478	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005481	-	ENST00000361919	PRC1	chr15	91512852	-	3354	2096	454	2277	607
ENST00000394156	CDH11	chr16	65005481	-	ENST00000361188	PRC1	chr15	91512852	-	3399	2096	454	2241	595
ENST00000394156	CDH11	chr16	65005481	-	ENST00000442656	PRC1	chr15	91512852	-	2599	2096	454	2277	607
ENST00000268603	CDH11	chr16	65005481	-	ENST00000394249	PRC1	chr15	91512852	-	3640	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005481	-	ENST00000361919	PRC1	chr15	91512852	-	3516	2258	616	2439	607
ENST00000268603	CDH11	chr16	65005481	-	ENST00000361188	PRC1	chr15	91512852	-	3561	2258	616	2403	595
ENST00000268603	CDH11	chr16	65005481	-	ENST00000442656	PRC1	chr15	91512852	-	2761	2258	616	2439	607

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394156	ENST00000394249	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000723957	0.9992761
ENST00000394156	ENST00000361919	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000674143	0.9993259
ENST00000394156	ENST00000361188	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000825512	0.9991744
ENST00000394156	ENST00000442656	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.001684335	0.9983157
ENST00000268603	ENST00000394249	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000868536	0.9991315
ENST00000268603	ENST00000361919	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000812285	0.99918777
ENST00000268603	ENST00000361188	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.000986681	0.9990133
ENST00000268603	ENST00000442656	CDH11	chr16	65005482	-	PRC1	chr15	91512853	-	0.001918191	0.9980818
ENST00000394156	ENST00000394249	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000723957	0.9992761
ENST00000394156	ENST00000361919	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000674143	0.9993259
ENST00000394156	ENST00000361188	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000825512	0.9991744
ENST00000394156	ENST00000442656	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.001684335	0.9983157
ENST00000268603	ENST00000394249	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000868536	0.9991315
ENST00000268603	ENST00000361919	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000812285	0.99918777
ENST00000268603	ENST00000361188	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.000986681	0.9990133
ENST00000268603	ENST00000442656	CDH11	chr16	65005481	-	PRC1	chr15	91512853	-	0.001918191	0.9980818
ENST00000394156	ENST00000394249	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000723957	0.9992761
ENST00000394156	ENST00000361919	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000674143	0.9993259
ENST00000394156	ENST00000361188	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000825512	0.9991744
ENST00000394156	ENST00000442656	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.001684335	0.9983157
ENST00000268603	ENST00000394249	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000868536	0.9991315
ENST00000268603	ENST00000361919	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000812285	0.99918777
ENST00000268603	ENST00000361188	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.000986681	0.9990133
ENST00000268603	ENST00000442656	CDH11	chr16	65005481	-	PRC1	chr15	91512852	-	0.001918191	0.9980818

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>14981_14981_1_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512852_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_2_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512852_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_3_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512852_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_4_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512852_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_5_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512853_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_6_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512853_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_7_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512853_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_8_CDH11-PRC1_CDH11_chr16_65005481_ENST00000268603_PRC1_chr15_91512853_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_9_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512852_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_10_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512852_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_11_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512852_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_12_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512852_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_13_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512853_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_14_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512853_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_15_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512853_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_16_CDH11-PRC1_CDH11_chr16_65005481_ENST00000394156_PRC1_chr15_91512853_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_17_CDH11-PRC1_CDH11_chr16_65005482_ENST00000268603_PRC1_chr15_91512853_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_18_CDH11-PRC1_CDH11_chr16_65005482_ENST00000268603_PRC1_chr15_91512853_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_19_CDH11-PRC1_CDH11_chr16_65005482_ENST00000268603_PRC1_chr15_91512853_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_20_CDH11-PRC1_CDH11_chr16_65005482_ENST00000268603_PRC1_chr15_91512853_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_21_CDH11-PRC1_CDH11_chr16_65005482_ENST00000394156_PRC1_chr15_91512853_ENST00000361188_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_22_CDH11-PRC1_CDH11_chr16_65005482_ENST00000394156_PRC1_chr15_91512853_ENST00000361919_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_23_CDH11-PRC1_CDH11_chr16_65005482_ENST00000394156_PRC1_chr15_91512853_ENST00000394249_length(amino acids)=595AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

>14981_14981_24_CDH11-PRC1_CDH11_chr16_65005482_ENST00000394156_PRC1_chr15_91512853_ENST00000442656_length(amino acids)=607AA_BP=547
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKY
ILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQ
SVYQMSVSEAAVPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREE
TAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:65005482/chr15:91512853)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDH11 P55287	.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

160_268

547.3333333333334

797.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

269_383

547.3333333333334

797.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

384_486

547.3333333333334

797.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

54_159

547.3333333333334

797.0

Domain

Cadherin 1

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

160_268

547.3333333333334

694.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

269_383

547.3333333333334

694.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

384_486

547.3333333333334

694.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

54_159

547.3333333333334

694.0

Domain

Cadherin 1

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

160_268

547.3333333333334

797.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

269_383

547.3333333333334

797.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

384_486

547.3333333333334

797.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

54_159

547.3333333333334

797.0

Domain

Cadherin 1

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

160_268

547.3333333333334

694.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

269_383

547.3333333333334

694.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

384_486

547.3333333333334

694.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

54_159

547.3333333333334

694.0

Domain

Cadherin 1

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

160_268

547.3333333333334

797.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

269_383

547.3333333333334

797.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

384_486

547.3333333333334

797.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

54_159

547.3333333333334

797.0

Domain

Cadherin 1

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

160_268

547.3333333333334

694.0

Domain

Cadherin 2

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

269_383

547.3333333333334

694.0

Domain

Cadherin 3

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

384_486

547.3333333333334

694.0

Domain

Cadherin 4

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

54_159

547.3333333333334

694.0

Domain

Cadherin 1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

487_612

547.3333333333334

797.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

487_612

547.3333333333334

694.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

487_612

547.3333333333334

797.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

487_612

547.3333333333334

694.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

487_612

547.3333333333334

797.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

487_612

547.3333333333334

694.0

Domain

Cadherin 5

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

54_617

547.3333333333334

797.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

641_796

547.3333333333334

797.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

54_617

547.3333333333334

694.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

641_796

547.3333333333334

694.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

54_617

547.3333333333334

797.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

641_796

547.3333333333334

797.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

54_617

547.3333333333334

694.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

641_796

547.3333333333334

694.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

54_617

547.3333333333334

797.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

641_796

547.3333333333334

797.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

54_617

547.3333333333334

694.0

Topological domain

Extracellular

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

641_796

547.3333333333334

694.0

Topological domain

Cytoplasmic

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000268603

618_640

547.3333333333334

797.0

Transmembrane

Helical

Hgene

CDH11

chr16:65005481

chr15:91512852

ENST00000394156

618_640

547.3333333333334

694.0

Transmembrane

Helical

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000268603

618_640

547.3333333333334

797.0

Transmembrane

Helical

Hgene

CDH11

chr16:65005481

chr15:91512853

ENST00000394156

618_640

547.3333333333334

694.0

Transmembrane

Helical

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000268603

618_640

547.3333333333334

797.0

Transmembrane

Helical

Hgene

CDH11

chr16:65005482

chr15:91512853

ENST00000394156

618_640

547.3333333333334

694.0

Transmembrane

Helical

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

211_304

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

383_463

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

96_133

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

211_304

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

383_463

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

96_133

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

211_304

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

383_463

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

96_133

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

211_304

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

383_463

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

96_133

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

211_304

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

383_463

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

96_133

524.0

621.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

211_304

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

383_463

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

96_133

483.0

526.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

1_341

524.0

621.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

342_466

524.0

621.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000394249

467_620

524.0

621.0

Region

Note=Unstructured%2C Arg/Lys rich

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

1_341

483.0

526.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

342_466

483.0

526.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005481

chr15:91512852

ENST00000442656

467_620

483.0

526.0

Region

Note=Unstructured%2C Arg/Lys rich

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

1_341

524.0

621.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

342_466

524.0

621.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000394249

467_620

524.0

621.0

Region

Note=Unstructured%2C Arg/Lys rich

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

1_341

483.0

526.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

342_466

483.0

526.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005481

chr15:91512853

ENST00000442656

467_620

483.0

526.0

Region

Note=Unstructured%2C Arg/Lys rich

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

1_341

524.0

621.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

342_466

524.0

621.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000394249

467_620

524.0

621.0

Region

Note=Unstructured%2C Arg/Lys rich

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

1_341

483.0

526.0

Region

Note=Dimerization

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

342_466

483.0

526.0

Region

Note=Spectrin-fold

Tgene

PRC1

chr16:65005482

chr15:91512853

ENST00000442656

467_620

483.0

526.0

Region

Note=Unstructured%2C Arg/Lys rich

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDH11
PRC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CDH11-PRC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CDH11-PRC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source