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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDH1-CCDC132

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDH1-CCDC132
FusionPDB ID: 15030
FusionGDB2.0 ID: 15048
HgeneTgene
Gene symbol

CDH1

CCDC132

Gene ID

51343

55610

Gene namefizzy and cell division cycle 20 related 1VPS50 subunit of EARP/GARPII complex
SynonymsCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1CCDC132|VPS54L
Cytomap

19p13.3

7q21.2-q21.3

Type of geneprotein-codingprotein-coding
Descriptionfizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1syndetinEARP/GARPII complex subunit VPS50VPS50, EARP/GARPII complex subunitcoiled-coil domain containing 132coiled-coil domain-containing protein 132
Modification date2020031320200313
UniProtAcc

Q9H159

.
Ensembl transtripts involved in fusion geneENST idsENST00000562836, ENST00000261769, 
ENST00000422392, 
ENST00000305866, 
ENST00000535481, ENST00000541136, 
ENST00000544910, ENST00000251739, 
ENST00000317751, ENST00000474412, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 16 X 8=26888 X 9 X 6=432
# samples 2910
** MAII scorelog2(29/2688*10)=-3.21240833276383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDH1 [Title/Abstract] AND CCDC132 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CCDC132(92940584)-CDH1(68862077), # samples:2
CDH1(68857529)-CCDC132(92952923), # samples:2
Anticipated loss of major functional domain due to fusion event.CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CCDC132-CDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

HgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

HgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826

TgeneCCDC132

GO:0032456

endocytic recycling

25799061


check buttonFusion gene breakpoints across CDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCDC132 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A12E-01ACDH1chr16

68857529

-CCDC132chr7

92952923

+
ChimerDB4BRCATCGA-AO-A12E-01ACDH1chr16

68857529

+CCDC132chr7

92952923

+
ChimerDB4BRCATCGA-AO-A12ECDH1chr16

68857529

+CCDC132chr7

92952922

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261769CDH1chr1668857529+ENST00000305866CCDC132chr792952922+398523554133941117
ENST00000261769CDH1chr1668857529+ENST00000541136CCDC132chr792952922+39792355412848935
ENST00000261769CDH1chr1668857529+ENST00000544910CCDC132chr792952922+398423554133941117
ENST00000261769CDH1chr1668857529+ENST00000535481CCDC132chr792952922+373623554133941117
ENST00000422392CDH1chr1668857529+ENST00000305866CCDC132chr792952922+367520456430841006
ENST00000422392CDH1chr1668857529+ENST00000541136CCDC132chr792952922+36692045642538824
ENST00000422392CDH1chr1668857529+ENST00000544910CCDC132chr792952922+367420456430841006
ENST00000422392CDH1chr1668857529+ENST00000535481CCDC132chr792952922+342620456430841006
ENST00000261769CDH1chr1668857529+ENST00000305866CCDC132chr792952923+398523554133941117
ENST00000261769CDH1chr1668857529+ENST00000541136CCDC132chr792952923+39792355412848935
ENST00000261769CDH1chr1668857529+ENST00000544910CCDC132chr792952923+398423554133941117
ENST00000261769CDH1chr1668857529+ENST00000535481CCDC132chr792952923+373623554133941117
ENST00000422392CDH1chr1668857529+ENST00000305866CCDC132chr792952923+367520456430841006
ENST00000422392CDH1chr1668857529+ENST00000541136CCDC132chr792952923+36692045642538824
ENST00000422392CDH1chr1668857529+ENST00000544910CCDC132chr792952923+367420456430841006
ENST00000422392CDH1chr1668857529+ENST00000535481CCDC132chr792952923+342620456430841006

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261769ENST00000305866CDH1chr1668857529+CCDC132chr792952922+0.0002966570.99970335
ENST00000261769ENST00000541136CDH1chr1668857529+CCDC132chr792952922+0.0001168450.9998832
ENST00000261769ENST00000544910CDH1chr1668857529+CCDC132chr792952922+0.0002965430.99970347
ENST00000261769ENST00000535481CDH1chr1668857529+CCDC132chr792952922+0.0004641510.9995359
ENST00000422392ENST00000305866CDH1chr1668857529+CCDC132chr792952922+0.0001376590.9998623
ENST00000422392ENST00000541136CDH1chr1668857529+CCDC132chr792952922+0.0001221280.9998778
ENST00000422392ENST00000544910CDH1chr1668857529+CCDC132chr792952922+0.0001375310.99986243
ENST00000422392ENST00000535481CDH1chr1668857529+CCDC132chr792952922+0.000224680.99977535
ENST00000261769ENST00000305866CDH1chr1668857529+CCDC132chr792952923+0.0002966570.99970335
ENST00000261769ENST00000541136CDH1chr1668857529+CCDC132chr792952923+0.0001168450.9998832
ENST00000261769ENST00000544910CDH1chr1668857529+CCDC132chr792952923+0.0002965430.99970347
ENST00000261769ENST00000535481CDH1chr1668857529+CCDC132chr792952923+0.0004641510.9995359
ENST00000422392ENST00000305866CDH1chr1668857529+CCDC132chr792952923+0.0001376590.9998623
ENST00000422392ENST00000541136CDH1chr1668857529+CCDC132chr792952923+0.0001221280.9998778
ENST00000422392ENST00000544910CDH1chr1668857529+CCDC132chr792952923+0.0001375310.99986243
ENST00000422392ENST00000535481CDH1chr1668857529+CCDC132chr792952923+0.000224680.99977535

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15030_15030_1_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952922_ENST00000305866_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_2_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952922_ENST00000535481_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_3_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952922_ENST00000541136_length(amino acids)=935AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ

--------------------------------------------------------------

>15030_15030_4_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952922_ENST00000544910_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_5_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952923_ENST00000305866_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_6_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952923_ENST00000535481_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_7_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952923_ENST00000541136_length(amino acids)=935AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ

--------------------------------------------------------------

>15030_15030_8_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000261769_CCDC132_chr7_92952923_ENST00000544910_length(amino acids)=1117AA_BP=772
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQA
SVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPL
DRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPE
LPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTD
ADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPE
KRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGT
LLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLM
DNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRN
DSLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQ
PHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRV
RIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREY

--------------------------------------------------------------

>15030_15030_9_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952922_ENST00000305866_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

--------------------------------------------------------------

>15030_15030_10_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952922_ENST00000535481_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

--------------------------------------------------------------

>15030_15030_11_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952922_ENST00000541136_length(amino acids)=824AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ

--------------------------------------------------------------

>15030_15030_12_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952922_ENST00000544910_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

--------------------------------------------------------------

>15030_15030_13_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952923_ENST00000305866_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

--------------------------------------------------------------

>15030_15030_14_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952923_ENST00000535481_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

--------------------------------------------------------------

>15030_15030_15_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952923_ENST00000541136_length(amino acids)=824AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ

--------------------------------------------------------------

>15030_15030_16_CDH1-CCDC132_CDH1_chr16_68857529_ENST00000422392_CCDC132_chr7_92952923_ENST00000544910_length(amino acids)=1006AA_BP=661
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS
NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGS
VMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT
AVITVTDTNDNPPIFNPTTGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQ
EPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIF
FCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGA
AGVCRKAQPVEAGLQIPAILGILGGILALLRKYMQMMNILKPIAFDVIHFMSQLFDYYLYAIYTFFGRNDSLESTGLGLSSSRLRTTLNR
IQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQ
TVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRT
IVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKAYYLTENDMERWIKEHREYSTKQLTNLVNVCLGSHINKKA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:92940584/chr7:68862077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH1

Q9H159

.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316155_262721.3333333333334883.0DomainCadherin 1
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316263_375721.3333333333334883.0DomainCadherin 2
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316376_486721.3333333333334883.0DomainCadherin 3
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316487_593721.3333333333334883.0DomainCadherin 4
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316594_697721.3333333333334883.0DomainCadherin 5
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316155_262721.3333333333334883.0DomainCadherin 1
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316263_375721.3333333333334883.0DomainCadherin 2
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316376_486721.3333333333334883.0DomainCadherin 3
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316487_593721.3333333333334883.0DomainCadherin 4
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316594_697721.3333333333334883.0DomainCadherin 5
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316155_709721.3333333333334883.0Topological domainExtracellular
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316155_709721.3333333333334883.0Topological domainExtracellular
TgeneCCDC132chr16:68857529chr7:92952922ENST00000251739012216_2440328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952922ENST0000025173901282_1050328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST00000251739012216_2440328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST0000025173901282_1050328.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316838_851721.3333333333334883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316838_851721.3333333333334883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316758_769721.3333333333334883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316811_882721.3333333333334883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316758_769721.3333333333334883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316811_882721.3333333333334883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316731_882721.3333333333334883.0Topological domainCytoplasmic
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316731_882721.3333333333334883.0Topological domainCytoplasmic
HgeneCDH1chr16:68857529chr7:92952922ENST00000261769+1316710_730721.3333333333334883.0TransmembraneHelical
HgeneCDH1chr16:68857529chr7:92952923ENST00000261769+1316710_730721.3333333333334883.0TransmembraneHelical
TgeneCCDC132chr16:68857529chr7:92952922ENST000003058661928216_244618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952922ENST00000305866192882_105618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952922ENST000005449102029216_244588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952922ENST00000544910202982_105588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST000003058661928216_244618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST00000305866192882_105618.3333333333334965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST000005449102029216_244588.3333333333334935.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr16:68857529chr7:92952923ENST00000544910202982_105588.3333333333334935.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDH1
CCDC132


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDH1-CCDC132


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDH1-CCDC132


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource