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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDH1-CIRH1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDH1-CIRH1A
FusionPDB ID: 15033
FusionGDB2.0 ID: 15046
HgeneTgene
Gene symbol

CDH1

CIRH1A

Gene ID

51343

84916

Gene namefizzy and cell division cycle 20 related 1UTP4 small subunit processome component
SynonymsCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1CIRH1A|CIRHIN|NAIC|TEX292
Cytomap

19p13.3

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionfizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1U3 small nucleolar RNA-associated protein 4 homologUTP4 small subunit (SSU) processome componentUTP4, small subunit (SSU) processome component, homologcirrhosis, autosomal recessive 1A (cirhin)testis expressed gene 292
Modification date2020031320200313
UniProtAcc

Q9H159

.
Ensembl transtripts involved in fusion geneENST idsENST00000562836, ENST00000261769, 
ENST00000422392, 		ENST00000314423, 
ENST00000352319, ENST00000563094, 
ENST00000569615, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 16 X 8=26884 X 8 X 6=192
# samples 298
** MAII scorelog2(29/2688*10)=-3.21240833276383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDH1 [Title/Abstract] AND CIRH1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDH1(68835796)-CIRH1A(69170598), # samples:1
CDH1(68849662)-CIRH1A(69194258), # samples:1
CDH1(68772314)-CIRH1A(69177080), # samples:1
Anticipated loss of major functional domain due to fusion event.CDH1-CIRH1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CIRH1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-CIRH1A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CDH1-CIRH1A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

HgeneCDH1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

HgeneCDH1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826

TgeneCIRH1A

GO:0006355

regulation of transcription, DNA-templated

19732766


check buttonFusion gene breakpoints across CDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CIRH1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A6VXCDH1chr16

68835796

+CIRH1Achr16

69170598

+
ChimerDB4ESCATCGA-L5-A8NFCDH1chr16

68849662

+CIRH1Achr16

69194258

+
ChimerDB4STADTCGA-D7-6518CDH1chr16

68772314

+CIRH1Achr16

69177080

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261769CDH1chr1668835796+ENST00000314423CIRH1Achr1669170598+2564578412479812
ENST00000261769CDH1chr1668835796+ENST00000352319CIRH1Achr1669170598+2218578412134697
ENST00000261769CDH1chr1668835796+ENST00000563094CIRH1Achr1669170598+4568578412296751
ENST00000422392CDH1chr1668835796+ENST00000314423CIRH1Achr1669170598+2437451642352762
ENST00000422392CDH1chr1668835796+ENST00000352319CIRH1Achr1669170598+2091451642007647
ENST00000422392CDH1chr1668835796+ENST00000563094CIRH1Achr1669170598+4441451642169701
ENST00000261769CDH1chr1668772314+ENST00000314423CIRH1Achr1669177080+1973354411888615
ENST00000261769CDH1chr1668772314+ENST00000352319CIRH1Achr1669177080+1627354411543500
ENST00000261769CDH1chr1668772314+ENST00000563094CIRH1Achr1669177080+3977354411705554
ENST00000422392CDH1chr1668772314+ENST00000314423CIRH1Achr1669177080+1846227641761565
ENST00000422392CDH1chr1668772314+ENST00000352319CIRH1Achr1669177080+1500227641416450
ENST00000422392CDH1chr1668772314+ENST00000563094CIRH1Achr1669177080+3850227641578504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261769ENST00000314423CDH1chr1668835796+CIRH1Achr1669170598+0.0028702550.99712974
ENST00000261769ENST00000352319CDH1chr1668835796+CIRH1Achr1669170598+0.0035914720.9964085
ENST00000261769ENST00000563094CDH1chr1668835796+CIRH1Achr1669170598+0.0012511610.9987488
ENST00000422392ENST00000314423CDH1chr1668835796+CIRH1Achr1669170598+0.0023568410.9976432
ENST00000422392ENST00000352319CDH1chr1668835796+CIRH1Achr1669170598+0.0028590740.997141
ENST00000422392ENST00000563094CDH1chr1668835796+CIRH1Achr1669170598+0.0010590730.9989409
ENST00000261769ENST00000314423CDH1chr1668772314+CIRH1Achr1669177080+0.0180806650.9819194
ENST00000261769ENST00000352319CDH1chr1668772314+CIRH1Achr1669177080+0.0070194230.9929806
ENST00000261769ENST00000563094CDH1chr1668772314+CIRH1Achr1669177080+0.0089660030.991034
ENST00000422392ENST00000314423CDH1chr1668772314+CIRH1Achr1669177080+0.015376030.9846239
ENST00000422392ENST00000352319CDH1chr1668772314+CIRH1Achr1669177080+0.00568930.99431074
ENST00000422392ENST00000563094CDH1chr1668772314+CIRH1Achr1669177080+0.0076232770.9923767

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15033_15033_1_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000261769_CIRH1A_chr16_69177080_ENST00000314423_length(amino acids)=615AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSF
VVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCS
KKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVS
KMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCT
VPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSL

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>15033_15033_2_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000261769_CIRH1A_chr16_69177080_ENST00000352319_length(amino acids)=500AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSF
VVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCS
KKRQLLLFQFAHHLELWRLGSTVATGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHS
DQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRR

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>15033_15033_3_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000261769_CIRH1A_chr16_69177080_ENST00000563094_length(amino acids)=554AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSF
VVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCS
KKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVS
KMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCT
VPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSL

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>15033_15033_4_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000422392_CIRH1A_chr16_69177080_ENST00000314423_length(amino acids)=565AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIIS
VDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALI
SGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPE
NIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQS
GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQG
FHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTL

--------------------------------------------------------------

>15033_15033_5_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000422392_CIRH1A_chr16_69177080_ENST00000352319_length(amino acids)=450AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIIS
VDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALI
SGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGTVEAMCLLAVSPDGNWLAASGTSA
GVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHI
LLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKFGT

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>15033_15033_6_CDH1-CIRH1A_CDH1_chr16_68772314_ENST00000422392_CIRH1A_chr16_69177080_ENST00000563094_length(amino acids)=504AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIIS
VDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALI
SGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPE
NIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQS
GTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQG

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>15033_15033_7_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000261769_CIRH1A_chr16_69170598_ENST00000314423_length(amino acids)=812AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQF
FPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQ
KSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLI
ANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYD
AALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFF
LYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGT
SAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPM
HILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLDDIIAQLPPPIKKKKF

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>15033_15033_8_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000261769_CIRH1A_chr16_69170598_ENST00000352319_length(amino acids)=697AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQF
FPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQ
KSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLI
ANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYD
AALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPV
TAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTL

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>15033_15033_9_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000261769_CIRH1A_chr16_69170598_ENST00000563094_length(amino acids)=751AA_BP=1
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQF
FPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQ
KSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLI
ANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYD
AALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLPLSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFF
LYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGT
SAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPM

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>15033_15033_10_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000422392_CIRH1A_chr16_69170598_ENST00000314423_length(amino acids)=762AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPI
WSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKR
KCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQ
HHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLP
LSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIV
QLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYS
IPDKQYTDWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKIS

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>15033_15033_11_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000422392_CIRH1A_chr16_69170598_ENST00000352319_length(amino acids)=647AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPI
WSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKR
KCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQ
HHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGTVEAMCL
LAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYSIPDKQYTDWSRTVQKQGFHHLWLQR
DTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDKTLLYNPFPPTNESDVIRRRTAHAFKISKIYKPLLFMDLLDERTLVAVERPLD

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>15033_15033_12_CDH1-CIRH1A_CDH1_chr16_68835796_ENST00000422392_CIRH1A_chr16_69170598_ENST00000563094_length(amino acids)=701AA_BP=0
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQFFPGHESRATEALCWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPI
WSMAASPSGSQLLVGCEDGSVKLFQITPDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKR
KCIVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVVGTAEGTVFHFQLVPVTSNSSEKQWVRTKPFQ
HHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYDAALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKNGDTLP
LSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKRVSKMPAFLRSALQILFSEDSTKLFVASNQGALHIV
QLSGGSFKHLHAFQPQSGTVEAMCLLAVSPDGNWLAASGTSAGVHVYNVKQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEYS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68835796/chr16:69170598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH1

Q9H159

.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417182_226175.33333333333334687.0RepeatNote=WD 5
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417227_275175.33333333333334687.0RepeatNote=WD 6
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417276_317175.33333333333334687.0RepeatNote=WD 7
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417318_377175.33333333333334687.0RepeatNote=WD 8
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417378_427175.33333333333334687.0RepeatNote=WD 9
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417428_475175.33333333333334687.0RepeatNote=WD 10
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417476_516175.33333333333334687.0RepeatNote=WD 11
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417517_566175.33333333333334687.0RepeatNote=WD 12
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417567_627175.33333333333334687.0RepeatNote=WD 13
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417628_666175.33333333333334687.0RepeatNote=WD 14
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414182_226175.33333333333334572.0RepeatNote=WD 5
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414227_275175.33333333333334572.0RepeatNote=WD 6
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414276_317175.33333333333334572.0RepeatNote=WD 7
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414318_377175.33333333333334572.0RepeatNote=WD 8
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414378_427175.33333333333334572.0RepeatNote=WD 9
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414428_475175.33333333333334572.0RepeatNote=WD 10
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414476_516175.33333333333334572.0RepeatNote=WD 11
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414517_566175.33333333333334572.0RepeatNote=WD 12
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414567_627175.33333333333334572.0RepeatNote=WD 13
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414628_666175.33333333333334572.0RepeatNote=WD 14
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415182_226175.33333333333334626.0RepeatNote=WD 5
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415227_275175.33333333333334626.0RepeatNote=WD 6
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415276_317175.33333333333334626.0RepeatNote=WD 7
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415318_377175.33333333333334626.0RepeatNote=WD 8
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415378_427175.33333333333334626.0RepeatNote=WD 9
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415428_475175.33333333333334626.0RepeatNote=WD 10
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415476_516175.33333333333334626.0RepeatNote=WD 11
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415517_566175.33333333333334626.0RepeatNote=WD 12
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415567_627175.33333333333334626.0RepeatNote=WD 13
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415628_666175.33333333333334626.0RepeatNote=WD 14
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117136_18153.0687.0RepeatNote=WD 4
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117182_22653.0687.0RepeatNote=WD 5
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117227_27553.0687.0RepeatNote=WD 6
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117276_31753.0687.0RepeatNote=WD 7
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117318_37753.0687.0RepeatNote=WD 8
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117378_42753.0687.0RepeatNote=WD 9
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117428_47553.0687.0RepeatNote=WD 10
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117476_51653.0687.0RepeatNote=WD 11
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117517_56653.0687.0RepeatNote=WD 12
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000031442311751_9253.0687.0RepeatNote=WD 2
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117567_62753.0687.0RepeatNote=WD 13
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000314423117628_66653.0687.0RepeatNote=WD 14
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000031442311793_13553.0687.0RepeatNote=WD 3
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114136_18153.0572.0RepeatNote=WD 4
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114182_22653.0572.0RepeatNote=WD 5
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114227_27553.0572.0RepeatNote=WD 6
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114276_31753.0572.0RepeatNote=WD 7
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114318_37753.0572.0RepeatNote=WD 8
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114378_42753.0572.0RepeatNote=WD 9
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114428_47553.0572.0RepeatNote=WD 10
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114476_51653.0572.0RepeatNote=WD 11
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114517_56653.0572.0RepeatNote=WD 12
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000035231911451_9253.0572.0RepeatNote=WD 2
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114567_62753.0572.0RepeatNote=WD 13
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000352319114628_66653.0572.0RepeatNote=WD 14
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000035231911493_13553.0572.0RepeatNote=WD 3
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115136_18153.0626.0RepeatNote=WD 4
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115182_22653.0626.0RepeatNote=WD 5
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115227_27553.0626.0RepeatNote=WD 6
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115276_31753.0626.0RepeatNote=WD 7
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115318_37753.0626.0RepeatNote=WD 8
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115378_42753.0626.0RepeatNote=WD 9
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115428_47553.0626.0RepeatNote=WD 10
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115476_51653.0626.0RepeatNote=WD 11
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115517_56653.0626.0RepeatNote=WD 12
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000056309411551_9253.0626.0RepeatNote=WD 2
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115567_62753.0626.0RepeatNote=WD 13
TgeneCIRH1Achr16:68835796chr16:69170598ENST00000563094115628_66653.0626.0RepeatNote=WD 14
TgeneCIRH1Achr16:68835796chr16:69170598ENST0000056309411593_13553.0626.0RepeatNote=WD 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216838_85154.333333333333336883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316838_851129.0883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216155_26254.333333333333336883.0DomainCadherin 1
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216263_37554.333333333333336883.0DomainCadherin 2
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216376_48654.333333333333336883.0DomainCadherin 3
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216487_59354.333333333333336883.0DomainCadherin 4
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216594_69754.333333333333336883.0DomainCadherin 5
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316155_262129.0883.0DomainCadherin 1
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316263_375129.0883.0DomainCadherin 2
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316376_486129.0883.0DomainCadherin 3
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316487_593129.0883.0DomainCadherin 4
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316594_697129.0883.0DomainCadherin 5
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216758_76954.333333333333336883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216811_88254.333333333333336883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316758_769129.0883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316811_882129.0883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216155_70954.333333333333336883.0Topological domainExtracellular
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216731_88254.333333333333336883.0Topological domainCytoplasmic
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316155_709129.0883.0Topological domainExtracellular
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316731_882129.0883.0Topological domainCytoplasmic
HgeneCDH1chr16:68772314chr16:69177080ENST00000261769+216710_73054.333333333333336883.0TransmembraneHelical
HgeneCDH1chr16:68835796chr16:69170598ENST00000261769+316710_730129.0883.0TransmembraneHelical
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000314423417136_181175.33333333333334687.0RepeatNote=WD 4
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000031442341751_92175.33333333333334687.0RepeatNote=WD 2
TgeneCIRH1Achr16:68772314chr16:69177080ENST000003144234177_50175.33333333333334687.0RepeatNote=WD 1
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000031442341793_135175.33333333333334687.0RepeatNote=WD 3
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000352319414136_181175.33333333333334572.0RepeatNote=WD 4
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000035231941451_92175.33333333333334572.0RepeatNote=WD 2
TgeneCIRH1Achr16:68772314chr16:69177080ENST000003523194147_50175.33333333333334572.0RepeatNote=WD 1
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000035231941493_135175.33333333333334572.0RepeatNote=WD 3
TgeneCIRH1Achr16:68772314chr16:69177080ENST00000563094415136_181175.33333333333334626.0RepeatNote=WD 4
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000056309441551_92175.33333333333334626.0RepeatNote=WD 2
TgeneCIRH1Achr16:68772314chr16:69177080ENST000005630944157_50175.33333333333334626.0RepeatNote=WD 1
TgeneCIRH1Achr16:68772314chr16:69177080ENST0000056309441593_135175.33333333333334626.0RepeatNote=WD 3
TgeneCIRH1Achr16:68835796chr16:69170598ENST000003144231177_5053.0687.0RepeatNote=WD 1
TgeneCIRH1Achr16:68835796chr16:69170598ENST000003523191147_5053.0572.0RepeatNote=WD 1
TgeneCIRH1Achr16:68835796chr16:69170598ENST000005630941157_5053.0626.0RepeatNote=WD 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDH1
CIRH1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDH1-CIRH1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDH1-CIRH1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource