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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDK12-FBXL20

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDK12-FBXL20
	FusionPDB ID: 15133
	FusionGDB2.0 ID: 15133
		Hgene	Tgene
	Gene symbol	CDK12	FBXL20
	Gene ID	51755	84961
	Gene name	cyclin dependent kinase 12	F-box and leucine rich repeat protein 20
	Synonyms	CRK7\|CRKR\|CRKRS	Fbl2\|Fbl20
	Cytomap	17q12	17q12
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12	F-box/LRR-repeat protein 20F-box protein FBL2
	Modification date	20200313	20200313
	UniProtAcc	Q9NYV4	Q96IG2
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000430627, ENST00000447079, ENST00000559545,	ENST00000264658, ENST00000394294, ENST00000577399, ENST00000583610,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 13 X 13=4901	13 X 9 X 6=702
	# samples	31	17
	** MAII score	log2(31/4901*10)=-3.98273602613552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/702*10)=-2.04593628416686 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDK12 [Title/Abstract] AND FBXL20 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDK12(37628016)-FBXL20(37439108), # samples:2 FBXL20(37557614)-CDK12(37657503), # samples:2
Anticipated loss of major functional domain due to fusion event.	CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. CDK12-FBXL20 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. FBXL20-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK12	GO:0046777	protein autophosphorylation	11683387

Fusion gene breakpoints across CDK12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FBXL20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A0JM-01A	CDK12	chr17	37628016	-	FBXL20	chr17	37439108	-
ChimerDB4	BRCA	TCGA-AO-A0JM-01A	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-
ChimerDB4	LAML	TCGA-AB-2839-03A	CDK12	chr17	37628016	+	FBXL20	chr17	37499494	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000430627	CDK12	chr17	37628016	+	ENST00000583610	FBXL20	chr17	37439108	-	3233	2242	185	3058	957
ENST00000430627	CDK12	chr17	37628016	+	ENST00000394294	FBXL20	chr17	37439108	-	3932	2242	185	3058	957
ENST00000430627	CDK12	chr17	37628016	+	ENST00000264658	FBXL20	chr17	37439108	-	3932	2242	185	3058	957
ENST00000430627	CDK12	chr17	37628016	+	ENST00000577399	FBXL20	chr17	37439108	-	3059	2242	185	3058	958
ENST00000447079	CDK12	chr17	37628016	+	ENST00000583610	FBXL20	chr17	37439108	-	2955	1964	33	2780	915
ENST00000447079	CDK12	chr17	37628016	+	ENST00000394294	FBXL20	chr17	37439108	-	3654	1964	33	2780	915
ENST00000447079	CDK12	chr17	37628016	+	ENST00000264658	FBXL20	chr17	37439108	-	3654	1964	33	2780	915
ENST00000447079	CDK12	chr17	37628016	+	ENST00000577399	FBXL20	chr17	37439108	-	2781	1964	33	2780	915

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000430627	ENST00000583610	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.003038023	0.996962
ENST00000430627	ENST00000394294	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.001298921	0.9987011
ENST00000430627	ENST00000264658	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.001298921	0.9987011
ENST00000430627	ENST00000577399	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.003447372	0.9965526
ENST00000447079	ENST00000583610	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.003887142	0.9961128
ENST00000447079	ENST00000394294	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.001487983	0.99851197
ENST00000447079	ENST00000264658	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.001487983	0.99851197
ENST00000447079	ENST00000577399	CDK12	chr17	37628016	+	FBXL20	chr17	37439108	-	0.004461195	0.9955388

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15133_15133_1_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000430627_FBXL20_chr17_37439108_ENST00000264658_length(amino acids)=957AA_BP=441
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------

>15133_15133_2_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000430627_FBXL20_chr17_37439108_ENST00000394294_length(amino acids)=957AA_BP=441
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------

>15133_15133_3_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000430627_FBXL20_chr17_37439108_ENST00000577399_length(amino acids)=958AA_BP=441
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------

>15133_15133_4_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000430627_FBXL20_chr17_37439108_ENST00000583610_length(amino acids)=957AA_BP=441
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------

>15133_15133_5_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000447079_FBXL20_chr17_37439108_ENST00000264658_length(amino acids)=915AA_BP=399
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

--------------------------------------------------------------

>15133_15133_6_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000447079_FBXL20_chr17_37439108_ENST00000394294_length(amino acids)=915AA_BP=399
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

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>15133_15133_7_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000447079_FBXL20_chr17_37439108_ENST00000577399_length(amino acids)=915AA_BP=399
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

--------------------------------------------------------------

>15133_15133_8_CDK12-FBXL20_CDK12_chr17_37628016_ENST00000447079_FBXL20_chr17_37439108_ENST00000583610_length(amino acids)=915AA_BP=399
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37628016/chr17:37439108)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK12 Q9NYV4	FBXL20 Q96IG2
FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269\|PubMed:11683387, ECO:0000269\|PubMed:19651820, ECO:0000269\|PubMed:20952539, ECO:0000269\|PubMed:22012619, ECO:0000269\|PubMed:24662513}.	FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

407_413

643.6666666666666

1482.0

Compositional bias

Note=Poly-Ala

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

535_540

643.6666666666666

1482.0

Compositional bias

Note=Poly-Pro

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

407_413

643.6666666666666

1491.0

Compositional bias

Note=Poly-Ala

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

535_540

643.6666666666666

1491.0

Compositional bias

Note=Poly-Pro

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

179_204

164.66666666666666

437.0

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

205_230

164.66666666666666

437.0

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

231_256

164.66666666666666

437.0

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

257_282

164.66666666666666

437.0

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

283_308

164.66666666666666

437.0

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

309_334

164.66666666666666

437.0

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

335_363

164.66666666666666

437.0

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

364_388

164.66666666666666

437.0

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

389_414

164.66666666666666

437.0

Repeat

Note=LRR 13

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

153_178

132.66666666666666

405.0

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

179_204

132.66666666666666

405.0

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

205_230

132.66666666666666

405.0

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

231_256

132.66666666666666

405.0

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

257_282

132.66666666666666

405.0

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

283_308

132.66666666666666

405.0

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

309_334

132.66666666666666

405.0

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

335_363

132.66666666666666

405.0

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

364_388

132.66666666666666

405.0

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

389_414

132.66666666666666

405.0

Repeat

Note=LRR 13

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

179_204

164.66666666666666

411.6666666666667

Repeat

Note=LRR 5

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

205_230

164.66666666666666

411.6666666666667

Repeat

Note=LRR 6

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

231_256

164.66666666666666

411.6666666666667

Repeat

Note=LRR 7

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

257_282

164.66666666666666

411.6666666666667

Repeat

Note=LRR 8

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

283_308

164.66666666666666

411.6666666666667

Repeat

Note=LRR 9

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

309_334

164.66666666666666

411.6666666666667

Repeat

Note=LRR 10

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

335_363

164.66666666666666

411.6666666666667

Repeat

Note=LRR 11

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

364_388

164.66666666666666

411.6666666666667

Repeat

Note=LRR 12

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

389_414

164.66666666666666

411.6666666666667

Repeat

Note=LRR 13

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

1266_1280

643.6666666666666

1482.0

Compositional bias

Note=Poly-Pro

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

1266_1280

643.6666666666666

1491.0

Compositional bias

Note=Poly-Pro

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

727_1020

643.6666666666666

1482.0

Domain

Protein kinase

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

727_1020

643.6666666666666

1491.0

Domain

Protein kinase

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

733_741

643.6666666666666

1482.0

Nucleotide binding

Note=ATP

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000430627

814_819

643.6666666666666

1482.0

Nucleotide binding

Note=ATP

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

733_741

643.6666666666666

1491.0

Nucleotide binding

Note=ATP

Hgene

CDK12

chr17:37628016

chr17:37439108

ENST00000447079

814_819

643.6666666666666

1491.0

Nucleotide binding

Note=ATP

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

22_68

164.66666666666666

437.0

Domain

F-box

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

22_68

132.66666666666666

405.0

Domain

F-box

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

22_68

164.66666666666666

411.6666666666667

Domain

F-box

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

101_126

164.66666666666666

437.0

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

127_152

164.66666666666666

437.0

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

153_178

164.66666666666666

437.0

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000264658

74_100

164.66666666666666

437.0

Repeat

Note=LRR 1

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

101_126

132.66666666666666

405.0

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

127_152

132.66666666666666

405.0

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000394294

74_100

132.66666666666666

405.0

Repeat

Note=LRR 1

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

101_126

164.66666666666666

411.6666666666667

Repeat

Note=LRR 2

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

127_152

164.66666666666666

411.6666666666667

Repeat

Note=LRR 3

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

153_178

164.66666666666666

411.6666666666667

Repeat

Note=LRR 4

Tgene

FBXL20

chr17:37628016

chr17:37439108

ENST00000583610

74_100

164.66666666666666

411.6666666666667

Repeat

Note=LRR 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDK12
FBXL20

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to CDK12-FBXL20

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CDK12-FBXL20

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source