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Fusion Protein:ACSL5-TCF7L2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ACSL5-TCF7L2 | FusionPDB ID: 1517 | FusionGDB2.0 ID: 1517 | Hgene | Tgene | Gene symbol | ACSL5 | TCF7L2 | Gene ID | 51703 | 6934 |
| Gene name | acyl-CoA synthetase long chain family member 5 | transcription factor 7 like 2 | |
| Synonyms | ACS2|ACS5|FACL5 | TCF-4|TCF4 | |
| Cytomap | 10q25.2 | 10q25.2-q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | long-chain-fatty-acid--CoA ligase 5FACL5 for fatty acid coenzyme A ligase 5LACS 5arachidonate--CoA ligasefatty acid coenzyme A ligase 5fatty-acid-Coenzyme A ligase, long-chain 5long-chain acyl-CoA synthetase 5long-chain fatty acid coenzyme A ligase | transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box) | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q9ULC5 | Q9NQB0 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000479936, ENST00000354273, ENST00000354655, ENST00000356116, ENST00000393081, ENST00000433418, ENST00000369410, | ENST00000355995, ENST00000534894, ENST00000536810, ENST00000543371, ENST00000545257, ENST00000349937, ENST00000352065, ENST00000355717, ENST00000369386, ENST00000369389, ENST00000369395, ENST00000369397, ENST00000466338, ENST00000538897, ENST00000542695, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 5=180 | 12 X 11 X 10=1320 |
| # samples | 6 | 17 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/1320*10)=-2.95693127810811 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ACSL5 [Title/Abstract] AND TCF7L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ACSL5(114154860)-TCF7L2(114724315), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ACSL5-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSL5-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ACSL5-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ACSL5-TCF7L2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACSL5 | GO:0001676 | long-chain fatty acid metabolic process | 24269233 |
| Tgene | TCF7L2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12799378 |
| Tgene | TCF7L2 | GO:0006357 | regulation of transcription by RNA polymerase II | 9727977 |
| Tgene | TCF7L2 | GO:0032092 | positive regulation of protein binding | 12799378 |
| Tgene | TCF7L2 | GO:0032350 | regulation of hormone metabolic process | 15525634 |
| Tgene | TCF7L2 | GO:0042593 | glucose homeostasis | 15525634 |
| Tgene | TCF7L2 | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 12799378 |
| Tgene | TCF7L2 | GO:0045444 | fat cell differentiation | 10937998 |
| Tgene | TCF7L2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12799378|15525634 |
| Tgene | TCF7L2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065401|19168596 |
| Tgene | TCF7L2 | GO:0048625 | myoblast fate commitment | 10937998 |
| Fusion gene breakpoints across ACSL5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TCF7L2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-AG-4007 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000354655 | ACSL5 | chr10 | 114154860 | + | ENST00000534894 | TCF7L2 | chr10 | 114724315 | + | 1541 | 437 | 254 | 1540 | 429 |
| ENST00000354655 | ACSL5 | chr10 | 114154860 | + | ENST00000536810 | TCF7L2 | chr10 | 114724315 | + | 3571 | 437 | 254 | 1864 | 536 |
| ENST00000354655 | ACSL5 | chr10 | 114154860 | + | ENST00000545257 | TCF7L2 | chr10 | 114724315 | + | 3622 | 437 | 254 | 1915 | 553 |
| ENST00000354655 | ACSL5 | chr10 | 114154860 | + | ENST00000355995 | TCF7L2 | chr10 | 114724315 | + | 3622 | 437 | 254 | 1915 | 553 |
| ENST00000354655 | ACSL5 | chr10 | 114154860 | + | ENST00000543371 | TCF7L2 | chr10 | 114724315 | + | 3571 | 437 | 254 | 1864 | 536 |
| ENST00000393081 | ACSL5 | chr10 | 114154860 | + | ENST00000534894 | TCF7L2 | chr10 | 114724315 | + | 1567 | 463 | 280 | 1566 | 429 |
| ENST00000393081 | ACSL5 | chr10 | 114154860 | + | ENST00000536810 | TCF7L2 | chr10 | 114724315 | + | 3597 | 463 | 280 | 1890 | 536 |
| ENST00000393081 | ACSL5 | chr10 | 114154860 | + | ENST00000545257 | TCF7L2 | chr10 | 114724315 | + | 3648 | 463 | 280 | 1941 | 553 |
| ENST00000393081 | ACSL5 | chr10 | 114154860 | + | ENST00000355995 | TCF7L2 | chr10 | 114724315 | + | 3648 | 463 | 280 | 1941 | 553 |
| ENST00000393081 | ACSL5 | chr10 | 114154860 | + | ENST00000543371 | TCF7L2 | chr10 | 114724315 | + | 3597 | 463 | 280 | 1890 | 536 |
| ENST00000433418 | ACSL5 | chr10 | 114154860 | + | ENST00000534894 | TCF7L2 | chr10 | 114724315 | + | 1540 | 436 | 49 | 1539 | 497 |
| ENST00000433418 | ACSL5 | chr10 | 114154860 | + | ENST00000536810 | TCF7L2 | chr10 | 114724315 | + | 3570 | 436 | 49 | 1863 | 604 |
| ENST00000433418 | ACSL5 | chr10 | 114154860 | + | ENST00000545257 | TCF7L2 | chr10 | 114724315 | + | 3621 | 436 | 49 | 1914 | 621 |
| ENST00000433418 | ACSL5 | chr10 | 114154860 | + | ENST00000355995 | TCF7L2 | chr10 | 114724315 | + | 3621 | 436 | 49 | 1914 | 621 |
| ENST00000433418 | ACSL5 | chr10 | 114154860 | + | ENST00000543371 | TCF7L2 | chr10 | 114724315 | + | 3570 | 436 | 49 | 1863 | 604 |
| ENST00000356116 | ACSL5 | chr10 | 114154860 | + | ENST00000534894 | TCF7L2 | chr10 | 114724315 | + | 1540 | 436 | 49 | 1539 | 497 |
| ENST00000356116 | ACSL5 | chr10 | 114154860 | + | ENST00000536810 | TCF7L2 | chr10 | 114724315 | + | 3570 | 436 | 49 | 1863 | 604 |
| ENST00000356116 | ACSL5 | chr10 | 114154860 | + | ENST00000545257 | TCF7L2 | chr10 | 114724315 | + | 3621 | 436 | 49 | 1914 | 621 |
| ENST00000356116 | ACSL5 | chr10 | 114154860 | + | ENST00000355995 | TCF7L2 | chr10 | 114724315 | + | 3621 | 436 | 49 | 1914 | 621 |
| ENST00000356116 | ACSL5 | chr10 | 114154860 | + | ENST00000543371 | TCF7L2 | chr10 | 114724315 | + | 3570 | 436 | 49 | 1863 | 604 |
| ENST00000354273 | ACSL5 | chr10 | 114154860 | + | ENST00000534894 | TCF7L2 | chr10 | 114724315 | + | 1539 | 435 | 48 | 1538 | 496 |
| ENST00000354273 | ACSL5 | chr10 | 114154860 | + | ENST00000536810 | TCF7L2 | chr10 | 114724315 | + | 3569 | 435 | 48 | 1862 | 604 |
| ENST00000354273 | ACSL5 | chr10 | 114154860 | + | ENST00000545257 | TCF7L2 | chr10 | 114724315 | + | 3620 | 435 | 48 | 1913 | 621 |
| ENST00000354273 | ACSL5 | chr10 | 114154860 | + | ENST00000355995 | TCF7L2 | chr10 | 114724315 | + | 3620 | 435 | 48 | 1913 | 621 |
| ENST00000354273 | ACSL5 | chr10 | 114154860 | + | ENST00000543371 | TCF7L2 | chr10 | 114724315 | + | 3569 | 435 | 48 | 1862 | 604 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000354655 | ENST00000534894 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.009694853 | 0.9903052 |
| ENST00000354655 | ENST00000536810 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.00086184 | 0.9991381 |
| ENST00000354655 | ENST00000545257 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001186319 | 0.99881375 |
| ENST00000354655 | ENST00000355995 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001197426 | 0.99880254 |
| ENST00000354655 | ENST00000543371 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.000862287 | 0.99913764 |
| ENST00000393081 | ENST00000534894 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.016347535 | 0.9836525 |
| ENST00000393081 | ENST00000536810 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001398348 | 0.9986016 |
| ENST00000393081 | ENST00000545257 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001842306 | 0.9981577 |
| ENST00000393081 | ENST00000355995 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001868171 | 0.9981318 |
| ENST00000393081 | ENST00000543371 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001365555 | 0.9986344 |
| ENST00000433418 | ENST00000534894 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.029703256 | 0.9702967 |
| ENST00000433418 | ENST00000536810 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001746129 | 0.9982539 |
| ENST00000433418 | ENST00000545257 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001957708 | 0.9980422 |
| ENST00000433418 | ENST00000355995 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.002094694 | 0.9979054 |
| ENST00000433418 | ENST00000543371 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001754867 | 0.9982451 |
| ENST00000356116 | ENST00000534894 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.029703256 | 0.9702967 |
| ENST00000356116 | ENST00000536810 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001746129 | 0.9982539 |
| ENST00000356116 | ENST00000545257 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001957708 | 0.9980422 |
| ENST00000356116 | ENST00000355995 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.002094694 | 0.9979054 |
| ENST00000356116 | ENST00000543371 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001754867 | 0.9982451 |
| ENST00000354273 | ENST00000534894 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.029906012 | 0.97009397 |
| ENST00000354273 | ENST00000536810 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.0017676 | 0.9982324 |
| ENST00000354273 | ENST00000545257 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001985815 | 0.9980142 |
| ENST00000354273 | ENST00000355995 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.002119226 | 0.9978808 |
| ENST00000354273 | ENST00000543371 | ACSL5 | chr10 | 114154860 | + | TCF7L2 | chr10 | 114724315 | + | 0.001777181 | 0.99822277 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >1517_1517_1_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354273_TCF7L2_chr10_114724315_ENST00000355995_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- >1517_1517_2_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354273_TCF7L2_chr10_114724315_ENST00000534894_length(amino acids)=496AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP -------------------------------------------------------------- >1517_1517_3_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354273_TCF7L2_chr10_114724315_ENST00000536810_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCR ARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_4_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354273_TCF7L2_chr10_114724315_ENST00000543371_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCR ALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_5_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354273_TCF7L2_chr10_114724315_ENST00000545257_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- >1517_1517_6_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354655_TCF7L2_chr10_114724315_ENST00000355995_length(amino acids)=553AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNL LGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGT -------------------------------------------------------------- >1517_1517_7_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354655_TCF7L2_chr10_114724315_ENST00000534894_length(amino acids)=429AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK -------------------------------------------------------------- >1517_1517_8_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354655_TCF7L2_chr10_114724315_ENST00000536810_length(amino acids)=536AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQP -------------------------------------------------------------- >1517_1517_9_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354655_TCF7L2_chr10_114724315_ENST00000543371_length(amino acids)=536AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQP -------------------------------------------------------------- >1517_1517_10_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000354655_TCF7L2_chr10_114724315_ENST00000545257_length(amino acids)=553AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNEHSECFLNPCLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNL LGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGT -------------------------------------------------------------- >1517_1517_11_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000356116_TCF7L2_chr10_114724315_ENST00000355995_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- >1517_1517_12_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000356116_TCF7L2_chr10_114724315_ENST00000534894_length(amino acids)=497AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP -------------------------------------------------------------- >1517_1517_13_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000356116_TCF7L2_chr10_114724315_ENST00000536810_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCR ARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_14_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000356116_TCF7L2_chr10_114724315_ENST00000543371_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCR ALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_15_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000356116_TCF7L2_chr10_114724315_ENST00000545257_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- >1517_1517_16_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000393081_TCF7L2_chr10_114724315_ENST00000355995_length(amino acids)=553AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNL LGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGT -------------------------------------------------------------- >1517_1517_17_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000393081_TCF7L2_chr10_114724315_ENST00000534894_length(amino acids)=429AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK -------------------------------------------------------------- >1517_1517_18_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000393081_TCF7L2_chr10_114724315_ENST00000536810_length(amino acids)=536AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQP -------------------------------------------------------------- >1517_1517_19_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000393081_TCF7L2_chr10_114724315_ENST00000543371_length(amino acids)=536AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQP -------------------------------------------------------------- >1517_1517_20_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000393081_TCF7L2_chr10_114724315_ENST00000545257_length(amino acids)=553AA_BP=61 MNFLLLFTKMLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKW PLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLS PGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKH QDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKK KKRKRDKQPGETNEHSECFLNPCLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNL LGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHKASALCPNGALDLPPAALQPAAPSSSIAQPSTSSLHSHSSLAGT -------------------------------------------------------------- >1517_1517_21_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000433418_TCF7L2_chr10_114724315_ENST00000355995_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- >1517_1517_22_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000433418_TCF7L2_chr10_114724315_ENST00000534894_length(amino acids)=497AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP -------------------------------------------------------------- >1517_1517_23_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000433418_TCF7L2_chr10_114724315_ENST00000536810_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDLSAPKKCR ARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_24_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000433418_TCF7L2_chr10_114724315_ENST00000543371_length(amino acids)=604AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNDANTPKKCR ALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPAL -------------------------------------------------------------- >1517_1517_25_ACSL5-TCF7L2_ACSL5_chr10_114154860_ENST00000433418_TCF7L2_chr10_114724315_ENST00000545257_length(amino acids)=621AA_BP=129 MTRDSSEQGRTGDTLGRPSACMDALKPPCLWRNHERGKKDRDSCGRKNSEPGSPHSLEALRDAAPSQGLNFLLLFTKMLFIFNFLFSPLP TPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIELHFQSGSTHYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSP SPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPV YPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFM LYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNP CLSLPPITDANTPKKCRALFGLDRQTLWCKPCRRKKKCVRYIQGEGSCLSPPSSDGSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:114154860/chr10:114724315) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACSL5 | TCF7L2 |
| FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269|PubMed:17681178, ECO:0000269|PubMed:18806831, ECO:0000269|PubMed:19459852, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}. | FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000269|PubMed:12408868, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:19443654, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9727977}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000354273 | + | 2 | 21 | 12_32 | 52.0 | 684.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000354655 | + | 2 | 21 | 12_32 | 52.0 | 684.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000356116 | + | 2 | 21 | 12_32 | 108.0 | 740.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000393081 | + | 2 | 21 | 12_32 | 52.0 | 684.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000433418 | + | 2 | 20 | 12_32 | 52.0 | 660.0 | Transmembrane | Helical%3B Signal-anchor for type III membrane protein |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000352065 | 0 | 15 | 178_317 | 0 | 386.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355717 | 0 | 13 | 178_317 | 0 | 490.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355995 | 2 | 15 | 178_317 | 127.0 | 620.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000369397 | 0 | 14 | 178_317 | 0 | 597.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000534894 | 2 | 15 | 178_317 | 127.0 | 495.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000536810 | 2 | 14 | 178_317 | 127.0 | 603.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000538897 | 2 | 14 | 178_317 | 127.0 | 483.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000543371 | 2 | 14 | 178_317 | 127.0 | 603.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000545257 | 2 | 15 | 178_317 | 127.0 | 620.0 | Compositional bias | Note=Pro-rich | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000352065 | 0 | 15 | 350_418 | 0 | 386.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355717 | 0 | 13 | 350_418 | 0 | 490.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355995 | 2 | 15 | 350_418 | 127.0 | 620.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000369397 | 0 | 14 | 350_418 | 0 | 597.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000534894 | 2 | 15 | 350_418 | 127.0 | 495.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000536810 | 2 | 14 | 350_418 | 127.0 | 603.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000538897 | 2 | 14 | 350_418 | 127.0 | 483.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000543371 | 2 | 14 | 350_418 | 127.0 | 603.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000545257 | 2 | 15 | 350_418 | 127.0 | 620.0 | DNA binding | HMG box | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000352065 | 0 | 15 | 425_430 | 0 | 386.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355717 | 0 | 13 | 425_430 | 0 | 490.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355995 | 2 | 15 | 425_430 | 127.0 | 620.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000369397 | 0 | 14 | 425_430 | 0 | 597.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000534894 | 2 | 15 | 425_430 | 127.0 | 495.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000536810 | 2 | 14 | 425_430 | 127.0 | 603.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000538897 | 2 | 14 | 425_430 | 127.0 | 483.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000543371 | 2 | 14 | 425_430 | 127.0 | 603.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000545257 | 2 | 15 | 425_430 | 127.0 | 620.0 | Motif | Nuclear localization signal | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000352065 | 0 | 15 | 1_53 | 0 | 386.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000352065 | 0 | 15 | 459_505 | 0 | 386.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355717 | 0 | 13 | 1_53 | 0 | 490.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355717 | 0 | 13 | 459_505 | 0 | 490.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355995 | 2 | 15 | 459_505 | 127.0 | 620.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000369397 | 0 | 14 | 1_53 | 0 | 597.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000369397 | 0 | 14 | 459_505 | 0 | 597.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000534894 | 2 | 15 | 459_505 | 127.0 | 495.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000536810 | 2 | 14 | 459_505 | 127.0 | 603.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000538897 | 2 | 14 | 459_505 | 127.0 | 483.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000543371 | 2 | 14 | 459_505 | 127.0 | 603.0 | Region | Note=Promoter-specific activation domain | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000545257 | 2 | 15 | 459_505 | 127.0 | 620.0 | Region | Note=Promoter-specific activation domain |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000354273 | + | 2 | 21 | 33_683 | 52.0 | 684.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000354655 | + | 2 | 21 | 33_683 | 52.0 | 684.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000356116 | + | 2 | 21 | 33_683 | 108.0 | 740.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000393081 | + | 2 | 21 | 33_683 | 52.0 | 684.0 | Topological domain | Cytoplasmic |
| Hgene | ACSL5 | chr10:114154860 | chr10:114724315 | ENST00000433418 | + | 2 | 20 | 33_683 | 52.0 | 660.0 | Topological domain | Cytoplasmic |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000355995 | 2 | 15 | 1_53 | 127.0 | 620.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000534894 | 2 | 15 | 1_53 | 127.0 | 495.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000536810 | 2 | 14 | 1_53 | 127.0 | 603.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000538897 | 2 | 14 | 1_53 | 127.0 | 483.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000543371 | 2 | 14 | 1_53 | 127.0 | 603.0 | Region | CTNNB1-binding | |
| Tgene | TCF7L2 | chr10:114154860 | chr10:114724315 | ENST00000545257 | 2 | 15 | 1_53 | 127.0 | 620.0 | Region | CTNNB1-binding |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| ACSL5 | CREB3, KIF11, FAM136A, COQ9, FBXO7, RNF4, RAB7A, SLC7A14, SLC35C2, AQP6, SLC10A1, PEX12, SLC16A7, TMEM14B, EPT1, FAM134C, SLC10A6, EBAG9, CAV2, ELK1, PAK1, PEBP1, PRKCB, PRKD1, SH2D3C, PDS5A, WDR5, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ACSL5 |  |
| TCF7L2 |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to ACSL5-TCF7L2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to ACSL5-TCF7L2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ACSL5 | C0003865 | Arthritis, Adjuvant-Induced | 1 | CTD_human |
| Hgene | ACSL5 | C0971858 | Arthritis, Collagen-Induced | 1 | CTD_human |
| Hgene | ACSL5 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
| Tgene | TCF7L2 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Tgene | TCF7L2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | CTD_human |
| Tgene | TCF7L2 | C0009402 | Colorectal Carcinoma | 2 | CTD_human;UNIPROT |
| Tgene | TCF7L2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| Tgene | TCF7L2 | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | TCF7L2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | TCF7L2 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Tgene | TCF7L2 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
| Tgene | TCF7L2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | TCF7L2 | C0010068 | Coronary heart disease | 1 | CTD_human |
| Tgene | TCF7L2 | C0020507 | Hyperplasia | 1 | CTD_human |
| Tgene | TCF7L2 | C0036337 | Schizoaffective Disorder | 1 | PSYGENET |
| Tgene | TCF7L2 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| Tgene | TCF7L2 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | TCF7L2 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
| Tgene | TCF7L2 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
| Tgene | TCF7L2 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
| Tgene | TCF7L2 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
| Tgene | TCF7L2 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
| Tgene | TCF7L2 | C0600519 | Ventricular Remodeling | 1 | CTD_human |
| Tgene | TCF7L2 | C0600520 | Left Ventricle Remodeling | 1 | CTD_human |
| Tgene | TCF7L2 | C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | CTD_human |
| Tgene | TCF7L2 | C1535926 | Neurodevelopmental Disorders | 1 | CTD_human |
| Tgene | TCF7L2 | C2931456 | Prostate cancer, familial | 1 | CTD_human |
| Tgene | TCF7L2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Tgene | TCF7L2 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| Tgene | TCF7L2 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
| Tgene | TCF7L2 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
| Tgene | TCF7L2 | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |
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