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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDK16-L3MBTL4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDK16-L3MBTL4
	FusionPDB ID: 15194
	FusionGDB2.0 ID: 15194
		Hgene	Tgene
	Gene symbol	CDK16	L3MBTL4
	Gene ID	5127	91133
	Gene name	cyclin dependent kinase 16	L3MBTL histone methyl-lysine binding protein 4
	Synonyms	PCTAIRE\|PCTAIRE1\|PCTGAIRE\|PCTK1	HsT1031
	Cytomap	Xp11.3	18p11.31
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 16PCTAIRE-motif protein kinase 1cell division protein kinase 16serine/threonine-protein kinase PCTAIRE-1testis secretory sperm-binding protein Li 224n	lethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L3MBTL4, histone methyl-lysine binding protein
	Modification date	20200313	20200313
	UniProtAcc	Q00536	Q8NA19
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000276052, ENST00000357227, ENST00000457458, ENST00000518022, ENST00000517997,	ENST00000578677, ENST00000284898, ENST00000317931, ENST00000400104, ENST00000400105, ENST00000535782,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 9 X 4=324	15 X 12 X 6=1080
	# samples	10	16
	** MAII score	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1080*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDK16 [Title/Abstract] AND L3MBTL4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDK16(47086102)-L3MBTL4(6093527), # samples:1
Anticipated loss of major functional domain due to fusion event.	CDK16-L3MBTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK16-L3MBTL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK16-L3MBTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK16-L3MBTL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CDK16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across L3MBTL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-43-5668-01A	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000457458	CDK16	chrX	47086102	+	ENST00000400105	L3MBTL4	chr18	6093527	-	3662	1475	255	2147	630
ENST00000457458	CDK16	chrX	47086102	+	ENST00000317931	L3MBTL4	chr18	6093527	-	3635	1475	255	2120	621
ENST00000457458	CDK16	chrX	47086102	+	ENST00000284898	L3MBTL4	chr18	6093527	-	3661	1475	255	2147	630
ENST00000457458	CDK16	chrX	47086102	+	ENST00000400104	L3MBTL4	chr18	6093527	-	4609	1475	255	1880	541
ENST00000457458	CDK16	chrX	47086102	+	ENST00000535782	L3MBTL4	chr18	6093527	-	3627	1475	255	2120	621
ENST00000357227	CDK16	chrX	47086102	+	ENST00000400105	L3MBTL4	chr18	6093527	-	3648	1461	73	2133	686
ENST00000357227	CDK16	chrX	47086102	+	ENST00000317931	L3MBTL4	chr18	6093527	-	3621	1461	73	2106	677
ENST00000357227	CDK16	chrX	47086102	+	ENST00000284898	L3MBTL4	chr18	6093527	-	3647	1461	73	2133	686
ENST00000357227	CDK16	chrX	47086102	+	ENST00000400104	L3MBTL4	chr18	6093527	-	4595	1461	73	1866	597
ENST00000357227	CDK16	chrX	47086102	+	ENST00000535782	L3MBTL4	chr18	6093527	-	3613	1461	73	2106	677
ENST00000518022	CDK16	chrX	47086102	+	ENST00000400105	L3MBTL4	chr18	6093527	-	3533	1346	57	2018	653
ENST00000518022	CDK16	chrX	47086102	+	ENST00000317931	L3MBTL4	chr18	6093527	-	3506	1346	57	1991	644
ENST00000518022	CDK16	chrX	47086102	+	ENST00000284898	L3MBTL4	chr18	6093527	-	3532	1346	57	2018	653
ENST00000518022	CDK16	chrX	47086102	+	ENST00000400104	L3MBTL4	chr18	6093527	-	4480	1346	57	1751	564
ENST00000518022	CDK16	chrX	47086102	+	ENST00000535782	L3MBTL4	chr18	6093527	-	3498	1346	57	1991	644
ENST00000276052	CDK16	chrX	47086102	+	ENST00000400105	L3MBTL4	chr18	6093527	-	3524	1337	48	2009	653
ENST00000276052	CDK16	chrX	47086102	+	ENST00000317931	L3MBTL4	chr18	6093527	-	3497	1337	48	1982	644
ENST00000276052	CDK16	chrX	47086102	+	ENST00000284898	L3MBTL4	chr18	6093527	-	3523	1337	48	2009	653
ENST00000276052	CDK16	chrX	47086102	+	ENST00000400104	L3MBTL4	chr18	6093527	-	4471	1337	48	1742	564
ENST00000276052	CDK16	chrX	47086102	+	ENST00000535782	L3MBTL4	chr18	6093527	-	3489	1337	48	1982	644

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000457458	ENST00000400105	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000961621	0.99903846
ENST00000457458	ENST00000317931	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001013033	0.9989869
ENST00000457458	ENST00000284898	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.00095704	0.9990429
ENST00000457458	ENST00000400104	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000807057	0.9991929
ENST00000457458	ENST00000535782	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001024967	0.99897504
ENST00000357227	ENST00000400105	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001150313	0.99884963
ENST00000357227	ENST00000317931	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001318567	0.99868137
ENST00000357227	ENST00000284898	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001143156	0.9988569
ENST00000357227	ENST00000400104	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000683699	0.99931633
ENST00000357227	ENST00000535782	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.001334084	0.9986659
ENST00000518022	ENST00000400105	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000822878	0.99917716
ENST00000518022	ENST00000317931	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000867167	0.9991328
ENST00000518022	ENST00000284898	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000821204	0.9991788
ENST00000518022	ENST00000400104	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000842972	0.9991571
ENST00000518022	ENST00000535782	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.0008713	0.99912876
ENST00000276052	ENST00000400105	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000807555	0.9991924
ENST00000276052	ENST00000317931	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.0008507	0.9991493
ENST00000276052	ENST00000284898	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000805904	0.9991941
ENST00000276052	ENST00000400104	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000841182	0.99915886
ENST00000276052	ENST00000535782	CDK16	chrX	47086102	+	L3MBTL4	chr18	6093527	-	0.000854571	0.9991454

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15194_15194_1_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000276052_L3MBTL4_chr18_6093527_ENST00000284898_length(amino acids)=653AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTV
SAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS

--------------------------------------------------------------

>15194_15194_2_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000276052_L3MBTL4_chr18_6093527_ENST00000317931_length(amino acids)=644AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLP
LGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQE

--------------------------------------------------------------

>15194_15194_3_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000276052_L3MBTL4_chr18_6093527_ENST00000400104_length(amino acids)=564AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRGRVRWLMPVIPALWEAEAGRSRDQEIKTI

--------------------------------------------------------------

>15194_15194_4_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000276052_L3MBTL4_chr18_6093527_ENST00000400105_length(amino acids)=653AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTV
SAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS

--------------------------------------------------------------

>15194_15194_5_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000276052_L3MBTL4_chr18_6093527_ENST00000535782_length(amino acids)=644AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLP
LGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQE

--------------------------------------------------------------

>15194_15194_6_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000357227_L3MBTL4_chr18_6093527_ENST00000284898_length(amino acids)=686AA_BP=463
MGSAATPRSDRSVPRAAVSTRIQAGANESGGIARSGQAHGRLSGTPPPPQPPPPPPPPPPQPAAARAQQPWLKTTGTGACGEQEEKEVAR
PHPGPPPQAPPRRPRGSEVARAPPPIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPL
SSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS
LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL
DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL
LGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLD
NLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKK

--------------------------------------------------------------

>15194_15194_7_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000357227_L3MBTL4_chr18_6093527_ENST00000317931_length(amino acids)=677AA_BP=463
MGSAATPRSDRSVPRAAVSTRIQAGANESGGIARSGQAHGRLSGTPPPPQPPPPPPPPPPQPAAARAQQPWLKTTGTGACGEQEEKEVAR
PHPGPPPQAPPRRPRGSEVARAPPPIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPL
SSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS
LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL
DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL
LGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLD
NLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFL

--------------------------------------------------------------

>15194_15194_8_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000357227_L3MBTL4_chr18_6093527_ENST00000400104_length(amino acids)=597AA_BP=463
MGSAATPRSDRSVPRAAVSTRIQAGANESGGIARSGQAHGRLSGTPPPPQPPPPPPPPPPQPAAARAQQPWLKTTGTGACGEQEEKEVAR
PHPGPPPQAPPRRPRGSEVARAPPPIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPL
SSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS
LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL
DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL
LGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLD

--------------------------------------------------------------

>15194_15194_9_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000357227_L3MBTL4_chr18_6093527_ENST00000400105_length(amino acids)=686AA_BP=463
MGSAATPRSDRSVPRAAVSTRIQAGANESGGIARSGQAHGRLSGTPPPPQPPPPPPPPPPQPAAARAQQPWLKTTGTGACGEQEEKEVAR
PHPGPPPQAPPRRPRGSEVARAPPPIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPL
SSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS
LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL
DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL
LGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLD
NLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKK

--------------------------------------------------------------

>15194_15194_10_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000357227_L3MBTL4_chr18_6093527_ENST00000535782_length(amino acids)=677AA_BP=463
MGSAATPRSDRSVPRAAVSTRIQAGANESGGIARSGQAHGRLSGTPPPPQPPPPPPPPPPQPAAARAQQPWLKTTGTGACGEQEEKEVAR
PHPGPPPQAPPRRPRGSEVARAPPPIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPL
SSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS
LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYL
DKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL
LGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLD
NLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFL

--------------------------------------------------------------

>15194_15194_11_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000457458_L3MBTL4_chr18_6093527_ENST00000284898_length(amino acids)=630AA_BP=407
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPE
QIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLS
LPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI
REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE
LKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS
LNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVA
DIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQELPEEDIASGQEVRG

--------------------------------------------------------------

>15194_15194_12_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000457458_L3MBTL4_chr18_6093527_ENST00000317931_length(amino acids)=621AA_BP=407
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPE
QIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLS
LPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI
REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE
LKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS
LNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVAR

--------------------------------------------------------------

>15194_15194_13_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000457458_L3MBTL4_chr18_6093527_ENST00000400104_length(amino acids)=541AA_BP=407
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPE
QIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLS
LPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI
REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE
LKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS
LNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRGRVRWLMPVIPALWEAEAGRSRDQEIKTILANAVKPRLYQKYKKLARRGGGC

--------------------------------------------------------------

>15194_15194_14_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000457458_L3MBTL4_chr18_6093527_ENST00000400105_length(amino acids)=630AA_BP=407
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPE
QIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLS
LPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI
REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE
LKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS
LNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVA
DIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQELPEEDIASGQEVRG

--------------------------------------------------------------

>15194_15194_15_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000457458_L3MBTL4_chr18_6093527_ENST00000535782_length(amino acids)=621AA_BP=407
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPE
QIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLS
LPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAI
REVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGE
LKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCS
LNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVAR

--------------------------------------------------------------

>15194_15194_16_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000518022_L3MBTL4_chr18_6093527_ENST00000284898_length(amino acids)=653AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTV
SAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS

--------------------------------------------------------------

>15194_15194_17_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000518022_L3MBTL4_chr18_6093527_ENST00000317931_length(amino acids)=644AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLP
LGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQE

--------------------------------------------------------------

>15194_15194_18_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000518022_L3MBTL4_chr18_6093527_ENST00000400104_length(amino acids)=564AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRGRVRWLMPVIPALWEAEAGRSRDQEIKTI

--------------------------------------------------------------

>15194_15194_19_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000518022_L3MBTL4_chr18_6093527_ENST00000400105_length(amino acids)=653AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTV
SAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNS

--------------------------------------------------------------

>15194_15194_20_CDK16-L3MBTL4_CDK16_chrX_47086102_ENST00000518022_L3MBTL4_chr18_6093527_ENST00000535782_length(amino acids)=644AA_BP=430
MAFEGGARGTMPLYGRARDHVTHPSILGTRPGRPMAGPITAAVPEKICNGAFCSCSGAFPLDPNNPSLGPLPSISHLNLRTQIAMDRMKK
IKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSP
VRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKL
TDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY
CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMCAFGCPYSDMNLKKEATLHDR
LREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFREYSVEQAQQVLHQSVSMSTVSAHPFRDLP
LGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:47086102/chr18:6093527)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK16 Q00536	L3MBTL4 Q8NA19
FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269\|PubMed:22184064, ECO:0000269\|PubMed:22796189, ECO:0000269\|PubMed:22798068}.	FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000276052

171_179

419.6666666666667

571.0

Nucleotide binding

ATP

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000357227

171_179

345.6666666666667

497.0

Nucleotide binding

ATP

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000457458

171_179

351.6666666666667

503.0

Nucleotide binding

ATP

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000518022

171_179

345.6666666666667

497.0

Nucleotide binding

ATP

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000284898

543_607

399.6666666666667

624.0

Domain

SAM

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400104

543_607

399.6666666666667

535.0

Domain

SAM

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400105

543_607

399.6666666666667

624.0

Domain

SAM

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000276052

165_446

419.6666666666667

571.0

Domain

Protein kinase

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000357227

165_446

345.6666666666667

497.0

Domain

Protein kinase

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000457458

165_446

351.6666666666667

503.0

Domain

Protein kinase

Hgene

CDK16

chrX:47086102

chr18:6093527

ENST00000518022

165_446

345.6666666666667

497.0

Domain

Protein kinase

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000284898

160_260

399.6666666666667

624.0

Repeat

Note=MBT 2

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000284898

269_364

399.6666666666667

624.0

Repeat

Note=MBT 3

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000284898

52_152

399.6666666666667

624.0

Repeat

Note=MBT 1

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400104

160_260

399.6666666666667

535.0

Repeat

Note=MBT 2

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400104

269_364

399.6666666666667

535.0

Repeat

Note=MBT 3

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400104

52_152

399.6666666666667

535.0

Repeat

Note=MBT 1

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400105

160_260

399.6666666666667

624.0

Repeat

Note=MBT 2

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400105

269_364

399.6666666666667

624.0

Repeat

Note=MBT 3

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400105

52_152

399.6666666666667

624.0

Repeat

Note=MBT 1

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000284898

370_414

399.6666666666667

624.0

Zinc finger

CCHHC-type

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400104

370_414

399.6666666666667

535.0

Zinc finger

CCHHC-type

Tgene

L3MBTL4

chrX:47086102

chr18:6093527

ENST00000400105

370_414

399.6666666666667

624.0

Zinc finger

CCHHC-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDK16
L3MBTL4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CDK16-L3MBTL4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CDK16-L3MBTL4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source