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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDK1-NRG1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDK1-NRG1
	FusionPDB ID: 15227
	FusionGDB2.0 ID: 15227
		Hgene	Tgene
	Gene symbol	CDK1	NRG1
	Gene ID	983	3084
	Gene name	cyclin dependent kinase 1	neuregulin 1
	Synonyms	CDC2\|CDC28A\|P34CDC2	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|MSTP131\|NDF\|NRG1-IT2\|SMDF
	Cytomap	10q21.2	8p12
	Type of gene	protein-coding	protein-coding
	Description	cyclin-dependent kinase 1cell cycle controller CDC2cell division control protein 2 homologcell division cycle 2, G1 to S and G2 to Mcell division protein kinase 1p34 protein kinase	pro-neuregulin-1, membrane-bound isoformacetylcholine receptor-inducing activityglial growth factor 2heregulin, alpha (45kD, ERBB2 p185-activator)neu differentiation factorpro-NRG1sensory and motor neuron derived factor
	Modification date	20200327	20200320
	UniProtAcc	Q9BWU1	Q02297
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000519760, ENST00000316629, ENST00000373809, ENST00000395284, ENST00000448257,	ENST00000287842, ENST00000287845, ENST00000338921, ENST00000341377, ENST00000356819, ENST00000405005, ENST00000519301, ENST00000520407, ENST00000520502, ENST00000521670, ENST00000523079, ENST00000539990, ENST00000523681,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 5 X 3=75	25 X 17 X 14=5950
	# samples	5	27
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/5950*10)=-4.46185835603184 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDK1 [Title/Abstract] AND NRG1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDK1(62539960)-NRG1(32585467), # samples:1
Anticipated loss of major functional domain due to fusion event.	CDK1-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK1-NRG1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK1-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK1-NRG1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK1	GO:0006468	protein phosphorylation	23509069\|23574715
Hgene	CDK1	GO:0018105	peptidyl-serine phosphorylation	11298763\|19879842
Hgene	CDK1	GO:0018107	peptidyl-threonine phosphorylation	11298763
Hgene	CDK1	GO:0034501	protein localization to kinetochore	18195732
Hgene	CDK1	GO:0043066	negative regulation of apoptotic process	11069302
Tgene	NRG1	GO:0003222	ventricular trabecula myocardium morphogenesis	17336907
Tgene	NRG1	GO:0031334	positive regulation of protein complex assembly	10559227
Tgene	NRG1	GO:0038127	ERBB signaling pathway	11389077
Tgene	NRG1	GO:0038129	ERBB3 signaling pathway	27353365
Tgene	NRG1	GO:0045892	negative regulation of transcription, DNA-templated	15073182
Tgene	NRG1	GO:0051048	negative regulation of secretion	10559227
Tgene	NRG1	GO:0060379	cardiac muscle cell myoblast differentiation	17336907
Tgene	NRG1	GO:0060956	endocardial cell differentiation	17336907

Fusion gene breakpoints across CDK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FD-A5BR-01A	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316629	CDK1	chr10	62539960	-	ENST00000519301	NRG1	chr8	32585467	+	1618	179	142	1614	490
ENST00000316629	CDK1	chr10	62539960	-	ENST00000520407	NRG1	chr8	32585467	+	859	179	12	320	102
ENST00000316629	CDK1	chr10	62539960	-	ENST00000523079	NRG1	chr8	32585467	+	1519	179	142	939	265
ENST00000316629	CDK1	chr10	62539960	-	ENST00000338921	NRG1	chr8	32585467	+	2252	179	142	1623	493
ENST00000316629	CDK1	chr10	62539960	-	ENST00000356819	NRG1	chr8	32585467	+	2243	179	142	1614	490
ENST00000316629	CDK1	chr10	62539960	-	ENST00000287845	NRG1	chr8	32585467	+	2243	179	142	1614	490
ENST00000316629	CDK1	chr10	62539960	-	ENST00000341377	NRG1	chr8	32585467	+	2287	179	420	1658	412
ENST00000316629	CDK1	chr10	62539960	-	ENST00000287842	NRG1	chr8	32585467	+	1700	179	142	1590	482
ENST00000316629	CDK1	chr10	62539960	-	ENST00000521670	NRG1	chr8	32585467	+	1338	179	142	1065	307
ENST00000316629	CDK1	chr10	62539960	-	ENST00000405005	NRG1	chr8	32585467	+	1669	179	142	1599	485
ENST00000316629	CDK1	chr10	62539960	-	ENST00000520502	NRG1	chr8	32585467	+	842	179	12	320	102
ENST00000316629	CDK1	chr10	62539960	-	ENST00000539990	NRG1	chr8	32585467	+	1697	179	142	1590	482
ENST00000395284	CDK1	chr10	62539960	-	ENST00000519301	NRG1	chr8	32585467	+	1618	179	142	1614	490
ENST00000395284	CDK1	chr10	62539960	-	ENST00000520407	NRG1	chr8	32585467	+	859	179	12	320	102
ENST00000395284	CDK1	chr10	62539960	-	ENST00000523079	NRG1	chr8	32585467	+	1519	179	142	939	265
ENST00000395284	CDK1	chr10	62539960	-	ENST00000338921	NRG1	chr8	32585467	+	2252	179	142	1623	493
ENST00000395284	CDK1	chr10	62539960	-	ENST00000356819	NRG1	chr8	32585467	+	2243	179	142	1614	490
ENST00000395284	CDK1	chr10	62539960	-	ENST00000287845	NRG1	chr8	32585467	+	2243	179	142	1614	490
ENST00000395284	CDK1	chr10	62539960	-	ENST00000341377	NRG1	chr8	32585467	+	2287	179	420	1658	412
ENST00000395284	CDK1	chr10	62539960	-	ENST00000287842	NRG1	chr8	32585467	+	1700	179	142	1590	482
ENST00000395284	CDK1	chr10	62539960	-	ENST00000521670	NRG1	chr8	32585467	+	1338	179	142	1065	307
ENST00000395284	CDK1	chr10	62539960	-	ENST00000405005	NRG1	chr8	32585467	+	1669	179	142	1599	485
ENST00000395284	CDK1	chr10	62539960	-	ENST00000520502	NRG1	chr8	32585467	+	842	179	12	320	102
ENST00000395284	CDK1	chr10	62539960	-	ENST00000539990	NRG1	chr8	32585467	+	1697	179	142	1590	482
ENST00000448257	CDK1	chr10	62539960	-	ENST00000519301	NRG1	chr8	32585467	+	1677	238	201	1673	490
ENST00000448257	CDK1	chr10	62539960	-	ENST00000520407	NRG1	chr8	32585467	+	918	238	201	461	86
ENST00000448257	CDK1	chr10	62539960	-	ENST00000523079	NRG1	chr8	32585467	+	1578	238	201	998	265
ENST00000448257	CDK1	chr10	62539960	-	ENST00000338921	NRG1	chr8	32585467	+	2311	238	201	1682	493
ENST00000448257	CDK1	chr10	62539960	-	ENST00000356819	NRG1	chr8	32585467	+	2302	238	201	1673	490
ENST00000448257	CDK1	chr10	62539960	-	ENST00000287845	NRG1	chr8	32585467	+	2302	238	201	1673	490
ENST00000448257	CDK1	chr10	62539960	-	ENST00000341377	NRG1	chr8	32585467	+	2346	238	479	1717	412
ENST00000448257	CDK1	chr10	62539960	-	ENST00000287842	NRG1	chr8	32585467	+	1759	238	201	1649	482
ENST00000448257	CDK1	chr10	62539960	-	ENST00000521670	NRG1	chr8	32585467	+	1397	238	201	1124	307
ENST00000448257	CDK1	chr10	62539960	-	ENST00000405005	NRG1	chr8	32585467	+	1728	238	201	1658	485
ENST00000448257	CDK1	chr10	62539960	-	ENST00000520502	NRG1	chr8	32585467	+	901	238	201	461	86
ENST00000448257	CDK1	chr10	62539960	-	ENST00000539990	NRG1	chr8	32585467	+	1756	238	201	1649	482
ENST00000373809	CDK1	chr10	62539960	-	ENST00000519301	NRG1	chr8	32585467	+	1489	50	13	1485	490
ENST00000373809	CDK1	chr10	62539960	-	ENST00000520407	NRG1	chr8	32585467	+	730	50	13	273	86
ENST00000373809	CDK1	chr10	62539960	-	ENST00000523079	NRG1	chr8	32585467	+	1390	50	13	810	265
ENST00000373809	CDK1	chr10	62539960	-	ENST00000338921	NRG1	chr8	32585467	+	2123	50	13	1494	493
ENST00000373809	CDK1	chr10	62539960	-	ENST00000356819	NRG1	chr8	32585467	+	2114	50	13	1485	490
ENST00000373809	CDK1	chr10	62539960	-	ENST00000287845	NRG1	chr8	32585467	+	2114	50	13	1485	490
ENST00000373809	CDK1	chr10	62539960	-	ENST00000341377	NRG1	chr8	32585467	+	2158	50	291	1529	412
ENST00000373809	CDK1	chr10	62539960	-	ENST00000287842	NRG1	chr8	32585467	+	1571	50	13	1461	482
ENST00000373809	CDK1	chr10	62539960	-	ENST00000521670	NRG1	chr8	32585467	+	1209	50	13	936	307
ENST00000373809	CDK1	chr10	62539960	-	ENST00000405005	NRG1	chr8	32585467	+	1540	50	13	1470	485
ENST00000373809	CDK1	chr10	62539960	-	ENST00000520502	NRG1	chr8	32585467	+	713	50	13	273	86
ENST00000373809	CDK1	chr10	62539960	-	ENST00000539990	NRG1	chr8	32585467	+	1568	50	13	1461	482

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316629	ENST00000519301	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.00731029	0.99268967
ENST00000316629	ENST00000520407	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.5029475	0.4970525
ENST00000316629	ENST00000523079	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.03506162	0.9649384
ENST00000316629	ENST00000338921	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002767893	0.99723214
ENST00000316629	ENST00000356819	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001999782	0.9980002
ENST00000316629	ENST00000287845	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001999782	0.9980002
ENST00000316629	ENST00000341377	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.003109179	0.99689084
ENST00000316629	ENST00000287842	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.005697317	0.99430275
ENST00000316629	ENST00000521670	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.042134006	0.95786595
ENST00000316629	ENST00000405005	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.004230952	0.995769
ENST00000316629	ENST00000520502	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.4872516	0.5127484
ENST00000316629	ENST00000539990	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.005812686	0.99418736
ENST00000395284	ENST00000519301	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.00731029	0.99268967
ENST00000395284	ENST00000520407	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.5029475	0.4970525
ENST00000395284	ENST00000523079	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.03506162	0.9649384
ENST00000395284	ENST00000338921	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002767893	0.99723214
ENST00000395284	ENST00000356819	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001999782	0.9980002
ENST00000395284	ENST00000287845	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001999782	0.9980002
ENST00000395284	ENST00000341377	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.003109179	0.99689084
ENST00000395284	ENST00000287842	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.005697317	0.99430275
ENST00000395284	ENST00000521670	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.042134006	0.95786595
ENST00000395284	ENST00000405005	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.004230952	0.995769
ENST00000395284	ENST00000520502	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.4872516	0.5127484
ENST00000395284	ENST00000539990	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.005812686	0.99418736
ENST00000448257	ENST00000519301	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.005777123	0.9942228
ENST00000448257	ENST00000520407	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.2983041	0.70169586
ENST00000448257	ENST00000523079	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.023292782	0.9767072
ENST00000448257	ENST00000338921	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002205076	0.997795
ENST00000448257	ENST00000356819	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001514745	0.99848527
ENST00000448257	ENST00000287845	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.001514745	0.99848527
ENST00000448257	ENST00000341377	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002355217	0.9976447
ENST00000448257	ENST00000287842	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.004935317	0.9950647
ENST00000448257	ENST00000521670	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.02976176	0.9702382
ENST00000448257	ENST00000405005	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.003492407	0.9965076
ENST00000448257	ENST00000520502	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.24362448	0.75637555
ENST00000448257	ENST00000539990	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.004980462	0.99501956
ENST00000373809	ENST00000519301	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.008702557	0.9912975
ENST00000373809	ENST00000520407	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.47772795	0.52227205
ENST00000373809	ENST00000523079	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.030514734	0.9694853
ENST00000373809	ENST00000338921	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002848679	0.9971513
ENST00000373809	ENST00000356819	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002055594	0.9979444
ENST00000373809	ENST00000287845	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.002055594	0.9979444
ENST00000373809	ENST00000341377	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.00319545	0.9968046
ENST00000373809	ENST00000287842	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.006709037	0.9932909
ENST00000373809	ENST00000521670	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.04782211	0.9521779
ENST00000373809	ENST00000405005	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.004884794	0.99511516
ENST00000373809	ENST00000520502	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.44064942	0.55935055
ENST00000373809	ENST00000539990	CDK1	chr10	62539960	-	NRG1	chr8	32585467	+	0.006773506	0.99322647

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15227_15227_1_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_2_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_3_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=493AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>15227_15227_4_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>15227_15227_5_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_6_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=485AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>15227_15227_7_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_8_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=102AA_BP=55
MKLLALGFKAGSWKLSGERRGCCSCRCGRRGIISRDLPYPLTNYGRLYQNRENWRSYIYIHHWDKPSCKMCGEGENFLCEWRGVLHGERP

--------------------------------------------------------------

>15227_15227_9_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=102AA_BP=55
MKLLALGFKAGSWKLSGERRGCCSCRCGRRGIISRDLPYPLTNYGRLYQNRENWRSYIYIHHWDKPSCKMCGEGENFLCEWRGVLHGERP

--------------------------------------------------------------

>15227_15227_10_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=307AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHN

--------------------------------------------------------------

>15227_15227_11_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=265AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT

--------------------------------------------------------------

>15227_15227_12_CDK1-NRG1_CDK1_chr10_62539960_ENST00000316629_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_13_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_14_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_15_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=493AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>15227_15227_16_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>15227_15227_17_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_18_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=485AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>15227_15227_19_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_20_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=86AA_BP=12

--------------------------------------------------------------

>15227_15227_21_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=86AA_BP=12

--------------------------------------------------------------

>15227_15227_22_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=307AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHN

--------------------------------------------------------------

>15227_15227_23_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=265AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT

--------------------------------------------------------------

>15227_15227_24_CDK1-NRG1_CDK1_chr10_62539960_ENST00000373809_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_25_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_26_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_27_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=493AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>15227_15227_28_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>15227_15227_29_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_30_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=485AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>15227_15227_31_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_32_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=102AA_BP=55
MKLLALGFKAGSWKLSGERRGCCSCRCGRRGIISRDLPYPLTNYGRLYQNRENWRSYIYIHHWDKPSCKMCGEGENFLCEWRGVLHGERP

--------------------------------------------------------------

>15227_15227_33_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=102AA_BP=55
MKLLALGFKAGSWKLSGERRGCCSCRCGRRGIISRDLPYPLTNYGRLYQNRENWRSYIYIHHWDKPSCKMCGEGENFLCEWRGVLHGERP

--------------------------------------------------------------

>15227_15227_34_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=307AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHN

--------------------------------------------------------------

>15227_15227_35_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=265AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT

--------------------------------------------------------------

>15227_15227_36_CDK1-NRG1_CDK1_chr10_62539960_ENST00000395284_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_37_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000287842_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

>15227_15227_38_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000287845_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_39_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000338921_length(amino acids)=493AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKHSGEPFPEAEE
LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVERE
AETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRD
SPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAH
DSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAA

--------------------------------------------------------------

>15227_15227_40_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000341377_length(amino acids)=412AA_BP=
MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVI
SSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHA
RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQF
SSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPF

--------------------------------------------------------------

>15227_15227_41_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000356819_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_42_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000405005_length(amino acids)=485AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYV
SAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPAS
PLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAF

--------------------------------------------------------------

>15227_15227_43_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000519301_length(amino acids)=490AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQ
KRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAET
SFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPH
SERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSN
SLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLE

--------------------------------------------------------------

>15227_15227_44_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000520407_length(amino acids)=86AA_BP=12

--------------------------------------------------------------

>15227_15227_45_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000520502_length(amino acids)=86AA_BP=12

--------------------------------------------------------------

>15227_15227_46_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000521670_length(amino acids)=307AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLT
ITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS
HYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERHN

--------------------------------------------------------------

>15227_15227_47_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000523079_length(amino acids)=265AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT

--------------------------------------------------------------

>15227_15227_48_CDK1-NRG1_CDK1_chr10_62539960_ENST00000448257_NRG1_chr8_32585467_ENST00000539990_length(amino acids)=482AA_BP=12
MEDYTKIEKIGEATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKAEELYQKRVLTITG
ICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYT
STAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAM
TTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLR
IVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:62539960/chr8:32585467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK1 Q9BWU1	NRG1 Q02297
	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250\|UniProtKB:P43322, ECO:0000269\|PubMed:10867024, ECO:0000269\|PubMed:1348215, ECO:0000269\|PubMed:20682778, ECO:0000269\|PubMed:7902537}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

165_177

167.33333333333334

638.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

165_177

167.33333333333334

525.3333333333334

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

165_177

167.33333333333334

646.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

165_177

167.33333333333334

641.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

165_177

112.33333333333333

591.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

165_177

167.33333333333334

477.3333333333333

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

165_177

167.33333333333334

421.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

178_222

167.33333333333334

638.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

178_222

167.33333333333334

525.3333333333334

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

178_222

167.33333333333334

646.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

178_222

167.33333333333334

641.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

178_222

112.33333333333333

591.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

178_222

167.33333333333334

477.3333333333333

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

178_222

167.33333333333334

421.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

266_640

167.33333333333334

638.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

266_640

167.33333333333334

525.3333333333334

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

266_640

167.33333333333334

646.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

266_640

167.33333333333334

641.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

266_640

112.33333333333333

591.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

266_640

222.33333333333334

297.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

266_640

167.33333333333334

477.3333333333333

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

266_640

167.33333333333334

421.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

243_265

167.33333333333334

638.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

243_265

167.33333333333334

525.3333333333334

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

243_265

167.33333333333334

646.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

243_265

167.33333333333334

641.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

243_265

112.33333333333333

591.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

243_265

222.33333333333334

297.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

243_265

167.33333333333334

477.3333333333333

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

243_265

167.33333333333334

421.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000316629

4_287

12.333333333333334

241.0

Domain

Protein kinase

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000373809

4_287

12.333333333333334

241.0

Domain

Protein kinase

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000395284

4_287

12.333333333333334

298.0

Domain

Protein kinase

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000448257

4_287

12.333333333333334

298.0

Domain

Protein kinase

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000316629

10_18

12.333333333333334

241.0

Nucleotide binding

ATP

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000373809

10_18

12.333333333333334

241.0

Nucleotide binding

ATP

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000395284

10_18

12.333333333333334

298.0

Nucleotide binding

ATP

Hgene

CDK1

chr10:62539960

chr8:32585467

ENST00000448257

10_18

12.333333333333334

298.0

Nucleotide binding

ATP

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

165_177

348.3333333333333

423.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

165_177

222.33333333333334

297.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

37_128

167.33333333333334

638.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

37_128

167.33333333333334

525.3333333333334

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

37_128

167.33333333333334

646.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

37_128

167.33333333333334

641.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

37_128

112.33333333333333

591.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

178_222

348.3333333333333

423.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

37_128

348.3333333333333

423.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

178_222

222.33333333333334

297.0

Domain

EGF-like

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

37_128

222.33333333333334

297.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

37_128

167.33333333333334

477.3333333333333

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

37_128

167.33333333333334

421.0

Domain

Note=Ig-like C2-type

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000287842

20_242

167.33333333333334

638.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000341377

20_242

167.33333333333334

525.3333333333334

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000356819

20_242

167.33333333333334

646.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000405005

20_242

167.33333333333334

641.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000519301

20_242

112.33333333333333

591.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

20_242

348.3333333333333

423.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

266_640

348.3333333333333

423.0

Topological domain

Cytoplasmic

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520502

20_242

222.33333333333334

297.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000521670

20_242

167.33333333333334

477.3333333333333

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000523079

20_242

167.33333333333334

421.0

Topological domain

Extracellular

Tgene

NRG1

chr10:62539960

chr8:32585467

ENST00000520407

243_265

348.3333333333333

423.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDK1
NRG1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CDK1-NRG1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CDK1-NRG1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NRG1	C0036341	Schizophrenia	7	CTD_human
Tgene	NRG1	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	NRG1	C0024809	Marijuana Abuse	3	PSYGENET
Tgene	NRG1	C0011570	Mental Depression	2	PSYGENET
Tgene	NRG1	C0011581	Depressive disorder	2	PSYGENET
Tgene	NRG1	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	NRG1	C0006870	Cannabis Dependence	1	PSYGENET
Tgene	NRG1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Tgene	NRG1	C0011616	Contact Dermatitis	1	CTD_human
Tgene	NRG1	C0018801	Heart failure	1	CTD_human
Tgene	NRG1	C0018802	Congestive heart failure	1	CTD_human
Tgene	NRG1	C0019569	Hirschsprung Disease	1	CTD_human
Tgene	NRG1	C0023212	Left-Sided Heart Failure	1	CTD_human
Tgene	NRG1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	NRG1	C0024121	Lung Neoplasms	1	CTD_human
Tgene	NRG1	C0026650	Movement Disorders	1	CTD_human
Tgene	NRG1	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	NRG1	C0030193	Pain	1	CTD_human
Tgene	NRG1	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	NRG1	C0038358	Gastric ulcer	1	CTD_human
Tgene	NRG1	C0085758	Aganglionosis, Colonic	1	CTD_human
Tgene	NRG1	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	NRG1	C0162351	Contact hypersensitivity	1	CTD_human
Tgene	NRG1	C0234230	Pain, Burning	1	CTD_human
Tgene	NRG1	C0234238	Ache	1	CTD_human
Tgene	NRG1	C0234254	Radiating pain	1	CTD_human
Tgene	NRG1	C0235527	Heart Failure, Right-Sided	1	CTD_human
Tgene	NRG1	C0236733	Amphetamine-Related Disorders	1	CTD_human
Tgene	NRG1	C0236804	Amphetamine Addiction	1	CTD_human
Tgene	NRG1	C0236807	Amphetamine Abuse	1	CTD_human
Tgene	NRG1	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	NRG1	C0266487	Etat Marbre	1	CTD_human
Tgene	NRG1	C0458257	Pain, Splitting	1	CTD_human
Tgene	NRG1	C0458259	Pain, Crushing	1	CTD_human
Tgene	NRG1	C0678222	Breast Carcinoma	1	CTD_human
Tgene	NRG1	C0751407	Pain, Migratory	1	CTD_human
Tgene	NRG1	C0751408	Suffering, Physical	1	CTD_human
Tgene	NRG1	C0876994	Cardiotoxicity	1	CTD_human
Tgene	NRG1	C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene	NRG1	C1257840	Aganglionosis, Rectosigmoid Colon	1	CTD_human
Tgene	NRG1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	NRG1	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	NRG1	C1959583	Myocardial Failure	1	CTD_human
Tgene	NRG1	C1961112	Heart Decompensation	1	CTD_human
Tgene	NRG1	C3495559	Juvenile arthritis	1	CTD_human
Tgene	NRG1	C3661523	Congenital Intestinal Aganglionosis	1	CTD_human
Tgene	NRG1	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	NRG1	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	NRG1	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human
Tgene	NRG1	C4704874	Mammary Carcinoma, Human	1	CTD_human