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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ACSM2A-ABCC6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ACSM2A-ABCC6
FusionPDB ID: 1525
FusionGDB2.0 ID: 1525
HgeneTgene
Gene symbol

ACSM2A

ABCC6

Gene ID

123876

368

Gene nameacyl-CoA synthetase medium chain family member 2AATP binding cassette subfamily C member 6
SynonymsA-923A4.1|ACSM2ABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7
Cytomap

16p12.3

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionacyl-coenzyme A synthetase ACSM2A, mitochondrialacyl-CoA synthetase medium-chain family member 2benzoate--CoA ligasebutyrate--CoA ligase 2Abutyryl-coenzyme A synthetase 2Amiddle-chain acyl-CoA synthetase 2Amultidrug resistance-associated protein 6URG7 proteinATP-binding cassette, sub-family C (CFTR/MRP), member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter E
Modification date2020032020200313
UniProtAcc

Q08AH3

O95255

Ensembl transtripts involved in fusion geneENST idsENST00000575558, ENST00000219054, 
ENST00000396104, ENST00000417235, 
ENST00000536134, ENST00000573854, 
ENST00000575690, ENST00000424070, 
ENST00000205557, ENST00000574094, 
ENST00000575728, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: ACSM2A [Title/Abstract] AND ABCC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ACSM2A(20492243)-ABCC6(16263710), # samples:1
Anticipated loss of major functional domain due to fusion event.ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACSM2A-ABCC6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACSM2A

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

19345228


check buttonFusion gene breakpoints across ACSM2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4801-01AACSM2Achr16

20492243

+ABCC6chr16

16263710

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000417235ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-43721442231661054
ENST00000536134ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-446415347093258849
ENST00000573854ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-455316239933471082
ENST00000219054ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-4580165013533741079
ENST00000575690ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-4909197946437031079
ENST00000396104ACSM2Achr1620492243+ENST00000205557ABCC6chr1616263710-44501520532441079

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000417235ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0023856580.9976144
ENST00000536134ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0042387150.99576133
ENST00000573854ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0026958830.9973041
ENST00000219054ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0028894410.9971105
ENST00000575690ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0034143690.9965856
ENST00000396104ENST00000205557ACSM2Achr1620492243+ABCC6chr1616263710-0.0024016590.99759835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>1525_1525_1_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000219054_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

--------------------------------------------------------------

>1525_1525_2_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000396104_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

--------------------------------------------------------------

>1525_1525_3_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000417235_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1054AA_BP=0
LSYCALFQGCRSSGAAGWRGGWTKLSLERHPERTWQAGKRLPSPALWWVNGKGKELMWNFRELSENSQQAANVLSGACGLQRGDRVAVVL
PRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEAST
THHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDP
LVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYM
GTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRI
GPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGG
IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLV
VAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR
WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPW
PQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDP
ILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQ

--------------------------------------------------------------

>1525_1525_4_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000536134_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=849AA_BP=275
MRHPPLITVWRLEAKMDAGWTGLQASDIMWTISDTGWILNILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRML
LQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEG
DIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPD
PVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA
RASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSL
YVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSK
AHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQG
VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAA
LETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVM

--------------------------------------------------------------

>1525_1525_5_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000573854_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1082AA_BP=2
MAGLNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRE
LSENSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECP
SLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGW
ILNILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGL
DIRESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLG
DRGIKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVAS
FCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE
TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFR
TQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV
SVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG
GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLC
LARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESG

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>1525_1525_6_ACSM2A-ABCC6_ACSM2A_chr16_20492243_ENST00000575690_ABCC6_chr16_16263710_ENST00000205557_length(amino acids)=1079AA_BP=1
MNMHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKAGKRLPSPALWWVNGKGKELMWNFRELSE
NSQQAANVLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLR
IKLLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILN
ILCSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCVTVGESLLPETLENWRAQTGLDIR
ESYGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGDFWLLGDRG
IKDEDGYFQFMGRANDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCR
GYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDT
VDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQA
PFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVE
RMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW
IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:20492243/chr16:16263710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACSM2A

Q08AH3

ABCC6

O95255

FUNCTION: Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity). {ECO:0000250|UniProtKB:Q68CK6}.FUNCTION: [Isoform 1]: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644). {ECO:0000269|PubMed:11880368, ECO:0000269|PubMed:12414644}.; FUNCTION: [Isoform 1]: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. {ECO:0000269|PubMed:24277820, ECO:0000269|PubMed:24969777}.; FUNCTION: [Isoform 2]: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. {ECO:0000269|PubMed:23912081}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACSM2Achr16:20492243chr16:16263710ENST00000219054+1315221_229503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000219054+1315359_364503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000396104+1113221_229503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000396104+1113359_364503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000573854+1214221_229503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000573854+1214359_364503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000575690+1315221_229503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000575690+1315359_364503.0578.0Nucleotide bindingATP
HgeneACSM2Achr16:20492243chr16:16263710ENST00000219054+1315469_471503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000396104+1113469_471503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000573854+1214469_471503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000575690+1315469_471503.0578.0RegionCoenzyme A binding
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311265_1499929.01504.0DomainABC transporter 2
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031947_1228929.01504.0DomainABC transmembrane type-1 2
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021265_14990100.0DomainABC transporter 2
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802311_5930100.0DomainABC transmembrane type-1 1
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802629_8530100.0DomainABC transporter 1
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802947_12280100.0DomainABC transmembrane type-1 2
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311299_1306929.01504.0Nucleotide bindingATP 2
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021299_13060100.0Nucleotide bindingATP 2
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802663_6700100.0Nucleotide bindingATP 1
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311019_1061929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311083_1083929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311105_1175929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311197_1198929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311220_1503929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031961_997929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021019_10610100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021083_10830100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021105_11750100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021197_11980100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802120_1310100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021220_15030100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802150_1670100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802189_3020100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021_310100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802324_3490100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802371_4260100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802448_4500100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802472_5330100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000005757280253_720100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802555_5750100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802597_9390100.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000005757280294_980100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802961_9970100.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311062_1082929.01504.0TransmembraneHelical%3B Name%3D14
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311084_1104929.01504.0TransmembraneHelical%3B Name%3D15
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311176_1196929.01504.0TransmembraneHelical%3B Name%3D16
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311199_1219929.01504.0TransmembraneHelical%3B Name%3D17
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031940_960929.01504.0TransmembraneHelical%3B Name%3D12
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031998_1018929.01504.0TransmembraneHelical%3B Name%3D13
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021062_10820100.0TransmembraneHelical%3B Name%3D14
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021084_11040100.0TransmembraneHelical%3B Name%3D15
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021176_11960100.0TransmembraneHelical%3B Name%3D16
TgeneABCC6chr16:20492243chr16:16263710ENST00000575728021199_12190100.0TransmembraneHelical%3B Name%3D17
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802132_1490100.0TransmembraneHelical%3B Name%3D4
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802168_1880100.0TransmembraneHelical%3B Name%3D5
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802303_3230100.0TransmembraneHelical%3B Name%3D6
TgeneABCC6chr16:20492243chr16:16263710ENST000005757280232_520100.0TransmembraneHelical%3B Name%3D1
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802350_3700100.0TransmembraneHelical%3B Name%3D7
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802427_4470100.0TransmembraneHelical%3B Name%3D8
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802451_4710100.0TransmembraneHelical%3B Name%3D9
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802534_5540100.0TransmembraneHelical%3B Name%3D10
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802576_5960100.0TransmembraneHelical%3B Name%3D11
TgeneABCC6chr16:20492243chr16:16263710ENST000005757280273_930100.0TransmembraneHelical%3B Name%3D2
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802940_9600100.0TransmembraneHelical%3B Name%3D12
TgeneABCC6chr16:20492243chr16:16263710ENST0000057572802998_10180100.0TransmembraneHelical%3B Name%3D13
TgeneABCC6chr16:20492243chr16:16263710ENST000005757280299_1190100.0TransmembraneHelical%3B Name%3D3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACSM2Achr16:20492243chr16:16263710ENST00000219054+1315540_542503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000396104+1113540_542503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000573854+1214540_542503.0578.0RegionCoenzyme A binding
HgeneACSM2Achr16:20492243chr16:16263710ENST00000575690+1315540_542503.0578.0RegionCoenzyme A binding
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031311_593929.01504.0DomainABC transmembrane type-1 1
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031629_853929.01504.0DomainABC transporter 1
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031663_670929.01504.0Nucleotide bindingATP 1
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031120_131929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031150_167929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031189_302929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST0000020555720311_31929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031324_349929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031371_426929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031448_450929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031472_533929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000205557203153_72929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031555_575929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031597_939929.01504.0Topological domainCytoplasmic
TgeneABCC6chr16:20492243chr16:16263710ENST00000205557203194_98929.01504.0Topological domainExtracellular
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031132_149929.01504.0TransmembraneHelical%3B Name%3D4
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031168_188929.01504.0TransmembraneHelical%3B Name%3D5
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031303_323929.01504.0TransmembraneHelical%3B Name%3D6
TgeneABCC6chr16:20492243chr16:16263710ENST00000205557203132_52929.01504.0TransmembraneHelical%3B Name%3D1
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031350_370929.01504.0TransmembraneHelical%3B Name%3D7
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031427_447929.01504.0TransmembraneHelical%3B Name%3D8
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031451_471929.01504.0TransmembraneHelical%3B Name%3D9
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031534_554929.01504.0TransmembraneHelical%3B Name%3D10
TgeneABCC6chr16:20492243chr16:16263710ENST000002055572031576_596929.01504.0TransmembraneHelical%3B Name%3D11
TgeneABCC6chr16:20492243chr16:16263710ENST00000205557203173_93929.01504.0TransmembraneHelical%3B Name%3D2
TgeneABCC6chr16:20492243chr16:16263710ENST00000205557203199_119929.01504.0TransmembraneHelical%3B Name%3D3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ACSM2A
ABCC6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ACSM2A-ABCC6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ACSM2A-ABCC6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource