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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CDK5RAP2-ENG

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CDK5RAP2-ENG
	FusionPDB ID: 15270
	FusionGDB2.0 ID: 15270
		Hgene	Tgene
	Gene symbol	CDK5RAP2	ENG
	Gene ID	55755	2022
	Gene name	CDK5 regulatory subunit associated protein 2	endoglin
	Synonyms	C48\|Cep215\|MCPH3	END\|HHT1\|ORW1
	Cytomap	9q33.2	9q34.11
	Type of gene	protein-coding	protein-coding
	Description	CDK5 regulatory subunit-associated protein 2CDK5 activator-binding protein C48centrosomal protein 215 kDacentrosomin	endoglinCD105 antigen
	Modification date	20200328	20200329
	UniProtAcc	Q96SN8	Q8NFI3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000349780, ENST00000359309, ENST00000360190, ENST00000360822, ENST00000480467,	ENST00000480266, ENST00000344849, ENST00000373203,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 13 X 5=780	6 X 7 X 4=168
	# samples	13	6
	** MAII score	log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CDK5RAP2 [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CDK5RAP2(123280705)-ENG(130588951), # samples:3
Anticipated loss of major functional domain due to fusion event.	CDK5RAP2-ENG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK5RAP2-ENG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDK5RAP2-ENG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDK5RAP2-ENG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDK5RAP2	GO:0000226	microtubule cytoskeleton organization	17959831
Hgene	CDK5RAP2	GO:0001578	microtubule bundle formation	19553473
Hgene	CDK5RAP2	GO:0045893	positive regulation of transcription, DNA-templated	19282672
Hgene	CDK5RAP2	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	19282672
Tgene	ENG	GO:0001934	positive regulation of protein phosphorylation	12015308
Tgene	ENG	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	12015308
Tgene	ENG	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	15702480
Tgene	ENG	GO:0030336	negative regulation of cell migration	19736306
Tgene	ENG	GO:0030513	positive regulation of BMP signaling pathway	17068149
Tgene	ENG	GO:0031953	negative regulation of protein autophosphorylation	12015308

Fusion gene breakpoints across CDK5RAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ENG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A14N-01A	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-
ChimerDB4	BRCA	TCGA-E2-A14N-01A	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360822	CDK5RAP2	chr9	123280705	-	ENST00000373203	ENG	chr9	130588951	-	3779	1492	181	3108	975
ENST00000360822	CDK5RAP2	chr9	123280705	-	ENST00000344849	ENG	chr9	130588951	-	3910	1492	181	3009	942
ENST00000359309	CDK5RAP2	chr9	123280705	-	ENST00000373203	ENG	chr9	130588951	-	3779	1492	181	3108	975
ENST00000359309	CDK5RAP2	chr9	123280705	-	ENST00000344849	ENG	chr9	130588951	-	3910	1492	181	3009	942
ENST00000349780	CDK5RAP2	chr9	123280705	-	ENST00000373203	ENG	chr9	130588951	-	3778	1491	180	3107	975
ENST00000349780	CDK5RAP2	chr9	123280705	-	ENST00000344849	ENG	chr9	130588951	-	3909	1491	180	3008	942
ENST00000360190	CDK5RAP2	chr9	123280705	-	ENST00000373203	ENG	chr9	130588951	-	3778	1491	180	3107	975
ENST00000360190	CDK5RAP2	chr9	123280705	-	ENST00000344849	ENG	chr9	130588951	-	3909	1491	180	3008	942
ENST00000360822	CDK5RAP2	chr9	123280704	-	ENST00000373203	ENG	chr9	130588950	-	3779	1492	181	3108	975
ENST00000360822	CDK5RAP2	chr9	123280704	-	ENST00000344849	ENG	chr9	130588950	-	3910	1492	181	3009	942
ENST00000359309	CDK5RAP2	chr9	123280704	-	ENST00000373203	ENG	chr9	130588950	-	3779	1492	181	3108	975
ENST00000359309	CDK5RAP2	chr9	123280704	-	ENST00000344849	ENG	chr9	130588950	-	3910	1492	181	3009	942
ENST00000349780	CDK5RAP2	chr9	123280704	-	ENST00000373203	ENG	chr9	130588950	-	3778	1491	180	3107	975
ENST00000349780	CDK5RAP2	chr9	123280704	-	ENST00000344849	ENG	chr9	130588950	-	3909	1491	180	3008	942
ENST00000360190	CDK5RAP2	chr9	123280704	-	ENST00000373203	ENG	chr9	130588950	-	3778	1491	180	3107	975
ENST00000360190	CDK5RAP2	chr9	123280704	-	ENST00000344849	ENG	chr9	130588950	-	3909	1491	180	3008	942

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360822	ENST00000373203	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004002903	0.9959971
ENST00000360822	ENST00000344849	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004559904	0.9954401
ENST00000359309	ENST00000373203	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004002903	0.9959971
ENST00000359309	ENST00000344849	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004559904	0.9954401
ENST00000349780	ENST00000373203	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.003995309	0.99600464
ENST00000349780	ENST00000344849	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004552767	0.9954472
ENST00000360190	ENST00000373203	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.003995309	0.99600464
ENST00000360190	ENST00000344849	CDK5RAP2	chr9	123280705	-	ENG	chr9	130588951	-	0.004552767	0.9954472
ENST00000360822	ENST00000373203	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004002903	0.9959971
ENST00000360822	ENST00000344849	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004559904	0.9954401
ENST00000359309	ENST00000373203	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004002903	0.9959971
ENST00000359309	ENST00000344849	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004559904	0.9954401
ENST00000349780	ENST00000373203	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.003995309	0.99600464
ENST00000349780	ENST00000344849	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004552767	0.9954472
ENST00000360190	ENST00000373203	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.003995309	0.99600464
ENST00000360190	ENST00000344849	CDK5RAP2	chr9	123280704	-	ENG	chr9	130588950	-	0.004552767	0.9954472

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15270_15270_1_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000349780_ENG_chr9_130588950_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_2_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000349780_ENG_chr9_130588950_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_3_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000359309_ENG_chr9_130588950_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_4_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000359309_ENG_chr9_130588950_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_5_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000360190_ENG_chr9_130588950_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_6_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000360190_ENG_chr9_130588950_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_7_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000360822_ENG_chr9_130588950_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_8_CDK5RAP2-ENG_CDK5RAP2_chr9_123280704_ENST00000360822_ENG_chr9_130588950_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_9_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000349780_ENG_chr9_130588951_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_10_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000349780_ENG_chr9_130588951_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_11_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000359309_ENG_chr9_130588951_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_12_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000359309_ENG_chr9_130588951_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_13_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000360190_ENG_chr9_130588951_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_14_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000360190_ENG_chr9_130588951_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_15_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000360822_ENG_chr9_130588951_ENST00000344849_length(amino acids)=942AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

>15270_15270_16_CDK5RAP2-ENG_CDK5RAP2_chr9_123280705_ENST00000360822_ENG_chr9_130588951_ENST00000373203_length(amino acids)=975AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRNSSLVTFQEPPGV
NTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRV
LPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVAS
FVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKF
VLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSC
HLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:123280705/chr9:130588951)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CDK5RAP2 Q96SN8	ENG Q8NFI3
FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250\|UniProtKB:Q8K389, ECO:0000269\|PubMed:17959831, ECO:0000269\|PubMed:18042621, ECO:0000269\|PubMed:19282672, ECO:0000269\|PubMed:19553473, ECO:0000269\|PubMed:26485573, ECO:0000269\|PubMed:29162697}.	FUNCTION: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269\|PubMed:12114544}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

336_576

120.0

626.0

Compositional bias

Note=Ser/Thr-rich

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

336_576

120.0

659.0

Compositional bias

Note=Ser/Thr-rich

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

336_576

120.0

626.0

Compositional bias

Note=Ser/Thr-rich

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

336_576

120.0

659.0

Compositional bias

Note=Ser/Thr-rich

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

363_533

120.0

626.0

Domain

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

363_533

120.0

659.0

Domain

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

363_533

120.0

626.0

Domain

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

363_533

120.0

659.0

Domain

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

399_401

120.0

626.0

Motif

Cell attachment site

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

399_401

120.0

659.0

Motif

Cell attachment site

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

399_401

120.0

626.0

Motif

Cell attachment site

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

399_401

120.0

659.0

Motif

Cell attachment site

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

200_330

120.0

626.0

Region

OR1%2C C-terminal part

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

200_330

120.0

659.0

Region

OR1%2C C-terminal part

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

200_330

120.0

626.0

Region

OR1%2C C-terminal part

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

200_330

120.0

659.0

Region

OR1%2C C-terminal part

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

612_658

120.0

626.0

Topological domain

Cytoplasmic

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

612_658

120.0

659.0

Topological domain

Cytoplasmic

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

612_658

120.0

626.0

Topological domain

Cytoplasmic

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

612_658

120.0

659.0

Topological domain

Cytoplasmic

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

587_611

120.0

626.0

Transmembrane

Helical

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

587_611

120.0

659.0

Transmembrane

Helical

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

587_611

120.0

626.0

Transmembrane

Helical

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

587_611

120.0

659.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

26_46

120.0

626.0

Region

OR1%2C N-terminal part

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

47_199

120.0

626.0

Region

OR2

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

26_46

120.0

659.0

Region

OR1%2C N-terminal part

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

47_199

120.0

659.0

Region

OR2

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

26_46

120.0

626.0

Region

OR1%2C N-terminal part

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

47_199

120.0

626.0

Region

OR2

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

26_46

120.0

659.0

Region

OR1%2C N-terminal part

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

47_199

120.0

659.0

Region

OR2

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000344849

26_586

120.0

626.0

Topological domain

Extracellular

Tgene

ENG

chr9:123280704

chr9:130588950

ENST00000373203

26_586

120.0

659.0

Topological domain

Extracellular

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000344849

26_586

120.0

626.0

Topological domain

Extracellular

Tgene

ENG

chr9:123280705

chr9:130588951

ENST00000373203

26_586

120.0

659.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CDK5RAP2
ENG

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000349780	-	12	38	1726_1768	437.0	1894.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000359309	-	12	37	1726_1768	437.0	1853.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360190	-	12	37	1726_1768	437.0	1815.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360822	-	12	37	1726_1768	437.0	1862.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000349780	-	12	38	1726_1768	437.0	1894.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000359309	-	12	37	1726_1768	437.0	1853.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360190	-	12	37	1726_1768	437.0	1815.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360822	-	12	37	1726_1768	437.0	1862.0	CDK5R1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000349780	-	12	38	926_1208	437.0	1894.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000359309	-	12	37	926_1208	437.0	1853.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360190	-	12	37	926_1208	437.0	1815.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360822	-	12	37	926_1208	437.0	1862.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000349780	-	12	38	926_1208	437.0	1894.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000359309	-	12	37	926_1208	437.0	1853.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360190	-	12	37	926_1208	437.0	1815.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360822	-	12	37	926_1208	437.0	1862.0	MAPRE1
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000349780	-	12	38	1726_1893	437.0	1894.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000359309	-	12	37	1726_1893	437.0	1853.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360190	-	12	37	1726_1893	437.0	1815.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280704	chr9:130588950	ENST00000360822	-	12	37	1726_1893	437.0	1862.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000349780	-	12	38	1726_1893	437.0	1894.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000359309	-	12	37	1726_1893	437.0	1853.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360190	-	12	37	1726_1893	437.0	1815.0	PCNT and AKAP9
Hgene	CDK5RAP2	chr9:123280705	chr9:130588951	ENST00000360822	-	12	37	1726_1893	437.0	1862.0	PCNT and AKAP9

Top

Related Drugs to CDK5RAP2-ENG

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to CDK5RAP2-ENG

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source