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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDKAL1-CRHR2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDKAL1-CRHR2
FusionPDB ID: 15327
FusionGDB2.0 ID: 15327
HgeneTgene
Gene symbol

CDKAL1

CRHR2

Gene ID

54901

1395

Gene nameCDK5 regulatory subunit associated protein 1 like 1corticotropin releasing hormone receptor 2
Synonyms-CRF-RB|CRF2|CRFR2|HM-CRF
Cytomap

6p22.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferasecorticotropin-releasing factor receptor 2CRF2 receptor, beta isoformCRH receptor 2 variant BCRH-R2
Modification date2020032220200313
UniProtAcc

Q5VV42

.
Ensembl transtripts involved in fusion geneENST idsENST00000274695, ENST00000378610, 
ENST00000378624, ENST00000476517, 
ENST00000462882, ENST00000341843, 
ENST00000348438, ENST00000471646, 
ENST00000506074, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score37 X 20 X 14=103603 X 3 X 2=18
# samples 393
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDKAL1 [Title/Abstract] AND CRHR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDKAL1(21108694)-CRHR2(30695628), # samples:2
Anticipated loss of major functional domain due to fusion event.CDKAL1-CRHR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-CRHR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-CRHR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKAL1-CRHR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRHR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-G3-A7M5-01ACDKAL1chr6

21108694

-CRHR2chr7

30695628

-
ChimerDB4LIHCTCGA-G3-A7M5-01ACDKAL1chr6

21108694

+CRHR2chr7

30695628

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr621108694+ENST00000471646CRHR2chr730695628-274714661671870567
ENST00000274695CDKAL1chr621108694+ENST00000341843CRHR2chr730695628-208414661671870567
ENST00000274695CDKAL1chr621108694+ENST00000348438CRHR2chr730695628-208414661671870567
ENST00000274695CDKAL1chr621108694+ENST00000506074CRHR2chr730695628-205514661671747526
ENST00000378610CDKAL1chr621108694+ENST00000471646CRHR2chr730695628-25901309101713567
ENST00000378610CDKAL1chr621108694+ENST00000341843CRHR2chr730695628-19271309101713567
ENST00000378610CDKAL1chr621108694+ENST00000348438CRHR2chr730695628-19271309101713567
ENST00000378610CDKAL1chr621108694+ENST00000506074CRHR2chr730695628-18981309101590526

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000471646CDKAL1chr621108694+CRHR2chr730695628-0.0009938630.9990062
ENST00000274695ENST00000341843CDKAL1chr621108694+CRHR2chr730695628-0.0005510780.99944896
ENST00000274695ENST00000348438CDKAL1chr621108694+CRHR2chr730695628-0.0005510780.99944896
ENST00000274695ENST00000506074CDKAL1chr621108694+CRHR2chr730695628-0.0004921640.9995078
ENST00000378610ENST00000471646CDKAL1chr621108694+CRHR2chr730695628-0.0012761320.9987238
ENST00000378610ENST00000341843CDKAL1chr621108694+CRHR2chr730695628-0.0007672730.99923277
ENST00000378610ENST00000348438CDKAL1chr621108694+CRHR2chr730695628-0.0007672730.99923277
ENST00000378610ENST00000506074CDKAL1chr621108694+CRHR2chr730695628-0.0006857320.9993143

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15327_15327_1_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000274695_CRHR2_chr7_30695628_ENST00000341843_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_2_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000274695_CRHR2_chr7_30695628_ENST00000348438_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_3_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000274695_CRHR2_chr7_30695628_ENST00000471646_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_4_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000274695_CRHR2_chr7_30695628_ENST00000506074_length(amino acids)=526AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL

--------------------------------------------------------------

>15327_15327_5_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000378610_CRHR2_chr7_30695628_ENST00000341843_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_6_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000378610_CRHR2_chr7_30695628_ENST00000348438_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_7_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000378610_CRHR2_chr7_30695628_ENST00000471646_length(amino acids)=567AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------

>15327_15327_8_CDKAL1-CRHR2_CDKAL1_chr6_21108694_ENST00000378610_CRHR2_chr7_30695628_ENST00000506074_length(amino acids)=526AA_BP=433
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:21108694/chr7:30695628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKAL1

Q5VV42

.
FUNCTION: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. {ECO:0000250|UniProtKB:Q91WE6}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316200_431433.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+131664_172433.0580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114200_431433.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+111464_172433.0580.0DomainMTTase N-terminal
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712292_302263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712328_334263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712365_411263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813328_334304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813365_411304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712292_302277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712328_334277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712365_411277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712266_291263.0398.0TransmembraneHelical%3B Name%3D5
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712303_327263.0398.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712335_364263.0398.0TransmembraneHelical%3B Name%3D7
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813303_327304.0439.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813335_364304.0439.0TransmembraneHelical%3B Name%3D7
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712303_327277.0412.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712335_364277.0412.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316431_493433.0580.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114431_493433.0580.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114200_4310489.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114431_4930489.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+11464_1720489.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316556_578433.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114556_578433.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114556_5780489.0TransmembraneHelical
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712140_146263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712172_185263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000003418437121_108263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712215_221263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712250_265263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813140_146304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813172_185304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000003484388131_108304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813215_221304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813250_265304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813292_302304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712140_146277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712172_185277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000004716467121_108277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712215_221277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712250_265277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712109_139263.0398.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712147_171263.0398.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712186_214263.0398.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712222_249263.0398.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813109_139304.0439.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813147_171304.0439.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813186_214304.0439.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813222_249304.0439.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813266_291304.0439.0TransmembraneHelical%3B Name%3D5
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712109_139277.0412.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712147_171277.0412.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712186_214277.0412.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712222_249277.0412.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712266_291277.0412.0TransmembraneHelical%3B Name%3D5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDKAL1
CRHR2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDKAL1-CRHR2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDKAL1-CRHR2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource