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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDKN2A-CAPZB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDKN2A-CAPZB
FusionPDB ID: 15397
FusionGDB2.0 ID: 15397
HgeneTgene
Gene symbol

CDKN2A

CAPZB

Gene ID

1029

832

Gene namecyclin dependent kinase inhibitor 2Acapping actin protein of muscle Z-line subunit beta
SynonymsARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16CAPB|CAPPB|CAPZ
Cytomap

9p21.3

1p36.13

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1F-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020032920200320
UniProtAcc

Q96HQ2

P47756

Ensembl transtripts involved in fusion geneENST idsENST00000304494, ENST00000446177, 
ENST00000498124, ENST00000579122, 
ENST00000361570, ENST00000470819, 
ENST00000479692, ENST00000494262, 
ENST00000497750, ENST00000498628, 
ENST00000530628, ENST00000578845, 
ENST00000579755, 		ENST00000375144, 
ENST00000482808, ENST00000264202, 
ENST00000264203, ENST00000375142, 
ENST00000401084, ENST00000433834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 9 X 11=138623 X 15 X 8=2760
# samples 1727
** MAII scorelog2(17/1386*10)=-3.02732060599951
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDKN2A [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDKN2A(21974677)-CAPZB(19671746), # samples:3
Anticipated loss of major functional domain due to fusion event.CDKN2A-CAPZB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2A-CAPZB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

HgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

HgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

HgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

HgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

HgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

HgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215


check buttonFusion gene breakpoints across CDKN2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A6MD-01ACDKN2Achr9

21974677

-CAPZBchr1

19671746

-
ChimerDB4BLCATCGA-E7-A6MDCDKN2Achr9

21974676

-CAPZBchr1

19671746

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000304494CDKN2Achr921974677-ENST00000401084CAPZBchr119671746-1409421124651175
ENST00000304494CDKN2Achr921974677-ENST00000264203CAPZBchr119671746-1329421124537137
ENST00000304494CDKN2Achr921974677-ENST00000375142CAPZBchr119671746-147242178676236
ENST00000304494CDKN2Achr921974677-ENST00000433834CAPZBchr119671746-823421124651175
ENST00000304494CDKN2Achr921974677-ENST00000264202CAPZBchr119671746-66742165476192
ENST00000579122CDKN2Achr921974677-ENST00000401084CAPZBchr119671746-116918131411126
ENST00000579122CDKN2Achr921974677-ENST00000264203CAPZBchr119671746-1089181961623112
ENST00000579122CDKN2Achr921974677-ENST00000375142CAPZBchr119671746-12321815461182
ENST00000579122CDKN2Achr921974677-ENST00000433834CAPZBchr119671746-58318131411126
ENST00000579122CDKN2Achr921974677-ENST00000264202CAPZBchr119671746-4271814141138
ENST00000498124CDKN2Achr921974677-ENST00000401084CAPZBchr119671746-117718939419126
ENST00000498124CDKN2Achr921974677-ENST00000264203CAPZBchr119671746-1097189969631112
ENST00000498124CDKN2Achr921974677-ENST00000375142CAPZBchr119671746-12401895540185
ENST00000498124CDKN2Achr921974677-ENST00000433834CAPZBchr119671746-59118939419126
ENST00000498124CDKN2Achr921974677-ENST00000264202CAPZBchr119671746-4351894220141
ENST00000446177CDKN2Achr921974677-ENST00000401084CAPZBchr119671746-135036265592175
ENST00000446177CDKN2Achr921974677-ENST00000264203CAPZBchr119671746-127036265478137
ENST00000446177CDKN2Achr921974677-ENST00000375142CAPZBchr119671746-141336272717236
ENST00000446177CDKN2Achr921974677-ENST00000433834CAPZBchr119671746-76436265592175
ENST00000446177CDKN2Achr921974677-ENST00000264202CAPZBchr119671746-60836259517192
ENST00000304494CDKN2Achr921974676-ENST00000401084CAPZBchr119671746-1409421124651175
ENST00000304494CDKN2Achr921974676-ENST00000264203CAPZBchr119671746-1329421124537137
ENST00000304494CDKN2Achr921974676-ENST00000375142CAPZBchr119671746-147242178676236
ENST00000304494CDKN2Achr921974676-ENST00000433834CAPZBchr119671746-823421124651175
ENST00000304494CDKN2Achr921974676-ENST00000264202CAPZBchr119671746-66742165476192
ENST00000579122CDKN2Achr921974676-ENST00000401084CAPZBchr119671746-116918131411126
ENST00000579122CDKN2Achr921974676-ENST00000264203CAPZBchr119671746-1089181961623112
ENST00000579122CDKN2Achr921974676-ENST00000375142CAPZBchr119671746-12321815461182
ENST00000579122CDKN2Achr921974676-ENST00000433834CAPZBchr119671746-58318131411126
ENST00000579122CDKN2Achr921974676-ENST00000264202CAPZBchr119671746-4271814141138
ENST00000498124CDKN2Achr921974676-ENST00000401084CAPZBchr119671746-117718939419126
ENST00000498124CDKN2Achr921974676-ENST00000264203CAPZBchr119671746-1097189969631112
ENST00000498124CDKN2Achr921974676-ENST00000375142CAPZBchr119671746-12401895540185
ENST00000498124CDKN2Achr921974676-ENST00000433834CAPZBchr119671746-59118939419126
ENST00000498124CDKN2Achr921974676-ENST00000264202CAPZBchr119671746-4351894220141
ENST00000446177CDKN2Achr921974676-ENST00000401084CAPZBchr119671746-135036265592175
ENST00000446177CDKN2Achr921974676-ENST00000264203CAPZBchr119671746-127036265478137
ENST00000446177CDKN2Achr921974676-ENST00000375142CAPZBchr119671746-141336272717236
ENST00000446177CDKN2Achr921974676-ENST00000433834CAPZBchr119671746-76436265592175
ENST00000446177CDKN2Achr921974676-ENST00000264202CAPZBchr119671746-60836259517192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000304494ENST00000401084CDKN2Achr921974677-CAPZBchr119671746-0.019744650.98025537
ENST00000304494ENST00000264203CDKN2Achr921974677-CAPZBchr119671746-0.39506490.60493517
ENST00000304494ENST00000375142CDKN2Achr921974677-CAPZBchr119671746-0.0195392580.9804607
ENST00000304494ENST00000433834CDKN2Achr921974677-CAPZBchr119671746-0.0123512340.9876488
ENST00000304494ENST00000264202CDKN2Achr921974677-CAPZBchr119671746-0.0077981520.9922018
ENST00000579122ENST00000401084CDKN2Achr921974677-CAPZBchr119671746-0.0108447090.98915535
ENST00000579122ENST00000264203CDKN2Achr921974677-CAPZBchr119671746-0.2101110.789889
ENST00000579122ENST00000375142CDKN2Achr921974677-CAPZBchr119671746-0.0057711580.99422884
ENST00000579122ENST00000433834CDKN2Achr921974677-CAPZBchr119671746-0.0036624120.99633765
ENST00000579122ENST00000264202CDKN2Achr921974677-CAPZBchr119671746-0.0054035620.9945964
ENST00000498124ENST00000401084CDKN2Achr921974677-CAPZBchr119671746-0.0063219320.99367803
ENST00000498124ENST00000264203CDKN2Achr921974677-CAPZBchr119671746-0.122498640.8775014
ENST00000498124ENST00000375142CDKN2Achr921974677-CAPZBchr119671746-0.005552130.9944478
ENST00000498124ENST00000433834CDKN2Achr921974677-CAPZBchr119671746-0.0030021730.99699783
ENST00000498124ENST00000264202CDKN2Achr921974677-CAPZBchr119671746-0.0047090140.995291
ENST00000446177ENST00000401084CDKN2Achr921974677-CAPZBchr119671746-0.0106572270.9893428
ENST00000446177ENST00000264203CDKN2Achr921974677-CAPZBchr119671746-0.209567320.79043275
ENST00000446177ENST00000375142CDKN2Achr921974677-CAPZBchr119671746-0.0111792910.9888207
ENST00000446177ENST00000433834CDKN2Achr921974677-CAPZBchr119671746-0.0075526210.9924474
ENST00000446177ENST00000264202CDKN2Achr921974677-CAPZBchr119671746-0.0057500450.99424994
ENST00000304494ENST00000401084CDKN2Achr921974676-CAPZBchr119671746-0.019744650.98025537
ENST00000304494ENST00000264203CDKN2Achr921974676-CAPZBchr119671746-0.39506490.60493517
ENST00000304494ENST00000375142CDKN2Achr921974676-CAPZBchr119671746-0.0195392580.9804607
ENST00000304494ENST00000433834CDKN2Achr921974676-CAPZBchr119671746-0.0123512340.9876488
ENST00000304494ENST00000264202CDKN2Achr921974676-CAPZBchr119671746-0.0077981520.9922018
ENST00000579122ENST00000401084CDKN2Achr921974676-CAPZBchr119671746-0.0108447090.98915535
ENST00000579122ENST00000264203CDKN2Achr921974676-CAPZBchr119671746-0.2101110.789889
ENST00000579122ENST00000375142CDKN2Achr921974676-CAPZBchr119671746-0.0057711580.99422884
ENST00000579122ENST00000433834CDKN2Achr921974676-CAPZBchr119671746-0.0036624120.99633765
ENST00000579122ENST00000264202CDKN2Achr921974676-CAPZBchr119671746-0.0054035620.9945964
ENST00000498124ENST00000401084CDKN2Achr921974676-CAPZBchr119671746-0.0063219320.99367803
ENST00000498124ENST00000264203CDKN2Achr921974676-CAPZBchr119671746-0.122498640.8775014
ENST00000498124ENST00000375142CDKN2Achr921974676-CAPZBchr119671746-0.005552130.9944478
ENST00000498124ENST00000433834CDKN2Achr921974676-CAPZBchr119671746-0.0030021730.99699783
ENST00000498124ENST00000264202CDKN2Achr921974676-CAPZBchr119671746-0.0047090140.995291
ENST00000446177ENST00000401084CDKN2Achr921974676-CAPZBchr119671746-0.0106572270.9893428
ENST00000446177ENST00000264203CDKN2Achr921974676-CAPZBchr119671746-0.209567320.79043275
ENST00000446177ENST00000375142CDKN2Achr921974676-CAPZBchr119671746-0.0111792910.9888207
ENST00000446177ENST00000433834CDKN2Achr921974676-CAPZBchr119671746-0.0075526210.9924474
ENST00000446177ENST00000264202CDKN2Achr921974676-CAPZBchr119671746-0.0057500450.99424994

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15397_15397_1_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000304494_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=192AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV
GQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLPALPLSAAAERTRSAPPSGDQPAPPLSSSGAGGRAPSDPVPQILW

--------------------------------------------------------------

>15397_15397_2_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000304494_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=137AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_3_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000304494_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=236AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_4_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000304494_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

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>15397_15397_5_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000304494_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_6_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000446177_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=192AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV
GQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLPALPLSAAAERTRSAPPSGDQPAPPLSSSGAGGRAPSDPVPQILW

--------------------------------------------------------------

>15397_15397_7_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000446177_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=137AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_8_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000446177_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=236AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_9_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000446177_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_10_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000446177_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_11_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000498124_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=141AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV

--------------------------------------------------------------

>15397_15397_12_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000498124_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=112AA_BP=
MHSIEIDRKAPGRKSGTVGGTPPSPHPAASVGRESLRRTAPRATSAPRAVPCPHDPQPQATPKHTRNKISSFSSLFHTPQLVHKIFLFYI

--------------------------------------------------------------

>15397_15397_13_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000498124_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=185AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_14_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000498124_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_15_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000498124_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_16_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000579122_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=138AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV

--------------------------------------------------------------

>15397_15397_17_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000579122_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=112AA_BP=
MHSIEIDRKAPGRKSGTVGGTPPSPHPAASVGRESLRRTAPRATSAPRAVPCPHDPQPQATPKHTRNKISSFSSLFHTPQLVHKIFLFYI

--------------------------------------------------------------

>15397_15397_18_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000579122_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=182AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_19_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000579122_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_20_CDKN2A-CAPZB_CDKN2A_chr9_21974676_ENST00000579122_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_21_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000304494_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=192AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV
GQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLPALPLSAAAERTRSAPPSGDQPAPPLSSSGAGGRAPSDPVPQILW

--------------------------------------------------------------

>15397_15397_22_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000304494_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=137AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_23_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000304494_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=236AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_24_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000304494_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_25_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000304494_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

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>15397_15397_26_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000446177_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=192AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV
GQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLPALPLSAAAERTRSAPPSGDQPAPPLSSSGAGGRAPSDPVPQILW

--------------------------------------------------------------

>15397_15397_27_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000446177_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=137AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

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>15397_15397_28_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000446177_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=236AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_29_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000446177_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

--------------------------------------------------------------

>15397_15397_30_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000446177_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=175AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP

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>15397_15397_31_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000498124_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=141AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV

--------------------------------------------------------------

>15397_15397_32_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000498124_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=112AA_BP=
MHSIEIDRKAPGRKSGTVGGTPPSPHPAASVGRESLRRTAPRATSAPRAVPCPHDPQPQATPKHTRNKISSFSSLFHTPQLVHKIFLFYI

--------------------------------------------------------------

>15397_15397_33_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000498124_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=185AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_34_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000498124_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_35_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000498124_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

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>15397_15397_36_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000579122_CAPZB_chr1_19671746_ENST00000264202_length(amino acids)=138AA_BP=1
MDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLVQRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCV

--------------------------------------------------------------

>15397_15397_37_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000579122_CAPZB_chr1_19671746_ENST00000264203_length(amino acids)=112AA_BP=
MHSIEIDRKAPGRKSGTVGGTPPSPHPAASVGRESLRRTAPRATSAPRAVPCPHDPQPQATPKHTRNKISSFSSLFHTPQLVHKIFLFYI

--------------------------------------------------------------

>15397_15397_38_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000579122_CAPZB_chr1_19671746_ENST00000375142_length(amino acids)=182AA_BP=1
MVSMKQRFSIAAFSSKPPPGHSSELLVLICLQKSAQTWIGLIIRLDVDLALGQHLRELPLQLLKLLVVRDSINRSQPIDDILCFSKVDLV
QRTSDFIFHVLYQAPDVGYVWGAVTHSFILLHLDRPPTVTIRCVGQRPRLQQRPHLLYPTPGRGRGQPVSRRLHAAPRRRLHAAPRRPLP

--------------------------------------------------------------

>15397_15397_39_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000579122_CAPZB_chr1_19671746_ENST00000401084_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

--------------------------------------------------------------

>15397_15397_40_CDKN2A-CAPZB_CDKN2A_chr9_21974677_ENST00000579122_CAPZB_chr1_19671746_ENST00000433834_length(amino acids)=126AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:21974677/chr1:19671746)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKN2A

Q96HQ2

CAPZB

P47756

FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000304494-1311_4050.0157.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000446177-1311_4050.0168.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498124-1411_4050.0130.66666666666666RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000304494-1311_4050.0157.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000446177-1311_4050.0168.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498124-1411_4050.0130.66666666666666RepeatNote=ANK 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000304494-13110_13950.0157.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000304494-1344_7250.0157.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000304494-1377_10650.0157.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000446177-13110_13950.0168.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000446177-1344_7250.0168.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000446177-1377_10650.0168.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000494262-14110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000494262-1411_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000494262-1444_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000494262-1477_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498124-14110_13950.0130.66666666666666RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498124-1444_7250.0130.66666666666666RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498124-1477_10650.0130.66666666666666RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498628-13110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498628-1311_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498628-1344_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000498628-1377_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000578845-12110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000578845-1211_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000578845-1244_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000578845-1277_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000304494-13110_13950.0157.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000304494-1344_7250.0157.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000304494-1377_10650.0157.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000446177-13110_13950.0168.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000446177-1344_7250.0168.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000446177-1377_10650.0168.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000494262-14110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000494262-1411_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000494262-1444_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000494262-1477_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498124-14110_13950.0130.66666666666666RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498124-1444_7250.0130.66666666666666RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498124-1477_10650.0130.66666666666666RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498628-13110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498628-1311_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498628-1344_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000498628-1377_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000578845-12110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000578845-1211_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000578845-1244_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000578845-1277_1060106.0RepeatNote=ANK 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDKN2A
CAPZB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000361570-131_640220.0CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000530628-131_640122.66666666666667CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974676chr1:19671746ENST00000579755-131_640134.33333333333334CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000361570-131_640220.0CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000530628-131_640122.66666666666667CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:19671746ENST00000579755-131_640134.33333333333334CDK5RAP3 and MDM2


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Related Drugs to CDKN2A-CAPZB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDKN2A-CAPZB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource