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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CELF1-FNBP4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CELF1-FNBP4
FusionPDB ID: 15588
FusionGDB2.0 ID: 15588
HgeneTgene
Gene symbol

CELF1

FNBP4

Gene ID

10658

23360

Gene nameCUGBP Elav-like family member 1formin binding protein 4
SynonymsBRUNOL2|CUG-BP|CUGBP|CUGBP1|EDEN-BP|NAB50|NAPOR|hNab50FBP30
Cytomap

11p11.2

11p11.2

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 150 kDa nuclear polyadenylated RNA-binding proteinCUG RNA-binding proteinCUG triplet repeat RNA-binding protein 1CUG-BP- and ETR-3-like factor 1EDEN-BP homologRNA-binding protein BRUNOL-2bruno-like 2bruno-like proteinformin-binding protein 4formin-binding protein 30
Modification date2020031320200313
UniProtAcc

Q92879

Q8N3X1

Ensembl transtripts involved in fusion geneENST idsENST00000310513, ENST00000358597, 
ENST00000361904, ENST00000395290, 
ENST00000395292, ENST00000531165, 
ENST00000532048, ENST00000539455, 
ENST00000263773, ENST00000534003, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 14=676211 X 15 X 8=1320
# samples 3519
** MAII scorelog2(35/6762*10)=-4.27202318906105
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1320*10)=-2.79646660591487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CELF1 [Title/Abstract] AND FNBP4 [Title/Abstract] AND fusion [Title/Abstract]

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma (pmid: 27165744)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CELF1(47505005)-FNBP4(47741638), # samples:3
CELF1(47504247)-FNBP4(47739064), # samples:3
Anticipated loss of major functional domain due to fusion event.CELF1-FNBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-FNBP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-FNBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-FNBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CELF1-FNBP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CELF1-FNBP4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF1

GO:0006376

mRNA splice site selection

11158314

HgeneCELF1

GO:0043484

regulation of RNA splicing

16946708


check buttonFusion gene breakpoints across CELF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FNBP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5LO-01ACELF1chr11

47505004

-FNBP4chr11

47741637

-
ChimerDB4ACCTCGA-OR-A5LO-01ACELF1chr11

47505005

-FNBP4chr11

47741638

-
ChimerDB4ACCTCGA-OR-A5LOCELF1chr11

47505004

-FNBP4chr11

47741638

-
ChimerDB4UCECTCGA-D1-A3JP-01ACELF1chr11

47493743

-FNBP4chr11

47755681

-
ChimerDB4UCSTCGA-N9-A4Q4-01ACELF1chr11

47504247

-FNBP4chr11

47739064

-
ChimerDB4UCSTCGA-N9-A4Q4CELF1chr11

47504246

-FNBP4chr11

47739064

-
ChimerDB4UCSTCGA-N9-A4Q4CELF1chr11

47504247

-FNBP4chr11

47739064

-
ChiTaRS5.0N/AEI794058CELF1chr11

47541983

+FNBP4chr11

47771768

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310513CELF1chr1147505005-ENST00000263773FNBP4chr1147741638-1812661136909257
ENST00000395292CELF1chr1147504247-ENST00000263773FNBP4chr1147739064-1881888135911258
ENST00000531165CELF1chr1147504247-ENST00000263773FNBP4chr1147739064-204010472521070272
ENST00000310513CELF1chr1147505004-ENST00000263773FNBP4chr1147741638-1812661136909257
ENST00000395292CELF1chr1147504246-ENST00000263773FNBP4chr1147739064-1881888135911258
ENST00000531165CELF1chr1147504246-ENST00000263773FNBP4chr1147739064-204010472521070272
ENST00000310513CELF1chr1147505004-ENST00000263773FNBP4chr1147741637-1812661136909257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310513ENST00000263773CELF1chr1147505005-FNBP4chr1147741638-0.0034815840.9965184
ENST00000395292ENST00000263773CELF1chr1147504247-FNBP4chr1147739064-0.0034048750.9965951
ENST00000531165ENST00000263773CELF1chr1147504247-FNBP4chr1147739064-0.003399280.9966008
ENST00000310513ENST00000263773CELF1chr1147505004-FNBP4chr1147741638-0.0034815840.9965184
ENST00000395292ENST00000263773CELF1chr1147504246-FNBP4chr1147739064-0.0034048750.9965951
ENST00000531165ENST00000263773CELF1chr1147504246-FNBP4chr1147739064-0.003399280.9966008
ENST00000310513ENST00000263773CELF1chr1147505004-FNBP4chr1147741637-0.0034815840.9965184

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15588_15588_1_CELF1-FNBP4_CELF1_chr11_47504246_ENST00000395292_FNBP4_chr11_47739064_ENST00000263773_length(amino acids)=258AA_BP=
MLILNNGSRSNNESNYLLSSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYT
RKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTR

--------------------------------------------------------------

>15588_15588_2_CELF1-FNBP4_CELF1_chr11_47504246_ENST00000531165_FNBP4_chr11_47739064_ENST00000263773_length(amino acids)=272AA_BP=
MASEGESEVMAAFKLDFLPEMMVDHCSLNSSPVSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQN
PPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD
GLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLAWHGRE

--------------------------------------------------------------

>15588_15588_3_CELF1-FNBP4_CELF1_chr11_47504247_ENST00000395292_FNBP4_chr11_47739064_ENST00000263773_length(amino acids)=258AA_BP=
MLILNNGSRSNNESNYLLSSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYT
RKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTR

--------------------------------------------------------------

>15588_15588_4_CELF1-FNBP4_CELF1_chr11_47504247_ENST00000531165_FNBP4_chr11_47739064_ENST00000263773_length(amino acids)=272AA_BP=
MASEGESEVMAAFKLDFLPEMMVDHCSLNSSPVSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQN
PPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD
GLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLAWHGRE

--------------------------------------------------------------

>15588_15588_5_CELF1-FNBP4_CELF1_chr11_47505004_ENST00000310513_FNBP4_chr11_47741637_ENST00000263773_length(amino acids)=257AA_BP=175
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEAKKSK

--------------------------------------------------------------

>15588_15588_6_CELF1-FNBP4_CELF1_chr11_47505004_ENST00000310513_FNBP4_chr11_47741638_ENST00000263773_length(amino acids)=257AA_BP=175
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEAKKSK

--------------------------------------------------------------

>15588_15588_7_CELF1-FNBP4_CELF1_chr11_47505005_ENST00000310513_FNBP4_chr11_47741638_ENST00000263773_length(amino acids)=257AA_BP=175
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHH
PIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEAKKSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:47505005/chr11:47741638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF1

Q92879

FNBP4

Q8N3X1

FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233). {ECO:0000250, ECO:0000269|PubMed:10536163, ECO:0000269|PubMed:11124939, ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:12799066, ECO:0000269|PubMed:14726956, ECO:0000269|PubMed:16601207, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:28431233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF1chr11:47504246chr11:47739064ENST00000310513-714108_188229.0596.6666666666666DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000310513-71416_99229.0596.6666666666666DomainRRM 1
HgeneCELF1chr11:47504246chr11:47739064ENST00000358597-613108_188229.0658.3333333333334DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000358597-61316_99229.0658.3333333333334DomainRRM 1
HgeneCELF1chr11:47504246chr11:47739064ENST00000361904-613108_188229.0475.0DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000361904-61316_99229.0475.0DomainRRM 1
HgeneCELF1chr11:47504246chr11:47739064ENST00000395290-613108_188228.02504.3333333333335DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000395290-61316_99228.02504.3333333333335DomainRRM 1
HgeneCELF1chr11:47504246chr11:47739064ENST00000395292-714108_188229.0579.6666666666666DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000395292-71416_99229.0579.6666666666666DomainRRM 1
HgeneCELF1chr11:47504246chr11:47739064ENST00000532048-916108_188255.0488.3333333333333DomainRRM 2
HgeneCELF1chr11:47504246chr11:47739064ENST00000532048-91616_99255.0488.3333333333333DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000310513-714108_188229.0596.6666666666666DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000310513-71416_99229.0596.6666666666666DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000358597-613108_188229.0658.3333333333334DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000358597-61316_99229.0658.3333333333334DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000361904-613108_188229.0475.0DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000361904-61316_99229.0475.0DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000395290-613108_188228.02504.3333333333335DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000395290-61316_99228.02504.3333333333335DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000395292-714108_188229.0579.6666666666666DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000395292-71416_99229.0579.6666666666666DomainRRM 1
HgeneCELF1chr11:47504247chr11:47739064ENST00000532048-916108_188255.0488.3333333333333DomainRRM 2
HgeneCELF1chr11:47504247chr11:47739064ENST00000532048-91616_99255.0488.3333333333333DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000310513-61416_99175.0596.6666666666666DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000358597-51316_99175.0658.3333333333334DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000361904-51316_99175.0475.0DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000395290-51316_99174.02504.3333333333335DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000395292-61416_99175.0579.6666666666666DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741637ENST00000532048-816108_188201.0488.3333333333333DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000532048-81616_99201.0488.3333333333333DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000310513-61416_99175.0596.6666666666666DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000358597-51316_99175.0658.3333333333334DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000361904-51316_99175.0475.0DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000395290-51316_99174.02504.3333333333335DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000395292-61416_99175.0579.6666666666666DomainRRM 1
HgeneCELF1chr11:47505004chr11:47741638ENST00000532048-816108_188201.0488.3333333333333DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000532048-81616_99201.0488.3333333333333DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000310513-61416_99175.0596.6666666666666DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000358597-51316_99175.0658.3333333333334DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000361904-51316_99175.0475.0DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000395290-51316_99174.02504.3333333333335DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000395292-61416_99175.0579.6666666666666DomainRRM 1
HgeneCELF1chr11:47505005chr11:47741638ENST00000532048-816108_188201.0488.3333333333333DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000532048-81616_99201.0488.3333333333333DomainRRM 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF1chr11:47504246chr11:47739064ENST00000310513-714287_308229.0596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000358597-613287_308229.0658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000361904-613287_308229.0475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000395290-613287_308228.02504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000395292-714287_308229.0579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000532048-916287_308255.0488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000310513-714287_308229.0596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000358597-613287_308229.0658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000361904-613287_308229.0475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000395290-613287_308228.02504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000395292-714287_308229.0579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504247chr11:47739064ENST00000532048-916287_308255.0488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000310513-614287_308175.0596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000358597-513287_308175.0658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000361904-513287_308175.0475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000395290-513287_308174.02504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000395292-614287_308175.0579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741637ENST00000532048-816287_308201.0488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000310513-614287_308175.0596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000358597-513287_308175.0658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000361904-513287_308175.0475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000395290-513287_308174.02504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000395292-614287_308175.0579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505004chr11:47741638ENST00000532048-816287_308201.0488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000310513-614287_308175.0596.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000358597-513287_308175.0658.3333333333334Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000361904-513287_308175.0475.0Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000395290-513287_308174.02504.3333333333335Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000395292-614287_308175.0579.6666666666666Compositional biasNote=Ser-rich
HgeneCELF1chr11:47505005chr11:47741638ENST00000532048-816287_308201.0488.3333333333333Compositional biasNote=Ser-rich
HgeneCELF1chr11:47504246chr11:47739064ENST00000310513-714401_479229.0596.6666666666666DomainRRM 3
HgeneCELF1chr11:47504246chr11:47739064ENST00000358597-613401_479229.0658.3333333333334DomainRRM 3
HgeneCELF1chr11:47504246chr11:47739064ENST00000361904-613401_479229.0475.0DomainRRM 3
HgeneCELF1chr11:47504246chr11:47739064ENST00000395290-613401_479228.02504.3333333333335DomainRRM 3
HgeneCELF1chr11:47504246chr11:47739064ENST00000395292-714401_479229.0579.6666666666666DomainRRM 3
HgeneCELF1chr11:47504246chr11:47739064ENST00000532048-916401_479255.0488.3333333333333DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000310513-714401_479229.0596.6666666666666DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000358597-613401_479229.0658.3333333333334DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000361904-613401_479229.0475.0DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000395290-613401_479228.02504.3333333333335DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000395292-714401_479229.0579.6666666666666DomainRRM 3
HgeneCELF1chr11:47504247chr11:47739064ENST00000532048-916401_479255.0488.3333333333333DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000310513-614108_188175.0596.6666666666666DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000310513-614401_479175.0596.6666666666666DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000358597-513108_188175.0658.3333333333334DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000358597-513401_479175.0658.3333333333334DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000361904-513108_188175.0475.0DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000361904-513401_479175.0475.0DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000395290-513108_188174.02504.3333333333335DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000395290-513401_479174.02504.3333333333335DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000395292-614108_188175.0579.6666666666666DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741637ENST00000395292-614401_479175.0579.6666666666666DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741637ENST00000532048-816401_479201.0488.3333333333333DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000310513-614108_188175.0596.6666666666666DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000310513-614401_479175.0596.6666666666666DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000358597-513108_188175.0658.3333333333334DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000358597-513401_479175.0658.3333333333334DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000361904-513108_188175.0475.0DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000361904-513401_479175.0475.0DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000395290-513108_188174.02504.3333333333335DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000395290-513401_479174.02504.3333333333335DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000395292-614108_188175.0579.6666666666666DomainRRM 2
HgeneCELF1chr11:47505004chr11:47741638ENST00000395292-614401_479175.0579.6666666666666DomainRRM 3
HgeneCELF1chr11:47505004chr11:47741638ENST00000532048-816401_479201.0488.3333333333333DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000310513-614108_188175.0596.6666666666666DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000310513-614401_479175.0596.6666666666666DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000358597-513108_188175.0658.3333333333334DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000358597-513401_479175.0658.3333333333334DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000361904-513108_188175.0475.0DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000361904-513401_479175.0475.0DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000395290-513108_188174.02504.3333333333335DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000395290-513401_479174.02504.3333333333335DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000395292-614108_188175.0579.6666666666666DomainRRM 2
HgeneCELF1chr11:47505005chr11:47741638ENST00000395292-614401_479175.0579.6666666666666DomainRRM 3
HgeneCELF1chr11:47505005chr11:47741638ENST00000532048-816401_479201.0488.3333333333333DomainRRM 3
TgeneFNBP4chr11:47504246chr11:47739064ENST000002637731517630_635987.66666666666661018.0Compositional biasNote=Poly-Glu
TgeneFNBP4chr11:47504246chr11:47739064ENST000002637731517701_731987.66666666666661018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47504246chr11:47739064ENST000002637731517905_925987.66666666666661018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47504247chr11:47739064ENST000002637731517630_635987.66666666666661018.0Compositional biasNote=Poly-Glu
TgeneFNBP4chr11:47504247chr11:47739064ENST000002637731517701_731987.66666666666661018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47504247chr11:47739064ENST000002637731517905_925987.66666666666661018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505004chr11:47741637ENST000002637731417630_635935.01018.0Compositional biasNote=Poly-Glu
TgeneFNBP4chr11:47505004chr11:47741637ENST000002637731417701_731935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505004chr11:47741637ENST000002637731417905_925935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505004chr11:47741638ENST000002637731417630_635935.01018.0Compositional biasNote=Poly-Glu
TgeneFNBP4chr11:47505004chr11:47741638ENST000002637731417701_731935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505004chr11:47741638ENST000002637731417905_925935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505005chr11:47741638ENST000002637731417630_635935.01018.0Compositional biasNote=Poly-Glu
TgeneFNBP4chr11:47505005chr11:47741638ENST000002637731417701_731935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47505005chr11:47741638ENST000002637731417905_925935.01018.0Compositional biasNote=Pro-rich
TgeneFNBP4chr11:47504246chr11:47739064ENST000002637731517214_248987.66666666666661018.0DomainWW 1
TgeneFNBP4chr11:47504246chr11:47739064ENST000002637731517595_629987.66666666666661018.0DomainWW 2
TgeneFNBP4chr11:47504247chr11:47739064ENST000002637731517214_248987.66666666666661018.0DomainWW 1
TgeneFNBP4chr11:47504247chr11:47739064ENST000002637731517595_629987.66666666666661018.0DomainWW 2
TgeneFNBP4chr11:47505004chr11:47741637ENST000002637731417214_248935.01018.0DomainWW 1
TgeneFNBP4chr11:47505004chr11:47741637ENST000002637731417595_629935.01018.0DomainWW 2
TgeneFNBP4chr11:47505004chr11:47741638ENST000002637731417214_248935.01018.0DomainWW 1
TgeneFNBP4chr11:47505004chr11:47741638ENST000002637731417595_629935.01018.0DomainWW 2
TgeneFNBP4chr11:47505005chr11:47741638ENST000002637731417214_248935.01018.0DomainWW 1
TgeneFNBP4chr11:47505005chr11:47741638ENST000002637731417595_629935.01018.0DomainWW 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>466_CELF1_47504247_FNBP4_47739064_ranked_0.pdbCELF14750500447504247ENST00000263773FNBP4chr1147739064-
MASEGESEVMAAFKLDFLPEMMVDHCSLNSSPVSKKMNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQN
PPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPD
GLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLAWHGRE
272


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CELF1_pLDDT.png
all structure
all structure
FNBP4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CELF1
FNBP4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CELF1-FNBP4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CELF1-FNBP4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource