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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CENPN-C16orf62

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CENPN-C16orf62
	FusionPDB ID: 15717
	FusionGDB2.0 ID: 15717
		Hgene	Tgene
	Gene symbol	CENPN	C16orf62
	Gene ID	55839	57020
	Gene name	centromere protein N	VPS35 endosomal protein sorting factor like
	Synonyms	BM039\|C16orf60\|CENP-N\|ICEN32	C16orf62
	Cytomap	16q23.2	16p12.3
	Type of gene	protein-coding	protein-coding
	Description	centromere protein Ninterphase centromere complex protein 32	VPS35 endosomal protein sorting factor-likeUPF0505 protein C16orf62esophageal cancer associated protein
	Modification date	20200313	20200313
	UniProtAcc	Q96H22	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000299572, ENST00000305850, ENST00000393335, ENST00000428963, ENST00000439957, ENST00000569461,	ENST00000538853, ENST00000544275, ENST00000251143, ENST00000417362, ENST00000438132, ENST00000448695, ENST00000542263, ENST00000543152,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	3 X 3 X 2=18	13 X 12 X 9=1404
	# samples	3	17
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(17/1404*10)=-3.04593628416686 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CENPN [Title/Abstract] AND C16orf62 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CENPN(81053881)-C16orf62(19644414), # samples:3
Anticipated loss of major functional domain due to fusion event.	CENPN-C16orf62 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CENPN-C16orf62 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CENPN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C16orf62 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5530-01A	CENPN	chr16	81053881	-	C16orf62	chr16	19644414	+
ChimerDB4	PRAD	TCGA-EJ-5530-01A	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+
ChimerDB4	PRAD	TCGA-EJ-5530	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000305850	CENPN	chr16	81053881	+	ENST00000438132	C16orf62	chr16	19644414	+	3307	1321	748	2658	636
ENST00000305850	CENPN	chr16	81053881	+	ENST00000542263	C16orf62	chr16	19644414	+	2792	1321	748	2580	610
ENST00000305850	CENPN	chr16	81053881	+	ENST00000417362	C16orf62	chr16	19644414	+	2792	1321	748	2580	610
ENST00000305850	CENPN	chr16	81053881	+	ENST00000251143	C16orf62	chr16	19644414	+	3303	1321	748	2658	636
ENST00000305850	CENPN	chr16	81053881	+	ENST00000543152	C16orf62	chr16	19644414	+	3309	1321	748	2658	636
ENST00000305850	CENPN	chr16	81053881	+	ENST00000448695	C16orf62	chr16	19644414	+	2867	1321	748	2658	636
ENST00000299572	CENPN	chr16	81053881	+	ENST00000438132	C16orf62	chr16	19644414	+	3253	1267	694	2604	636
ENST00000299572	CENPN	chr16	81053881	+	ENST00000542263	C16orf62	chr16	19644414	+	2738	1267	694	2526	610
ENST00000299572	CENPN	chr16	81053881	+	ENST00000417362	C16orf62	chr16	19644414	+	2738	1267	694	2526	610
ENST00000299572	CENPN	chr16	81053881	+	ENST00000251143	C16orf62	chr16	19644414	+	3249	1267	694	2604	636
ENST00000299572	CENPN	chr16	81053881	+	ENST00000543152	C16orf62	chr16	19644414	+	3255	1267	694	2604	636
ENST00000299572	CENPN	chr16	81053881	+	ENST00000448695	C16orf62	chr16	19644414	+	2813	1267	694	2604	636
ENST00000439957	CENPN	chr16	81053881	+	ENST00000438132	C16orf62	chr16	19644414	+	2538	552	39	1889	616
ENST00000439957	CENPN	chr16	81053881	+	ENST00000542263	C16orf62	chr16	19644414	+	2023	552	39	1811	590
ENST00000439957	CENPN	chr16	81053881	+	ENST00000417362	C16orf62	chr16	19644414	+	2023	552	39	1811	590
ENST00000439957	CENPN	chr16	81053881	+	ENST00000251143	C16orf62	chr16	19644414	+	2534	552	39	1889	616
ENST00000439957	CENPN	chr16	81053881	+	ENST00000543152	C16orf62	chr16	19644414	+	2540	552	39	1889	616
ENST00000439957	CENPN	chr16	81053881	+	ENST00000448695	C16orf62	chr16	19644414	+	2098	552	39	1889	616
ENST00000393335	CENPN	chr16	81053881	+	ENST00000438132	C16orf62	chr16	19644414	+	2591	605	32	1942	636
ENST00000393335	CENPN	chr16	81053881	+	ENST00000542263	C16orf62	chr16	19644414	+	2076	605	32	1864	610
ENST00000393335	CENPN	chr16	81053881	+	ENST00000417362	C16orf62	chr16	19644414	+	2076	605	32	1864	610
ENST00000393335	CENPN	chr16	81053881	+	ENST00000251143	C16orf62	chr16	19644414	+	2587	605	32	1942	636
ENST00000393335	CENPN	chr16	81053881	+	ENST00000543152	C16orf62	chr16	19644414	+	2593	605	32	1942	636
ENST00000393335	CENPN	chr16	81053881	+	ENST00000448695	C16orf62	chr16	19644414	+	2151	605	32	1942	636
ENST00000428963	CENPN	chr16	81053881	+	ENST00000438132	C16orf62	chr16	19644414	+	2561	575	2	1912	636
ENST00000428963	CENPN	chr16	81053881	+	ENST00000542263	C16orf62	chr16	19644414	+	2046	575	2	1834	610
ENST00000428963	CENPN	chr16	81053881	+	ENST00000417362	C16orf62	chr16	19644414	+	2046	575	2	1834	610
ENST00000428963	CENPN	chr16	81053881	+	ENST00000251143	C16orf62	chr16	19644414	+	2557	575	2	1912	636
ENST00000428963	CENPN	chr16	81053881	+	ENST00000543152	C16orf62	chr16	19644414	+	2563	575	2	1912	636
ENST00000428963	CENPN	chr16	81053881	+	ENST00000448695	C16orf62	chr16	19644414	+	2121	575	2	1912	636

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305850	ENST00000438132	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.008035818	0.9919642
ENST00000305850	ENST00000542263	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007154021	0.99284595
ENST00000305850	ENST00000417362	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007154021	0.99284595
ENST00000305850	ENST00000251143	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007877825	0.9921221
ENST00000305850	ENST00000543152	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.008041898	0.99195814
ENST00000305850	ENST00000448695	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.009310606	0.9906894
ENST00000299572	ENST00000438132	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007779038	0.99222094
ENST00000299572	ENST00000542263	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.006871912	0.99312806
ENST00000299572	ENST00000417362	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.006871912	0.99312806
ENST00000299572	ENST00000251143	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007624742	0.9923753
ENST00000299572	ENST00000543152	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.007793022	0.992207
ENST00000299572	ENST00000448695	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.008937368	0.99106264
ENST00000439957	ENST00000438132	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003955998	0.99604404
ENST00000439957	ENST00000542263	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003627151	0.9963728
ENST00000439957	ENST00000417362	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003627151	0.9963728
ENST00000439957	ENST00000251143	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003835232	0.9961648
ENST00000439957	ENST00000543152	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003960187	0.99603975
ENST00000439957	ENST00000448695	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.004116503	0.9958835
ENST00000393335	ENST00000438132	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003888072	0.9961119
ENST00000393335	ENST00000542263	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.002859333	0.99714065
ENST00000393335	ENST00000417362	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.002859333	0.99714065
ENST00000393335	ENST00000251143	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003772233	0.99622774
ENST00000393335	ENST00000543152	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003891228	0.9961087
ENST00000393335	ENST00000448695	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.004008707	0.9959913
ENST00000428963	ENST00000438132	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003581417	0.9964186
ENST00000428963	ENST00000542263	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.002551633	0.99744844
ENST00000428963	ENST00000417362	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.002551633	0.99744844
ENST00000428963	ENST00000251143	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003476537	0.99652344
ENST00000428963	ENST00000543152	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003586722	0.9964133
ENST00000428963	ENST00000448695	CENPN	chr16	81053881	+	C16orf62	chr16	19644414	+	0.003558866	0.99644107

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15717_15717_1_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000251143_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_2_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000417362_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_3_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000438132_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_4_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000448695_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_5_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000542263_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_6_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000299572_C16orf62_chr16_19644414_ENST00000543152_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_7_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000251143_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_8_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000417362_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_9_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000438132_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_10_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000448695_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_11_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000542263_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_12_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000305850_C16orf62_chr16_19644414_ENST00000543152_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_13_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000251143_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_14_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000417362_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_15_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000438132_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_16_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000448695_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_17_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000542263_length(amino acids)=610AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_18_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000393335_C16orf62_chr16_19644414_ENST00000543152_length(amino acids)=636AA_BP=191
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_19_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000251143_length(amino acids)=636AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_20_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000417362_length(amino acids)=610AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_21_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000438132_length(amino acids)=636AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_22_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000448695_length(amino acids)=636AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_23_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000542263_length(amino acids)=610AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIP
SLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLN
VIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLS

--------------------------------------------------------------

>15717_15717_24_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000428963_C16orf62_chr16_19644414_ENST00000543152_length(amino acids)=636AA_BP=191
LRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF
HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS
MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ
QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK
VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC
NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV
MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL

--------------------------------------------------------------

>15717_15717_25_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000251143_length(amino acids)=616AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAY
CFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFL
VRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQ

--------------------------------------------------------------

>15717_15717_26_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000417362_length(amino acids)=590AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIPSLAGIFTRLNLYLHSGQVAL
ANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTC
VLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLS

--------------------------------------------------------------

>15717_15717_27_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000438132_length(amino acids)=616AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAY
CFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFL
VRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQ

--------------------------------------------------------------

>15717_15717_28_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000448695_length(amino acids)=616AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAY
CFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFL
VRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQ

--------------------------------------------------------------

>15717_15717_29_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000542263_length(amino acids)=590AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHACVAYCFITIPSLAGIFTRLNLYLHSGQVAL
ANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTC
VLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLS

--------------------------------------------------------------

>15717_15717_30_CENPN-C16orf62_CENPN_chr16_81053881_ENST00000439957_C16orf62_chr16_19644414_ENST00000543152_length(amino acids)=616AA_BP=171
MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIICEDV
DLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQKREVNTVLA
DVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTM
HDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAY
CFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFFSTLLIVPDHPEHGVLFL
VRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:81053881/chr16:19644414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CENPN Q96H22	.
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269\|PubMed:16622419, ECO:0000269\|PubMed:16716197, ECO:0000269\|PubMed:18007590, ECO:0000269\|PubMed:19543270}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C16orf62

chr16:81053881

chr16:19644414

ENST00000251143

703_719

518.0

964.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C16orf62

chr16:81053881

chr16:19644414

ENST00000251143

53_71

518.0

964.0

Compositional bias

Note=Ser-rich

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1333_CENPN_81053881_C16orf62_19644414_1333_CENPN_81053881_C16orf62_19644414_ranked_0.pdb	CENPN	81053881	81053881	ENST00000448695	C16orf62	chr16	19644414	+	MRSETAGDVGRAKEMDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQF HQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSS MLRRNTPLLGQKREVNTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQ QEPTKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVESRSMFCNLEPVLVQLIHSVNRLAMETRK VMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLC NFFSTLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETV MAQILEHLKTLAKDEALKRQSSLGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRL	636

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CENPN_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CENPN
C16orf62

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CENPN-C16orf62

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CENPN-C16orf62

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source